5′-triphosphate siRNA targeting HBx elicits a potent anti-HBV immune response in pAAV-HBV transfected miceArticle Published on 2019-01-012023-06-18 Journal: Antiviral Research [Category] B형 간염, [키워드] HBV Immunotherapy RIG-I RNA interference [DOI] 10.1016/j.antiviral.2018.11.006
Lethal influenza A virus preferentially activates TLR3 and triggers a severe inflammatory responseArticle Published on 2018-09-152023-06-24 Journal: Virus research [Category] 신종인플루엔자, [키워드] Inflammatory response Lethal avian influenza A virus RIG-I TLR3 [DOI] 10.1016/j.virusres.2018.09.012
HBV Bypasses the Innate Immune Response and Does Not Protect HCV From Antiviral Activity of InterferonArticle Published on 2018-05-012023-06-16 Journal: Gastroenterology [Category] B형 간염, [키워드] Coinfection interferon-stimulated gene PRR RIG-I [DOI] 10.1053/j.gastro.2018.01.044
Avian infectious bronchitis virus disrupts the melanoma differentiation associated gene 5 (MDA5) signaling pathway by cleavage of the adaptor protein MAVSResearch Article Published on 2017-11-132022-10-28 Journal: BMC veterinary research [Category] Coronavirus, MERS, [키워드] absence activate Activation Antiviral antiviral immune response bronchitis Cell cells cleavage cleave cytoplasmic disrupt downstream early stage exhibited host antiviral response IBV IBV infection IFN-β induce Infection infectious agent Infectious Bronchitis Virus influence Innate immunity interferon MAVS MDA5 Melanoma Melanoma differentiation associated gene 5 platform Protein question raise Result Retinoic acid-inducible gene-I RIG-I signaling pathway supplementary material susceptibility transfected with Viral RNA virus [DOI] 10.1186/s12917-017-1253-7 PMC 바로가기 [Article Type] Research Article
RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infectionResearch Published on 2017-09-022023-06-07 Journal: Respiratory Research [Category] Fulltext, 신종인플루엔자, [키워드] cytokine Influenza virus lung RIG-I smoking Transgenic mouse [DOI] 10.1186/s12931-017-0649-z PMC 바로가기 [Article Type] Research
The nucleocapsid proteins of mouse hepatitis virus and severe acute respiratory syndrome coronavirus share the same IFN-β antagonizing mechanism: attenuation of PACT-mediated RIG-I/MDA5 activationResearch Paper Published on 2017-07-252022-10-28 Journal: Oncotarget [Category] Coronavirus, [키워드] activate Activation acute respiratory syndrome antiviral response association cellular circumvent coronavirus CoV CoV-infected cells CoVs epidemic diarrhea Human IFN IFN-β IFNs inhibited Innate immunity innate immunity evasion Interaction interferon MDA5 mechanism Melanoma MHV molecular mouse hepatitis virus N protein N proteins Nidovirale nucleocapsid protein PACT PEDV Protein reproductive RIG-I RIG-I/MDA5 SARS-CoV N protein Sendai virus syndrome the N protein turn type I interferon upstream Viral protein virus [DOI] 10.18632/oncotarget.17912 PMC 바로가기 [Article Type] Research Paper
Gene expression profile after activation of RIG-I in 5’ppp-dsRNA challenged DF1Article Published on 2016-12-012023-06-03 Journal: Developmental and comparative immunology [Category] 조류인플루엔자, [키워드] Crosstalk duck expression profile RIG-I RNA-Seq [DOI] 10.1016/j.dci.2016.07.009
The nucleolar protein GLTSCR2 is required for efficient viral replicationArticle Published on 2016-11-082022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated attenuate blocking cells cellular contributed coronavirus cytoplasm cytoplasmic glioma host cell IFN-β Infection innate immune response NES nuclear nucleus protease Protein required RIG-I sequence suggested Support supported therapeutic translocation triple interaction tumor suppressor type I interferon USP15 viral infection viral replication [DOI] 10.1038/srep36226 PMC 바로가기 [Article Type] Article
Human primary airway epithelial cells isolated from active smokers have epigenetically impaired antiviral responsesResearch Published on 2016-09-072023-06-07 Journal: Respiratory Research [Category] Fulltext, 신종인플루엔자, [키워드] COPD HBEC Human Influenza Innate immunity interferon lung RIG-I TLR3 [DOI] 10.1186/s12931-016-0428-2 PMC 바로가기 [Article Type] Research
Middle East respiratory syndrome coronavirus ORF4b protein inhibits type I interferon production through both cytoplasmic and nuclear targetsArticle Published on 2015-12-032022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] abrogated Analysis Antiviral antiviral response antiviral responses antiviral signaling Asia binding contribute coronavirus country cytoplasm cytoplasmic determinant Europe evade highly pathogenic IFN IFN-α/β IFN-β IKKε inhibit Interaction interferon IRF3 IκB MAVS MDA5 mechanism MERS-CoV Middle East mitochondrial molecular interaction Mortality North nuclear nuclear localization signal nucleus ORF4b other coronavirus Pathogenesis pathogenicity Phosphorylation previous study Protein Regulatory respiratory syndrome coronavirus RIG-I shown significantly spread to subsequent suppress TANK target TBK1 the interferon therapeutic Type I IFN type I interferon virulence virus [DOI] 10.1038/srep17554 PMC 바로가기 [Article Type] Article