Bronchoalveolar lavage affects thorax computed tomography of healthy and SARS-CoV-2 infected rhesus macaques ( Macaca mulatta )기관지폐포 세척은 건강한 SARS-CoV-2에 감염된 붉은털 원숭이(Macaca mulatta)의 흉부 컴퓨터 단층 촬영에 영향을 미칩니다.Research Article Published on 2021-07-092022-09-12 Journal: PLoS ONE [Category] SARS, 진단, [키워드] 24 hour 24 hours addition Affect alteration BAL Bronchoalveolar lavage Computed tomography determine diagnostic Effect evaluated female healthy Hounsfield units immune increase in Interference investigated Local Lower respiratory tract lung Medical imaging non-human primate non-human primates Research resolved rhesus macaque rhesus macaques SARS-CoV-2 SARS-COV-2 infection scoring system semi-quantitative significant difference subsequent the healthy Thorax virus production [DOI] 10.1371/journal.pone.0252941 PMC 바로가기 [Article Type] Research Article
Host- and Species-Dependent Quasispecies Divergence of Severe Acute Respiratory Syndrome Coronavirus-2 in Non-human Primate ModelsMicrobiology Published on 2021-07-092022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] 3′-UTR 5′-untranslated region acute respiratory syndrome Analysis average cells coding coronavirus deep sequencing diagnostics Divergence eight evaluated Evolution Frequency genetic information genetic variants Genome Host individual Infection Interpretation longitudinal study lung macaques Model N gene NHPs non-coding region Non-human non-human primate ORF1ab ORF3a ORF8 performed polymorphism primate Protein ranged reported respiratory rhesus macaque rhesus macaques SARS-CoV-2 significantly Single nucleotide polymorphism Single nucleotide variant single-nucleotide SNP SNPs SNVs the SARS-CoV-2 UTR Vaccine variant Variation viral titer virus [DOI] 10.3389/fmicb.2021.694897 PMC 바로가기 [Article Type] Microbiology
Early treatment with a combination of two potent neutralizing antibodies improves clinical outcomes and reduces virus replication and lung inflammation in SARS-CoV-2 infected macaques2개의 강력한 중화 항체 조합을 통한 조기 치료는 SARS-CoV-2에 감염된 원숭이에서 임상 결과를 개선하고 바이러스 복제 및 폐 염증을 감소시킵니다.Research Article Published on 2021-07-062022-09-10 Journal: PLoS Pathogens [Category] SARS, 변종, 진단, [키워드] 24 hour 24 hours animal animals anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibodies antibody antibody combination clinic clinical development Clinical outcome Clinical signs Clinical studies clinical testing Combination combinations controls COVID-19 COVID-19 disease develop dose early infection effective extension group half-lives High dose high risk histology Human IMPROVE infected individual Infection inoculated interstitial pneumonia intra-tracheally intranasally intravenously investigated less Lower respiratory tract lung Lung inflammation macaque maintain monoclonal antibodies monoclonal antibody mutations neutralize neutralizing antibody neutralizing monoclonal antibodies Placebo progression promise Prophylactic provide reduce reduced respiratory respiratory tract rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection severe COVID-19 disease shown significantly Support tested therapeutic efficacy therapeutic intervention Therapeutic strategies three groups treated Treatment upper and lower respiratory tract variant Viral Viral variants virus replication [DOI] 10.1371/journal.ppat.1009688 PMC 바로가기 [Article Type] Research Article
Low-dose Ad26.COV2.S protection against SARS-CoV-2 challenge in rhesus macaques붉은털 원숭이의 SARS-CoV-2 공격에 대한 저용량 Ad26.COV2.S 보호Article Published on 2021-06-242022-09-12 Journal: Cell [Category] MERS, SARS, 비임상, 진단, [키워드] Ad26.COV2.S Adenovirus binding Bronchoalveolar lavage correlated COVID-19 disease dose Efficacy evaluate expressing humoral Humoral immunity immunization immunized immunology low dose memory B memory B cell memory B cells nasal swabs Neutralizing antibody titer non-human primates protection Protective provided reduced reported required rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 spike serotype upper respiratory tract vaccination Vaccine vaccine dose vaccine doses viral particle [DOI] 10.1016/j.cell.2021.05.040 PMC 바로가기 [Article Type] Article
Protective efficacy of Ad26.COV2.S against SARS-CoV-2 B.1.351 in macaques원숭이에서 SARS-CoV-2 B.1.351에 대한 Ad26.COV2.S의 보호 효능Article Published on 2021-06-232022-09-10 Journal: Nature [Category] MERS, SARS, 변종, 비임상, 유전자 메커니즘, 진단, [키워드] Ad26 Ad26.COV2.S Ad26.COV2.S vaccine B.1.1.7 B.1.351 B.1.351 variant binding Bronchoalveolar lavage CAL.20C variants CD4 CD8 Cellular immune response comparable COVID-19 COVID-19 vaccine cross-react demonstrated Efficacy elicit elicited evade expresse Human humoral Humoral and cellular immune responses immune responses implication induce Infection macaque nasal swab nasal swabs Neutralizing antibodies neutralizing antibody P.1 PROTECT Protective provided rhesus macaque rhesus macaques robust SARS-CoV-2 SARS-CoV-2 variant SARS-CoV-2 variants sequenced South Africa Spike protein stabilized spike protein symptomatic symptomatic COVID-19 T cell T cell response These data Vaccine Vaccines virus virus replication viruses WA1/2020 [DOI] 10.1038/s41586-021-03732-8 PMC 바로가기 [Article Type] Article
Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates2개의 새로운 아데노바이러스 매개된 COVID-19 백신 후보로 생쥐와 붉은털 원숭이의 프라임 부스트 백신 접종Research Article Published on 2021-06-012022-09-10 Journal: Emerging Microbes & Infections [Category] SARS, 진단, 치료기술, [키워드] Adenovirus animals anti-RBD anti-S binding antibody candidate CD4 cells changes COVID-19 vaccine COVID-19 vaccines detectable dose-dependent manner elicit evaluated FIVE followed by full-length human adenovirus 49 vector IFN-γ IL-2 immune response immune responses Immunity immunization immunogenicity macaque macaques mice mice and non-human primates nCoV pathologic peptide peptides preparation prime-boost regimen prime-boost vaccination priming pseudovirus neutralizing antibody response rhesus macaque rhesus macaques SARS-CoV-2 spike protein simian adenovirus 23 vector Specific Spike protein T cell T-cell Response the vaccine trials vaccination Vaccine [DOI] 10.1080/22221751.2021.1931466 PMC 바로가기 [Article Type] Research Article
Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirusResearch Article Published on 2021-05-242022-10-30 Journal: JCI Insight [Category] COVID-19, [키워드] acute respiratory syndrome Adaptive immunity binding Cellular immune response Clinical symptoms controls coronavirus Coronaviruses disease DNA vaccine dose effective exhibited full-length human-to-human transmission immunized Infectious disease Intradermal intramuscular lung macaque MERS-CoV MERS-CoV infection Middle East morbidity and mortality neutralizing antibody PROTECT Protein reduced regimen reservoirs respiratory syndrome coronavirus rhesus macaque rhesus macaques SARS-CoV SARS-CoV-2 severity Support Transmission vaccination Vaccine Vaccines zoonotic [DOI] 10.1172/jci.insight.146082 PMC 바로가기 [Article Type] Research Article
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in nonhuman primates중화 항체 LY-CoV555는 비인간 영장류에서 SARS-CoV-2 감염을 예방합니다Research Article Published on 2021-05-122022-09-12 Journal: Science Translational Medicine [Category] MERS, SARS, 비임상, 진단, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus airway airways angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 Anti-spike antibody Antigen antigen-specific B cell Antigen-specific B cells B cells bamlanivimab binding characterized clearance clinical testing Clinical use collected conducted convalescent patient coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 demonstrated evaluated functional high-affinity binding Hospitalized in vitro in vivo indications individual infected with SARS-CoV-2 Infection Interaction Jone Jones less Lower respiratory tract LY-CoV555 mAb mAbs monoclonal monoclonal antibodies monoclonal antibody neutralize Neutralizing activity Neutralizing antibodies neutralizing antibody offer patients with COVID-19 pharmacokinetic Population prevented prophylactic dose prophylactic doses prophylactic treatment PROTECT public health threat Receptor-binding domain reduced respiratory distress Respiratory distress syndrome rhesus rhesus macaque SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 spike severe acute respiratory distress syndrome Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spectrum Spike protein Support syndrome tested the receptor-binding domain therapeutic therapeutic agent therapeutic option Therapeutics These data Treatment upper and lower respiratory tract upper and lower respiratory tracts vaccination viral replication widespread [DOI] 10.1126/scitranslmed.abf1906 PMC 바로가기 [Article Type] Research Article
Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques붉은털 원숭이의 점막 백신에 의한 SARS-CoV-2 감염에 대한 보호Research Article Published on 2021-04-282022-09-10 Journal: JCI Insight [Category] MERS, SARS, 진단, 치료기술, [키워드] Adaptive immunity binding boost cellular immunity complementary controls COVID-19 demonstrated detectable dimeric Efficacy elicited IFN-α IgA IL-15 immunization Innate immunity intramuscularly intranasal Lower respiratory tract mucosal multiple dose multiple doses naive controls nasal Nasal cavity neutralizing antibody PROTECT protection Protective protective mechanism protective mechanisms respiratory response rhesus macaque rhesus macaques RNA robust Safe SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 vaccine Spike protein spike protein S1 Subunit vaccine subunit vaccines systemically T cell TLR agonists Vaccine Vaccines Viral viral replication virus [DOI] 10.1172/jci.insight.148494 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responsesReport Published on 2021-04-052022-10-31 Journal: Cell Reports Medicine [Category] COVID-19, MERS, SARS, [키워드] Abstract antibody Antibody Response Antibody titer boost demonstrated detectable effective elicit exceptional Follow-up health emergency host cells Human human donor immunization macaques magnitude memory B cell mice MONITOR Neutralizing antibodies Neutralizing antibody response Neutralizing antibody titer Neutralizing titer outbreak prefusion conformation Prophylactic Protein protein subunit vaccine response rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 protein SARS-CoV-2 spike SARS-CoV-2 spike glycoprotein seropositive single dose spike glycoprotein Spike protein Spread stimulate subunit subunit vaccines Support Trimers vaccination Vaccine [DOI] 10.1016/j.xcrm.2021.100252 PMC 바로가기 [Article Type] Report