Nanobodies Protecting From Lethal SARS-CoV-2 Infection Target Receptor Binding Epitopes Preserved in Virus Variants Other Than Omicron치명적인 SARS-CoV-2 감염 표적 수용체 결합 에피토프로부터 보호하는 나노바디는 오미크론 이외의 바이러스 변이체에 보존되어 있습니다Article Published on 2022-04-252022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 변종, [키워드] affinity antibody binding binding epitope binding mode blocked cell cultures cell entry cell entry receptor competition coronavirus COVID-19 COVID-19 pandemic cryo Cryo-electron microscopy electron microscopy Epitopes fusion glycoprotein groups hACE2 heavy chain human ACE2 humanized immune Immune escape immunized lethal mice Microscopy mono MOST nanobodies nanobody neutralization neutralized Neutralizing Neutralizing antibodies neutralizing antibody nine omicron Other Prevent prevented progression Protecting pseudotyped RBD RBD binding RBM receptor receptor binding motif Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 RBD SARS-CoV-2 variant SARS-CoV-2 variants selected target the receptor-binding domain the S protein therapeutic potential Therapeutics Vaccine variant variants of concern virus [DOI] 10.3389/fimmu.2022.863831 PMC 바로가기 [Article Type] Article
CA 15-3 prognostic biomarker in SARS-CoV-2 pneumoniaSARS-CoV-2 폐렴의 CA 15-3 예후 바이오마커Observational Study Published on 2022-04-252022-09-11 Journal: Scientific Reports [Category] COVID19(2023년), SARS, 바이오마커, 임상, 진단, [키워드] 2019 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 adjusted adjusted odds ratio Admission analyzed Antigen Biobank blood sample Blood samples C-reactive protein Complication Concentration coronavirus coronavirus disease correlated Course COVID-19 CRP D-dimer death died discharge discharged evaluated fibrosis help higher risk IL6 In-hospital in-hospital complication in-hospital complications increased risk Infection Intensive intensive care interleukin interleukin 6 lung damage lung involvement Male sex marker men NT-proBNP observational study Occurrence Older age Other oxygen Oxygen therapy Patient patients with SARS-CoV-2 Pneumonia predict Prognosis prognostic biomarker Prognostic factor Prognostic marker recruited Registered required respiratory retrospective Risk factors SARS-CoV-2 SARS-CoV-2 pneumonia severe acute respiratory syndrome Coronavirus severity supplemental oxygen Support the mean troponin T troponine U/mL [DOI] 10.1038/s41598-022-10726-7 PMC 바로가기 [Article Type] Observational Study
Clinical features of thrombosis and bleeding in COVID-19Research article Published on 2022-04-222022-10-05 Journal: Blood [Category] COVID19(2023년), SARS, 임상, [키워드] Admission appear Arterial thrombosis bleeding clinical COVID-19 COVID-19 disease COVID-19 symptom D-dimer dose events extracorporeal membrane oxygenation Factor feature fibrinogen higher risk hospital include indications Infection intensive care unit less Lymphocyte count Mortality multifactorial Myocardial infarction Other parameter Patient presenting pulmonary receive resulting risk Severe COVID-19 Infection stroke the patient the SARS-CoV-2 virus Thromboprophylaxis thrombosis treated Treatment unique venous Venous thrombosis von Willebrand factor VTE with COVID-19 [DOI] 10.1182/blood.2021012247 [Article Type] Research article
Controversies about immunoglobulin replacement therapy in HSCT recipients with hypogammaglobulinemia Reviews Published on 2022-04-192022-10-05 Journal: Bone marrow transplantation [Category] 치료제, [키워드] accelerate administration antibody available data Bacterial infection benefit Blood Cell Characteristics chimeric antigen receptor clinical clinical trial CLL deficiency demonstrated disease dosage Efficacy Evidence Hematological malignancy heterogeneous HSCT HSCT recipient Hypogammaglobulinemia IgG immune Immunoglobulin immunoglobulin replacement therapy infection risk leukemia Meta-analysis monoclonal antibody Mortality MOST Multiple myeloma Other other disease Patient Prophylactic randomized trial regimen subsequent T-cell therapy utility [DOI] 10.1038/s41409-022-01680-z [Article Type] Reviews
Opening up safely: public health system requirements for ongoing COVID-19 management based on evaluation of Australia’s surveillance system performance안전한 개방: 호주의 감시 시스템 성능 평가를 기반으로 한 지속적인 COVID-19 관리를 위한 공중 보건 시스템 요구 사항Article Published on 2022-04-152022-09-11 Journal: BMC Medicine [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료기술, [키워드] acute respiratory illness acute respiratory syndrome acute respiratory syndrome coronavirus Analysis available data average Characteristics Cluster Community community transmission coronavirus coronavirus disease Coronavirus disease 2019 Coverage COVID-19 Critical described detection eliminated Engagement epidemiological epidemiologically evaluated FIVE General population genomic sequencing Government increase in International maintenance management mechanism opening Other outbreak Outbreaks performed positive Public public health public health measure quarantine SARS-CoV-2 sensitivity sequencing data severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 state study period Support supported Surveillance symptomatic Timeliness to define Transmission vaccination Vaccine variant variants variants of concern VOCs was tested [DOI] 10.1186/s12916-022-02344-x PMC 바로가기 [Article Type] Article
Enabling work participation for people with musculoskeletal conditions: lessons from work changes imposed by COVID-19: a mixed-method studyObservational Study Published on 2022-04-072022-10-05 Journal: BMJ Open [Category] 임상, [키워드] Analysis Anxiety benefit change changes in Cohort collected conditions COVID-19 COVID-19 pandemic disadvantage Effect Enabling female flexible greater Health help Home working Impact individual industrial medicine Inflammatory arthritis lockdown median age Mental Musculoskeletal occupational & offered Other Pain physical physical activity positive primary care psoriatic arthritis Qualitative qualitative research quantified questionnaire reported rheumatology secondary outcome selected semistructured interviews spondyloarthritis subset Symptoms worsened [DOI] 10.1136/bmjopen-2021-057919 PMC 바로가기 [Article Type] Observational Study
Gatekeeper training for vendors to reduce pesticide self-poisoning in rural South Asia: a study protocol for a stepped-wedge cluster randomised controlled trial남아시아 농촌 지역에서 살충제 중독을 줄이기 위한 공급업체를 위한 게이트키퍼 교육: 계단식 쐐기형 클러스터 무작위 통제 시험을 위한 연구 프로토콜Article Published on 2022-04-042022-09-11 Journal: BMJ Open [Category] Coronavirus, 임상, [키워드] 24 hours alcohol approved Asia Attempted suicide Cluster Committee conducted COVID-19 division divisions Edinburgh Effectiveness Ethics ethics committee evaluate faculty Faculty of Medicine form high risk hospital identify individual Intervention introduced kill Other outcome outcome measure outcome measures peer-reviewed pesticide pesticides poisoning Prevent Primary outcome public health random randomised controlled trial Randomised trial reduce registration number Research Ethics restriction Result review secondary Secondary outcomes self-harm South Study protocol Suicide suicide & Surveillance toxicology university [DOI] 10.1136/bmjopen-2021-054061 PMC 바로가기 [Article Type] Article
Convalescent plasma therapy in patients with severe COVID-19, A single-arm, retrospective studyObservational Study Published on 2022-04-012022-10-04 Journal: Microbial pathogenesis [Category] COVID19(2023년), SARS, 바이오마커, 임상, [키워드] Admission age association Blood Group Characteristics Clinical outcome collected conditions conducted convalescent plasma COVID COVID-19 COVID-19 mortality CP therapy death demographic diagnosed dose Effect effective Effectiveness Efficacy evaluate Evidence hospital discharge Inflammatory biomarker Laboratory laboratory parameter median medical record Mortality Older age Other Patient plasma prothrombin randomized clinical trial respiratory retrospective cohort Retrospective study SARS-CoV-2 Secondary outcomes severe COVID-19 Sex significantly single-arm Stage suggested Symptom the disease therapy Treatment Treatment outcome Viral diseases [DOI] 10.1016/j.micpath.2022.105482 PMC 바로가기 [Article Type] Observational Study
First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech mRNA COVID-19 Vaccine (BNT162b2, Comirnaty): an Extremely Rare Idiosyncratic Hypersensitivity ReactionPfizer-BioNTech mRNA COVID-19 백신(BNT162b2, Comirnaty)의 초기 투여 후 치명적인 전격성 괴사성 호산구성 심근염의 첫 번째 확인된 사례: 극히 드문 특발성 과민 반응Case Reports Published on 2022-04-012022-09-12 Journal: Journal of Clinical Immunology [Category] 진단, [키워드] adverse event adverse events Autopsy benefit BNT162b2 cause Complete Complication COVID-19 COVID-19 infection COVID-19 vaccines death described drug early diagnosis eosinophil Eosinophilic eosinophilic myocarditis facilitate first dose fulminant Hospital admission hypersensitivity hypersensitivity reaction Identified Intervention less male Mild mortality risk mRNA mRNA COVID-19 vaccines mRNA-based myocarditis Myopericarditis non-specific clinical feature observation occurred Other Pfizer-BioNTech reaction risk second dose Transient Treatment triggered vaccination Vaccine variety [DOI] 10.1007/s10875-021-01187-0 PMC 바로가기 [Article Type] Case Reports
Development of Receptor Binding Domain (RBD)-Conjugated Nanoparticle Vaccines with Broad Neutralization against SARS-CoV-2 Delta and Other VariantsSARS-CoV-2 Delta 및 기타 변이체에 대한 광범위한 중화를 갖는 수용체 결합 도메인(RBD)-접합 나노입자 백신의 개발Article Published on 2022-04-012022-09-11 Journal: Advanced Science [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] B.1.617.2 Beta Breakthrough infection breakthrough infections cross-protective Delta delta variant Delta variants develop development dominant hACE2 Incubation period induce Infection mice NAb NAbs nanoparticle nanoparticle vaccines. Neutralizing antibodies neutralizing antibody notable omicron Omicron variant Other PROTECT Receptor binding domain recipients rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 delta SARS-CoV-2 variant SARS-CoV-2 variants significantly strain Strains Transmission trivalent Vaccine Vaccines variant Viral Viral load VoC [DOI] 10.1002/advs.202105378 PMC 바로가기 [Article Type] Article