Immune response to SARS-CoV-2 Omicron variant in patients and vaccinees following homologous and heterologous vaccinationsArticle Published on 2022-09-022022-11-16 Journal: Communications Biology [Category] SARS, 변종, [키워드] antibody Antibody Response booster dose Course COVID-19 COVID-19 patient cross-protection delta variant drastic reduction elicited ENhance evaluate Heterologous highest homologous Immunity mRNA vaccine Mutation natural infection neutralization capacity neutralize omicron Patient regimen replaced SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 virus serum sample survivor susceptibility tested the spike protein vaccinated individual vaccination Vaccine vaccinee variant wild-type virus [DOI] 10.1038/s42003-022-03849-0 PMC 바로가기
Characterization of ACE2 naturally occurring missense variants: impact on subcellular localization and traffickingArticle Published on 2022-09-022022-11-16 Journal: Human Genomics [Category] SARS, 변종, [키워드] ACE2 ACE2 gene ACE2 protein ACE2 receptor ACE2 variant acting acute respiratory syndrome Amino acid Analysis angiotensin-converting enzyme 2 Angiotensin-converting enzyme 2 (ACE2) approach binding characterization clinical manifestation contribute COVID-19 Critical Deleterious demonstrated domain Effect enzyme explain expression genetic variability Genetic variation Human human cell in silico analysis Infection Missense missense variant plasma membrane polymorphism predicted RAS receptor renin-angiotensin system required S protein SARS-CoV-2 selected sequence severity significant effect subcellular subcellular localization Subcellular trafficking. suggested susceptibility the SARS-CoV-2 the spike protein transmembrane type I variant Variation viral spike viruses [DOI] 10.1186/s40246-022-00411-1 PMC 바로가기
Dual effects of supplemental oxygen on pulmonary infection, inflammatory lung injury, and neuromodulation in aging and COVID-19Review article Published on 2022-09-012022-10-05 Journal: Free radical biology & medicine [Category] SARS, 바이오마커, 유전자 메커니즘, [키워드] activating Activation acute lung injury acute respiratory distress syndrome (ARDS) age aging Analysis Anti-inflammatory antioxidant ARDS attenuate Biomarkers Blood oxygen saturation Brain cause caused cellular cellular damage Central nervous system Cholinergic anti-inflammatory pathway chronic inflammation clinical Clinical outcome COVID-19 COVID-19 patient COVID-19 patients death decrease Defense distress dysregulated Effect function functions humans hyperinflammation IMPROVE increase in infected with SARS-CoV-2 infections Inflammation inflammatory lung injury Inflammatory response inhibiting Innate immunity likelihood lung lung cells Lung inflammation macrophages master regulator Mitochondria morbidity and mortality oxidative oxidative stress oxygen Oxygen therapy pathway positive correlation positively correlated Postmortem prolonged exposure Pulmonary infection reactive oxygen specy receiving receptor regulate regulated resulting ROS Safe Sepsis shown Signaling supplemental oxygen Supplemental oxygen therapy susceptibility syndrome Therapeutic approach Toxicity treat α7 nicotinic acetylcholine receptor α7nAChR [DOI] 10.1016/j.freeradbiomed.2022.08.004 [Article Type] Review article
Gout and susceptibility and severity of COVID-19: A bidirectional Mendelian randomization analysisCorrespondence Published on 2022-09-012022-10-05 Journal: The Journal of Infection [Category] 유전자 메커니즘, [키워드] Analysis bidirectional mendelian randomization Mendelian randomization analysis suggested that gout was genetically associated with an increased risk of critically ill COVID-19 severity susceptibility [DOI] 10.1016/j.jinf.2022.05.042 [Article Type] Correspondence
The risk of contracting SARS-CoV-2 or developing COVID-19 for people with cancer: A systematic review of the early evidenceSARS-CoV-2에 감염되거나 암에 걸린 사람에게 COVID-19가 발병할 위험: 초기 증거에 대한 체계적인 검토Review Published on 2022-09-012022-09-12 Journal: Journal of cancer policy [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] addition age Analysis article articles Cancer cancer type clinician Comorbidities conducted Contact COVID-19 COVID-19 incidence COVID-19 vaccine database develop Diagnosis diagnosis of COVID-19 Evidence Haematological cancer Health Service high risk Immunocompromise individuals infected with SARS-CoV-2 infection risk lower risk measure methodological limitations Neoplasms Odds ratio Patient peer-reviewed performed positive Positive test primary endpoint Protective quantitative synthesis random random effect reported risk risk of bia SARS-CoV-2 SARS-CoV-2 test Sex suggested susceptibility systematic review the Newcastle-Ottawa Scale Treatment vaccination virus while [DOI] 10.1016/j.jcpo.2022.100338 PMC 바로가기 [Article Type] Review
The basis of mink susceptibility to SARS-CoV-2 infectionSARS-CoV-2 감염에 대한 밍크 감수성의 근거Review Published on 2022-09-012022-09-11 Journal: Journal of applied genetics [Category] Coronavirus, COVID19(2023년), SARS, 변종, [키워드] ACE2 angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 animals B.1.1.7 B.1.617.1 B.1.617.2 coronavirus coronavirus disease COVID-19 COVID-19 pandemic Critical Cross-species infection Cross-species transmission D614G death rate disease Evolution highest Host host range Human humans Infection interact issue Minks Mutation Occurrence over Pathogens phenomenon possession Protein raise RBD receptor Receptor-binding domain S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant sequence Sequence alignment spike Spike protein susceptibility the receptor-binding domain Transmission variants Viral diseases viral pathogenesis viral pathogens virus Y453F [DOI] 10.1007/s13353-022-00689-w PMC 바로가기 [Article Type] Review
Changes in virus detection in hospitalized children before and after the severe acute respiratory syndrome coronavirus 2 pandemic중증급성호흡기증후군 코로나바이러스 2 팬데믹 전후 입원 아동의 바이러스 검출 변화Article Published on 2022-09-012022-09-11 Journal: Influenza and Other Respiratory Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] accumulate acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adenovirus change children coronavirus Epidemiology examined Hospitalization Hospitalized human metapneumovirus Infection Infectious disease Infectious diseases Influenza Influenza virus non-enveloped viruses pandemic parainfluenza Prevalence preventive measure preventive measures respiratory virus respiratory viruses rhinovirus SARS-CoV-2 SARS-CoV-2 pandemic severe acute respiratory syndrome Coronavirus susceptibility the SARS-CoV-2 virus virus detection [DOI] 10.1111/irv.12995 PMC 바로가기 [Article Type] Article
Durability of Immune Response After COVID-19 Booster Vaccination and Association With COVID-19 Omicron InfectionArticle Published on 2022-09-012022-11-15 Journal: JAMA Network Open [Category] SARS, 변종, 진단, [키워드] 95% CI age antibody antibody kinetics Antibody titer antibody waning association avidity BNT162b2 BNT162b2 vaccine booster dose COVID-19 delta variant demonstrated dose effective Effectiveness faster Follow-up geometric mean titer greater Health care worker Humoral response IgG IgG level immune response incidence Infection longitudinal cohort study microneutralization mononuclear cell mononuclear cells neutralization neutralizing antibody Older omicron outcome participant Peripheral blood Primary outcome response SARS-CoV-2 second dose secondary outcome sera Strains susceptibility T cell T cell activation tested Transmission Vaccine vaccine dose vaccine doses variant variant of SARS-CoV-2 variants of concern were assessed were used wild type women [DOI] 10.1001/jamanetworkopen.2022.31778 PMC 바로가기
Hair cortisol as a risk marker for increased depressive symptoms among older adults during the COVID-19 pandemicCOVID-19 대유행 기간 동안 노인들 사이에서 증가된 우울 증상에 대한 위험 마커로서의 헤어 코르티솔Article Published on 2022-09-012022-09-11 Journal: Psychoneuroendocrinology [Category] 바이오마커, 유전자 메커니즘, [키워드] 95% CI adjusted Ageing applied association center clinically collected cortisol covariate COVID-19 COVID-19 pandemic Depression depressive depressive symptom Depressive symptoms Determining Effect elevated environmental stress epidemiological studies Evidence evidence of exposure to female finding hair help identify individual investigated likelihood logistic regression model longitudinal longitudinal study marker mental health Modification no evidence of Older Older adults pandemic Pathways phenotype predicted psychological health risk risk markers scale Sex significant interaction significantly Stress susceptibility Wave were assessed [DOI] 10.1016/j.psyneuen.2022.105847 PMC 바로가기 [Article Type] Article
Rapid and accurate identification of SARS-CoV-2 Omicron variants using droplet digital PCR (RT-ddPCR)Droplet Digital PCR(RT-ddPCR)을 사용한 SARS-CoV-2 Omicron 변이체의 빠르고 정확한 식별Article Published on 2022-09-012022-09-11 Journal: Journal of Clinical Virology [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] Allelic discrimination amino acids B.1.1.529 B.1.1.529. Clinical treatment clinician Concentration confounding factor Delta described develop digital PCR Efficacy Frequency genome sequence Genome sequences genotyping identify Laboratory medium Mutation mutations NGS omicron Omicron variants positive Prevalence primer probe sequences problem professionals Protein public health Rapid reaction Receptor binding domain respiratory viruses RNA robust S-gene SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 variants Sensitivity and specificity shifting specimen spike Spike protein state substantial reduction substantial reductions susceptibility tested the SARS-CoV-2 therapy Transmission Transport transport medium Vaccine vaccine efficacy variant variants Variation Washington [DOI] 10.1016/j.jcv.2022.105218 PMC 바로가기 [Article Type] Article