mononuclear cell – Page 8 – Communicable Diseases Research

Differential Co-Expression Network Analysis Reveals Key Hub-High Traffic Genes as Potential Therapeutic Targets for COVID-19 Pandemic

차등 공동 발현 네트워크 분석, 코로나19 팬데믹에 대한 잠재적인 치료 표적으로 핵심 허브-높은 트래픽 유전자 밝혀

Immunology

Published on 2021-12-152022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘,

Transcriptomic Profiles Reveal Downregulation of Low-Density Lipoprotein Particle Receptor Pathway Activity in Patients Surviving Severe COVID-19

심각한 COVID-19에서 생존한 환자의 저밀도 지단백질 입자 수용체 경로 활동의 하향 조절을 나타내는 전사체 프로필

Article

Published on 2021-12-102022-09-11
Journal: Cells [Category] SARS, 유전자 메커니즘,

[키워드] activity AnxA2 applied approach bioinformatics Biology cargo receptor activity CD36 characterized cholesterol cholesterol homeostasis COVID-19 COVID-19 infection died disease downregulation Endpoint expression Gene expression profiling generate GO ontology Infection intensive care unit ITGAV LDL LDL particle receptor activity leukocyte leukocyte differentiation lipoprotein low-density Low-density lipoprotein mononuclear cell mononuclear cells nonsurvivor nonsurvivors Particle pathway Patient patients who survived patients with COVID-19 patients with SARS-CoV-2 PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells PPARG profile Prognosis receptor reduced RNA-seq analysis Russia SARS-COV-2 infection severe COVID-19 STAB1 state surviving patient survivor transcriptional transcriptional response Transcriptome university virus
[DOI] 10.3390/cells10123495 PMC 바로가기 [Article Type] Article

Overlapping but Disparate Inflammatory and Immunosuppressive Responses to SARS-CoV-2 and Bacterial Sepsis: An Immunological Time Course Analysis

Observational Study

Published on 2021-12-092022-10-04
Journal: Frontiers in Immunology [Category] SARS, 임상,

[키워드] addition Admission Analysis Bacterial sepsis Cell cellular circulating Clinical outcome clinical outcomes Cohort Course COVID patient Critically ill patient dyscrasia elevated ELISPOT enzyme-linked immunospot assay etiology Ex vivo exhibited expression functional healthy control HLA-DR hospitalized patient IFN-gamma immune immune response Immune suppression immunological Immunosuppression incidence Infection Inflammation Inflammatory marker initial less leukocyte MDSC mononuclear cell organ dysfunction patients physiologic derangement plasma biomarker reduced response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient secondary bacterial infection Secondary infection secondary infections severe SARS-CoV-2 significantly higher subjects suffered suppressed time TNF-alpha
[DOI] 10.3389/fimmu.2021.792448 PMC 바로가기 [Article Type] Observational Study

Sex differences in innate anti-viral immune responses to respiratory viruses and in their clinical outcomes in a birth cohort study

Article

Published on 2021-12-092022-10-04
Journal: Scientific Reports [Category] SARS, 치료제,

Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients

Azvudine은 COVID-19 환자 치료에 효과적인 흉선 유도 항 SARS-CoV-2 약물입니다.

Article

Published on 2021-12-062022-09-10
Journal: Signal Transduction and Targeted Therapy [Category] Fulltext, SARS, 임상, 치료법, 치료제,

[키워드] (RdRp) active form agent anti-SARS-CoV-2 Anti-SARS-CoV-2 Activity Azvudine cells chest X-ray clinical trial compassionate use coronavirus COVID-19 COVID-19 patients cured Dizziness Drug development effective followed by Ground-glass opacities ground-glass opacity HCoV HCoV-OC43 HIV-1 hospital discharge rate Immunity Infectious diseases Inflammation inhibit inhibited lymphocyte mononuclear cell mononuclear cells monophosphate nausea Negative conversion nucleoside oral administration organ damage patients PBMC Peripheral blood Peripheral blood mononuclear cells phase profiles promoted promotion Randomized RATs RdRP reduced rhesus macaque rhesus macaques Ribonucleic acid RNA polymerase RNA-dependent RNA polymerase SARS-CoV-2 selective Sequencing Side-effect single-arm suggested thymus treating treating COVID-19 patient Trial triphosphate Viral Viral load viral ribonucleic acid virus viruses
[DOI] 10.1038/s41392-021-00835-6 PMC 바로가기 [Article Type] Article

Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium

중증 COVID-19 환자의 비갑상선 질환 증후군(NTIS): Na/K 펌프 유전자 발현 및 가수전해 평형에 대한 T3의 역할

Research

Published on 2021-12-032022-09-10
Journal: Journal of Translational Medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

[키워드] acute phase addition administration Admission affected Analysis analyzed benefit Bioelectrical Impedance Analysis Bioelectrical Impedance Analysis, BIA Body body composition coding Combination condition conditions correlated correlation Course COVID-19 COVID-19 patient COVID-19 patients Critical Critically ill demonstrated develop disease dose-dependent manner Effect Endpoint evaluate evaluated exhibited expression extracellular water fraction functional Gene Expression highest hormone Hospitalized Hydration Hypothyroid ICU illness illnesses increase in Indicator intensive care intensive care unit intracellular water inverse correlation involved isoform lowest mammals mass mechanism mononuclear cell mRNA mRNA expression myxedema Na⁺/K⁺ pump gene nonthyroidal illness syndrome Nonthyroidal Illness Syndrome, NTIS occur outpatients parameter Pathogenesis Patient patients PBMC performed Peripheral blood Peripheral blood mononuclear cells Potassium pump reduction retrieved Rome salt serum severe COVID-19 severity similarity sodium Sodium/potassium exchangeable ratio stimulate syndrome the disease the patient these cell These cells Thyroid Thyroid diseases thyroid function thyroid hormone Thyroid hormones Total total body total body water Transcriptome transcriptome analysis treated Treatment trials university water
[DOI] 10.1186/s12967-021-03163-z PMC 바로가기 [Article Type] Research

Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder

Research article

Published on 2021-12-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘,

COVID-19 Specific Immune Markers Revealed by Single Cell Phenotypic Profiling

Article

Published on 2021-11-292022-10-28
Journal: Biomedicines [Category] COVID-19,

[키워드] acute respiratory syndrome Affect alteration caused Cell cell receptors characterized clinical outcomes complex coronavirus correlated COVID-19 COVID-19 patients CXCR4 defined Diagnosis Disease progression Effect exhibited expressed expression flow cytometry healthy blood donor heterogeneity highlight IFNGR1 immune Immune cell immune cells immune functions immune response increase in infected with SARS-CoV-2 inflammatory process less mononuclear cell patients with COVID-19 PBMCs performed Peripheral blood Profiling respiratory tract Revealed SARS-CoV-2 signaling pathway Single-cell RNA sequencing Specific subjects subset surface marker surface markers transcript viral infection was reduced
[DOI] 10.3390/biomedicines9121794 PMC 바로가기 [Article Type] Article

Clonal Hematopoiesis of Indeterminate Potential Is Associated with Increased Age-Independent Morbidity and Mortality in Patients with COVID-19- the Beyond DNA COVID-19 Project

Conference abstract

Published on 2021-11-242022-10-05
Journal: Blood [Category] 변종,

[키워드] accounted affected age age and sex allele approved assays association ASXL1 ATAC-seq baseline Blood blueprint carried ChIP clinically collected common Comorbidities comparable Coverage COVID-19 COVID-19 diagnosis COVID-19 disease severity COVID-19 patient CRP CRS cytokine cytokine levels Cytokine release syndrome Cytokines database death defined described Detection limit DNA download elevated ELISA assay entire cohort figure Fisher Follow-up funding Genes grade 3 group had more hazard healthy individual Hematopoiesis Hospitalization hypoxemic hypoxic respiratory failure identify IL6 Increased increased mortality indeterminate indicated individuals Infection Inflammation Inflammatory inflammatory cascade Inflammatory marker IRB male Mayo Clinic MCP-1 median median age mononuclear cell morbidity Mortality MPL Mutation mutations neutropenia no difference observé Older pathophysiology Patient patients patients with COVID-19 PBMC Peripheral blood Potential proteomic study reached regression models remained Research resolved Respiratory failure RNA scale Sequencing severe disease severity Sex SF3B1 Single Cell ssDNA subsequent survival survival analysis TET2 the Kaplan-Meier method the WHO TNF-a TP53 two groups variables variant was performed WHO Wilcoxon rank sum with COVID-19
[DOI] 10.1182/blood-2021-151548 [Article Type] Conference abstract

SARS-CoV-2 Spike Protein-Induced Interleukin 6 Signaling Is Blocked by a Plant-Produced Anti-Interleukin 6 Receptor Monoclonal Antibody

Article

Published on 2021-11-202022-10-28
Journal: Vaccines [Category] COVID-19,

[키워드] acute respiratory distress acute respiratory syndrome anti-IL-6 receptor anti-IL-6R caused coronavirus COVID-19 COVID-19 pandemic COVID-19 patients cytokine signaling Cytokine storm death Efficacy examined expressed feasibility homogeneity IL-6 IL-6 receptor (IL-6R) IL-6 signaling IL-6R in vitro model inhibit interleukin 6 interleukin 6 (IL-6) mAb monoclonal antibody monoclonal antibody (mAb) mononuclear cell Nicotiana benthamiana Peripheral blood plant plant-made antibody plant-made therapeutics producing Proinflammatory cytokine purification reducing sarilumab SARS-CoV-2 SARS-COV-2 infection shown spike spike protein (S) suppressed syndrome the spike protein utility
[DOI] 10.3390/vaccines9111365 PMC 바로가기 [Article Type] Article