One year of SARS-CoV-2 evolutionSARS-CoV-2 진화의 1년Article Published on 2021-04-142022-09-11 Journal: Cell Host & Microbe [Category] SARS, 변종, [키워드] COVID-19 pandemic effort etiologic agent Evolution Mutation outbreak SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome sequence SARS-CoV-2 genome sequences Transmission viral genome virus [DOI] 10.1016/j.chom.2021.02.017 PMC 바로가기 [Article Type] Article
High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19높은 처리량, 단일 사본 시퀀싱은 급성 COVID-19 동안 체액 면역 증가와 일치하는 SARS-CoV-2 스파이크 변이체를 보여줍니다Clinical Trial Published on 2021-04-082022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, 임상, 치료기술, 치료제, [키워드] acute COVID-19 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 acute respiratory syndrome coronavirus-2 Analysis Antibody binding Antiviral antiviral drug antiviral therapies antiviral therapy applied approach arising autologous antibodies binding Cell culture clearance Clinical outcome Clustering contribute coronavirus coronavirus disease Coronavirus disease 2019 Coronavirus-2 COVID-19 cross-sectional analysis detect detectable domain epitope evade Evolution exhibit Frame furin furin cleavage site Genetic genetic diversity Genome genomic RNA Haplotype help Humoral immunity immune response immune responses Immune-mediated in vitro in vivo increase in independent individual individuals with COVID-19 infected individual infected individuals infecting initial intra-individual longitudinal analysis Mutation mutations Non-synonymous mutation NTD one individual participant Pathogenesis predominant regions respiratory reveal SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome SARS-CoV-2 genomes SARS-CoV-2 replication SARS-CoV-2 spike protein SARS-CoV-2 spike variant SARS-CoV-2 variant SARS-CoV-2 variants selected selection of variant sequence Sequencing sequencing technology serum serum sample Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 Spike protein study participant surface protein surface proteins susceptibility the SARS-CoV-2 Time frame upper respiratory sample variant variants Variation virion virus virus RNA virus variants viruses WA-1 reference with COVID-19 [DOI] 10.1371/journal.ppat.1009431 PMC 바로가기 [Article Type] Clinical Trial
Temporal dynamics of SARS-CoV-2 mutation accumulation within and across infected hosts감염된 숙주 내 및 전체에 걸친 SARS-CoV-2 돌연변이 축적의 시간적 역학Research Article Published on 2021-04-072022-08-13 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] accumulate can not chance Cluster Cohort collected Community Consensus consensus sequence consensus sequences convergent evolution Coverage Critical defined determine Epidemic Epidemiology Evolution Frequency genetic diversity Genetic variant Genome sequencing genomes help high resolution hospitalized COVID-19 patient hospitalized COVID-19 patients Host identify identifying individual Infection investigated lineages low frequencies Metadata MONITOR Mutation Outbreaks Prevent Public health intervention Public health interventions reflect RNA SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 mutation SARS-CoV-2 transmission sequence sequenced Sequencing single medical center specimen Spread Strains symptom onset Temporal Transmission transmission of SARS-CoV-2 understanding unlikely utility variant variants Variation Viral Viral genome sequencing Viral load viral variant [DOI] 10.1371/journal.ppat.1009499 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 evolution during treatment of chronic infection만성 감염 치료 중 SARS-CoV-2 진화Case Reports Published on 2021-04-012022-09-11 Journal: Nature [Category] MERS, SARS, 변종, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody chronic infection compensating convalescent plasma Convalescent plasma therapy convalescent plasma treatment coronavirus Course Critical Deletion deletion mutant dominant Engagement Evidence evidence of Final Frequency Genotype human Ace2 protein Immunosuppressed in vitro individuals mutant Mutation N-terminal domain Neutralizing antibodies neutralizing antibody reduced Remdesivir respiratory S2 subunit SARS-CoV-2 SARS-CoV-2 evolution sensitivity sequence Sequencing serum antibodies serum antibody severe acute respiratory syndrome Coronavirus Spike protein Substitution susceptibility the spike protein These data transferred treated Treatment Viral viral evolution viral strain viral variant Viral variants virus virus infection viruses whole-genome wild-type wild-type SARS-CoV-2 wild-type virus [DOI] 10.1038/s41586-021-03291-y PMC 바로가기 [Article Type] Case Reports
Indels in SARS-CoV-2 occur at template-switching hotspotsResearch Published on 2021-03-202022-10-28 Journal: BioData Mining [Category] COVID-19, [키워드] Analysis breakpoint consensus sequence consensus sequences consequence COVID-19 pandemic de novo Deletion Evidence evolutionary dynamics Genome Genomics GISAID GISAID database heterogeneity homogeneity homologous Host hotspot IMPROVE INDEL indels independent insertion loci mechanism occur other coronaviruses predicted raw reads RdRP Recombination recombination event Region Regulatory replicate RNA RNA secondary structure RNA virus RNA viruses RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 evolution secondary structure sequence Single nucleotide polymorphism Structural variation Structure supplementary material the SARS-CoV-2 Transcription Transcriptome TRS [DOI] 10.1186/s13040-021-00251-0 PMC 바로가기 [Article Type] Research
Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolutionArticle Published on 2021-03-112022-10-04 Journal: Nature Communications [Category] SARS, 변종, [키워드] activity bat binding cell entry cell membranes cellular receptor comparable conformational coronavirus Coronaviruses Critical Cross-species transmission cryo-EM structure Cryoelectron microscopy ectodomain electron microscopy Evolution Evolution of SARS-CoV-2 glycoprotein human ACE2 receptor implication inactive Infection pseudovirus RaTG13 RBD RBDs Receptor-binding domain recognizing required residue SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 spike spike spike glycoprotein spike trimer spikes Structure the RBD the SARS-CoV-2 Viral protein virus [DOI] 10.1038/s41467-021-21767-3 PMC 바로가기 [Article Type] Article
Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies다클론성 인간 혈장 항체의 인식에 영향을 미치는 SARS-CoV-2 수용체 결합 도메인의 돌연변이에 대한 포괄적인 매핑Article Published on 2021-03-102022-09-11 Journal: Cell Host & Microbe [Category] MERS, SARS, 변종, 진단, [키워드] Affect affected antibody Antibody binding antibody escape Antibody-mediated immunity Comprehensive convalescent plasma deep mutational scanning domain epitope Epitopes Evolution Evolution of SARS-CoV-2 facilitate heterogeneity Human plasma Immunity impacted impair individual lineages longitudinal samples Mutation mutations neutralization Neutralizing activity occur plasma plasma antibody polyclonal polyclonal immunity RBD Receptor-binding domain receptor-binding motif Recognition reduce reduced SARS-CoV-2 SARS-CoV-2 evolution spike Surveillance the RBD the SARS-CoV-2 virus [DOI] 10.1016/j.chom.2021.02.003 PMC 바로가기 [Article Type] Article
The great escape? SARS-CoV-2 variants evading neutralizing responses대단한 탈출? 중화 반응을 회피하는 SARS-CoV-2 변종Article Published on 2021-03-102022-09-11 Journal: Cell Host & Microbe [Category] Fulltext, SARS, 변종, 진단, [키워드] article Efficacy highlight immunotherapies microbe Mutation neutralizing response neutralizing responses Receptor binding domain Reinfection SARS-CoV-2 evolution SARS-CoV-2 variant spike Spike receptor binding domain Surveillance the SARS-CoV-2 Vaccine vaccine efficacy variant [DOI] 10.1016/j.chom.2021.02.010 PMC 바로가기 [Article Type] Article
The Mutation Profile of SARS-CoV-2 Is Primarily Shaped by the Host Antiviral DefenseSARS-CoV-2의 돌연변이 프로필은 주로 숙주 항바이러스 방어에 의해 형성됩니다Article Published on 2021-03-022022-09-10 Journal: Viruses [Category] SARS, 변종, 유전자 메커니즘, [키워드] ADAR Antiviral APOBEC approach contribute COVID-19 COVID-19 pandemic effort event Evolution Genome genomes heterogeneous Host independent independent of mechanism Mutagenesis Mutation number of infected oxygen Phylogenetic tree phylogenetics profile Proteins reactive oxygen species reference genome ROS SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genomes SARS-CoV-2 isolates understanding virus virus genome virus genomes ZAP [DOI] 10.3390/v13030394 PMC 바로가기 [Article Type] Article
Host-directed editing of the SARS-CoV-2 genomeSARS-CoV-2 게놈의 숙주 주도 편집Review Published on 2021-01-292022-09-11 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 유전자 메커니즘, [키워드] acting ADAR adenosine adenosine deaminase Antiviral APOBEC Apolipoprotein B catalytic Defense defense mechanisms directional Evolution facilitated Genome editing Host implication instance instances mechanisms mRNA Mutation oxygen pandemic Protein reactive oxygen species reactive oxygen specy RNA ROS SARS-CoV-2 SARS-CoV-2 evolution SARS-CoV-2 genome sequence the SARS-CoV-2 genome Viral viral genome Virus evolution [DOI] 10.1016/j.bbrc.2020.10.092 PMC 바로가기 [Article Type] Review