Combination of a Sindbis-SARS-CoV-2 Spike Vaccine and αOX40 Antibody Elicits Protective Immunity Against SARS-CoV-2 Induced Disease and Potentiates Long-Term SARS-CoV-2-Specific Humoral and T-Cell Immunitysindbis-sars-cov-2 스파이크 백신과 αOX40 항체의 조합은 SARS-COV-2 유도 질환에 대한 보호 면역을 유도하고 장기 SARS-COV-2- 특이 적 유머 및 T- 세포 면역을 강화시킨다.Immunology Published on 2021-07-292022-08-31 Journal: Frontiers in Immunology [Category] SARS, 바이오마커, 변종, 진단, [키워드] αOX40 activated T cells Against alphavirus vaccine Analysis antibody approach can be used caused cellular coronavirus coronavirus SARS-CoV-2 COVID-19 pandemic COVID19 develop dose effective effective vaccine effector memory effort elicit elicited expressing functions generate hACE2 human ACE2 receptor immune protection immune response immunization immunize Immunophenotyping immunostimulatory induced Infection infection assay inhibit long-lasting neutralizing antibodies long-lasting neutralizing antibody lung tissue mice MOST mounted Neutralizing antibodies OX40 Pathogens platform profiles protective immunity Protein binding provided reprogramming RNA robust SARS-CoV-2 SARS-CoV-2 immunity SARS-CoV-2 spike protein SARS-CoV-2 vaccine sera Sindbis virus vaccine spike Spike protein synergistic combination SARS-CoV-2 vaccine strategy T cell T cells T-cell Response T-cell responses the SARS-CoV-2 the vaccine Transcriptome transgenic mice Vaccine vaccine platform variant variants [DOI] 10.3389/fimmu.2021.719077 PMC 바로가기 [Article Type] Immunology
SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescenceSARS-COV-2- 특이 적 순환 T 여포 헬퍼 세포는 중화 항체와 관련이 있으며 조기 회복기 동안 증가합니다.Research Article Published on 2021-07-162022-08-13 Journal: PLoS Pathogens [Category] Biochemistry, SARS, 진단, 치료기술, 치료법, [키워드] addition Antibody neutralization Antigen approved assist Blood caused CD4 T cells CD4 T-cell Cell circulating contribute convalescence convalescent convalescent individuals coronavirus disease Coronavirus disease 2019 correlated correlation COVID-19 CXCR5 declined defined detectable examined follicular Frequency generate greater helper cells helping immune response immune responses individual Infection M protein magnitude majority median morbidity and mortality mounted N protein Neutralizing antibodies neutralizing antibody neutralizing antibody responses pandemic PD1 post-symptom onset PROTECT Protein response responses responses against robust S protein SARS-CoV-2 SARS-COV-2 infection specificity Spike protein structural protein structural proteins subset symptom onset T cells T cells) T follicular helper cells T-cell immunity T-cell Response T-cell responses Tfh the spike protein the strongest These cells These data Vaccine [DOI] 10.1371/journal.ppat.1009761 PMC 바로가기 [Article Type] Research Article
Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients신장 이식 환자에서 SARS-CoV-2 BNT162b2(토지나메란) 프라임-부스트 백신 접종 후 체액 및 세포 면역 손상Article Published on 2021-07-152022-09-12 Journal: The Journal of Clinical Investigation [Category] SARS, 진단, [키워드] accompanied Adaptive immunity Affect age analyzed antibody approach BNT162b2 booster caused CD4+ CD8+ T cell cellular immunity cellular response change combating Control COVID-19 cytokine production dialysis dose Frequency global pandemic healthy healthy control Hemodialysis humoral IgA IgG immune immunization immunology immunosuppressed patients Immunosuppressive medication Impaired impairment individual kidney transplant recipient less majority memory mounted mRNA-based vaccine novel organ transplantation Patient patients powerful tool promotion reduced rejection renal response responses risk SARS-CoV-2 SARS-CoV-2 BNT162b2 second vaccination Seroconversion severe COVID-19 significantly Still T cells T helper cell transplantation undetectable vaccination Vaccine-induced immunity vaccinee [DOI] 10.1172/JCI150175 PMC 바로가기 [Article Type] Article
Sex Differences in Lung Imaging and SARS-CoV-2 Antibody Responses in a COVID-19 Golden Syrian Hamster ModelCOVID-19 골든 시리아 햄스터 모델에서 폐 영상 및 SARS-CoV-2 항체 반응의 성별 차이Research Article Published on 2021-07-132022-09-10 Journal: mBio [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Alter animal animal model animal models body mass cause caused causes Chest computed tomography comparable Computed tomography concentrations coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 Culture cytokine deaths difference dose estradiol euthanized female females greater hamster Hospitalization hospitalizations human population IFN-β IgA response IgA responses IgG IgG antibodies IgG antibody IgM imaging Infection Infectious virus infective Infective dose inoculated interferon intranasally Lungs male Model morbidity Mortality mounted mutant nasal turbinates outcome pandemic Pathogenesis pathogenesis of SARS-CoV-2 plasma Pneumonia pulmonary damage RBDs Receptor-binding domain reported respiratory respiratory tissues response S-RBD SARS-CoV-2 SARS-CoV-2 variants severe acute respiratory syndrome Coronavirus Sex difference sex differences significantly Spike protein TCID the receptor-binding domain the spike protein tissue tissue culture TNF-α Trachea Tumor tumor necrosis tumor necrosis factor tumor necrosis factor-α virus virus titers virus-neutralizing antibodies virus-neutralizing antibody [DOI] 10.1128/mBio.00974-21 PMC 바로가기 [Article Type] Research Article
Review of Early Immune Response to SARS-CoV-2 Vaccination Among Patients With CKDClinical Research Published on 2021-07-062022-10-29 Journal: Kidney International Reports [Category] COVID-19, [키워드] Abstract acute respiratory syndrome adverse effect antibody Autoimmune disease cellular immunity cellular response Chronic kidney disease CKD Clinical practice control group coronavirus Coronavirus-2 COVID COVID-19 de novo detectable dialysis dose Effect Effectiveness Efficacy enrolled evaluate Follow-up humoral immune responses Immunity Kidney disease kidney transplant measure mounted mRNA vaccine pandemic participant Patient platform populations public health receiving recipient recipients rejection reported response review Sample size SARS-CoV-2 SARS-CoV-2 vaccination Surveillance Transplant vaccination Vaccine [DOI] 10.1016/j.ekir.2021.06.027 PMC 바로가기 [Article Type] Clinical Research
A Summary of the SARS-CoV-2 Vaccines and Technologies Available or under DevelopmentReview Published on 2021-06-222022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] age clinical trial clinical trials country COVID-19 COVID-19 pandemic develop development DNA vaccines dosage Effect effective Factor humans immune response inactivated viruses include initiated Live attenuated vaccines Messenger RNA Modification mounted mRNA mutated variant mutated variants outcomes parameters Phase 3 Protein protocol researcher SARS-CoV-2 Seven Side effects storage conditions subunits technology the SARS-CoV-2 Vaccine vaccinee Vaccines vectors viral-like particles [DOI] 10.3390/pathogens10070788 PMC 바로가기 [Article Type] Review
Risk communication and community engagement strategies for COVID-19 in 13 African countriesReview Published on 2021-05-192022-10-31 Journal: Health Promotion Perspectives [Category] COVID-19, [키워드] activity Africa African Algeria Angola approach Community Community engagement conducted coronavirus Coronavirus disease 2019 country COVID-19 develop Evidence Government Health Organization health system include information Intervention Kenya Mauritius MOST mounted National Nigeria outbreak pandemic peer-reviewed public health reported response responses risk Risk communication South Africa Spread Transmission Uganda [DOI] 10.34172/hpp.2021.18 PMC 바로가기 [Article Type] Review
Detection of SARS-CoV-2 antibodies in pediatric kidney transplant patientsResearch Article Published on 2021-04-072022-10-28 Journal: BMC Nephrology [Category] COVID-19, [키워드] antibody Asymptomatic Blood children commercial immunoassay detection Follow-up follow-up time humoral immune response IgG IgG antibody immunosuppressants implication IQR kidney transplant majority median mild symptoms mounted nucleocapsid one patient outpatient clinic Patient pediatric positive positive PCR test positive result positive SARS-CoV-2 PCR positive serology post infection Protein recipient Result SARS-CoV-2 SARS-CoV-2 antibody SARS-CoV-2 IgG antibody SARS-COV-2 infection SARS-CoV-2 spike protein screened serological serology test subsequent symptomatic tested vaccination efficacy [DOI] 10.1186/s12882-021-02325-x PMC 바로가기 [Article Type] Research Article
Cross-reactive antibody against human coronavirus OC43 spike protein correlates with disease severity in COVID-19 patients: a retrospective study인간 코로나바이러스 OC43 스파이크 단백질에 대한 교차 반응성 항체는 COVID-19 환자의 질병 중증도와 상관관계가 있습니다: 후향적 연구Research Article Published on 2021-04-022022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술, [키워드] age antibody Antibody titre antigenic change collected correlated correlation correlations COVID-19 COVID-19 pathogenesis COVID-19 patients cross-reactive antibody cross-reactivity detectable disease severity evaluated HCoV HCoV-229E HCoV-NL63 HCoV-OC43 HCoV-OC43 spike HCoVs healthy control healthy controls HKU1 human coronavirus human coronavirus OC43 human populations humoral Humoral response IgG IgG antibody mechanical ventilation mild patient mild patients mounted Neutralizing antibodies NL63 OC43 Pathogenesis Patient plasma sample plasma samples positive Protein PSO Retrospective study S protein SARS-CoV-2 seasonal severe disease severity significant increase significantly higher Spike protein Spike proteins Spread symptom onset tested the disease titre [DOI] 10.1080/22221751.2021.1905488 PMC 바로가기 [Article Type] Research Article
Assessing visible aerosol generation during vitrectomy in the era of Covid-19Covid-19 시대의 유리체 절제술 중 가시적인 에어로졸 생성 평가Article Published on 2021-04-012022-09-11 Journal: Eye (London, England) [Category] MERS, SARS, 치료제, [키워드] aerosol Aerosol generation anterior chamber Assessing Cadaveric cannula cannulas competent condition droplet droplets Evidence evidence of following mounted no evidence of opening physical produced recorded was performed was used [DOI] 10.1038/s41433-020-1052-4 PMC 바로가기 [Article Type] Article