mouse – Page 8 – Communicable Diseases Research

Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

Research Letter

Published on 2021-12-012022-10-31
Journal: Emerging Infectious Diseases [Category] COVID-19, SARS,

The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

alpha/B.1.1.7 SARS-CoV-2 변이체는 ACE-2에 대해 훨씬 더 높은 친화성을 나타내며 K18-hACE2 마우스에서 질병을 유발하기 위해 더 낮은 접종 용량이 필요합니다

Research Article

Published on 2021-11-252022-09-10
Journal: eLife [Category] MERS, SARS, 변종, 진단,

[키워드] a minor ACE-2 affinity Alpha angiotensin angiotensin-converting enzyme-2 anti-RBD Antibody neutralization asparagine B.1.1.7 B.1.1.7 variant convalescent individual convalescent individuals COVID-19 case disease Disease progression domination dose driven by elevated enzyme Epidemiology European exhibit faster functional hACE2 Human human Angiotensin-converting enzyme immunology incidence Infection K18-hACE2 mice low dose mice minor monoclonal antibodies mouse mouse model N501Y other variant other variants RBD Receptor-binding domain residue responsible SARS-CoV-2 SARS-CoV-2 lineage SARS-CoV-2 variant sera severity significantly higher Strains the receptor-binding domain transgenic transmission rate transmitted tyrosine United Kingdom variant Winter
[DOI] 10.7554/eLife.70002 PMC 바로가기 [Article Type] Research Article

The N-Terminal Region of Middle East Respiratory Syndrome Coronavirus Accessory Protein 8b Is Essential for Enhanced Virulence of an Attenuated Murine Coronavirus

Pathogenesis and Immunity

Published on 2021-11-242022-10-30
Journal: Journal of Virology [Category] COVID-19, MERS,

[키워드] Accessory accessory protein accessory protein 8b accessory proteins addition Affect antiviral immune response beta coronavirus C-terminal contribute coronavirus CoV CoVs demonstrated ENCODE Endoplasmic reticulum ENhance enhanced Essential expressing FIVE Genome global public health Hepatitis high variability Host IFN-I in vitro in vivo infected cells inhibit inhibitory effect innate immune response Innate immunity interfere introduced membrane MERS-CoV MERS-CoV infection methionine MHV mice Middle East mouse mouse hepatitis virus Multiple murine N-terminal domain not affect ORF8b Pathogenesis Protein protein 3 Region regulate renal Replication respiratory respiratory syndrome coronavirus responsible RNA-seq analysis SARS-CoV SARS-CoV-2 severe pneumonia severe respiratory infection shown significantly threat type I interferon variant viral replication Viral virulence virulence virus
[DOI] 10.1128/JVI.01842-21 PMC 바로가기 [Article Type] Pathogenesis and Immunity

Inhibition of Autophagy Suppresses SARS-CoV-2 Replication and Ameliorates Pneumonia in hACE2 Transgenic Mice and Xenografted Human Lung Tissues

자가포식 억제는 SARS-CoV-2 복제를 억제하고 hACE2 형질전환 마우스 및 이종이식 인간 폐 조직에서 폐렴을 개선합니다

Article

Published on 2021-11-232022-09-11
Journal: Journal of Virology [Category] SARS, 유전자 메커니즘,

[키워드] 3-MA accompanied Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin animal model animal models anti-SARS-CoV-2 therapeutics Atg13 ATG14 Atg5 autophagic autophagy autophagy-inhibiting agent autophagy-inhibiting agents block caused Combination complex complexes contribute coronavirus Crab-eating macaque Critical elements enzyme events experimental evidence global pandemic hACE2 Huh-7 cells Human human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 human lung human lung tissue IMPROVE in vitro in vivo induce Infection inhibit inhibition insight interfere involved mechanism mice modulation mouse mTOR pathway Pneumonia potential therapeutic target potential therapeutic targets SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 suppresse therapeutic agent therapeutic agents thought tissues transgenic mice Transgenic mouse Vero E6 virus infection Virus-host interaction Virus-host interactions Vps34
[DOI] 10.1128/JVI.01537-21 PMC 바로가기 [Article Type] Article

A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

Article

Published on 2021-11-162023-06-08
Journal: eLife [Category] 신종인플루엔자,

[키워드] Cell-mediated immunity cross-protection hemagglutinin stalk mouse superantigen
[DOI] 10.7554/eLife.71725 PMC 바로가기

Susceptibility of Dog, Hamster, and Mouse Cells to the Replication-Competent Adenovirus 11p E1/E3 Green Fluorescence Protein Vector Has Implications for the Selection of Animal Vaccine Models

Microbiology

Published on 2021-10-272022-10-31
Journal: Frontiers in Microbiology [Category] COVID-19,

[키워드] Ad5 Adenovirus animal animal cells animal model Antigen can be used candidate CD46 Cell cell line cell lines cellular receptor CHO cells Critical cytotoxicity DNA replication dog dose E1/E3 vector Efficacy Express expressed expression Fluorescence generate GFP GFP expression green hamster host cell Human in vitro experiments infect infecting Infection manifested MDCK cells Model mouse not express Protein qPCR assay RCAd11pGFP SARS-CoV-2 vaccine Selection specificity susceptibility the vaccine Trial undetectable Vaccine Vaccines vector viral DNA virus virus infection virus particle
[DOI] 10.3389/fmicb.2021.698999 PMC 바로가기 [Article Type] Microbiology

Isolation and Characterization of Mouse Monoclonal Antibodies That Neutralize SARS-CoV-2 and Its Variants of Concern Alpha, Beta, Gamma and Delta by Binding Conformational Epitopes of Glycosylated RBD With High Potency

Immunology

Published on 2021-10-262022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, SARS,

[키워드] B.1.1.7 B.1.167.2 B.1.351 Beta binding efficiency Blot Cell characterization characterized concern conformational contribute convalescent sera COVID-19 Delta Delta VOC Diagnosis Efficacy epitope epitopes expression Escherichia coli expressed flow cytometry full-length spike protein functional Gamma glycosylated HEK293T cell immunoprecipitation inhibit initial lentivirus mAb mAbs majority mammalian mice immunization monoclonal antibody mouse Mutation NAb neutralization Neutralizing activity neutralizing antibody neutralizing monoclonal antibodies P.1 Pathogenesis plaque-reduction neutralization test potency produced Protein pseudotyped RBD reduction reference sequence response rRBD SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 spike glycoprotein SARS-CoV-2 variant SARS-CoV-2 variants Spike protein suggested supernatant the RBD the SARS-CoV-2 therapy transmembrane Vaccine variants of concern VoC Wuhan
[DOI] 10.3389/fimmu.2021.750386 PMC 바로가기 [Article Type] Immunology

Deep Learning-Based Real-Time AI Virtual Mouse System Using Computer Vision to Avoid COVID-19 Spread

COVID-19 확산 방지를 위해 컴퓨터 비전을 사용하는 딥 러닝 기반 실시간 AI 가상 마우스 시스템

Research Article

Published on 2021-10-252022-09-10
Journal: Journal of Healthcare Engineering [Category] MERS, SARS, 치료기술,

[키워드] Algorithm battery Bluetooth computer computer vision COVID-19 deep deep learning dependency dongle eliminating functions hands Intervention mouse overcome physical power Spread System vision webcam
[DOI] 10.1155/2021/8133076 PMC 바로가기 [Article Type] Research Article

Emerging SARS-CoV-2 variants expand species tropism to murines

Research Paper

Published on 2021-10-212023-06-17
Journal: EBioMedicine [Category] MERS, SARS,

[키워드] mouse murine N501Y RAT SARS-CoV-2 variants susceptibility
[DOI] 10.1016/j.ebiom.2021.103643 PMC 바로가기 [Article Type] Research Paper

Linking functional and molecular mechanisms of host resilience to malaria infection

말라리아 감염에 대한 숙주 회복력의 기능적 및 분자적 메커니즘 연결

Article

Published on 2021-10-122024-08-08
Journal: eLife [Category] 말라리아,

[키워드] Bayesian hierarchical model Innate immunity malaria mouse Plasmodium chabaudi within-host model
[DOI] 10.7554/eLife.65846 PMC 바로가기