In silico comparative study of SARS-CoV-2 proteins and antigenic proteins in BCG, OPV, MMR and other vaccines: evidence of a possible putative protective effectResearch Article Published on 2021-03-262022-10-27 Journal: BMC Bioinformatics [Category] COVID-19, [키워드] Analysis antigenic antigenic protein antigenicity BCG Combination COVID-19 Evidence explain HBV humans identify immunogenic immunogenicity induce investigated Measle MMR OPV pandemic disease protective effect Protein Putative protection regions Result SARS-CoV-2 SARS-CoV-2 protein sequence severe pneumonia severity supplementary material Tetanus the disease Vaccine Vaccines Variation [DOI] 10.1186/s12859-021-04045-3 PMC 바로가기 [Article Type] Research Article
Mutations in SARS-CoV-2; Consequences in structure, function, and pathogenicity of the virusReview Published on 2021-03-132023-07-01 Journal: Microbial pathogenesis [Category] SARS, [키워드] COVID-19 Mutation pandemic disease pathogenicity SARS-CoV-2 [DOI] 10.1016/j.micpath.2021.104831 PMC 바로가기 [Article Type] Review
Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variantsSARS-CoV-2 치료 표적 및 비동의어 변이체에 초점을 맞춘 DockThor-VS 웹 서버를 통한 약물 설계 및 용도 변경Article Published on 2021-03-102022-08-31 Journal: Scientific Reports [Category] SARS, 변종, 신약개발, 치료제, [키워드] (RdRp) 3CLpro 3D structure caused Computational platforms and environments COVID-19 curated disease docking domain drug Drug repurposing effective experiment facilitate FDA-approved drug FDA-approved drugs genetic information Health Organization High-throughput screening identify market methodology MPro Mutation N protein Non-synonymous Nsp12 Nsp15 Nsp3 nsp5 pandemic disease Papain performed platform PLPro potential therapeutic target potential therapeutic targets present provide RdRP SARS-CoV-2 SARS-CoV-2 infections SARS-CoV-2 virus selected spike Structure Structure-based drug design the SARS-CoV-2 virus therapeutic target therapeutic targets Treatment variant variations Virtual drug screening Virtual screening web server WHO wild type World Health Organization [DOI] 10.1038/s41598-021-84700-0 PMC 바로가기 [Article Type] Article
Nanotechnology against the novel coronavirus (severe acute respiratory syndrome coronavirus 2): diagnosis, treatment, therapy and future perspectivesReview Published on 2021-03-082022-10-30 Journal: Nanomedicine [Category] COVID-19, SARS, [키워드] Abstract acute respiratory syndrome affected antiviral agent approved caused coronavirus COVID-19 COVID-19 disease Diagnosis diagnostic effective HIV human cell human papillomavirus include Infectious disease management Modification morbidity Mortality mRNA vaccine Nanotechnology New coronavirus Novel coronavirus pandemic disease Particle Pathogens peptide-based Perspective preclinical study respiratory viruses SARS-CoV-2 therapeutic agent therapy Treatment unique Vaccine variety virus [DOI] 10.2217/nnm-2020-0441 PMC 바로가기 [Article Type] Review
COVID-19 in Farm Animals: Host Susceptibility and Prevention StrategiesReview Published on 2021-02-282022-10-28 Journal: Animals : an Open Access Journal from MDPI [Category] COVID-19, [키워드] affected African animals biosecurity measures caused Contact Coronaviridae coronavirus COVID-19 COVID-19 infection demonstrated effective farm highly pathogenic Human Impact Influenza measure mechanism outbreak pandemic disease prevention reported SARS-CoV-2 simple Spread Strategy Transmission vaccination Vaccine virus zoonotic [DOI] 10.3390/ani11030640 PMC 바로가기 [Article Type] Review
Frequency of Comorbidities in Admitting COVID-19 Pneumonia Patients in a Tertiary Care Setup: An Observational StudyEmergency Medicine Published on 2021-02-252022-10-31 Journal: Cureus [Category] COVID-19, [키워드] Admission age airway Care clinical examination Comorbidities Comorbidity conducted Coronavirus disease 2019 COVID-19 covid-19 and diabetes COVID-19 patient cross-sectional determine diabete diabetes diagnosed with COVID-19 disease End-stage renal disease (ESRD) evaluated fatal complication females Frequency had no healthcare professionals highest hospital hypertension idiopathic hypertension illness increase in Infection Interstitial lung disease ischemic heart disease Isolation Karachi male morbidity and mortality MOST novel coronavirus disease Obstructive other disease pandemic disease Patient patients with pneumonia performed Pneumonia presence of comorbidity required Restrictive lung disease Result risk risk of COVID-19 Science study population Symptom Tertiary treated university with COVID-19 [DOI] 10.7759/cureus.13546 PMC 바로가기 [Article Type] Emergency Medicine
Possible Therapeutic Use of Natural Compounds Against COVID-19Article Published on 2021-02-182022-10-29 Journal: Journal of cellular signaling [Category] COVID-19, [키워드] Against autophagy Cell cellular proteases Compound Coronavirus disease-19 COVID-19 COVID-19 pathogenesis cytosol endolysosome Endolysosomes Evidence greater infect inhibit SARS-CoV-2 morbidity and mortality mTOR signaling natural natural compounds Naturally outbreak pandemic disease pathway priming replicate SARS-CoV-2 SARS-COV-2 infection Structure target therapeutic therapeutic intervention PMC 바로가기 [Article Type] Article
Variants in ACE2; potential influences on virus infection and COVID-19 severityReview Published on 2021-02-172023-06-14 Journal: Infection, genetics and evolution : journal of mol [Category] MERS, SARS, [키워드] ACE2 COVID-19 pandemic disease pathogenicity SARS-CoV-2 [DOI] 10.1016/j.meegid.2021.104773 PMC 바로가기 [Article Type] Review
Mortality and morbidity in COVID-19 orthopedic trauma patients: is early surgery the keystone?Case Series Published on 2021-02-122022-10-28 Journal: The Pan African Medical Journal [Category] COVID-19, MERS, [키워드] adverse event age applied ASA grade C-reactive protein caused collected complications control group COVID-19 COVID-19 negative D-dimer demographics Diagnosis diagnosis of COVID-19 early surgery Emergency evaluate First wave fractures Frame Hospitalization independent risk factor Infection Laboratory Laboratory test Leukocytosis lymphopenia management men morbidity Mortality orthopedic outcomes pandemic pandemic disease pathway Patient Perioperative positive radiological recorded Registered room SARS-CoV-2 virus study group the study group trauma trauma patient treated treatment for COVID-19 women [DOI] 10.11604/pamj.2021.38.163.27125 PMC 바로가기 [Article Type] Case Series
Challenges and advances in clinical applications of mesenchymal stromal cells간엽 기질 세포의 임상 응용 분야에서의 도전과 발전Review Published on 2021-02-122022-09-10 Journal: Journal of Hematology & Oncology [Category] Fulltext, MERS, 비임상, [키워드] approach Artificial intelligence (AI) breath challenge Clinical applications clinical trial COVID-19 COVID-19 pandemic criteria disease disease models Diversity Extracellular vesicles Factor heterogeneity highest human disease human diseases identity improvement investigated majority Mesenchymal stem cells Mesenchymal stromal cell Mesenchymal stromal cells modify MSC MSC therapy MSCs outcome overcome pandemic disease Registered stem cells stromal cell stromal cells therapeutic potential [DOI] 10.1186/s13045-021-01037-x PMC 바로가기 [Article Type] Review