Towards complete and error-free genome assemblies of all vertebrate speciesArticle Published on 2021-04-282022-10-04 Journal: Nature [Category] 유전자 메커니즘, [키워드] breakpoint canonical chromosome Complete complex develop disease duplications effort evaluate Evolutionary genetics GC-rich generate Genome genome assembly Genome assembly algorithms genomes Genomes Project Haplotype help include increases in independent International lineages molecular evolution protein-coding gene reference genome regions Regulatory repeated representing Research data sequence sequencing technology Vertebrate [DOI] 10.1038/s41586-021-03451-0 PMC 바로가기 [Article Type] Article
Evolutionary and genomic analysis of four SARS-CoV-2 isolates circulating in March 2020 in Sri Lanka; Additional evidence on multiple introduction and further transmissionShort Paper Published on 2021-03-162022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, SARS, [키워드] acute respiratory syndrome Asia Belgium circulating circulation Cluster collected conducted coronavirus coronavirus disease COVID-19 disease transmission England Epidemics epidemiological Epidemiological study Europe Evidence Evolution France Genetic genomic Genomic analysis Germany help highest India Italy Local Measures molecular Molecular epidemiology molecular evolution North America pandemic Patient Phylogenetic analysis Phylogeny positive patient provide reported SARS-CoV-2 SARS-CoV-2 isolate SARS-CoV-2 strain sequence South Africa Sri Lanka strain Transmission virus Wuhan, China [DOI] 10.1017/S0950268821000583 PMC 바로가기 [Article Type] Short Paper
Variable routes to genomic and host adaptation among coronavirusesArticle Published on 2021-03-102023-05-31 Journal: Journal of Evolutionary Biology [Category] 조류인플루엔자, [키워드] Coronaviruses Genomics molecular evolution role of selection in host switches Spike protein viral adaptation zoonoses [DOI] 10.1111/jeb.13771 PMC 바로가기
SARS-CoV-2 Variant of Concern 202012/01 Has about Twofold Replicative Advantage and Acquires Concerning MutationsSARS-CoV-2 우려 변종 202012/01은 약 2배의 복제 이점을 갖고 돌연변이와 관련하여 획득Article Published on 2021-03-012022-09-10 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] 20A.EU1 variant B.1.1.7 binding cleavage site collected concern country COVID-19 pandemic Denmark E484K Efficiency England Evolution expand fixation Genome Genome sequencing growth rate growth rates immune escape mutation immune escape mutations initiated L18F Lineage molecular molecular evolution MONITOR mutant Mutation Neutralizing antibodies polybasic Q677H receptor binding motif replicative reported S1/S2 boundary SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequenced spike L18F Spike protein Spread United Kingdom USA Vaccine VoC VOC-202012/01 [DOI] 10.3390/v13030392 PMC 바로가기 [Article Type] Article
COVID-19: molecular pathophysiology, genetic evolution and prospective therapeutics—a reviewCOVID-19: 분자 병태생리학, 유전적 진화 및 전향적 치료법—검토Review Published on 2021-02-082022-08-31 Journal: Archives of Microbiology [Category] 신약개발, 치료제, [키워드] Chloroquine clinical trial contagious continuous monitoring convalescent plasma treatment COVID-19 COVID-19 pandemic Dexamethasone disease drug Drug discovery Drug repositioning/repurposing drug target effective Evolution Favipiravir form Genetic genomic globe had no Hydroxychloroquine life-threatening Lopinavir Lopinavir-ritonavir medical emergency molecular molecular evolution Molecular targets mortality rate no effect pandemic pathophysiology Patient Phylogenetic analysis recent recent finding recent findings recording reduce mortality reducing Remdesivir Ribavarin ribavirin Ritonavir severe forms of COVID-19 shown Side effects specific treatment Spread therapeutic therapeutic option Treatment Trial Viral [DOI] 10.1007/s00203-021-02183-z PMC 바로가기 [Article Type] Review
Synonymous mutations and the molecular evolution of SARS-CoV-2 originsResearch Article Published on 2021-01-302022-10-28 Journal: Virus Evolution [Category] COVID-19, [키워드] 95% CI acute respiratory syndrome affected Amino acid Analysis average bats caused coronavirus driven by Evolution Genetic Human human SARS-CoV-2 Hypothesis increase in less Lineage majority molecular molecular evolution Mutation natural selection nonsynonymous mutation pandemic RaTG13 RBD Recombination RmYN02 SARS-CoV-2 similarity strain Strains Support synonymous synonymous mutations the RBD the receptor-binding domain the spike protein viral fitness virus [DOI] 10.1093/ve/veaa098 PMC 바로가기 [Article Type] Research Article
The D614G mutations in the SARS-CoV-2 spike protein: Implications for viral infectivity, disease severity and vaccine designSARS-CoV-2 스파이크 단백질의 D614G 돌연변이: 바이러스 감염성, 질병 중증도 및 백신 설계에 대한 의미Review Published on 2021-01-292022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, [키워드] Asia Characteristics Clinical outcome coronavirus D614G D614G mutation D614G variant disease severity dominant effort Europe Evidence Evolution Host immune response Infection molecular molecular evolution Mutation neutralising antibody pandemic Point mutation SARS-CoV-2 SARS-CoV-2 pandemic Sequencing spike Spike protein Spread the SARS-CoV-2 the spike protein USA Vaccine design viral infectivity virus virus spread [DOI] 10.1016/j.bbrc.2020.10.109 PMC 바로가기 [Article Type] Review
Potentially adaptive SARS-CoV-2 mutations discovered with novel spatiotemporal and explainable AI modelsResearch Published on 2020-12-232022-11-01 Journal: Genome Biology [Category] COVID-19, SARS, [키워드] adaptive adaptive mutation Algorithm Analysis build change contrary coronavirus COVID-19 COVID-19 pandemic dispersal drug expression Frequency functional Haplotype Helicase High-resolution Host hotspot identify implication information Local adaptation molecular molecular evolution Mutagenesis Mutation nsp13 Pandemics Positive selection Pro rapid expansion reduced Result RNA-dependent RNA polymerase robust SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 mutation sequence spatiotemporal spike glycoprotein Spread subsequent Surveillance These data tissue Transmission USA virus [DOI] 10.1186/s13059-020-02191-0 PMC 바로가기 [Article Type] Research
Stepwise evolution of Salmonella Typhimurium ST313 causing bloodstream infection in Africa아프리카에서 혈류 감염을 일으키는 살모넬라 타이피무리움 ST313의 단계적 진화Article Published on 2020-12-212024-08-19 Journal: Nature Microbiology [Category] 살모넬라증, [키워드] Computational biology and bioinformatics Genome informatics molecular evolution phylogenetics Phylogeny [DOI] 10.1038/s41564-020-00836-1 PMC 바로가기 [Article Type] Article
Parallel evolution in the emergence of highly pathogenic avian influenza A virusesArticle Published on 2020-11-022023-05-31 Journal: Nature Communications [Category] Fulltext, 조류인플루엔자, [키워드] Influenza virus molecular evolution phylogenetics viral evolution [DOI] 10.1038/s41467-020-19364-x PMC 바로가기 [Article Type] Article