CRISPR-based assay reveals SARS-CoV-2 RNA dynamic changes and redistribution patterns in non-human primate modelCRISPR 기반 분석은 비인간 영장류 모델에서 SARS-CoV-2 RNA 동적 변화 및 재배포 패턴을 보여줍니다Coronaviruses Published on 2022-02-212022-09-10 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 진단, 치료기술, [키워드] administration Affect breath change changes in COVID-19 case CRISPR decrease detect detectable Diagnosis distribution dose evaluate evaluated Evidence increase indicate infect Infection invasive Kinetics Mounting mucosal multi-site specimens nasal NHPs non-human primate non-human primate model pharyngeal plasma positive result Post-infection progression rectal rectal swab reduced respiratory reveal RT-qPCR RT–PCR SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RNA sensitivity specimen specimens tissues upper respiratory tract [DOI] 10.1080/22221751.2022.2038020 PMC 바로가기 [Article Type] Coronaviruses
Tocilizumab and COVID-19: Timing of Administration and EfficacyPharmacology Published on 2022-02-182022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] “cytokine storm” acute respiratory distress syndrome Admission Concentration Corticosteroids COVID-19 COVID-19 infection COVID-19 pandemic Cytokine storm demonstrated described Effect Efficacy and safety Evidence highlighting Host humanized monoclonal antibody immune immune dysregulation immunomodulatory impairment Infection intensive care intensive care unit interleukin-6 interleukin-6 receptor interleukine -6 receptor antagonist Intervention Invasive mechanical ventilation investigated key factor mechanical ventilation Mortality observational study outcome pathophysiology patients patients with COVID-19 Pneumonia positive result Potential treatment Prognostic factor Proinflammatory response Randomized controlled trial reported risk SARS-COV-2 infection selected shown Standard of care Support therapy Tocilizumab with COVID-19 [DOI] 10.3389/fphar.2022.825749 PMC 바로가기 [Article Type] Pharmacology
Morphologically, immunohistochemically and PCR proven lymphocytic viral peri-, endo-, myocarditis in patients with fatal COVID-19치명적인 COVID-19 환자에서 형태학, 면역조직화학 및 PCR로 입증된 림프구성 바이러스성 심근주위, 내막, 심근염Short Report Published on 2022-02-172022-09-11 Journal: Diagnostic Pathology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] absence antibody cardiac injury CD20 CD3 characterized clinically coronavirus Coronavirus infection COVID-19 criteria criterion determine diagnosed diagnosis of COVID-19 eight Elderly patient Endocarditis eosin Evidence evidence of expression fatal COVID-19 female heart hematoxylin Hematoxylin and eosin histological Inclusion Increased increased expression Infection infiltration Inflammation Injury less Lymphocytes lymphocytic myocarditis male Microvascular thrombosis Morphological Morphological and immunohistochemical study myocarditis Myocardium neutrophil Neutrophils New coronavirus Patient PCR perforin Pericarditis Pneumonia positive PCR positive result reported Result RNA SARS-CoV-2 staining T lymphocyte T lymphocytes thrombosis TLR Toll-like receptor Toll-like receptors Van Gieson Viral viral myocarditis Viral pneumonia Viral RNA was performed [DOI] 10.1186/s13000-022-01207-6 PMC 바로가기 [Article Type] Short Report
A review on the induction of host immunity by the current COVID-19 vaccines and a brief non-pharmaceutical intervention to mitigate the pandemicReview Published on 2022-02-162022-10-28 Journal: Bulletin of the National Research Centre [Category] COVID-19, [키워드] Abstract antiviral drug approach approaches avoidance cellular COVID-19 pandemic COVID-19 severity COVID-19 situation COVID-19 vaccine effective Genetic global public health Health host immunity humoral immune response Intervention knowledge MERS-CoV Middle East mitigate Non-pharmaceutical interventions pandemic platform positive result present Protective Respiratory Coronavirus respiratory syndrome coronavirus SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 variants second wave similarity the SARS-CoV-2 vaccination Vaccine Vaccine development Vaccines variants variants of SARS-CoV-2 viral escape while [DOI] 10.1186/s42269-022-00719-x PMC 바로가기 [Article Type] Review
Clinical and Laboratory Approach to Diagnose COVID-19 Using Machine LearningOriginal Research Article Published on 2022-02-082022-10-30 Journal: Interdisciplinary sciences, computational life sci [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Abstract acute respiratory syndrome Additive approach artificial intelligence automated Blood blood test blood tests calculate chain Classifier clinical clinician coronavirus 2 cough COVID-19 COVID-19 infection Critical CT scans dataset diagnose diagnosed Diagnosis emergency situation eosinophils explanation false-negative Health help IMPROVE Laboratory leukocyte machine learning machine-learning Monocytes new strain outbreak outcomes pandemic parameter patients Platelet positive result predict reaction RT-PCR RT-PCR test SARS-CoV-2 sensitivity synthetic technique virus were used [DOI] 10.1007/s12539-021-00499-4 PMC 바로가기 [Article Type] Original Research Article
Serologic Survey of IgG Against SARS-CoV-2 Among Hospital Visitors Without a History of SARS-CoV-2 Infection in Tokyo, 2020–2021도쿄에서 SARS-CoV-2 감염 이력이 없는 병원 방문자 중 SARS-CoV-2에 대한 IgG의 혈청학적 조사, 2020-2021Original Article Published on 2022-02-052022-09-12 Journal: Journal of Epidemiology [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] 95% CI 95% confidence interval Against age All participants anti–SARS-CoV-2 IgG antibody blood collection Capital chemiluminescence immunoassay China confirmed cases coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19-related symptom COVID-19-related symptoms cross-sectional cross-sectional study diagnosed ENhance Epidemic exhibited high risk history hospital hospital visitors iFlash IgG IgG seroprevalence individual Infection Japan participant Patient positive result Randomly Respiratory Coronavirus Result SARS-CoV-2 SARS-CoV-2 epidemic SARS-COV-2 infection selected serologic seropositive Seroprevalence serum serum sample serum samples Sex Shenzhen Shenzhen YHLO Biotech survey the SARS-CoV-2 Tokyo Visitor was tested [DOI] 10.2188/jea.JE20210324 PMC 바로가기 [Article Type] Original Article
Sensitivity of RT-PCR testing of upper respiratory tract samples for SARS-CoV-2 in hospitalised patients: a retrospective cohort studyResearch Article Published on 2022-02-012022-10-28 Journal: Wellcome Open Research [Category] COVID-19, [키워드] 95% confidence interval acute respiratory syndrome analysed Clinical diagnosis Clinical features clinically coronavirus disease Coronavirus-2 COVID-19 defined determine Diagnosis diagnostics discharge gold standard Haematology hospitalised hospitalised patient increase majority multiplex negative and positive negative RT-PCR NHS Patient positive positive result proportion respiratory sample retrospective cohort study reverse transcription PCR RNase P RT-PCR RT-PCR test RT-PCR testing RT-PCR tests SARS-CoV-2 SARS-CoV-2 RT-PCR sensitivity Sensitivity and specificity sequence tested United Kingdom upper respiratory tract [DOI] 10.12688/wellcomeopenres.16342.2 PMC 바로가기 [Article Type] Research Article
SARS‐CoV‐2 intralineage variation and temporal patterns of COVID‐19 risk factors in three cities of southeastern Brazil: Age, sex, and raceResearch Article Published on 2022-02-012022-10-04 Journal: Journal of medical virology [Category] COVID19(2023년), MERS, SARS, 치료기술, [키워드] acute respiratory syndrome age airway André association B.1.1.28 Brazil center circulation Complete coronavirus Coronavirus infection COVID‐19 COVID‐19 declining detect ENCODE epidemic wave Epidemiology evaluated Genetic variation genomic sequence GISAID highest homeostasis interfere investigated isolates Lineage linear models ORF3a P.1 P.2 pandemic pathogenic Patient Point positive positive result Protein public health Regional reported resulting risk factor RT‐PCR RT‐PCR SARS‐CoV‐2 second wave Sex specific mutation symptomatic individual Variation were assessed [DOI] 10.1002/jmv.27607 PMC 바로가기 [Article Type] Research Article
Changes in Anterior Chamber Parameters Measured by Pentacam in Coronavirus Disease 2019 Infection: A Longitudinal StudyResearch Article Published on 2022-02-012022-10-31 Journal: Journal of Ophthalmology [Category] COVID-19, [키워드] Affect age Anterior anterior chamber baseline chamber change changes in coronavirus disease COVID-19 COVID-19 infection diagnosis of COVID-19 enrolled evaluate exhibited females Follow-up Germany increase in Infection longitudinal measurement nasopharyngeal Oculus parameter Patient patients positive result repeated Result statistical significance statistically subject Volume was performed [DOI] 10.1155/2022/6828924 PMC 바로가기 [Article Type] Research Article
COVID-19-associated pulmonary aspergillosis in a tertiary care center in Shenzhen CityArticle Published on 2022-02-012022-11-16 Journal: Journal of infection and public health [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory distress Anti-Aspergillus IgG Antibody detection Antigen ARDS Aspergillus BALF Bronchoalveolar lavage fluid Care characterized China city clinical care Co-infection collected COVID-19 Culture diagnosed with COVID-19 Diagnosis died eight fungal galactomannan high mortality rate include invasive outcomes Patient positive positive result pulmonary aspergillosis risk Sequencing analysis severe coronavirus disease Shenzhen single center sputum syndrome tested Therapies therapy underlying conditions [DOI] 10.1016/j.jiph.2021.12.015 PMC 바로가기