SARS-CoV-2 suppresses anticoagulant and fibrinolytic gene expression in the lungSARS-CoV-2는 폐에서 항응고제 및 섬유소 용해 유전자 발현을 억제합니다Research Article Published on 2021-03-082022-09-10 Journal: eLife [Category] SARS, 유전자 메커니즘, 진단, [키워드] Analysis Anticoagulant BALF Blood coagulation bronchoalvelolar Bronchoalveolar lavage fluid C1-Inhibitor circulating clearance Coagulation Coagulopathies Coagulopathy COVID-19 COVID-19 patient COVID-19 patients driver Drivers endothelial examined expression Extensive FIBRIN fibrinolysis fibrinolytic Gene Expression Human identify inflammatory disorders initiate Kinin limit Local lung Lungs molecular mechanism molecular mechanisms mRNA level mRNA levels not increased pathway Pathways promote Protein protein C receptor reduced SARS-CoV-2 significantly suppresse thrombomodulin tissue Tissue Factor transcript transcriptional profile transcriptional profiles transcripts urokinase while [DOI] 10.7554/eLife.64330 PMC 바로가기 [Article Type] Research Article
TOR functions as a molecular switch connecting an iron cue with host innate defense against bacterial infectionTOR는 철 신호를 박테리아 감염에 대한 숙주의 타고난 방어와 연결하는 분자 스위치로 기능합니다.Research Article Published on 2021-03-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated activating autophagy Bacterial infection Bacterial infections Caenorhabditis elegan Caenorhabditis elegans conditions defend Defense Degradation essential nutrient ferritin function Host host defense host innate immunity host-pathogen interactions hosts increase in Increased induce Infection iron modulate modulating molecular molecular mechanism organism pathogen pathogenic pathogenic bacterium Pathogens PROTECT Protein protein level Rapamycin regulator required reveal Salmonella subunit suppresse suppressed survival target transcript transcripts transition turn upregulated worm worms [DOI] 10.1371/journal.pgen.1009383 PMC 바로가기 [Article Type] Research Article
SARS-CoV-2 nsp12 attenuates type I interferon production by inhibiting IRF3 nuclear translocationSARS-CoV-2 nsp12는 IRF3 핵 전위를 억제하여 I형 인터페론 생산을 약화시킵니다Article Published on 2021-02-262022-09-11 Journal: Cellular and Molecular Immunology [Category] MERS, SARS, 변종, 치료제, [키워드] (RdRp) Activation Analysis Antiviral antiviral immunity antiviral responses attenuate COVID-19 dependent on dose-dependent manner global pandemic Host host antiviral responses IFN IFN-β immune evasion impair inducer inhibited inhibiting Innate immunity IRF3 MAVS MDA5 not dependent Nsp12 nuclear translocation overexpression pathogenic Phosphorylation poly(I:C) polymerase promoter provide RdRP respiratory respiratory RNA viruses reveal RIG-I RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 RdRp Sendai virus SeV suggested suppresse suppressed triggered type I interferon Viral viral infection viral pathogenesis Viral RNA viral RNA-dependent RNA polymerase [DOI] 10.1038/s41423-020-00619-y PMC 바로가기 [Article Type] Article
Structure of the SARS-CoV-2 RNA-dependent RNA polymerase in the presence of favipiravir-RTPfavipiravir-RTP 존재 시 SARS-CoV-2 RNA 의존성 RNA 중합효소의 구조407 Published on 2021-02-162022-08-13 Journal: Proceedings of the National Academy of Sciences of [Category] Biochemistry, COVID-19, [키워드] (RdRp acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approved bind binding binding pocket catalytic site clinical trial clinical trials complex conformation coronavirus COVID-19 pandemic cryoEM determine determined by develop drug Drug administration drug design drugs targeting effort enzyme Evidence explain Favipiravir FDA food help incorporation Infection information inhibitor Ion ions mechanism mechanism of action molecular basis nucleoside nucleoside analog nucleotide nucleotides polymerase polymerases RdRP Remdesivir Replication respiratory reveal RNA RNA polymerase RNA polymerase inhibitor RNA primer RNA-dependent RNA polymerase SARS coronaviruses SARS-CoV-2 SARS-CoV-2 RdRp SARS-CoV-2 RNA severe acute respiratory syndrome Coronavirus side chains Significance structural biology Structure suppresse T-705 Template the SARS-CoV-2 Treatment triphosphate US Food and Drug Administration Viral while [DOI] 10.1073/pnas.2021946118 PMC 바로가기 [Article Type] 407
Tryptophan Metabolites and Aryl Hydrocarbon Receptor in Severe Acute Respiratory Syndrome, Coronavirus-2 (SARS-CoV-2) PathophysiologyReview Published on 2021-02-052022-10-29 Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS, [키워드] activate Activation acute respiratory syndrome age alteration antiviral response aryl Aryl hydrocarbon receptor Butyrate CD8+ T cells circulating condition conditions Coronavirus-2 COVID-19 COVID-19 pandemic diabete driven by dysregulated Effect EGCG expression level gallate Gut high risk hydrocarbon immune cells immune response Implications increase in increased risk indole Infection inhibit initial LPS macrophages Mast cells melatonin metabolism Mitochondrial function natural killer cell Neutrophils nutraceutical obesity physiological pro-inflammatory cytokine pyruvate Regulation Research respiratory response resveratrol SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome suppresse Treatment Tryptophan [DOI] 10.3390/ijms22041597 PMC 바로가기 [Article Type] Review
Mechanisms of Coronavirus Nsp1-Mediated Control of Host and Viral Gene ExpressionReview Published on 2021-02-022022-10-31 Journal: Cells [Category] COVID-19, MERS, [키워드] activity acute respiratory syndrome Amino acid antiviral responses biological function cell interaction cellular cleavage contribute Control Coronaviruses CoVs disrupt endonucleolytic cleavage evade function Gene Expression genomes highly pathogenic Host host gene expression host gene expression suppression host mRNA human coronavirus identity involved mechanism MERS-CoV Middle East mRNA mRNA degradation nonstructural protein 1 nsp1 pathogenic SARS-CoV SARS-CoV-2 suppresse syndrome translation translational suppression viral mRNA viral pathogenicity Viral protein viral replication virulence virulence factor virus virus pathogenesis [DOI] 10.3390/cells10020300 PMC 바로가기 [Article Type] Review
Anti-inflammatory potential of Quercetin in COVID-19 treatmentHypothesis Published on 2021-01-282022-10-29 Journal: Journal of Inflammation (London, England) [Category] COVID-19, [키워드] active form acute lung injury acute respiratory distress affected affecting Anti-inflammatory antioxidant bat coronaviruses Betacoronavirus complexes condition consequence COVID-19 cytokine Cytokine storm cytosolic DAMPs death determine Effect excessive inflammation generate IL-18 IL-1β include Inflammatory less life-threatening multiple organ dysfunction NLRP3 inflammasome Nrf2 patients patients with COVID-19 Pneumonia Potential treatment quercetin responsible risk factor SARS-CoV SARS-CoV-2 severe inflammation similarity SIRT1 suppresse syndrome the disease the SARS-CoV-2 virus Treatment TXNIP [DOI] 10.1186/s12950-021-00268-6 PMC 바로가기 [Article Type] Hypothesis
ADID-UNET—a segmentation model for COVID-19 infection from lung CT scansHuman-Computer Interaction Published on 2021-01-262022-10-29 Journal: PeerJ Computer Science [Category] COVID-19, [키워드] Accuracy acquisition Attention Attention gate Automatic coefficient Computed tomography Convolution COVID-19 COVID-19 infection COVID-19 pulmonary infection Dense network detect Dice Dilation disease Effect ENhance feature greater Health IMPROVE Improved Improved dilation convolution intensity lung lung CT scan Lung CT segmentation Lung infection measure Metrics network New coronavirus problem Pulmonary infection regions suppresse UNET Variation [DOI] 10.7717/peerj-cs.349 PMC 바로가기 [Article Type] Human-Computer Interaction
SARS-CoV-2 Nucleocapsid Protein Interacts with RIG-I and Represses RIG-Mediated IFN-β ProductionSARS-CoV-2 뉴클레오캡시드 단백질은 RIG-I와 상호작용하고 RIG 매개 IFN-β 생산을 억제합니다Article Published on 2020-12-302022-09-10 Journal: Viruses [Category] MERS, SARS, 치료법, [키워드] ATPase binding cellular clinical Clinical data Coronavirus disease 2019 COVID-19 demonstrated domain downstream highly pathogenic Human IFN IFN-β immunostimulatory Infection initial innate immune interferon interferon beta N protein nucleocapsid pathway Pattern recognition pattern recognition receptor poly(I:C poly(I:C) Production Protein PRR public health represse repressed responsible retinoic acid retinoic acid-inducible gene I RIG-I RNA viruses RNAs SARS-CoV-2 SARS-CoV-2 N protein Sendai virus SeV severe acute respiratory syndrome coronavirus 2 signaling molecule signaling molecules suggested suppresse suppressed the SARS-CoV-2 type I interferon virus infection [DOI] 10.3390/v13010047 PMC 바로가기 [Article Type] Article
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M) protein inhibits type I and III interferon production by targeting RIG-I/MDA-5 signaling중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 막(M) 단백질은 RIG-I/MDA-5 신호전달을 표적으로 하여 I형 및 III형 인터페론 생산을 억제합니다Article Published on 2020-12-282022-09-10 Journal: Signal Transduction and Targeted Therapy [Category] MERS, SARS, 변종, 유전자 메커니즘, 치료법, [키워드] Activation acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition affected Antiviral antiviral immunity attenuate caused coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 cytosolic ectopic expression ENhance evade facilitate IFN Immune suppression individuals Infection Infectious diseases inhibit Innate immunity interact interferon Interpretation IRF3 M protein MAVS mechanism membrane molecular mechanism multiprotein complex nuclear translocation pathogenic pathway Phosphorylation Protein provide Replication reported respiratory RIG-I SARS-CoV-2 SeV severe acute respiratory syndrome Coronavirus Signaling Spread stimulated stomatitis suppresse suppression TBK1 the SARS-CoV-2 TRAF3 type I type I and III IFNs vesicular stomatitis vesicular stomatitis virus Viral viral replication [DOI] 10.1038/s41392-020-00438-7 PMC 바로가기 [Article Type] Article