S2 subunit – Page 8 – Communicable Diseases Research

S Protein-Reactive IgG and Memory B Cell Production after Human SARS-CoV-2 Infection Includes Broad Reactivity to the S2 Subunit

Research Article

Published on 2020-09-252022-10-29
Journal: mBio [Category] COVID-19, SARS,

Impact of glycan cloud on the B-cell epitope prediction of SARS-CoV-2 Spike protein

Article

Published on 2020-09-042022-10-04
Journal: NPJ Vaccines [Category] 진단,

Unlocking COVID therapeutic targets: A structure-based rationale against SARS-CoV-2, SARS-CoV and MERS-CoV Spike

Research Article

Published on 2020-07-312022-10-31
Journal: Computational and Structural Biotechnology Journal [Category] COVID-19,

[키워드] aa, amino acid Abstract ACE2, angiotensin-converting enzyme2 antibody approach approved Bat-SL-CoVs, bat SARS-like coronavirus beta-CoVs Beta-CoVs, betacoronavirus Betacoronavirus CC, conserved cluster CD, connector domain CDP, consensus druggable pocket CDR, consensus druggable residue CH, central helix Consensus conserved coronavirus disease COVID COVID-19 CoVs, coronavirus CP, cytoplasmic domain CR, connecting region Critical CS, conservation score described DGSS, DoGSiteScorer domain DPP4, dipeptidyl peptidase-4 drug design Druggability prediction feature Features FP, fusion peptide HR1, heptad repeat 1 HR2, heptad repeat 2 hSARSr-CoVs, human Severe acute respiratory syndrome-related coronavirus Human in viral Infection inhibitors MERS-CoV MERS-CoVs, middle east respiratory syndrome coronavirus MERSr-CoVs, middle east respiratory syndrome-related coronavirus modulation molecular MSA, multiple sequence alignment New new SARS-CoV-2 Novel antiviral targets NTD, N-terminal domain nts, nucleotides Pathogenesis PDB, Protein Data Bank PDS, PockDrug-Server performed pharmacological Protein provide RBD RBD, receptor-binding domain Region regions Research residue Resilience responsible resulting S, spike S1 and S2 S2 subunit SARS-CoV SARS-CoV-2 SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2 SARS-CoVs, severe acute respiratory syndrome coronavirus SARSr-CoV SARSr-CoVs, severe acute respiratory syndrome-related coronavirus SD1, subdomain 1 SD2, subdomain 2 Sequence analysis Sequence conservation SF, SiteFinder from MOE SP, small pocket spike Spike protein subunits Sv, shorter variant T-RHS, top-ranked hot spots the Spike therapeutic TMPRSS2, Transmembrane Protease Serine 2
[DOI] 10.1016/j.csbj.2020.07.017 PMC 바로가기 [Article Type] Research Article

Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein

Article

Published on 2020-07-172022-10-04
Journal: Nature Communications [Category] SARS, 변종, 치료제,

Monoclonal antibodies for the S2 subunit of spike of SARS-CoV-1 cross-react with the newly-emerged SARS-CoV-2

Research

Published on 2020-07-162022-10-31
Journal: Eurosurveillance [Category] COVID-19, SARS,

[키워드] Ability ACE2 acute respiratory syndrome aligned angiotensin-converting enzyme 2 antibody binding cause Cell common-cold conserved Coronavirus disease 2019 Coronaviruses COVID-19 cross-react cross-reactive cross-reactive antibodies cross-reactivity demonstrated detect diagnostic domain ELISA expressed expressing full length host cell receptor human infections immunogenic interact mAb mAbs mammalian cell MERS Middle East monoclonal antibody murine Novel coronavirus outbreak Part performed Protein raised recombinant S protein responsible Result S protein S2 subunit sandwich ELISA SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 infected cell SARS-CoV-2 research SARS-CoV-2 S protein SARS-CoV-2-infected cell sequence spike glycoprotein Spike protein syndrome tested the S protein while
[DOI] 10.2807/1560-7917.ES.2020.25.28.2000291 PMC 바로가기 [Article Type] Research

Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution

Article

Published on 2020-06-172022-10-29
Journal: Nature Communications [Category] COVID-19,

Highly Conserved Homotrimer Cavity Formed by the SARS-CoV-2 Spike Glycoprotein: A Novel Binding Site

Article

Published on 2020-05-142022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] ACE2 ACE2 receptor acute respiratory syndrome addition Angiotensin converting enzyme-2 assist binding binding site Cavity Cell chitosan conserved coronavirus Coronavirus disease 2019 (COVID-19) CoV domain domains Drug discovery drug target examined exhibit facilitate feasibility feature fluctuation homotrimer host cell receptor identify indicated inhibit inhibitor inhibitors Interaction mammalian MD simulation mechanism molecular molecular docking molecular dynamics monomer novel pathway Protein RBD Receptor binding domain Region S2 subunit SARS-CoV-2 sequence variability Site spike spike glycoprotein Spike protein suggested the SARS-CoV-2 the SARS-CoV-2 virus the spike protein trimer trimer cavity Variability viral genome Virtual screening viruses
[DOI] 10.3390/jcm9051473 PMC 바로가기 [Article Type] Article

Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion

Article

Published on 2020-03-302022-10-04
Journal: Cell Research [Category] MERS, SARS, 치료제,

Cryo-EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans

530

Published on 2020-01-212022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] Coronavirus,

Identification of the immunodominant neutralizing regions in the spike glycoprotein of porcine deltacoronavirus

Article

Published on 2019-12-062022-11-01
Journal: Virus research [Category] Coronavirus, MERS,