Cryo-EM as a powerful tool for drug discovery: recent structural based studies of SARS-CoV-2Review Published on 2021-09-252022-10-27 Journal: Applied Microscopy [Category] COVID-19, [키워드] acute respiratory distress acute respiratory syndrome affecting ARDS binding coronavirus Cryo-electron microscopy cryo-EM death drug drug candidates drug design Drug discovery effective fragment-based drug discovery global pandemic help High-resolution in silico Infection Novel coronavirus pandemic powerful tool Protein Regulation Respiratory system rising SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 Structure-based drug design syndrome therapeutic transmission electron microscopy [DOI] 10.1186/s42649-021-00062-x PMC 바로가기 [Article Type] Review
Cloning of a Passage-Free SARS-CoV-2 Genome and Mutagenesis Using Red Recombination무계대 SARS-CoV-2 게놈의 복제 및 적색 재조합을 사용한 돌연변이 유발Article Published on 2021-09-222022-09-10 Journal: International Journal of Molecular Sciences [Category] SARS, 치료기술, 치료법, [키워드] acute respiratory syndrome Antiviral applied approach BAC Bacterial bacterial artificial chromosome Biology biology of SARS-CoV-2 caused Cell culture chromosome click chemistry clone Cloning Combination concerning contribute coronavirus CoV COVID-19 COVID-19 pandemic disease economic devastation facilitate Features FLAG Frame full-length generate Genetic global effort global efforts incoming viral particles labeling Lambda marker morbidity Mortality nucleocapsid Open reading frame pandemic coronavirus platform powerful tool question recombinant virus Recombination Red red recombination replicated Replication reporter reporter virus respiratory reverse genetics SARS-CoV-2 Severe acute respiratory syndrome Severe Acute Respiratory Syndrome CoV single-cell level spatiotemporal Spread Viral viral particle viral replication Viral RNA viral RNA synthesis virus viruses Visualization [DOI] 10.3390/ijms221910188 PMC 바로가기 [Article Type] Article
Shooting at a Moving Target—Effectiveness and Emerging Challenges for SARS-CoV-2 Vaccine DevelopmentReview Published on 2021-09-222022-10-28 Journal: Vaccines [Category] COVID-19, [키워드] accelerate addressed adverse effects applied approval Breakthrough infection challenge clinical evaluation Compliance COVID-19 development Effectiveness Healthcare systems heterologous vaccination highlight Immune escape immunization implementation IMPROVE infected individual Infection Isolation Long COVID Mask measure mRNA vaccine normality Occurrence pandemic pathway positive powerful tool Prevent PROTECT restrict Safe SARS-CoV-2 SARS-CoV-2 pandemic SARS-CoV-2 vaccine SARS-CoV-2 vaccines second generation vaccines severe COVID-19 Shooting Side effect social distancing Transmission Vaccination strategy Vaccine Vaccine development vaccine effectiveness vaccine safety Vaccines variants Variation Viral antigen virus transmission virus variant virus variants [DOI] 10.3390/vaccines9101052 PMC 바로가기 [Article Type] Review
High COVID-19 Vaccine Hesitancy Among Healthcare Workers: Should Such a Trend Require Closer Attention by Policymakers?Public Health Published on 2021-09-152022-10-31 Journal: Cureus [Category] COVID-19, [키워드] adverse effect association Attention conducted coronavirus disease COVID-19 COVID-19 vaccination cross-sectional effective flu vaccine General population HCW HCWs healthcare worker Healthcare workers Hesitancy highest India information objective pandemic powerful tool questionnaire receive Result risk secure statistically significant Tamil Nadu the vaccine trend vaccination Vaccine Vaccine acceptance Vaccine development Vaccine hesitancy vaccine literacy [DOI] 10.7759/cureus.17990 PMC 바로가기 [Article Type] Public Health
Target Discovery for Host-Directed Antiviral Therapies: Application of Proteomics ApproachesMinireview Published on 2021-09-142022-10-29 Journal: mSystems [Category] COVID-19, [키워드] AIDS antiviral activity antiviral therapy application Compound coronavirus disease COVID-19 current Drug repurposing drug-resistant Epidemics flu Health help Host-directed therapies host-pathogen interaction host-pathogen interactions identify knowledge less limitation pandemic Pathogens powerful tool proteomics Spread Systems biology target tested therapeutic vaccination Viral diseases viral replication viral strains while [DOI] 10.1128/mSystems.00388-21 PMC 바로가기 [Article Type] Minireview
Implementation of an efficient SARS-CoV-2 specimen pooling strategy for high throughput diagnostic testing높은 처리량 진단 테스트를위한 효율적인 SARS-COV-2 시편 풀링 전략 구현Article Published on 2021-09-072022-09-01 Journal: Scientific Reports [Category] SARS, 진단, 치료기술, [키워드] Antigen approach Asymptomatic automated Automation Ct values detect diagnostic gold gold standard group identify implementation individual infected individual infected individuals Infection Infectious-disease diagnostics Isolation lateral flow Population positive powerful tool presymptomatic Prevalence professional sports reduced required RT-PCR RT-PCR detection RT-PCR testing Sample SARS-CoV-2 SARS-COV-2 infection sensitivity shown significantly lower South Africa specimen Spread Transmission Viral [DOI] 10.1038/s41598-021-96934-z PMC 바로가기 [Article Type] Article
Ethacridine inhibits SARS-CoV-2 by inactivating viral particlesResearch Article Published on 2021-09-032022-10-29 Journal: PLoS Pathogens [Category] COVID-19, [키워드] Air-liquid interface antiprotease antiviral activity assays binding BSL2 caused cell types cells coronavirus coronavirus SARS-CoV-2 COVID-19 demonstrated drug drugs effective FDA-approved drug host cells identify immunofluorescence inactivation inhibit inhibiting inhibitor living cell MPro nasal epithelial cell other disease plaque powerful tool Protease inhibitor Respiratory disease RT-PCR SARS-CoV-2 screened Stage viral infection viral particle Viral particles [DOI] 10.1371/journal.ppat.1009898 PMC 바로가기 [Article Type] Research Article
A comprehensive analysis of the efficacy and safety of COVID-19 vaccinesCOVID-19 백신의 유효성 및 안전성에 대한 포괄적인 분석Meta-Analysis Published on 2021-09-012022-09-11 Journal: Molecular therapy : the journal of the American So [Category] MERS, SARS, 변종, 임상, 진단, [키워드] addition addressed ADR ADRS Adverse Adverse drug reaction Adverse drug reactions African American black can be used comprehensive analysis coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 pandemic COVID-19 vaccine COVID-19 vaccines death doses Efficacy Efficacy and safety exceeded fatigue Grade 1 greater headache highest male MOST myocarditis Pain performed Pericarditis powerful tool reaction Reactions real-world data Reporting Research Safety SARS-CoV-2 severity Spectrum System the vaccine the vaccines thromboembolic Thromboembolic events tolerable Trial vaccination Vaccine [DOI] 10.1016/j.ymthe.2021.08.001 PMC 바로가기 [Article Type] Meta-Analysis
Intracellular Life Cycle Kinetics of SARS-CoV-2 Predicted Using Mathematical ModellingSARS-COV-2의 세포 내 수명 사이클 동역학은 수학적 모델링을 사용하여 예측되었습니다.Article Published on 2021-08-312022-09-10 Journal: Viruses [Category] MERS, SARS, 치료제, [키워드] Analysis antiviral drug target approach contributing to COVID-19 cycle cytoplasm Degradation deterministic model disease Health Infection Intracellular intracellular replication kinetic Kinetics life life cycle mathematical model mechanism non-structural protein non-structural proteins parameter Phenotypes plethora positive powerful tool progeny provide Replication SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 life cycle sensitivity analysis Stage targets for drugs the SARS-CoV-2 the strongest threshold Transcription translation Viral viral replication vRNA [DOI] 10.3390/v13091735 PMC 바로가기 [Article Type] Article
A model predictive control approach to optimally devise a two‐dose vaccination rollout: A case study on COVID‐19 in ItalySpecial Issue Article Published on 2021-08-252022-10-30 Journal: International Journal of Robust and Nonlinear Control [Category] COVID-19, [키워드] adopted approach assist complex COVID‐19 Determining diffusion doses early phase effective Effectiveness Efficacy Epidemic epidemic control Epidemic modeling Epidemics first dose flexible healthcare help immunization include Italy model predictive control nonlinear modeling nonlinear optimization nonpharmaceutical intervention pandemic parameter powerful tool Predictive public health authority reported second dose the epidemic vaccination Vaccination strategy Vaccine Vaccines virus [DOI] 10.1002/rnc.5728 PMC 바로가기 [Article Type] Special Issue Article