Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans
Research Article
[키워드] acute respiratory syndrome
affected
analyzed
Antigen
approach
Atlanta
Bacterial
coronavirus
Coronavirus disease 2019
correlated
COVID-19
COVID-19 patient
COVID-19 patients
COVID-19 severity
disease
disease severity
expression
flow cytometry
healthy individual
healthy individuals
HLA-DR
Hong Kong
hospitalized COVID-19 patient
Human
Human immune system
human immunity
IFN-stimulated genes
IFN-α
Immune cell
immune modulation
immune response
immune system
Immunity
immunotype
Infection
Inflammatory
influence
information
Interferon-α
knowledge
lack
leukocyte
mammalian
mechanism
Mild
mononuclear cell
myeloid cell
parameters
Patient
PBMC
PBMCs
performed
Peripheral blood
plasma
plasmacytoid dendritic cells
potential therapeutic target
Proinflammatory cytokine
Rapamycin
reduced
respond
response
SARS-CoV-2
Science
severe COVID-19
Severe COVID-19 Infection
Signaling
Single-cell transcriptomics
System
Systems biology
therapeutic interventions
TNFSF14
transcriptomics
transient expression
type I IFNs
United States
with COVID-19
[DOI] 10.1126/science.abc6261 PMC 바로가기 [Article Type] Research Article
[DOI] 10.1126/science.abc6261 PMC 바로가기 [Article Type] Research Article