H1N1 exposure during the convalescent stage of SARS-CoV-2 infection results in enhanced lung pathologic damage in hACE2 transgenic miceResearch Article Published on 2021-06-132022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, SARS, 신종인플루엔자, [키워드] activated addressed alternate infection antiviral therapeutics Characteristics convalescent stage COVID-19 pandemic distribution dose flu H1N1 H1N1 infection H1N1 virus hACE2 hACE2 transgenic mice in vivo Infection infection with SARS-CoV-2 infiltration influenza A virus lung lymphocyte mice observation pathologic patients PBMC public health risk SARS-CoV-2 SARS-COV-2 infection severe inflammation subsequent suppressed T cell tissue transgenic mice Vaccine viral shedding virus [DOI] 10.1080/22221751.2021.1938241 PMC 바로가기 [Article Type] Research Article
A Case of COVID-19 Mimicking Acute Appendicitis in Multi-System Inflammatory SyndromePediatrics Published on 2021-06-112022-10-31 Journal: Cureus [Category] COVID-19, [키워드] abdominal pain addition Adults Affect African American age Anemia Antibiotics BNP Brain children Course COVID-19 criteria diagnose diagnosed discharge Educating effective elevated female Fever headache healthy hypercoagulability immune system Immunoglobulin implication increasingly individual Inflammation Inflammatory Inflammatory marker inflammatory markers initial Kawasaki disease Kikuchi disease macrophage activation syndrome mechanical ventilation Methylprednisolone MIS-C multi-system inflammatory syndrome in children (mis-c) organ systems pathologic peptide positive preventative measure returned SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 test Shock Symptoms syndrome systemic lupus erythematosus the patient treat Treatment TSS unique urinary tract infection UTI vasopressors virus [DOI] 10.7759/cureus.15600 PMC 바로가기 [Article Type] Pediatrics
Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates2개의 새로운 아데노바이러스 매개된 COVID-19 백신 후보로 생쥐와 붉은털 원숭이의 프라임 부스트 백신 접종Research Article Published on 2021-06-012022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술, [키워드] Adenovirus animals anti-RBD anti-S binding antibody candidate CD4 cells changes COVID-19 vaccine COVID-19 vaccines detectable dose-dependent manner elicit evaluated FIVE followed by full-length human adenovirus 49 vector IFN-γ IL-2 immune response immune responses Immunity immunization immunogenicity macaque macaques mice mice and non-human primates nCoV pathologic peptide peptides preparation prime-boost regimen prime-boost vaccination priming pseudovirus neutralizing antibody response rhesus macaque rhesus macaques SARS-CoV-2 spike protein simian adenovirus 23 vector Specific Spike protein T cell T-cell Response the vaccine trials vaccination Vaccine [DOI] 10.1080/22221751.2021.1931466 PMC 바로가기 [Article Type] Research Article
Chloroquine- and Hydroxychloroquine-Induced Cardiomyopathy: A Case Report and Brief Literature Review클로로퀸 및 하이드록시클로로퀸으로 유발된 심근병증: 증례 보고 및 간략한 문헌 검토Review Published on 2021-05-182022-09-11 Journal: American journal of clinical pathology [Category] 진단, 치료제, [키워드] administration antimalarial drug Antimalarial drugs cardiac and skeletal muscle Cardiomyopathy Cardiotoxicity caused change Chloroquine clinical trials coronavirus disease Coronavirus disease 2019 correlation country COVID-19 deposition described diagnosed drug Efficacy Endomyocardial biopsy HCQ histologic Hydroxychloroquine identify Including Inclusion inclusion bodies index case LIGHT literature literature review medical history metabolite myopathies Myopathy nonspecific overlap pathologic pathology Patient report review rheumatic disease Rheumatic diseases severe adverse effect Skeletal muscle the patient the United State United States vacuolated was performed were recorded [DOI] 10.1093/ajcp/aqaa253 PMC 바로가기 [Article Type] Review
Postmortem radiologic and pathologic findings in COVID-19: The Toronto experience with pre-hospitalization deaths in the communityCOVID-19의 사후 방사선 및 병리학적 발견: 지역사회에서 입원 전 사망에 대한 토론토 경험Case Reports Published on 2021-05-012022-09-11 Journal: Forensic science international [Category] SARS, 치료기술, [키워드] Admission alveolar damage Autopsies Autopsy cellular change clinical care Community Computed tomography connection consolidation Course COVID-19 COVID-19 pandemic Critical dead death description diagnosis of COVID-19 died Diffuse alveolar damage disease Evolution fatal COVID-19 fatality feature feedback FIVE Healthcare system Healthcare systems Histopathology hospital Hospitalization in vivo individual information initial Intensive involved knowledge lung Lung histopathology lung parenchyma Medical imaging MOST over pandemic pathologic pattern performed Postmortem Postmortem CT scan Public public health radiologic SARS-CoV-2 Stage subject the disease Toronto Treatment [DOI] 10.1016/j.forsciint.2021.110755 PMC 바로가기 [Article Type] Case Reports
Pathological findings in organs and tissues of patients with COVID-19: A systematic reviewResearch Article Published on 2021-04-282022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] addition Autopsy bronchopneumonia Case report case sery caused Cell chain change CNS Coagulopathy COVID-19 COVID-19 case COVID-19 infection DAD database death demonstrated described Diffuse alveolar damage disease edema Endothelial cell GI Tract hemodynamic Hepatitis immunofluorescence immunohistochemistry inclusion criteria intestine kidney liver lung medRxiv Microscopy myocarditis Necrosis nervous organ organ damage organ-specific organs pandemic pathologic pathological Patient PCR performed Placenta positive reaction reported resulting SARS-CoV-2 SARS-CoV-2 viral particle screened skin biopsy System systematic review tissue was performed [DOI] 10.1371/journal.pone.0250708 PMC 바로가기 [Article Type] Research Article
Myelodysplastic syndrome in a 30-year-old man with coronavirus disease 2019 (COVID-19): a diagnostic challengeClinical Case Report Published on 2021-04-232022-10-27 Journal: Autopsy & Case Reports [Category] COVID-19, [키워드] addition Affect Analysis bilateral pneumonia Bone marrow cells chills clinical evaluation Combination condition coronavirus disease coughing COVID-19 COVID-19 patients Cytogenetics cytopenia demonstrated diagnosed Diagnosis diagnostic Dizziness dysplastic feature Fever flow cytometry hospital Hospitalization immunohistochemistry individual male management MDs Mild mimicking moderate molecular molecular feature Mutation Myelodysplastic syndrome myelodysplastic syndromes myelofibrosis neutrophil occur pathologic Patient patients patients with COVID-19 Peripheral blood raised reactive repeated reported SARS-CoV-2 Sequencing SF3B1 Shortness of breath subsequent weakness [DOI] 10.4322/acr.2021.274 PMC 바로가기 [Article Type] Clinical Case Report
Silibinin as potential tool against SARS‐Cov ‐2: In silico spike receptor‐binding domain and main protease molecular docking analysis, and in vitro endothelial protective effectsShort Communication Published on 2021-04-062022-10-29 Journal: Phytotherapy research : PTR [Category] COVID-19, MERS, SARS, [키워드] Analysis Anticoagulant antiinflammatory binding affinity Coagulation Coagulopathy complex interaction COVID‐19 Critical Cytokine storm demonstrated docking domain drug dysfunction Effect endothelial Endothelial cell Endothelial dysfunction Endothelium form Gene Expression IL‐6 in silico in vitro Inflammation inhibiting interact involved lack lifecycle management molecular docking analysis MPro pathologic peptide Perspective proinflammatory gene protease protective effect rapid response reduced Replication Research residue SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 silibinin Silybum Spike protein spike protein RBD Spread stable complex target protein target proteins thrombosis umbilical vasoconstriction viral entry [DOI] 10.1002/ptr.7107 PMC 바로가기 [Article Type] Short Communication
Cutaneous Vasculopathy in a COVID-19 Critically Ill Patient: A Histologic, Immunohistochemical, and Electron Microscopy StudyCase Report Published on 2021-04-032022-10-31 Journal: Case Reports in Critical Care [Category] COVID-19, [키워드] affected characterized clinical Coagulopathy complement Course COVID-19 Critically ill Cutaneous Disseminated intravascular coagulation electron evidenced fibrinogen Hypothesis Ill Injury Laboratory lesion Manifestations mechanism Microscopy occlusive pathologic Patient positive rashes Respiratory failure SARS-CoV-2 skin lesions small vessel the disease thrombotic Vascular Vasculopathy [DOI] 10.1155/2021/6644853 PMC 바로가기 [Article Type] Case Report
The Gastrointestinal Tract Is an Alternative Route for SARS-CoV-2 Infection in a Nonhuman Primate Model위장관은 비인간 영장류 모델에서 SARS-CoV-2 감염에 대한 대체 경로입니다Article Published on 2021-04-012022-09-11 Journal: Gastroenterology [Category] MERS, SARS, 바이오마커, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 caspase 3 caused CD68 Chain Reaction change cleaved Clinical sign Clinical signs connection coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytokine Cytokines digestive dysfunction evaluated fecal Fecal-Oral Route Gastrointestinal GI Tract goblet cells Histopathology host responses Hypothesis immunohistochemistry increased expression increasingly Infection Inflammation Inflammatory cytokines inoculation intranasal investigated involved Ki67 lung macrophages manifestation Model mucin NHP Pathogenesis pathogenesis of COVID-19 pathogenesis of SARS-CoV-2 pathologic Patient periodic acid Pneumonia polymerase chain polymerase chain reaction primate quantified Quantitative reported respiratory respiratory tissue respiratory tissues response reverse transcription rhesus Rhesus monkeys route SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe infections staining tissue tissues tract Viral viral genomic RNA viral infection were infected were recorded [DOI] 10.1053/j.gastro.2020.12.001 PMC 바로가기 [Article Type] Article