Androgen regulation of pulmonary AR, TMPRSS2 and ACE2 with implications for sex-discordant COVID-19 outcomes성 불일치 COVID-19 결과에 대한 영향과 함께 폐 AR, TMPRSS2 및 ACE2의 안드로겐 조절Article Published on 2021-05-272022-09-10 Journal: Scientific Reports [Category] 유전자 메커니즘, 진단, 치료기술, [키워드] ACE2 ACE2 expression administration androgen Androgen receptor androgens anti-androgens changes in clinical trial COVID-19 decrease enzalutamide Evidence expression female females Human Hypothesis implication independent independent of investigated lung Lungs male males mechanism mice Modification outcome Prostate cancer receptor receptor antagonist Regulation severity Sex Sex difference Steroid hormones Steroids subject susceptibility therapy tissue TMPRSS2 TMPRSS2 expression Treatment Viral viral entry [DOI] 10.1038/s41598-021-90491-1 PMC 바로가기 [Article Type] Article
Sex as an important factor in nanomedicineReview Article Published on 2021-05-202022-10-04 Journal: Nature Communications [Category] 바이오마커, [키워드] cellular and molecular clinical trials Critical demonstrated develop diagnostic drug delivery Efficacy Factors Health status Healthcare systems highlight IMPROVE individuals Interaction MOST nanomedicine outcome parameter Physiological levels researcher Sex Sex difference therapeutic Variation [DOI] 10.1038/s41467-021-23230-9 PMC 바로가기 [Article Type] Review Article
Immunological aspects and gender bias during respiratory viral infections including novel Coronavirus disease‐19 (COVID‐19): A scoping reviewReview Published on 2021-05-192022-11-01 Journal: Journal of medical virology [Category] COVID-19, [키워드] adaptive immune responses antibodies autoimmune disorder Cell cellular clearance COVID‐19 detrimental discrepancy disease severity effective Estrogen evidenced exaggerated immune response exhibited female females Gender gender biasness hormone Host Human immune system Humoral immunity immune response immune system immunological Infection Inflammation inflammatory disease Inflammatory response less male males microbe novel pathogen Pathogens Patient respiratory infection respiratory viral respiratory viral infection responsible restrict SARS‐CoV‐2 SARS‐CoV‐2 infection SARS‐CoV‐2 severity Sex difference sex hormone Sex hormones Spread T lymphocytes unique [DOI] 10.1002/jmv.27081 PMC 바로가기 [Article Type] Review
Sensitive to Infection but Strong in Defense—Female Sex and the Power of Oestradiol in the COVID-19 PandemicGlobal Women's Health Published on 2021-05-112022-10-31 Journal: Frontiers in Global Women's Health [Category] COVID-19, [키워드] ACE2 acute respiratory syndrome age Ang II Angiotensin converting enzyme-2 Cell condition Contact coronavirus SARS-CoV-2 COVID-19 COVID-19 disease dominant Effect enzyme Epidemics explain expression expression level Factor Fatality rate female female hormone high risk Hormone therapy immune responsiveness immune-related genes incidence increase Infection infection rates infection risk infections knowledge less Long COVID Male sex mandatory men MERS Middle East morbidity and mortality Mortality Oestradiol Oestrogen power Premenopausal Protective receptor reducing Regulation SARS-CoV 2 SARS-CoV2 infection sensitive Sex Sex difference signaling pathway significantly higher Strong syndrome the disease virus virus infection women X chromosome [DOI] 10.3389/fgwh.2021.651752 PMC 바로가기 [Article Type] Global Women's Health
Dying from COVID-19 in nursing homes-sex differences in symptom occurrenceResearch Published on 2021-05-062022-10-27 Journal: BMC Geriatrics [Category] COVID-19, [키워드] age analysed Anxiety clinical Confusion Coronavirus disease 2019 COVID-19 death Dementia Diagnosis died disease Dying Dyspnoea End-of-life care fatal COVID-19 hospitals less men multivariate logistic regression nausea nursing homes Occurrence Older Pain palliative Palliative care remained reported resident Result Retrospective study Sex Sex difference shown supplementary material Swedish Symptom women [DOI] 10.1186/s12877-021-02228-4 PMC 바로가기 [Article Type] Research
Dying from COVID-19 in nursing homes-sex differences in symptom occurrenceResearch Published on 2021-05-062022-10-27 Journal: BMC Geriatrics [Category] Coronavirus, COVID-19, SARS, [키워드] age analysed Anxiety clinical Confusion Coronavirus disease 2019 COVID-19 death Dementia Diagnosis died disease Dying Dyspnoea End-of-life care fatal COVID-19 hospitals less men multivariate logistic regression nausea nursing homes Occurrence Older Pain palliative Palliative care remained reported resident Result Retrospective study Sex Sex difference shown supplementary material Swedish Symptom women [DOI] 10.1186/s12877-021-02228-4 PMC 바로가기 [Article Type] Research
Sex differences in the case-fatality rates for COVID-19—A comparison of the age-related differences and consistency over seven countriesResearch Article Published on 2021-04-292022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, SARS, [키워드] age agency Canada CFR CFRs conducted country COVID-19 COVID-19 pandemic death Denmark Diseases England estimate evaluate examined Factor female females greater heterogeneity incidence Italy magnitude male mechanism meta-analytic method meta-regression Mortality National patients Prevalence Result sensitivity analysis Seven severity of COVID-19 Sex Sex difference Spain the disease underlying disease were used [DOI] 10.1371/journal.pone.0250523 PMC 바로가기 [Article Type] Research Article
Sex differences in inflammatory markers in patients hospitalized with COVID-19 infection: Insights from the MGH COVID-19 patient registryCOVID-19 감염으로 입원한 환자의 염증 마커의 성별 차이: MGH COVID-19 환자 레지스트리의 통찰력Research Article Published on 2021-04-282022-09-10 Journal: PLoS ONE [Category] MERS, SARS, 바이오마커, [키워드] 95% CI Activation age Analysis association baseline Better Clinical outcome clinical outcomes contribute COVID-19 infection COVID-19 patient CRP death disease severity evidenced examined exhibited Exploratory analyses ferritin General Hospital greater higher risk Hospitalized ICU admission IL-6 immune activation immune response immune responses Infection Inflammatory Inflammatory marker inflammatory markers initial insight Interaction Linear regression model Massachusetts General Hospital men men and women multivariable logistic regression outcome pathophysiology patients hospitalized PCT peak inflammatory Result robust serious complication Sex Sex difference Study design systemic inflammation were used with COVID-19 women [DOI] 10.1371/journal.pone.0250774 PMC 바로가기 [Article Type] Research Article
Sex differences in clinical characteristics and risk factors for disease severity of hospitalized patients with COVID‐19Original Article Published on 2021-04-082022-10-30 Journal: MedComm [Category] COVID-19, [키워드] 95% confidence interval Admission Affect Beijing BMI body mass index CHD Clinical characteristics clinical complication Clinical efficacy Clinical symptoms Comorbidities Coronary heart disease coronavirus COVID‐19 COVID‐19 diagnosed disease disease severity Factor female female group Female patients females groups Hospitalization hospitalized patient Laboratory less male male group median age NAFLD no significant difference nonalcoholic fatty liver obesity Odds ratio Older outcome Patient Pneumonia proportion recent regression analysis reported risk factor Risk factors Sankey diagram SARS‐CoV‐2 SARS‐CoV‐2 Sex difference sex differences smoking two groups [DOI] 10.1002/mco2.66 PMC 바로가기 [Article Type] Original Article
Sex and age differences in COVID-19 mortality in EuropeArticle Published on 2021-04-012023-07-12 Journal: Wiener Klinische Wochenschrift [Category] SARS, [키워드] Cumulative mortality rates European regions relative risks SARS-CoV‑2 Sex difference [DOI] 10.1007/s00508-020-01793-9 PMC 바로가기