Chaetomugilins and Chaetoviridins—Promising Natural Metabolites: Structures, Separation, Characterization, Biosynthesis, Bioactivities, Molecular Docking, and Molecular DynamicsReview Published on 2022-01-272022-10-30 Journal: Journal of Fungi [Category] COVID-19, [키워드] analyzed Antiviral binding energy bioactivities Biosynthesis Chaetomaceae chaetomugilins chaetoviridins characterization complexes Course COVID-19 crystal structure docking docking score docking study Dynamics evaluated exhibited feature fungal fungi generate inhibitor investigated metabolite metabolites molecular molecular docking natural oxygenated PDB Predictive produced protease reported Research separation stability structures the SARS-CoV-2 therapeutic agents unique [DOI] 10.3390/jof8020127 PMC 바로가기 [Article Type] Review
Oral Pathology in COVID-19 and SARS-CoV-2 Infection—Molecular AspectsCOVID-19 및 SARS-CoV-2 감염의 구강 병리 - 분자 측면Review Published on 2022-01-272022-09-12 Journal: International Journal of Molecular Sciences [Category] 진단, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 aerosol Aerosols angiotensin angiotensin converting enzyme article aspect Cell cellular cellular damage Clinical sign Clinical signs contribute coronavirus COVID-19 COVID-19 transmission crevicular fluid data extraction database dental pulp Diagnosis enzyme epithelia evaluate Evidence Express Factor Factors Final Fractions furin Gingiva Health Organization infected patients Infection information Local molecular mucosa oral oral cavity oral mucosa performed periodontium produced Replication respiratory droplet Respiratory droplets Saliva salivary salivary gland SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 virus Serine severe acute respiratory syndrome Coronavirus Signs and symptoms Spread structures Symptom systemic infection the disease TMPRSS2 tongue transmembrane serine protease transmembrane serine protease 2 Transmission Treatment Type Vaccine virus virus infection virus particle virus particles were used World Health Organization [DOI] 10.3390/ijms23031431 PMC 바로가기 [Article Type] Review
Changing self-concept in the time of COVID-19: a close look at physician reflections on social mediaCOVID-19 시대의 변화하는 자아 개념: 소셜 미디어에 대한 의사의 성찰 자세히 살펴보기Research Published on 2022-01-262022-09-10 Journal: Philosophy, Ethics, and Humanities in Medicine : P [Category] SARS, 치료기술, 치료제, [키워드] adopted affected Analysis assessment tool Burnout changed Changing Community concern coping coping mechanisms coronavirus COVID-19 COVID-19 pandemic criteria delivery detect Disruption distress Effect Effectiveness Efficacy evaluate evaluated explain family Health healthcare include inclusion/exclusion criteria institution Intervention mechanism mechanisms media Mental morbidity morbidity and mortality offered Personal experiences Personhood physical physician Physicians post-traumatic professional Reflections resource response Result Ring Ring Theory of Personhood screened self Self-concept self-esteem social media Society state Stress structures supplementary material Support theory was used weakened [DOI] 10.1186/s13010-021-00113-x PMC 바로가기 [Article Type] Research
The structure of a novel antibody against the spike protein inhibits Middle East respiratory syndrome coronavirus infectionsArticle Published on 2022-01-242022-10-29 Journal: Scientific Reports [Category] Coronavirus, [키워드] antibody cellular membrane contribute Critical Drug administration epitope escaped Fatality rate function Host host antibody response Human humans immunology Infection inhibit MERS-CoV Middle East molecular Molecular biology mutant neutralization Neutralizing Neutralizing activity neutralizing antibody outbreak provided RBD respiratory syndrome coronavirus responsible severe respiratory illness Spike protein structural biology structures supported the RBD the spike protein therapeutic United State Vaccine virion virus X-ray crystallography zoonotic [DOI] 10.1038/s41598-022-05318-4 PMC 바로가기 [Article Type] Article
A Computer-Aided Approach for the Discovery of D-Peptides as Inhibitors of SARS-CoV-2 Main ProteaseMolecular Biosciences Published on 2022-01-242022-10-31 Journal: Frontiers in Molecular Biosciences [Category] COVID-19, [키워드] 3CL pro 3CLpro approach Area caused cleavage conducted conserved cysteine protease D-peptide drug candidate drug target enzymatic assay Free energy calculation highlighting identify in silico Approach inhibiting inhibitor Mechanics molecular Molecular dynamics simulation nonstructural protein polyprotein pp1a pp1ab problem protease protease active site Protein Replication reported responsible SARS-CoV-2 SARS-CoV-2 main protease structures subsequent surface therapeutic agents Virtual screening virus [DOI] 10.3389/fmolb.2021.816166 PMC 바로가기 [Article Type] Molecular Biosciences
DrugDevCovid19: An Atlas of Anti-COVID-19 Compounds Derived by Computer-Aided Drug DesignDrugDevcovid19 : 컴퓨터 보조 약물 설계에 의해 유래 된 항 코비드 -19 화합물의 아틀라스Review Published on 2022-01-212022-08-31 Journal: Molecules [Category] 신약개발, 치료제, [키워드] analyses analyzed Atla bioinformatics Compound computer-aided drug design COVID-19 COVID-19 therapeutics database docking drug drug design facilitate feature Neck organized outbreak performed SARS-CoV-2 structures subsequent target protein these compounds valuable resource [DOI] 10.3390/molecules27030683 PMC 바로가기 [Article Type] Review
Emerging Zoonotic Infections, Social Processes and Their Measurement and Enhanced Surveillance to Improve Zoonotic Epidemic Responses: A “Big Events” PerspectiveConcept Paper Published on 2022-01-172022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, Fulltext, SARS, 조류인플루엔자, [키워드] addition adverse outcome Affect approach assist Big events changes in COVID-19 disease enhanced Epidemic Epidemics facilitate Frame greater Health help HIV/AIDS Host Intervention measurement Measures mitigate outbreak Pandemics pathogen predict public health responses sociobehavioral surveys Spread Structure structures Surveillance Transmission zoonose zoonoses [DOI] 10.3390/ijerph19020995 PMC 바로가기 [Article Type] Concept Paper
Structural assessment of HLA-A2-restricted SARS-CoV-2 spike epitopes recognized by public and private T-cell receptors공공 및 민간 T 세포 수용체가 인식하는 HLA-A2 제한 SARS-CoV-2 스파이크 에피토프의 구조적 평가Article Published on 2022-01-102022-09-10 Journal: Nature Communications [Category] 변종, 유전자 메커니즘, [키워드] antibody B-cell cellular immunity complex conserved Convalescent patients COVID-19 convalescent patient Critical determine effort elicit epitope Epitopes germline gene homologous epitope homologous epitopes immune response Immunity immunodominant immunology infective agent information less long-term memory mechanism Memory responses Neutralizing antibodies neutralizing antibody receptors Recognition recognize SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 spike protein seasonal coronaviruses Spike protein Structure structures T cell T cell receptors T cells T-cell receptor T-Cell Receptors target targeted epitope TCR TCRs Vaccine variant X-ray crystallography [DOI] 10.1038/s41467-021-27669-8 PMC 바로가기 [Article Type] Article
Healthcare Workers Attitudes, Practices and Sources of Information for COVID-19 Vaccination: An Italian National SurveyArticle Published on 2022-01-102022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] adhere auxiliary aversion category collected communication COVID-19 COVID-19 pandemic COVID-19 vaccination Critical Diseases favor females flu vaccination greater HCW HCWs healthcare healthcare worker Healthcare workers Hesitancy immunization immunization campaign infection control information Italian Italy mandatory National Health Service Nurse Nurses overcome Patient platform Practice predictor professional professionals questionnaire refusal Region regions SARS-CoV-2 Sex Source sources of information structures Support survey vaccination Vaccine hesitancy was related worker [DOI] 10.3390/ijerph19020733 PMC 바로가기 [Article Type] Article
Cognitive cascades: How to model (and potentially counter) the spread of fake newsResearch Article Published on 2022-01-072022-10-28 Journal: PLoS ONE [Category] Coronavirus, SARS, [키워드] aggregate Analysis approach cascade cascades cognitive Cognitive function diffusion disease spread Effect epidemiologists expressive increasingly individual Interaction lack media Mental network outcome POD rejection reported researcher Spread structures Topology understanding [DOI] 10.1371/journal.pone.0261811 PMC 바로가기 [Article Type] Research Article