Susceptibility of neuroblastoma and glioblastoma cell lines to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 신경모세포종 및 교모세포종 세포주의 감수성Article Published on 2021-05-012022-09-11 Journal: Brain research [Category] SARS, 치료기술, [키워드] Analysis Apoptosis Cell cell line cell lines cell type cells Coronavirus-2 CTSB CTSL Cytopathic effect death demonstrated described downregulation epithelial cell epithelial cells Express Gene Expression Genes Glioblastoma Glutamate idea In situ hybridization infected cell infected cells Infection maintain MOI MOIs Neuroblastoma neuronal neurotropism Perspective quantification replicate retinoic acid RNA SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain severe acute respiratory coronavirus Severe acute respiratory coronavirus-2 SH-SY5Y susceptibility tropism upregulation Vero E6 VERO E6 cells virus were expressed were infected [DOI] 10.1016/j.brainres.2021.147344 PMC 바로가기 [Article Type] Article
Serum neurofilament light chain (sNfL) values in a large cross-sectional population of children with asymptomatic to moderate COVID-19Original Communication Published on 2021-04-232022-10-29 Journal: Journal of Neurology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome antibody antibody screening antibody status association Asymptomatic Biomarker Brain children Cohort coronavirus COVID-19 cross-sectional disease Dizziness elevated evaluate Evidence Germany healthy children immunoassay independent infected with COVID-19 Infection Inflammatory Level Loss of Smell Moderate COVID-19 multivariate regression analysis muscle aches neurofilament Neurological disorders NEUROLOGY neuronal objective pandemic coronavirus pediatric positive Quantitative recruited reported Result SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody syndrome [DOI] 10.1007/s00415-021-10554-1 PMC 바로가기 [Article Type] Original Communication
Interleukin 6 and depression in patients affected by Covid-19코비드-19에 영향을 받은 환자의 인터루킨 6과 우울증Observational Study Published on 2021-04-092022-09-11 Journal: Medicina clínica [Category] 바이오마커, 임상, [키워드] 95% CI affected changes correlation COVID-19 cytokine Cytokines deficiency Depresión Depression depressive depressive disorder depressive symptom Depressive symptoms disorder IL-1β IL-6 IL-6 level IL-6 levels Infection interleukin interleukin 6 molecular mechanisms neuronal neurotransmitter no correlation noradrenaline observational study Older Patient resulting scale Serotonin Stress sustained TNF-α Vascular was used [DOI] 10.1016/j.medcli.2020.11.010 PMC 바로가기 [Article Type] Observational Study
Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular healthCOVID-19 전염병 동안 뇌에 미치는 신체 운동 효과: 정신 건강과 심혈관 건강 간의 연관성Review Published on 2021-04-012022-09-11 Journal: Neurological Sciences [Category] 유전자 메커니즘, [키워드] ACE2 ACE2 expression Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition Affect affected Ang 1-7 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme-2 antiinflammatory Anxiety BDNF binding Brain cardiovascular complications Cardiovascular health caused Chronic diseases Corona Corona virus coronavirus COVID-19 COVID-19 pandemic death Depression disorders Effect Elevation ENhance enzyme ERK exercise FNDC5 Health heart host cell host cells IGF-1 IMPROVE individual induce Infection Inflammation life lung Lungs maintenance Mental mental health Mobility molecular mechanism molecular mechanisms neurological neuronal other tissues outbreak oxygen oxygen supply pandemic pathological mechanism pathway physical physical activity Physical exercise physiological response PI3K Quality of life quarantine Quarantine period receptor reducing SARS-CoV-2 SARS-COV-2 infection Sedentary behavior severe acute respiratory syndrome Coronavirus survival Treatment Virus Disease [DOI] 10.1007/s10072-021-05082-9 PMC 바로가기 [Article Type] Review
Endothelial cell damage is the central part of COVID-19 and a mouse model induced by injection of the S1 subunit of the spike protein내피 세포 손상은 COVID-19의 중심 부분이며 스파이크 단백질의 S1 서브유닛을 주입하여 유도된 마우스 모델Article Published on 2021-04-012022-09-11 Journal: Annals of diagnostic pathology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] ACE2 Analysis Autopsy Behavior Brain Brain tissues C5b-9 caspase caspase 3 caspase-3 cell damage Complication COVID-19 demonstrated detect diagnostic died endothelial Endothelial cell endothelial cell damage endothelial damage envelope eosin examined fatal COVID-19 full length hematoxylin Hematoxylin and eosin host response IL6 immunohistochemistry increased thirst incubated injected injection Localization membrane protein Membrane proteins MFSD2a mice neurologic neurologic signs Neuron neuronal neuronal cell neuronal cells NOS pathologist pathology positive Protein Proteins pseudovirion pseudovirions S1 subunit S2 subunit SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 proteins SARS-CoV2 SHIP1 spike Spike protein subunit subunits symptomatic symptomatic COVID-19 tail the S1 subunit the spike protein tissue TNFα Viral RNA were used wild type [DOI] 10.1016/j.anndiagpath.2020.151682 PMC 바로가기 [Article Type] Article
Stroke in SARS-CoV-2 Infection: A Pictorial Overview of the PathoetiologyCardiovascular Medicine Published on 2021-03-292022-10-31 Journal: Frontiers in Cardiovascular Medicine [Category] COVID-19, [키워드] Activation acute respiratory syndrome addition Anticoagulant antiplatelet approach arrhythmia association Blood coagulation cardiovascular complication Central nervous system chemokine CNS Coagulopathy Comorbidity Complication coronavirus COVID-19 drug elevated Endotheliitis hematogenous hypoxia ill patients immune system incidence infected patients Infection Invasion medications neuroimmunomodulation neuronal Numerous pandemic pathophysiology Patient patients with SARS-CoV-2 peripheral tissue Pharmacology pro-inflammatory cytokine renin-angiotensin system risk SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2-infected patients stroke susceptible the SARS-CoV-2 Vasculitis viral infection [DOI] 10.3389/fcvm.2021.649922 PMC 바로가기 [Article Type] Cardiovascular Medicine
COVID-19 and Neurological Impairment: Hypothalamic Circuits and BeyondCOVID-19와 신경학적 손상: 시상하부 회로 및 그 이상Review Published on 2021-03-172022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affected Autopsy Capital Cell Central nervous system characterized China circuit clinical CNS complex composed coronavirus coronavirus disease Coronavirus disease 2019 country COVID-19 COVID-19 infection COVID-19 patient Critical demonstrated focus groups Headaches homeostatic hypothalamic circuits hypothalamic–pituitary–adrenocortical axis hypothalamus immune response immune responses mechanism nausea nervous system neurologic neurological manifestation neurological manifestations Neurological symptom Neurological symptoms neuronal Novel coronavirus nuclei olfactory bulb Patient Peripheral nervous system respiratory respiratory centers SARS-CoV SARS-CoV-2 severe acute respiratory syndrome Coronavirus Symptoms Viral viral infection viral infections virus infection vomiting Wuhan [DOI] 10.3390/v13030498 PMC 바로가기 [Article Type] Review
COVID-19 patient transcriptomic and genomic profiling reveals comorbidity interactions with psychiatric disordersCOVID-19 환자 전사체 및 게놈 프로파일링은 정신 장애와의 동반 질환 상호 작용을 나타냅니다Article Published on 2021-03-152022-09-10 Journal: Translational Psychiatry [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] affected analysed Analysis Anti-inflammatory Bipolar disorder causes co-expression Comorbidity comparison conditions correlated COVID-19 COVID-19 pandemic COVID-19 patient COVID-19 patients dataset disorder exacerbate gene cluster gene clusters Gene Expression Genome-wide association study genomic GWAS highlight Human behaviour identify immune immune responses immune system in some Infection inflammatory pathway interact Interaction Medical genetics medication mononuclear cell mononuclear cells Neuron neuronal neurons Ontology overlapped pathway Pathways Patient patients PBMC performed Peripheral blood Peripheral blood mononuclear cells Post-traumatic stress disorder profile Psychiatric psychiatric disorder Psychiatric disorders Psychiatric symptom Psychiatric symptoms PTSD reveal SARS-COV-2 infection Schizophrenia Support susceptibilities symptomatic targets transcript Transcriptome transcriptomic Treatment Usage Whole-genome sequence with COVID-19 [DOI] 10.1038/s41398-020-01151-3 PMC 바로가기 [Article Type] Article
High frequency of cerebrospinal fluid autoantibodies in COVID-19 patients with neurological symptoms신경계 증상이 있는 코로나19 환자에서 뇌척수액 자가항체의 높은 빈도Article Published on 2021-03-012022-09-12 Journal: Brain, behavior, and immunity [Category] MERS, 진단, [키워드] absence analyzed autoantibodies autoantibody autoantigen Autoimmunity binding Brain brain tissue cerebrospinal fluid Clinical symptoms COVID-19 COVID-19 patient Critically ill CSF delirium disease Encephalitis Endothelium Epitopes explain Frequency ganglia hyperexcitability immunofluorescence Immunotherapy intensive care patient monoclonal murine neurological Neurological symptom NEUROLOGY neuronal NMDA olfactory Patient potential molecular presenting Protein receptor SARS-CoV-2 SARS-CoV-2 antibodies Seizures selected serum surface proteins Undetermined vessel Viral-triggered. virus-neutralizing antibody [DOI] 10.1016/j.bbi.2020.12.022 PMC 바로가기 [Article Type] Article
Neurological Consequences of SARS-CoV-2 Infection and Concurrence of Treatment-Induced Neuropsychiatric Adverse Events in COVID-19 Patients: Navigating the UnchartedMolecular Biosciences Published on 2021-02-182022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome Adverse adverse event Affect angiotensin-converting enzyme 2 anti-retroviral drug Antibiotics bind Central nervous system Chloroquine clinically CNS Combination Complication concurrence consequence contributing to coronavirus Corticosteroid COVID - 19 COVID-19 Critical Dexamethasone Diseases dissemination Drug interactions drug-drug interaction Encephalitis Encephalopathy event Evidence Favipiravir Guillain-barrè syndrome help hematogenous Hemorrhagic highlight human cell Hydroxychloroquine Hypogeusia Hyposmia immune responses include induce Injury leukoencephalopathy Lopinavir-ritonavir mechanism mechanisms medication Meningitis morbidity and mortality nervous system neurologic neurologic manifestations Neurological disorder neurological manifestation neuronal Neuropsychiatric neuropsychiatric adverse effects neurotropic neurotropism off-label outcome pandemic pathophysiological Pathways Perspective Pneumonia Post-infection potential therapy Psychiatric disorders psychological Impact receptor Remdesivir Repurposed drug researchers Respiratory complications SARS – CoV – 2 SARS-CoV-2 SARS-COV-2 infection stroke syndrome therapeutic potential thrombosis Tocilizumab Uncharted venous virus virus infection with COVID-19 [DOI] 10.3389/fmolb.2021.627723 PMC 바로가기 [Article Type] Molecular Biosciences