PBMC – Page 8 – Communicable Diseases Research

Nonthyroidal illness syndrome (NTIS) in severe COVID-19 patients: role of T3 on the Na/K pump gene expression and on hydroelectrolytic equilibrium

중증 COVID-19 환자의 비갑상선 질환 증후군(NTIS): Na/K 펌프 유전자 발현 및 가수전해 평형에 대한 T3의 역할

Research

Published on 2021-12-032022-09-10
Journal: Journal of Translational Medicine [Category] SARS, 유전자 메커니즘, 치료기술, 치료제,

Binding of phosphatidylserine-positive microparticles by PBMCs classifies disease severity in COVID-19 patients

PBMC에 의한 포스파티딜세린 양성 미세입자의 결합은 COVID-19 환자의 질병 중증도를 분류합니다

Article

Published on 2021-12-012022-09-11
Journal: Journal of Extracellular Vesicles [Category] 유전자 메커니즘,

[키워드] activated addition Affect Apoptosis blood cell Blood cells Blood coagulation carried cascade CD8 CD8+ CD8+ T cells cells Clinical course Coagulation complement complement system correlated strongly COVID-19 COVID-19 diagnosis COVID-19 patient COVID-19 patients disease severity distribution dying cells Frequency gene expression signature immune cells immune dysfunction Inflammation Inflammatory responses initial investigated Laboratory leucocyte lymphocyte Lymphocytes lymphopenia marker memory T cells Microparticle occur Patient PBMC PBMCs PD-L1 Phosphatidylserine Platelet platelet-derived microparticle Platelets SARS-CoV-2 severe lymphopenia T cell T cells Thromboinflammation thrombotic
[DOI] 10.1002/jev2.12173 PMC 바로가기 [Article Type] Article

Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder

Research article

Published on 2021-12-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘,

A new p65 isoform that bind the glucocorticoid hormone and is expressed in inflammation liver diseases and COVID-19

Article

Published on 2021-11-252022-10-04
Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단,

[키워드] affected amplifying antagonist anti-inflammatory agent anti-inflammatory response bind Cancer cause cirrhosis complex Corticosteroid COVID-19 Critical deregulation Dexamethasone disease Diseases expressed Factor gene expression level glucocorticoid HCC healthy subjects Hepatocellular carcinoma Human identify immunology IMPROVE Inflammation isoform knowledge liver Liver disease mice Molecular biology mRNA level NF-kB opposite p65 Patient PBMC physiological quantified receptor Regulation SARS-CoV-2 disease therapeutic target Transcription transcription factor transcription factors variant wild type
[DOI] 10.1038/s41598-021-02119-z PMC 바로가기 [Article Type] Article

Clonal Hematopoiesis of Indeterminate Potential Is Associated with Increased Age-Independent Morbidity and Mortality in Patients with COVID-19- the Beyond DNA COVID-19 Project

Conference abstract

Published on 2021-11-242022-10-05
Journal: Blood [Category] 변종,

[키워드] accounted affected age age and sex allele approved assays association ASXL1 ATAC-seq baseline Blood blueprint carried ChIP clinically collected common Comorbidities comparable Coverage COVID-19 COVID-19 diagnosis COVID-19 disease severity COVID-19 patient CRP CRS cytokine cytokine levels Cytokine release syndrome Cytokines database death defined described Detection limit DNA download elevated ELISA assay entire cohort figure Fisher Follow-up funding Genes grade 3 group had more hazard healthy individual Hematopoiesis Hospitalization hypoxemic hypoxic respiratory failure identify IL6 Increased increased mortality indeterminate indicated individuals Infection Inflammation Inflammatory inflammatory cascade Inflammatory marker IRB male Mayo Clinic MCP-1 median median age mononuclear cell morbidity Mortality MPL Mutation mutations neutropenia no difference observé Older pathophysiology Patient patients patients with COVID-19 PBMC Peripheral blood Potential proteomic study reached regression models remained Research resolved Respiratory failure RNA scale Sequencing severe disease severity Sex SF3B1 Single Cell ssDNA subsequent survival survival analysis TET2 the Kaplan-Meier method the WHO TNF-a TP53 two groups variables variant was performed WHO Wilcoxon rank sum with COVID-19
[DOI] 10.1182/blood-2021-151548 [Article Type] Conference abstract

Detection of Antibodies Against the SARS-CoV-2 Spike Protein and Analysis of the Peripheral Blood Mononuclear Cell Transcriptomic Profile, 15 Years After Recovery From SARS

SARS-CoV-2 스파이크 단백질에 대한 항체 검출 및 SARS 회복 15년 후의 말초혈액 단핵세포 전사체 프로파일 분석

Cellular and Infection Microbiology

Published on 2021-11-182022-09-11
Journal: Frontiers in Cellular and Infection Microbiology [Category] MERS, SARS, 유전자 메커니즘, 진단, 치료기술, 치료제,

[키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus Against antibodies antibody binding cellular entry cellular immunity chemiluminescence chemokine clinical manifestations collected conducted convalescent patient Convalescent patients coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cross-reactivity cytokine detection elicit epitope Epitopes exhibited expressed Genes heatmap homology immune immune cross-reactivity Immune status Immunity immunoassay in vitro inhibit interferon gamma microsphere mononuclear cell mRNA mRNAs pandemic patients with COVID-19 patients with SARS PBMC PBMCs peptide peptide epitope peripheral Peripheral blood Peripheral blood mononuclear cells Post-infection profile protein sequences Research respiratory responses SARS-CoV SARS-CoV-2 SARS-CoV-2 spike protein serum serum antibodies severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Signal transduction significantly spike Spike protein stimulated the SARS-CoV-2 transcriptomic profile was obtained were used Year
[DOI] 10.3389/fcimb.2021.768993 PMC 바로가기 [Article Type] Cellular and Infection Microbiology

Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis

차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견

Case Study

Published on 2021-11-172022-09-01
Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome
[DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study

Altered increase in STAT1 expression and phosphorylation in severe COVID‐19

Clinical Trial

Published on 2021-11-172022-10-04
Journal: European Journal of Immunology [Category] MERS, SARS, 임상,

[키워드] abnormality absence Altered antiviral defense mechanism baseline Biomarker CD14+ monocyte CD169 component correlated COVID‐19 COVID‐19 Cytokine storm downstream element expression flow cytometry IFN IFN signaling IFN‐γ Immune cell increase in induce interferon interferon pathway interferon signaling investigated IRF1 IRF9 ISRE JAK/STAT JAK/STAT signaling limit lower expression Mild mild cases monocyte Monocytes Patient PBMC Phosphorylation plasmablast Predictive pSTAT1 SARS‐CoV‐2 infection Severe case Severe infection severely infected patient Signaling STAT Stat1 STAT2 stimulated Stratification T cell target therapeutic target Transcription Transcriptional upregulation type I interferon upregulation
[DOI] 10.1002/eji.202149575 PMC 바로가기 [Article Type] Clinical Trial

Curcumin Inhibits In Vitro SARS-CoV-2 Infection In Vero E6 Cells through Multiple Antiviral Mechanisms

Curcumin은 다중 항바이러스 메커니즘을 통해 Vero E6 세포의 시험관 내 SARS-CoV-2 감염을 억제합니다

Article

Published on 2021-11-162022-09-10
Journal: Molecules [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료제,

[키워드] addition Affect anti-inflammatory effect anti-inflammatory property Antiviral antiviral activity Antiviral effect COVID-19 Curcumin Cytokines cytotoxicity D614G D614G strain delta variant ELISA evaluated exhibit exhibited IL-1β IL-6 IL-8 immune response in vitro independent Infection Inflammation inhibited investigated mononuclear cell mononuclear cells MTT Multiple PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells Plaque assay Post-infection pro-inflammatory cytokine pro-inflammatory cytokines qPCR quantified released replicative required SARS-CoV-2 SARS-COV-2 infection scarcity the SARS-CoV-2 Therapeutic approach therapeutic approaches to define Treatment treatment strategy triggered Vero E6 VERO E6 cells Viral viral titer virucidal were used
[DOI] 10.3390/molecules26226900 PMC 바로가기 [Article Type] Article

Recognition of Variants of Concern by Antibodies and T Cells Induced by a SARS-CoV-2 Inactivated Vaccine

SARS-COV-2 불활성 백신에 의해 유도 된 항체 및 T 세포에 의한 관심의 변이체 인식

Clinical Trial

Published on 2021-11-092022-08-13
Journal: Frontiers in Immunology [Category] MERS, SARS, 변종, 임상, 진단, 치료기술,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus addition Alpha antibodies antibody approved B.1.1.7 B.1.351 Beta Beta variant binding cellular response Cellular responses Chilean circulating variant clinical trial concern CoronaVac coronavirus D614G death rate Delta delta variant described detect dose elicited ELISPOT enrolled evaluate evaluated Gamma genetic difference genetic differences geometric mean Geometric means house human ACE2 receptor immune response immunization immunization schedule immunization schedules immunized immunogenic in-house ELISA inactivated induced Infection interferon interferon-γ-secreting T cell interferon-γ-secreting T cells Lineage microneutralization neutralization neutralize Neutralizing antibodies neutralizing antibody neutralizing capacity P.1 pandemic PBMC PBMCs Phase 3 phase 3 clinical trial promote Protective RBD Receptor binding domain Recognition reduced respiratory responsible Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants secreted secretion Seropositivity severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 shown significant differences spike stimulate subject T cell immunity T cells tested the RBD the SARS-CoV-2 the vaccine titers Vaccine variant variants variants of concern virus Volunteer volunteers were used Wuhan Wuhan, China
[DOI] 10.3389/fimmu.2021.747830 PMC 바로가기 [Article Type] Clinical Trial