Immunoreactivity of the SARS-CoV-2 entry proteins ACE-2 and TMPRSS-2 in murine models of hormonal manipulation, ageing, and cardiac injuryArticle Published on 2021-12-142022-10-29 Journal: Scientific Reports [Category] COVID-19, [키워드] ACE-2 addition age Alter analyzed angiotensin-converting enzyme 2 association Cardiology cardiovascular disease Cell clinical study contrary correlation COVID-19 disease Diseases explain expression female gonadal hormone immunology immunostaining independent indicate Injury kidney liver lower expression Lung alveoli lung tissue Medical research men mice Molecular medicine Mouse models murine model myocardial injury protease Protein protein expression regulated respiratory tract SARS-CoV-2 virus serine 2 Sex Sex difference Sex hormones sinusoids the SARS-CoV-2 transmembrane variety of tissue [DOI] 10.1038/s41598-021-03181-3 PMC 바로가기 [Article Type] Article
Amantadine inhibits known and novel ion channels encoded by SARS-CoV-2 in vitroArticle Published on 2021-12-012022-10-04 Journal: Communications Biology [Category] SARS, 신약개발, 치료제, [키워드] amantadine anti-influenza drug approved drugs binding block cellular clinical study conserved Coronaviruses COVID-19 COVID-19 patients COVID-19 treatment derivative Effect emodin evaluated expression identify in vitro indicated inhibit inhibitor ion channel blocker molecular molecular basis Molecular medicine NMR Oocyte ORF10 ORF7b pathophysiology SARS-CoV-2 suggested target Treatment viral infection Xanthene [DOI] 10.1038/s42003-021-02866-9 PMC 바로가기 [Article Type] Article
The JAK/STAT signaling pathway: from bench to clinicReview Article Published on 2021-11-262022-10-04 Journal: Signal Transduction and Targeted Therapy [Category] 바이오마커, 변종, 치료제, [키워드] Activation Autoimmune diseases Cancer cellular processes Critical Diseases dysregulation Evidence expression highlight Immunopathogenesis induce Inflammation inhibitor JAK/STAT JAK/STAT pathway JAK/STAT signaling janus knowledge Molecular biology Molecular medicine Regulation Signaling signaling pathway Transcription [DOI] 10.1038/s41392-021-00791-1 PMC 바로가기 [Article Type] Review Article
In silico evaluation of the interaction between ACE2 and SARS-CoV-2 Spike protein in a hyperglycemic environmentArticle Published on 2021-11-242022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] ACE2 ACE2 receptor Analysis approach computational analysis Computational biology and bioinformatics condition Contact decrease Diabetes Mellitus endocrinology entry routes evaluate human ACE2 human ACE2 receptor Hydrogen bond Interaction interactions lysine Molecular medicine outcome polar Protein reduced residue salt bridges SARS-CoV-2 significantly spike susceptible the Spike undergo van der Waal virus was performed X-ray crystallographic structure [DOI] 10.1038/s41598-021-02297-w PMC 바로가기 [Article Type] Article
Association between prognostic factors and the outcomes of patients infected with SARS-CoV-2 harboring multiple spike protein mutations다중 스파이크 단백질 돌연변이가 있는 SARS-CoV-2에 감염된 환자의 예후 인자와 결과 사이의 연관성Article Published on 2021-11-012022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] 95% CI age Anticoagulant anticoagulant therapy association clade Comorbidities conducted correlated COVID-19 COVID-19 patient COVID-19 patients Critical D614G mutation determined by diabetes disease Factor Factors followed by genomic Genomic surveillance Hospitalization hospitalized patient hospitalized patients host genetics hypertension Illumina Miseq infected with SARS-CoV-2 investigated Mild symptom mild symptoms moderate Molecular medicine Mortality Most patient Most patients Multivariate analysis Mutation mutations no symptom no symptoms outcome outcomes Patient patients with COVID-19 patients’ mortality Prognostic factor Prognostic factors reached recruited Risk factors S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants Sequencing significant difference significantly Spike protein steroid Surveillance Viral whole-genome sequencing [DOI] 10.1038/s41598-021-00459-4 PMC 바로가기 [Article Type] Article
Evaluation of a saliva molecular point of care for the detection of SARS-CoV-2 in ambulatory care외래 치료에서 SARS-COV-2의 검출을위한 타액 분자 관리 지점의 평가Article Published on 2021-10-262022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, [키워드] Antigen Care Community conducted cornerstone COVID-19 criteria Ct values Diagnosis evaluate facilitate False negative infected individuals Infectious diseases LAMP molecular Molecular medicine nasopharyngeal nasopharyngeal swabs participant point of care point-of-care test positive Prospective Study ranged Rapid reference tests registration number RNA RT-LAMP RT-PCR Saliva SARS-CoV-2 SARS-CoV-2 RNA detection SARS-CoV-2-infected individual SARS-CoV-2-infected individuals SARS-CoV2 sensitivity Sensitivity and specificity significantly lower subject tested Virology virus spread [DOI] 10.1038/s41598-021-00560-8 PMC 바로가기 [Article Type] Article
Prediction of severe adverse events, modes of action and drug treatments for COVID-19’s complicationsCOVID-19의 합병증에 대한 심각한 부작용, 작용 방식 및 약물 치료 예측Article Published on 2021-10-212022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 신약개발, 유전자 메커니즘, 임상, 치료제, [키워드] adverse events blood clot Blood clots category clinical manifestation clinical manifestations Comorbidity Complication complications Computational biology and bioinformatics Computational models COVID-19 patient COVID-19 phenotypes cytokine Cytokine storms disease drug Drug discovery Drug screening drug treatment drug treatments etiology FDA-approved drug FDA-approved drugs GWAS hallmark help Host human protein human proteins input Ligand machine learning mapped methodology molecular basis molecular feature molecular features molecular mechanism Molecular medicine neoplasm Neoplasms Neurological symptoms oncogenesis oncovirus Pathway analysis predict predicted prediction Prevalence Protein protein targets Respiratory failure resulting SARS-CoV-2 SARS-COV-2 infection severe adverse event severe adverse events Signs and symptoms subject Target identification treat Viral viral replication Virtual drug screening [DOI] 10.1038/s41598-021-00368-6 PMC 바로가기 [Article Type] Article
Increased serum catalytic iron may mediate tissue injury and death in patients with COVID-19증가 된 혈청 촉매 철분은 Covid-19 환자에서 조직 손상 및 사망을 매개 할 수 있습니다.Article Published on 2021-10-042022-09-10 Journal: Scientific Reports [Category] MERS, SARS, 바이오마커, 임상, 치료기술, [키워드] 95% CI active form Adult patients adverse outcome adverse outcomes age age and gender Analysis association baseline levels Biomarkers catalytic Clinical diagnosis Composite COVID-19 cross-sectional death determine disease disease severity enrolled examined Factor ferritin ferritin level ferritin levels hepcidin in-hospital mortality Increased Infectious diseases iron iron chelation Iron metabolism joint kidney males mechanical ventilation median age metabolism Molecular biology Molecular medicine occurred outcome parameter Pathogenesis pathophysiologic pathophysiology pathway Patient patients patients hospitalized patients with COVID-19 Previous studies previous study Primary outcome Prognostic markers raising replacement therapy serum significantly therapy tissue injury Transferrin Ventilation was done [DOI] 10.1038/s41598-021-99142-x PMC 바로가기 [Article Type] Article
Viral S protein histochemistry reveals few potential SARS-CoV-2 entry sites in human ocular tissuesArticle Published on 2021-09-272022-10-29 Journal: Scientific Reports [Category] COVID-19, SARS, [키워드] ACE2 addition antibodies binding antibody auxiliary Cell Certain disease ciliary clinical evidence determine Epitopes examined expression Factor immunohistochemistry immunoreactivity increase in infect Infection infection with SARS-CoV-2 Inflammation investigated iris stroma lid low expression lung tissue margin Molecular medicine ocular performed positive positive controls Potential protein expression reported Retina reveal risk RNA RNA expression RNA sequencing RPE S protein SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2 receptor specimen staining supported tissue tissue sample tissues TMPRSS2 TMPRSS2 expression viral entry viral S protein was used were used while [DOI] 10.1038/s41598-021-98709-y PMC 바로가기 [Article Type] Article
First report of Borrelia burgdorferi sensu stricto detection in a commune genospecies in Apodemus agrarius in Gwangju, South KoreaArticle Published on 2021-09-142023-05-31 Journal: Scientific Reports [Category] Fulltext, 조류인플루엔자, [키워드] Diseases Microbiology Molecular medicine [DOI] 10.1038/s41598-021-97411-3 PMC 바로가기 [Article Type] Article