Profiling Antibody Response Patterns in COVID-19: Spike S1-Reactive IgA Signature in the Evolution of SARS-CoV-2 InfectionCOVID-19의 항체 반응 패턴 프로파일링: SARS-CoV-2 감염의 진화에서 스파이크 S1-반응성 IgA 서명Immunology Published on 2021-11-032022-09-12 Journal: Frontiers in Immunology [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody antibody level antibody production Antibody Response antigens baseline Characteristics Clinical course Clinical management clinical manifestations Clinical outcome Cohort coronavirus coronavirus disease COVID-19 COVID-19 patient detectable diagnosed driver dropped exhibiting First wave heterogeneous IgA IgG IgG level IgM Italy levels of antibodies long-lasting magnitude majority marker Neutralizing Neutralizing activity Neutralizing antibodies pandemic Patient pattern persistence Perspective predict Profiling reactive reflect response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 S1 severity signature spike statistical subsequent the antibody response the disease the SARS-CoV-2 Vaccination strategies VoC [DOI] 10.3389/fimmu.2021.772239 PMC 바로가기 [Article Type] Immunology
Adiponectin to leptin ratio reflects inflammatory burden and survival in COVID-19Observational Study Published on 2021-11-012022-10-05 Journal: Diabetes & metabolism [Category] 임상, [키워드] adiponectin Admission Anti-inflammatory C reactive protein cardiometabolic Cohort contributing to correlated COVID-19 COVID-19 patient CRP death diabete diabetes disease female gender groups Health highest hospitalised hypertension ICU Inflammation Inflammatory intensive care investigated Leptin Linear regression lowest mechanism Mild moderate Mortality obesity Patient patients with moderate predicted predictors pro-inflammatory prospective observational study reduced reflect risk factor SARS-CoV-2 severity significantly Spearman survival systemic inflammation were measured [DOI] 10.1016/j.diabet.2021.101268 PMC 바로가기 [Article Type] Observational Study
The potential role of neopterin in Covid-19: a new perspectiveCovid-19에서 네오프테린의 잠재적 역할: 새로운 관점Review Published on 2021-11-012022-09-11 Journal: Molecular and cellular biochemistry [Category] MERS, 바이오마커, [키워드] Activation Adhesion Molecule adhesion molecules Anti-inflammatory antibody antioxidant effect antioxidant effects attenuate cellular Clinical symptoms compensatory mechanism complications COVID-19 patients COVID-19 severity Dyspnea endothelial feature foam cells Hospitalization hyper-inflammation immune activation immune response Incubation period independent INF-γ inflammasomes Inflammation interferon gamma Macrophage macrophage foam cell Macrophage stimulation macrophages macrophages activation marker mechanism member Migration monocyte Monocytes monocytes/macrophage Neopterin NF-κB NF-κB signaling NLRP3 organ damage oxidative stress Patient Perspective Prognostic factor Protective raise reflect SARS-COV-2 infection severity stimulated T helper Th1 [DOI] 10.1007/s11010-021-04232-z PMC 바로가기 [Article Type] Review
Sex-differences in COVID-19 associated excess mortality is not exceptional for the COVID-19 pandemicArticle Published on 2021-10-212022-10-29 Journal: Scientific Reports [Category] COVID-19, MERS, SARS, [키워드] COVID-19 COVID-19 pandemic death Epidemiology Europe European country exceptional female females highest incidence incidence rate increase Increased investigated linear male males Mortality person year reflect Risk factors were expressed [DOI] 10.1038/s41598-021-00213-w PMC 바로가기 [Article Type] Article
Individualized stress detection using an unmodified car steering wheelArticle Published on 2021-10-192022-10-04 Journal: Scientific Reports [Category] 바이오마커, [키워드] Accuracy Biomarker cohort analysis conditions detect driving Engineering Frequency mass reflect Risk factors significantly higher Signs and symptoms spring Stress stress condition turn [DOI] 10.1038/s41598-021-00062-7 PMC 바로가기 [Article Type] Article
A rapid review of early guidance to prevent and control COVID-19 in custodial settingsResearch Article Published on 2021-10-152022-11-01 Journal: Health & Justice [Category] COVID-19, [키워드] Analysis breadth coding Community conducted COVID-19 COVID-19 disease Critical Custodial settings domain early stage Effectiveness eligible emotional Evidence Forensic psychiatric facilities Guidance Health Service identify Immigration detention implementation incarcerated independent information measure pandemic peer-reviewed physical Prevent Prevention and control prisons Psychological public health rapid review recommendation recommendations reducing reflect Result risk searched supplementary material Surveillance Transmission unique website Youth detention [DOI] 10.1186/s40352-021-00150-w PMC 바로가기 [Article Type] Research Article
Impact of Host Immune Status on Discordant Anti-SARS-CoV-2 Circulating B Cell Frequencies and Antibody Levels불일치 항 SARS-CoV-2 순환 B 세포 주파수 및 항체 수준에 대한 숙주 면역 상태의 영향Article Published on 2021-10-142022-09-12 Journal: International Journal of Molecular Sciences [Category] MERS, SARS, 진단, [키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibody antibody synthesis Antiviral antiviral antibodies B cell B cell repertoire caution circulating clone clones Comorbidities convalescent COVID-19 determined by develop failure frequencies Frequency functional healthcare personnel hospitalized patient hospitalized patients Human monoclonal antibody immortalized immunofluorescence Impact indirect immunofluorescence individual infected cells Level low-grade inflammation Neutralizing protective immunity reflect regulate responses reveal SARS-CoV-2 SARS-CoV-2 infected cells severe COVID-19 Severe patient severe patients statistically status two group two groups [DOI] 10.3390/ijms222011095 PMC 바로가기 [Article Type] Article
Estimated pulse wave velocity improves risk stratification for all-cause mortality in patients with COVID-19Article Published on 2021-10-122022-10-04 Journal: Scientific Reports [Category] MERS, 임상, [키워드] 4C Mortality added adjusted age all-cause mortality analyzed approach arterial Arterial stiffness blood pressure calculated Cohort Comorbidity component control group COVID-19 COVID-19 patient Deceased Estimated evaluate hospitalized COVID-19 patient hospitalized patient IMPROVE longitudinal cohort study marker Mortality Patient patients with COVID-19 Predictive markers prognostic Prognostic markers Prognostic value provided pulse recruited reflect retrospective risk factor risk stratification Sex subject survivor Therapeutic strategies total population viral infection with COVID-19 [DOI] 10.1038/s41598-021-99050-0 PMC 바로가기 [Article Type] Article
COVID-19 cynomolgus macaque model reflecting human COVID-19 pathological conditions인간의 COVID-19 병리학적 상태를 반영하는 COVID-19 시노몰구스 원숭이 모델423 Published on 2021-10-082022-09-10 Journal: Proceedings of the National Academy of Sciences of [Category] MERS, SARS, 진단, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age animal model animals chemokine chemokines clinical condition Computed tomography coronavirus COVID-19 COVID-19 crisis cynomolgus macaques Cytokines elderly elderly patients examined Health healthy Human indicated individual Infection Inflammatory response Inflammatory responses initial inoculated intranasally life macaque metabolic disease mucosal nonhuman primate overcome pandemic pathogenicity pathological condition pathological conditions pathology pathophysiology Patient Pneumonia Primary infection Prophylactic reflect Reinfection required respiratory SARS-CoV-2 serum cytokine serum cytokines severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 severe pneumonia shown Significance swab samples therapeutic therapeutic agent therapeutic agents underlying disease underlying diseases Vaccines Viral Viral RNA virus detection were infected [DOI] 10.1073/pnas.2104847118 PMC 바로가기 [Article Type] 423
Procalcitonin Levels in COVID-19 Patients Are Strongly Associated with Mortality and ICU Acceptance in an Underserved, Inner City PopulationObservational Study Published on 2021-10-072022-10-04 Journal: Medicina [Category] MERS, SARS, 임상, [키워드] 95% CI 95% confidence interval acceptance age ARDS association Biomarkers Blood Blood urea nitrogen C-reactive protein Care city clinical factor correlated COVID-19 COVID-19 infection COVID19 COVID19 patient Critical care death elevated expired Factors First wave help ICU identify Inner intensive care intensivist Level likelihood logistic regression model magnitude material Mortality multivariate analyses neutrophil New York Non-survivors objective Observational cohort study Odds ratio pandemic Patient Platelet Pneumonia Population procalcitonin procalcitonin level quartile reflect Result retrospective Science severity Sex significantly single-center state survived Survivors university [DOI] 10.3390/medicina57101070 PMC 바로가기 [Article Type] Observational Study