Biomarker-guided duration of Antibiotic Treatment in Children Hospitalised with confirmed or suspected bacterial infection (BATCH): protocol for a randomised controlled trial확인 된 또는 의심되는 박테리아 감염 (Batch)으로 입원 한 어린이의 바이오 마커 유도 항생제 치료 기간 : 무작위 대조 시험을위한 프로토콜Paediatrics Published on 2022-01-252022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 바이오마커, 임상, [키워드] Adverse drug reactions adverse effect Algorithm Analysis Antibiotic treatment antibiotic use Antibiotics approved Bacterial infection best Biomarker C reactive protein children clinician commenced conducted conjunction control arm Controlled COVID-19 pandemic death Diagnostic microbiology discharge dissemination East Ethics Follow-up Health hospital Hospital stay HRA include infections Infectious diseases International Intervention intravenous antibiotics National Health Service NHS North outcome paediatric intensive & critical care PCT peer-reviewed procalcitonin protocol public health randomised controlled trial RCT REC recruit reduce registration number Relapse Research respond Safety measure secondary Secondary outcomes treated Treatment trial protocol Two-arm utility West [DOI] 10.1136/bmjopen-2020-047490 PMC 바로가기 [Article Type] Paediatrics
The MITRE trial protocol: a study to evaluate the microbiome as a biomarker of efficacy and toxicity in cancer patients receiving immune checkpoint inhibitor therapyMITER 시험 프로토콜 : 면역 체크 포인트 억제제 요법을받는 암 환자에서 효능 및 독성의 바이오 마커로서 미생물 군집을 평가하는 연구Study Protocol Published on 2022-01-242022-09-10 Journal: BMC Cancer [Category] 비임상, [키워드] advanced disease adverse event antibody Antigen association Bacterial Biomarker Biomarkers biopsy breath buffy coat Cancer cancer patient Cell collected correlation COVID-19 CTCAE disease Disease progression drug during treatment Efficacy evaluate Exploratory analyses genomic Gut gut microbiome help identify immune Immune checkpoint inhibitor Immune checkpoint inhibitors immunological Immunotherapy implicated IMPROVE include information inhibitor limit longitudinal lung cancer patient marker Melanoma microbial Microbiome mononuclear cell mononuclear cells mouse model non-responder Non-small cell lung cancer observation organ outcome outcomes Patient patient selection PBMCs Peripheral blood Peripheral blood mononuclear cells plasma predict Predictive primary outcome measure Prospective Study receive receiving recruited recurrence Registered Relapse renal Renal cancer responders responsible RNA secondary Secondary outcomes Stool supplementary material survival therapeutic therapeutic potential therapy tissue Toxicity transfer Treatment Treatment response Trial Whole blood [DOI] 10.1186/s12885-021-09156-x PMC 바로가기 [Article Type] Study Protocol
Outside any therapeutic trial prescription of hydroxychloroquine for hospitalized patients with covid-19 during the first wave of the pandemic: A national inquiry of prescription patterns among French hospitalists전염병의 첫 번째 물결 동안 Covid-19를 가진 입원 환자를위한 Hydroxychloroquine의 치료 시험 처방 외부에서 프랑스 병원의 처방전 패턴에 대한 국가 조사Research Article Published on 2022-01-212022-09-10 Journal: PLoS ONE [Category] SARS, 신약개발, 치료제, [키워드] 95% CI 95% confidence interval acute respiratory syndrome adjusted adjusted odds ratio determinant determinants Efficacy email evaluate Evidence-based medicine Factor First wave framework French HCQ hospital hospitalized patient Hydroxychloroquine IMPROVE in vitro activity Infectious disease Infectious diseases inquiry internal medicine material member Multivariate analysis National other treatment other treatments outcome pandemic Patient patients patients hospitalized Primary outcome profile raise respiratory Result retained SARS-CoV-2 secondary Secondary outcomes Severe acute respiratory syndrome Society submitted therapeutic therapeutic trial treat Trial [DOI] 10.1371/journal.pone.0261843 PMC 바로가기 [Article Type] Research Article
A phase 2 single center open label randomised control trial for convalescent plasma therapy in patients with severe COVID-19중증 COVID-19 환자의 회복기 혈장 치료를 위한 2상 단일 센터 공개 라벨 무작위 대조 시험Clinical Trial Published on 2022-01-192022-09-12 Journal: Nature Communications [Category] SARS, 임상, 진단, 치료기술, 치료법, [키워드] 95% confidence interval adverse effect Adverse reaction all-cause mortality ARDS benefit characterized clinical clinical benefit clinical trial clinical trials Controlled trial convalescent plasma Convalescent plasma therapy COVID-19 disease cytokine Cytokines enrolment Evidence FiO2 General Hospital hazard hyper-inflammation immunization immunological inclusion criteria India Infectious disease Infectious diseases Intervention Kolkata log-rank log-rank test Mantel-Haenszel mechanical ventilation Mild Mild ARDS moderate moderate ARDS Mortality neutralizing antibody not affect not significantly different on mechanical ventilation open label outcome Outcomes research p value PaO2 paO2/fiO2 passive immunization Patient patients patients hospitalized PCR Phase 2 plasma plasma therapy prespecified outcomes Primary outcome Primary outcomes proteome randomised randomised controlled trial Randomized Ratio recruited Registered registry reported response to therapy secondary outcome Secondary outcomes severe COVID-19 severe COVID-19 disease severe COVID-19 patient severe COVID-19 patients single center Standard of care systemic hyper-inflammation the systemic hyper-inflammation therapy treat Treatment treatment arm Trial viral infection Viral RNA was done [DOI] 10.1038/s41467-022-28064-7 PMC 바로가기 [Article Type] Clinical Trial
Mental imagery interventions to promote face covering use among UK university students and employees during the COVID-19 pandemic: study protocol for a randomized controlled trial.COVID-19 팬데믹 기간 동안 영국 대학생과 직원의 안면 가리개 사용을 촉진하기 위한 정신적 이미지 개입: 무작위 통제 시험을 위한 연구 프로토콜.Study Protocol Published on 2022-01-182022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 2020 COVID-19 pandemic age anticipated Arm assigned Attitudes baseline Behaviour behavioural cognitive Complete concerning conscientiousness contribute Control control condition core COVID-19 COVID-19 pandemic defined Effectiveness effort Evidence Factor Follow-up Frequency hand washing Health Imagery face coverings include individual Intention Intervention intervention effect Intervention effects library Medicine Mental narcissism Norms outcome participant personality traits post-intervention preventive measure preventive measures Primary outcome promote PROTECT protocol Randomized randomized controlled study Randomized controlled trial Randomly recruited Registered reported secondary Secondary outcomes Self-efficacy separate condition social distancing Spread Study protocol supplementary material time traits Trial Trial registration understanding university students Viral viral infection virus [DOI] 10.1186/s13063-021-05852-y PMC 바로가기 [Article Type] Study Protocol
A Randomized Clinical Trial to Assess the Efficacy of Online-Treatment with Trial-Based Cognitive Therapy, Mindfulness-Based Health Promotion and Positive Psychotherapy for Post-Traumatic Stress Disorder during the COVID-19 Pandemic: A Study ProtocolCOVID-19 팬데믹 기간 동안 외상 후 스트레스 장애에 대한 시험 기반 인지 치료, 마음챙김 기반 건강 증진 및 긍정적 심리 치료를 통한 온라인 치료의 효능을 평가하기 위한 무작위 임상 시험: 연구 프로토콜Study Protocol Published on 2022-01-122022-09-10 Journal: International Journal of Environmental Research an [Category] SARS, 임상, [키워드] Alliance Anxiety ARMS belief CAPS clinical clinical trial cognitive Cognitive Therapy conducted contribute core coronavirus disease Coronavirus disease 2019 COVID-19 Depression dissemination dropout rate effective Efficacy evaluate expected form guilt HADS Health Health promotion Intervention inventory Mindfulness-based mindfulness-based health promotion multicenter NCBI negative no statistical difference outcome Patient positive psychotherapy Post-traumatic stress disorder Primary outcome professional professionals promotion psychotherapy PTSD Randomized receive reduce reduced scale secondary outcome Secondary outcomes single-blind statistical Symptom symptoms of PTSD therapy trauma treated Treatment trial-based cognitive therapy variable Well-being [DOI] 10.3390/ijerph19020819 PMC 바로가기 [Article Type] Study Protocol
Red Blood Cell Distribution Width in Hospitalized COVID-19 PatientsMedicine Published on 2022-01-072022-10-31 Journal: Frontiers in Medicine [Category] COVID-19, [키워드] 95%CI Absolute lymphocyte count acute respiratory syndrome age Anemia association body mass index caused chronic obstructive Clinical outcome confounder Coronary artery disease Coronavirus-2 COVID-19 COVID-19 patient defined Diabetes Mellitus Diseases elevated ferritin hospitalized COVID-19 hospitalized COVID-19 patient hypertension in-hospital mortality increased risk Lactate Length of stay LOS mechanical ventilation median morbidity and mortality Mortality outcome Prevalence Primary outcome pulmonary disease Red Red cell distribution width (RDW) remained risk SARS-CoV-2 Secondary outcomes Septic shock Sex significantly increased width [DOI] 10.3389/fmed.2021.582403 PMC 바로가기 [Article Type] Medicine
Double-blind placebo-controlled randomized clinical trial to assess the efficacy of montelukast in mild to moderate respiratory symptoms of patients with long COVID: E-SPERANZA COVID Project study protocol장기간 COVID-19 환자의 경증에서 중등도의 호흡기 증상에 대한 몬테루카스트의 효능을 평가하기 위한 이중 맹검 위약 대조 무작위 임상 시험: E-SPERANZA COVID 프로젝트 연구 프로토콜Study Protocol Published on 2022-01-062022-09-10 Journal: Trials [Category] SARS, 임상, [키워드] 1:1 acute phase Affect Ageusia Analysis Anosmia approved assessment asthenia Awareness Brain Clinical research clinical trial clinician Confusion control group COPD coronavirus disease Coronavirus disease 2019 COVID COVID-19 COVID-19 symptom COVID-19 symptoms defined Desaturation disabling symptoms dissemination double-blind Dyspnea effective Efficacy Ethics ethics committee EudraCT evaluate evaluate the effect Exercise capacity exertion explained functional Functional status globe headache Health Health status healthcare include Infection Intervention life Likert scale Long COVID Mental mental confusion Mild mild to moderate moderate Montelukast Mortality objective Open Access oxygen oxygen saturation pandemic participant pathophysiology Patient patients with SARS-CoV-2 peer-reviewed phase Placebo placebo group placebo-controlled primary care Primary outcome professionals Quality of life questionnaire Randomized randomized clinical trial Randomized controlled trial Randomly reference number Registered Research Ethics respiratory respiratory symptom respiratory symptoms SARS-CoV-2 SARS-COV-2 infection Secondary objectives Secondary outcomes sick Side effect Study protocol subgroup of patient Test the SARS-CoV-2 Treatment Trial Trial registration while [DOI] 10.1186/s13063-021-05951-w PMC 바로가기 [Article Type] Study Protocol
Effectiveness and feasibility of telerehabilitation in patients with COVID-19: a protocol for a systematic review and meta-analysisCOVID-19 환자의 텔레 호출의 효과 및 타당성 : 체계적인 검토 및 메타 분석을위한 프로토콜Article Published on 2022-01-062022-08-31 Journal: BMJ Open [Category] meta-analysis, SARS, [키워드] 95% CI adverse events alleviate analysed Behavioural intervention behavioural interventions Cardiopulmonary Cochrane Library collaboration completion rate Controlled trial controlled trials COVID-19 database Direct effective Effectiveness Ethical approval Ethics evaluate events exercise Factors feasibility functional functional capacity Google Scholar heterogeneity highlight IMPROVE inception include infected with COVID-19 life management mean difference Meta-analysis mortality rate outcome p value Patient patients with COVID-19 peer-reviewed Physiotherapy Primary outcome Primary outcomes PROSPERO protocol Quality of life Randomised controlled trials reason reason for recent registration number rehabilitation rehabilitation medicine required respiratory review risk of bia Risk of bias Safe Satisfaction Science Science Direct searched secondary Secondary outcomes sleep quality statistical analysis Symptom systematic review Telemedicine telerehabilitation Treatment used to calculate variables Web of Science Withdrawal [DOI] 10.1136/bmjopen-2021-058932 PMC 바로가기 [Article Type] Article
Assessment of Regional Variability in COVID-19 Outcomes Among Patients With Cancer in the United StatesResearch Published on 2022-01-042022-10-29 Journal: JAMA Network Open [Category] COVID-19, [키워드] 30-Day mortality 30-day mortality rate 95% CI adjusted adjusted odds ratio Admission age all-cause mortality assessment association Attention black Cancer Cancer center Care Characteristics cohort study collected Community continuum COVID-19 COVID-19 diagnosis COVID-19 pandemic death Diagnosis division divisions exposure female finding help heterogeneity higher risk Hispanic Importance IMPROVE individuals intensive care invasive laboratory-confirmed SARS-CoV-2 infection less measure mechanical ventilation median mixed-effects model mortality rate neoplasm no significant difference objective oncology outcome outcomes participant Patient patient population Patients with cancer Point Primary outcome quantified ranged Regional Relevance reported resource Result retrospective cohort study risk factor Secondary outcomes setting severe complication significant difference significantly South spatiotemporal statistically significant difference the United State The United States Treatment Variation vulnerable patients West [DOI] 10.1001/jamanetworkopen.2021.42046 PMC 바로가기 [Article Type] Research