Shortening Epitopes to Survive: The Case of SARS-CoV-2 Lambda VariantArticle Published on 2021-10-102022-10-28 Journal: Biomolecules [Category] COVID-19, SARS, [키워드] affecting Analysis Combination Effect epitope epitope loop shortening host immunity immunoevasion immunogenic in silico interaction energy interest investigated Lambda Lambda variant Mutation N-glycosylation site parameter Protein Region SARS-CoV-2 shortening South spread to stability the Spike thermodynamic variant viral variant [DOI] 10.3390/biom11101494 PMC 바로가기 [Article Type] Article
Hamster organotypic modeling of SARS-CoV-2 lung and brainstem infectionArticle Published on 2021-10-042022-10-04 Journal: Nature Communications [Category] SARS, 유전자 메커니즘, 치료제, [키워드] acute respiratory syndrome Anti-viral antivirals Apoptosis Brain can be used cause caused cell death Central nervous system characterized complex compounds COVID-19 Culture Evidence Ex vivo global pandemic granular hamster immune response induce infect Infection innate immune response Interaction interferon Local lung lung tissue necroptosis neurological neurons offer organ pyroptosis SARS-CoV-2 spread to tissue pathology unique viral infection viral pathogenesis viral tropism virus [DOI] 10.1038/s41467-021-26096-z PMC 바로가기 [Article Type] Article
Dermatological aspects of SARS-CoV-2 infection: mechanisms and manifestationsSARS-CoV-2 감염의 피부과적 측면: 기전 및 징후Review Published on 2021-10-012022-09-11 Journal: Archives of dermatological research [Category] Coronavirus, SARS, 유전자 메커니즘, [키워드] ACE2 addition Affect caused clinical phenotype condition COVID-19 COVID-19 patient Cutaneous cutaneous manifestation Cutaneous manifestations Dermatology described diarrhea Evidence evidence of explain expression extrapulmonary tissues Factor gastrointestinal tract high risk human infection human tissues implication IMPROVE include individual infect infected patient infected patients Infection infections infective Injury International laboratory-confirmed SARS-CoV-2 infection Lungs majority manifestation mechanism Multiorgan observation pandemic pathophysiological mechanism pathophysiological mechanisms Patient patients with SARS-CoV-2 pattern Pneumonia preoccupation public health emergency raised Rash respiratory and gastrointestinal tracts risk SARS-CoV-2 SARS-COV-2 infection severely ill patients skin skin infections spread to the disease TMPRSS2 viral entry Viral skin infections. virus [DOI] 10.1007/s00403-020-02156-0 PMC 바로가기 [Article Type] Review
Unrecognized introduction of SARS-CoV-2 variants of concern to Central Africa: Import and local transmission of B.1.1.7 in Gabon in the very early stage of the variant spread to the African continent중앙 아프리카에 대한 SARS-CoV-2 변종의 인식되지 않은 도입: 변종이 아프리카 대륙으로 확산되는 초기 단계에서 가봉에서 B.1.1.7의 수입 및 지역 전파Article Published on 2021-10-012022-09-11 Journal: Journal of medical virology [Category] SARS, 변종, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Africa African Analysis B.1.1.7 B.1.1.7 variant B.1.1.7 variants coronavirus early stage Gabon genomic higher infectivity Hospitalized import increase in Infection infections initial introduced Local Patient Phylogenetic analysis Phylogeny regions risk SARS-CoV-2 SARS-CoV-2 variant severe acute respiratory syndrome Coronavirus Spread spread to The B.1.1.7 Transmission variant variants variants of concern [DOI] 10.1002/jmv.27164 PMC 바로가기 [Article Type] Article
A Barcoded Flow Cytometric Assay to Explore the Antibody Responses Against SARS-CoV-2 Spike and Its VariantsSARS-CoV-2 스파이크 및 그 변이체에 대한 항체 반응을 조사하기 위한 바코드 유세포 분석 분석Immunology Published on 2021-09-232022-09-11 Journal: Frontiers in Immunology [Category] SARS, 변종, 진단, [키워드] accumulate Against Alpha Alpha variant B cell Beta Beta variant boost cell line characteristic chimeric color coronavirus COVID-19 COVID-19 patient COVID-19 patients E484K effort evaluate expressed expression Flow flow cytometric flow cytometry fusion protein generate Health Health crisis higher affinity human immune response human population humoral immune response Humoral immunity IgA class IgG IgG response Immune escape immune response less life-threatening lymphoma mutant Mutation N501Y Pneumonia Point mutation Protein protocol RBD receptor ACE2 receptor-binding domains reduce expression response S protein SARS-CoV-2 SARS-CoV-2 pandemic serum antibody severe disease manifestation spike Spike protein Spread spread to the patient the receptor-binding domain this new coronavirus vaccination variant variant of SARS-CoV-2 variants variants of SARS-CoV-2 Viral viral entry virus virus variants wild type WT S [DOI] 10.3389/fimmu.2021.730766 PMC 바로가기 [Article Type] Immunology
A Deep Learning Based Approach for Patient Pulmonary CT Image Screening to Predict Coronavirus (SARS-CoV-2) InfectionArticle Published on 2021-09-212022-10-31 Journal: Diagnostics [Category] COVID-19, [키워드] Accuracy acute respiratory disease candidate China collected convolution neural network country COVID-19 COVID-19 patient deep deep learning Deep Learning Model Epidemic evaluated healthy help Human identify Image infected with COVID-19 Infection learning location attention network machine learning nCOV-2019 Novel coronavirus Patient patients with influenza Pneumonia predict pulmonary pulmonary computed tomography responsible robust SARS-CoV-2 Screening Spread spread to variant virus Wuhan [DOI] 10.3390/diagnostics11091735 PMC 바로가기 [Article Type] Article
COVID-19 mortality with regard to healthcare services availability, health risks, and socio-spatial factors at department level in France: A spatial cross-sectional analysisResearch Article Published on 2021-09-172022-10-28 Journal: PLoS ONE [Category] COVID-19, [키워드] Analysis association autocorrelation bias risk concerning coronavirus COVID-19 COVID-19 mortality COVID-19 pandemic cross-sectional cross-sectional analysis cumulative mortality death dissemination Drivers ecological Epidemic example Exploratory analysis Factor Factors First wave FIVE form France Health Health services healthcare service hospital hospitals independent variables inherent lack limitation outcome performed physician positive Region regions regression models risk factor Risk factors Spread spread to were used Wuhan, China [DOI] 10.1371/journal.pone.0256857 PMC 바로가기 [Article Type] Research Article
Performance of COVID-19 associated symptoms and temperature checking as a screening tool for SARS-CoV-2 infectionSARS-CoV-2 감염 선별 도구로서의 코로나19 관련 증상 수행 및 체온 측정Research Article Published on 2021-09-172022-09-12 Journal: PLoS ONE [Category] MERS, 진단, [키워드] Affect analysed Analysis approach Asymptomatic benefit carried clinical symptom Clinical symptoms Contact coronavirus disease cough country COVID-19 COVID-19 associated symptom COVID-19 disease cut-off detect determine diagnosing diagnosis of COVID-19 disease effective facemask Fever Final final diagnosis hand hygiene hospital hygiene Isolation lack lockdown loss of sense of smell MOST P-value participant performance positive presenting pressure preventing infection public space quarantine receiver operator characteristics Result ROC ROC analysis SARS-CoV-2 SARS-CoV-2 infected patients SARS-COV-2 infection SARS-CoV-2 positivity sense sense of smell sense of taste sensitivity significantly higher social distancing spread to Symptom Tamale Taste Teaching temperature Transmission true positive vaccination [DOI] 10.1371/journal.pone.0257450 PMC 바로가기 [Article Type] Research Article
Application of omics technology to combat the COVID‐19 pandemicReview Published on 2021-09-162022-10-30 Journal: MedComm [Category] COVID-19, [키워드] acute respiratory syndrome application applied approach caused Clinical treatment clinician confirmed cases contribute coronavirus coronavirus disease COVID‐19 COVID‐19 deaths Diagnosis diagnostic methods Disease progression drug target feature Features Genomics Guidance help knowledge metabolomics pandemic Pathogenesis Patient Prognosis proteomics receive reduce reported Research researcher risk Risk factors SARS‐CoV‐2 spread to Surveillance transcriptomics Treatment variant World Health Organization [DOI] 10.1002/mco2.90 PMC 바로가기 [Article Type] Review
Add-On Effect of Honeysuckle in the Treatment of Coronavirus Disease 2019: A Systematic Review and Meta-AnalysisPharmacology Published on 2021-09-152022-10-31 Journal: Frontiers in Pharmacology [Category] COVID-19, [키워드] 95% confidence interval 95%CI applied Bia Biology C-reactive protein (CRP) China Chinese Clinical efficacy Clinical symptoms Cochrane Library combination therapy Computed tomography coronavirus disease Coronavirus disease 2019 cough COVID-19 curative Data analysis database Effect effective Efficacy and safety enrolled evaluate events Fever honeysuckle identify IMPROVE Inflammatory biomarker Infrastructure journal Laboratory lung Lung CT Medicine Meta-analysis Methodological quality nine outbreak Patient Randomized controlled trial Randomized controlled trials RCT RCTs reducing reduction reported review risk Science searched Severe case severe cases spread to Symptom systematic review technology therapy Treatment Trial trials was used WBC White blood cell with COVID-19 [DOI] 10.3389/fphar.2021.708636 PMC 바로가기 [Article Type] Pharmacology