Familial Clusters of Coronavirus Disease in 10 Prefectures, Japan, February−May 2020Dispatch Published on 2021-03-012022-10-31 Journal: Emerging Infectious Diseases [Category] COVID-19, SARS, [키워드] Asymptomatic coronavirus disease COVID-19 diagnosed Familial Familial clusters Japan prefectures respiratory infections SAR SARS-CoV-2 secondary attack rate severe acute respiratory syndrome coronavirus 2 symptom onset viruses [DOI] 10.3201/eid2703.203882 PMC 바로가기 [Article Type] Dispatch
Establishing an Analogue Based In Silico Pipeline in the Pursuit of Novel Inhibitory Scaffolds against the SARS Coronavirus 2 Papain-Like ProteaseSARS 코로나바이러스 2 파파인 유사 프로테아제에 대한 새로운 억제 스캐폴드를 추구하기 위해 인실리코 파이프라인 기반 유사체 구축Article Published on 2021-02-202022-09-10 Journal: Molecules [Category] MERS, 신약개발, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus analogue analogues approved AutoDock AutoDock tools binding affinities binding affinity caused comparable Compound conducted Consequences coronavirus COVID-19 crystal structure cysteine cysteine proteases docked docking drug Drug discovery drug-likeness electrostatic Enamine Establishing fatality feature identify in silico in vitro inhibit inhibitor inhibitors Interaction knowledge lack Ligand M pro molecular docking novel outbreak pandemic Papain Papain-like protease performed PLpro predicted profiles protease protein-ligand interaction Region Replication respiratory SAR SARS coronavirus 2 SARS coronaviruses SARS-CoV-1 SARS-CoV-2 scaffold hopping severe acute respiratory syndrome Coronavirus similarity targets Viral viral replication Virtual screening [DOI] 10.3390/molecules26041134 PMC 바로가기 [Article Type] Article
Novel Synthetic Routes to Prepare Biologically Active Quinoxalines and Their Derivatives: A Synthetic Review for the Last Two Decades생물학적 활성 퀴녹살린 및 그 유도체를 준비하기 위한 새로운 합성 경로: 지난 20년 동안의 종합 검토Review Published on 2021-02-182022-09-10 Journal: Molecules [Category] MERS, 치료제, [키워드] AIDS Antibacterial Antifungal antimicrobial Antiviral approach Bacteria Biological agents biological applications caused cells class compounds derivative derivatives Diseases drug Effect explained focus fungi green chemistry highlight Infectious diseases Last novel pandemic pathogen Pathogens pharmacological quinoxaline Research researchers review route SAR Schizophrenia synthetic therapeutic therapeutic use treat viruses [DOI] 10.3390/molecules26041055 PMC 바로가기 [Article Type] Review
Coronavirus disease 2019 (COVID-19) outbreak during a Chinese New Year dinner in a restaurant, Hong Kong Special Administrative Region SAR (China), 2020Covid-19 Published on 2021-02-162022-10-28 Journal: Western Pacific Surveillance and Response Journal [Category] COVID-19, MERS, [키워드] China Chinese New Year Coronavirus disease 2019 COVID-19 Hong Kong outbreak Region SAR [DOI] 10.5365/wpsar.2020.11.2.006 PMC 바로가기 [Article Type] Covid-19
Dietary Intake and Mental Health among Saudi Adults during COVID-19 LockdownArticle Published on 2021-02-092022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] age Anxiety conducted consequence continuous monitoring COVID-19 COVID-19 pandemic cross-sectional Depression dietary dietary intake elevated Healthcare provider high risk higher risk identify Insomnia intake lockdown lower risk median Mental mental illness multivitamin pandemic participant predictor Prevalence Psychological regression analysis required SAR Saudi Arabia student Support was used [DOI] 10.3390/ijerph18041653 PMC 바로가기 [Article Type] Article
Epidemiology of COVID-19 in Northern Ireland, 26 February 2020–26 April 2020Original Paper Published on 2021-01-292022-11-01 Journal: Epidemiology and Infection [Category] COVID-19, [키워드] 95% CI Analysis category collected Contact Contact tracing coronavirus coronavirus disease COVID-19 cumulative effective intervention Epidemiology higher odd household contact household transmission incidence individual Infection Ireland Laboratory laboratory-confirmed locus Logistic regression analysis Mortality pandemic positive reduce risk of infection ROI SAR SARS-CoV-2 SARS-CoV-2 transmission secondary attack rate study period Surveillance Transmission urgency [DOI] 10.1017/S0950268821000224 PMC 바로가기 [Article Type] Original Paper
COVID-19: Detecting Government Pandemic Measures and Public Concerns from Twitter Arabic Data Using Distributed Machine LearningArticle Published on 2021-01-012022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, [키워드] Algorithms allocation Analysis Apache Spark Arabic Arabic language big data Blood components concern coronavirus COVID-19 COVID-19 case COVID-19 pandemic dataset deaths described detect distributed computing Effectiveness event events example FIVE Government information Kingdom knowledge Latent machine learning measure Measures media pandemic progression Public quarantine reduced SAR Saudi Arabia smart cities smart governance smart healthcare social media Triple Bottom Line (TBL) Twitter [DOI] 10.3390/ijerph18010282 PMC 바로가기 [Article Type] Article
Discovery of New Hydroxyethylamine Analogs against 3CL pro Protein Target of SARS-CoV-2: Molecular Docking, Molecular Dynamics Simulation, and Structure-Activity Relationship StudiesSARS-CoV-2의 3CL pro 단백질 표적에 대한 새로운 하이드록시에틸아민 유사체 발견: 분자 도킹, 분자 역학 시뮬레이션 및 구조-활성 관계 연구Article Published on 2020-12-282022-09-11 Journal: Journal of Chemical Information and Modeling [Category] SARS, 신약개발, 치료제, [키워드] 3CL pro Analysis Antiviral antiviral drugs approach approved bind binding pocket caused chymotrypsin Compound computer-aided drug design COVID-19 crystal structure cysteine cysteine protease demonstrated described docking docking score domain domains drug target Dynamics enzyme Health highlight in viral Indinavir initial screening lead linker M pro molecular docking molecular dynamics New Novel coronavirus pandemic parameters performed protease Protein relationship Replication reported SAR SARS-CoV SARS-CoV-2 Simulation stability supported target therapeutic Vaccine Viral viral replication Virtual screening virus [DOI] 10.1021/acs.jcim.0c00326 PMC 바로가기 [Article Type] Article
Bioactivity Potential of Marine Natural Products from Scleractinia-Associated Microbes and In Silico Anti-SARS-COV-2 EvaluationScleractinia 관련 미생물 및 In Silico Anti-SARS-COV-2 평가에서 해양 천연 제품의 생물학적 활성 가능성Review Published on 2020-12-162022-09-10 Journal: Marine Drugs [Category] SARS, 치료제, [키워드] (RdRp activity ADME ADME analysis Analysis Bacteria biological activity Cancer Compound compounds Coverage determine Diseases drug filtered fungi hierarchy Inflammation investigated leads malaria marine bacteria marine fungi marine natural products methyltransferase microbe molecular docking molecular docking studies natural organism Organisms Physicochemical properties Potential producing product RdRP Research responsible RNA dependent RNA polymerase RNA polymerase RNA-dependent RNA polymerase SAR SARS-CoV-2 SARS-CoV-2 RNA Scleractinia Secondary Metabolite secondary metabolites selected structure activity relationship target these compound Viral diseases zooxanthellae [DOI] 10.3390/md18120645 PMC 바로가기 [Article Type] Review
Plasmodial Kinase Inhibitors Targeting Malaria: Recent Developments말라리아를 겨냥한 플라스모디움 키나제 억제제: 최근 발전Review Published on 2020-12-152024-08-11 Journal: Molecules [Category] 말라리아, [키워드] Kinase inhibitor malaria Medicinal chemistry Plasmodium SAR [DOI] 10.3390/molecules25245949 PMC 바로가기 [Article Type] Review