the cell – Page 8 – Communicable Diseases Research

Influence of aging on deterioration of patients with COVID-19

COVID-19 환자의 악화에 대한 노화의 영향

Review

Published on 2020-12-312022-09-10
Journal: Aging (Albany NY) [Category] SARS, 바이오마커,

Free SARS-CoV-2 Spike Protein S1 Particles May Play a Role in the Pathogenesis of COVID-19 Infection

무료 SARS-CoV-2 스파이크 단백질 S1 입자는 COVID-19 감염의 병인에서 역할을 할 수 있습니다

Hypothesis

Published on 2020-12-302022-09-01
Journal: Biochemistry. Biokhimiia [Category] SARS, 변종, 진단,

[키워드] accompanied ACE ACE2 angiotensin angiotensin (1-7) Angiotensin II Angiotensin-converting enzyme angiotensin-converting enzyme 2 association caused Cell cell surface circulation cleavage site COVID-19 COVID-19 disease COVID-19 infection COVID-19 pathogenesis D614G D614G mutation decrease disease downregulate downregulated Effect expression fraction Free furin furin protease higher infectivity Hypothesis Imbalance in vivo infected cell infected cells Infection Inflammation investigated lack lead less lung Lungs membrane-bound murine model mutant natural infection Particle Pathogenesis pathogenesis of COVID-19 Prevalence Protein pulmonary damage receptor-binding domains Recombinant spike protein Renin renin-angiotensin system reported role S protein S1 and S2 S1 subunit S1 subunit shedding SARS-CoV virus SARS-CoV-2 SARS-CoV-2 S protein SARS-CoV-2 strain separation severity shown spike Spike protein subunits the cell the receptor-binding domain the S protein the S1 subunit the SARS-CoV-2 thrombosis trimer unlikely Viral Viral load virion virions wild type
[DOI] 10.1134/S0006297921030032 PMC 바로가기 [Article Type] Hypothesis

Phosphatidylserine inside out: a possible underlying mechanism in the inflammation and coagulation abnormalities of COVID-19

포스파티딜세린 인사이드 아웃: COVID-19의 염증 및 응고 이상에서 가능한 기본 메커니즘

Review

Published on 2020-12-272022-09-10
Journal: Cell Communication and Signaling : CCS [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] Abnormalities abnormality ACE2 Activation Acute inflammation ADAM17 ADAMTS13 addition aggregation association biochemical C reactive protein cascade cause cell membrane clinical complication clinical complications Coagulation coagulation cascade coronavirus coronavirus disease COVID-19 COVID-19 pathophysiology Cytokines damage death DIC-COVID-19 EGFR Endothelial cell endothelial cells Endothelium explained expression extrinsic pathway factor VII Health humans IFN-γ IL-1β IL-6 IL-6R IL-8 immune induce infected cell Inflammation Inflammatory response inhibitory action involved management mechanism membrane monocyte pathophysiological pathophysiology Phosphatidylserine plasma Platelet Platelets pro-inflammatory cytokines pro-inflammatory molecule pro-inflammatory molecules SARS-CoV-2 Spread Support the cell the SARS-CoV-2 thrombi tissue Tissue Factor TNF-α Vascular Viral viral infection
[DOI] 10.1186/s12964-020-00687-7 PMC 바로가기 [Article Type] Review

Female reproductive tract has low concentration of SARS-CoV2 receptors

여성 생식기는 SARS-CoV2 수용체 농도가 낮습니다.

Research Article

Published on 2020-12-142022-09-10
Journal: PLoS ONE [Category] MERS, SARS, 치료기술,

Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection

TMPRSS2와 카텝신 B/L을 함께 표적으로 삼는 것은 SARS-CoV-2 감염에 대해 상승적일 수 있습니다

Research Article

Published on 2020-12-082022-08-13
Journal: PLoS Computational Biology [Category] Biochemistry, COVID-19, SARS,

[키워드] ‘repurposing’ drugs achievement activate Activation blockade blocking blocking virus entry cathepsin Cathepsin B/L Cell cell lines cell population levels cell types cells clinical trials combination therapies combination therapy corresponding protease expression level COVID-19 COVID-19 pandemic cysteine cysteine protease cysteine proteases deployability dose-dependent manner drug drug combination drug combinations drugs targeting Effect Efficacy Efficiency effort entry of SARS-CoV-2 Evidence expression level facilitate help highlighting host protease host proteases host serine protease IMPROVE in vitro in vitro data in vivo independent independent entry pathway inhibitor inhibitors involved mathematical mathematical model minimal toxicities pathway Pathways potential treatment option predict predicted Prevent protease Proteases required SARS-CoV entry SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection Serine Single Cell Spike protein synergistic Synergistic drug combination Synergistic drug combinations synergy target cell target cells targeting the cell tissue tropism TMPRSS2 toxicities Treatment triggered virus entry
[DOI] 10.1371/journal.pcbi.1008461 PMC 바로가기 [Article Type] Research Article

De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2

SARS-CoV-2를 무력화하는 강력하고 탄력적인 hACE2 미끼의 새로운 설계

Report

Published on 2020-12-042022-09-10
Journal: Science (New York, N.y.) [Category] Fulltext, SARS, 치료제,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Affect angiotensin best binding Cell cells coronavirus cryo-EM de novo decoy decrease develop effort Extracellular hACE2 hamster hamsters host protein host receptor human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo infect Interaction intranasal intrinsically Microscopy mutant nanomolar affinity neutralize neutralized Neutralizing optimization pathogen Pathogens prophylactic dose Protein Protein design RBD RBDs Receptor-binding domain replicate respiratory SARS-CoV-2 SARS-COV-2 infection Science severe acute respiratory syndrome Coronavirus specificity Spike protein subsequent the cell the receptor-binding domain the spike protein therapeutic therapy unlikely Viral virus
[DOI] 10.1126/science.abe0075 PMC 바로가기 [Article Type] Report

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

안드로겐 신호는 SARS-CoV-2 수용체 수준을 조절하고 남성의 심각한 COVID-19 증상과 관련이 있습니다

Article

Published on 2020-12-032022-09-11
Journal: Cell Stem Cell [Category] Fulltext, MERS, 변종, 신약개발, 유전자 메커니즘, 치료제,

[키워드] 5-alpha reductase inhibitors ACE2 ACE2 expression ACE2 regulation Analysis androgen androgen signaling angiotensin angiotensin converting enzyme angiotensin converting enzyme 2 binding Cell cell membrane Clinical data Compound COVID-19 COVID-19 patient COVID-19 risk factors COVID-19 sex bias deep learning demonstrated disease disease severity disease susceptibility Diseases drug drug re-purposing elevated embryonic embryonic stem cell enzyme Genetic variant genetic variants Health Health crisis high content screening hPSC-based disease modeling identify Infection Level lung organoid lung organoids mechanism men occur offer potential treatment option Prostate reduce reduced risk risk factor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infection model screening strategy Sex stem cell susceptibility target the cell the disease virtual drug screen. virus
[DOI] 10.1016/j.stem.2020.11.009 PMC 바로가기 [Article Type] Article

SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses

SARS-CoV-2는 호스트 방어를 억제하기 위해 스플라이싱, 번역 및 단백질 트래피킹을 방해합니다.

Article

Published on 2020-11-252022-09-11
Journal: Cell [Category] MERS, SARS, 유전자 메커니즘,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus bind cause cell membrane cellular cellular processe coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 disrupt Disruption domain engage function Host host defenses Infection Interaction interfere interferon interferon response leads molecular basis mRNA mRNA splicing mRNA translation nsp1 nsp16 NSP8 Nsp9 Protein protein trafficking protein translation respiratory Respiratory disease ribosomal RNA ribosome RNA RNA-protein interactions RNAs SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 pathogenesis SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 snRNA splicing suppress the cell the interferon translation Viral viral infection
[DOI] 10.1016/j.cell.2020.10.004 PMC 바로가기 [Article Type] Article

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

SARS-CoV-2 성장, 퓨린 절단 부위 적응 및 급성 감염 입원 COVID-19 환자의 혈청을 사용한 중화

Research Article

Published on 2020-11-212022-09-10
Journal: The Journal of General Virology [Category] MERS, SARS, 변종, 진단,

[키워드] acute respiratory syndrome acute respiratory syndrome coronavirus adaptation angiotensin antigenic target Betacoronavirus both viruses causative agent caused Cell cell lysate cell surface cells characterized cleavage clinical isolates comparable coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 deaths deleted Deletion demonstrated disease expand furin furin cleavage generate glycoprotein growth hACE2 Healthcare system Healthcare systems hospitalized COVID-19 patient host range human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 in vitro in vivo indirect immunofluorescence inefficient Infection insertion investigated Like MinION Munich neutralization Neutralizing antibodies neutralizing antibody titre neutralizing antibody titres Pathogenesis patients reached receptor respiratory S glycoprotein S protein SARS-CoV SARS-CoV-2 SARS-CoV-2 spike Sequencing serum serum sample severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spread to strain the cell the S protein the SARS-CoV-2 variant Vero E6 Vero E6 cell VERO E6 cells virus virus stock virus stocks viruses
[DOI] 10.1099/jgv.0.001481 PMC 바로가기 [Article Type] Research Article

A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury

뮤신-1 감소 화합물에 대한 고함량 선별 검사를 통해 포스타마티닙을 급성 폐 손상의 신속한 용도 변경 후보로 확인

Article

Published on 2020-10-292022-09-11
Journal: Cell Reports Medicine [Category] 비임상, 신약개발,

[키워드] acute lung injury acute respiratory distress acute respiratory distress syndrome ALI approved ARDS breath candidate Cell cell surface clinical development clinical outcomes Compound COVID-19 drug drug candidate Drug repurposing epithelial cells fostamatinib fostamatinib. identify Immune thrombocytopenia inhibitor lung lung epithelial cell Lung epithelial cells Lung injury metabolite mouse model MUC1 mucin pandemic pandemic spread Potential treatment potential treatments predict promote Protein R788 Rapid reduce repurposing respiratory distress Respiratory distress syndrome SARS-CoV-2 Screen spleen Spread Stage SYK syndrome the cell thrombocytopenia Treatment tyrosine
[DOI] 10.1016/j.xcrm.2020.100137 PMC 바로가기 [Article Type] Article