Infectious Aerosol Capture Mask as Environmental Control to Reduce Spread of Respiratory Viral Particles호흡기 바이러스 입자의 확산을 줄이기 위한 환경 제어로서의 감염성 에어로졸 캡처 마스크Article Published on 2022-06-112022-09-11 Journal: Viruses [Category] COVID19(2023년), SARS, 치료기술, [키워드] activities aerosol aerosol capture airborne isolation. alternative alternatives breath breathing can be used capture CFD collected Computational fluid dynamics Control coughing COVID-19 patient COVID-19 patients Critical described escaped evaluated experiment Filter indicated infected individual infected individuals Isolation Isolation room Laboratory Mask negative Negative pressure nosocomial Nosocomial transmission Particle Particles Patient respiratory RNA RNA copies SARS-CoV-2 Simulation speaking the patient These data Transmission undetectable virus concentration [DOI] 10.3390/v14061275 PMC 바로가기 [Article Type] Article
The Cross-Protective Immunity Landscape Among Different SARS-CoV-2 Variant RBDs다양한 SARS-CoV-2 변종 RBD 간의 교차 보호 면역 환경Article Published on 2022-06-102022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Alpha antibody Antigen antigens Beta COVID-19 vaccine design cross-neutralization cross-neutralizing cross-protective cross-protective immunity Delta effective evaluated expressed IgG antibodies immune protection immunize Lambda landscape mice neutralization neutralization antibodies Neutralizing activity new SARS-CoV-2 omicron pentavalent pseudovirus pseudoviruses RBD RBD antigen RBD protein SARS-CoV-2 SARS-CoV-2 vaccine SARS-CoV-2 vaccines SARS-CoV-2 variant SARS-CoV-2 variants the epidemic These data titers of IgG Vaccine vaccine strain Vaccines variant variants wild type [DOI] 10.3389/fimmu.2022.898520 PMC 바로가기 [Article Type] Article
Elevated plasma level of the glycolysis byproduct methylglyoxal on admission is an independent biomarker of mortality in ICU COVID-19 patients입원 시 해당과정 부산물인 메틸글리옥살의 혈장 수준 상승은 ICU COVID-19 환자의 사망률에 대한 독립적인 바이오마커입니다Article Published on 2022-06-092022-09-11 Journal: Scientific Reports [Category] MERS, 바이오마커, 치료기술, 치료법, [키워드] Admission Biomarker Biomarkers byproduct Care correlated COVID-19 patient COVID-19 patients CRP death died elevated enzyme Evidence evidence of explained glutathione Glycolysis high risk ICU ICU patient ICU Patients identify IL-1β independent inflammation markers Logistic regression analysis management methylglyoxal monocyte Monocytes Mortality on admission Patient plasma Plasma levels predict provide regression analysis survived therapeutic These data TNF-α uninfected control Variability [DOI] 10.1038/s41598-022-12751-y PMC 바로가기 [Article Type] Article
Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2오미크론 특이적 mRNA 백신 단독 및 SARS-CoV-2에 대한 이종 부스터Article Published on 2022-06-062022-09-11 Journal: Nature Communications [Category] COVID19(2023년), MERS, SARS, 변종, 유전자 메커니즘, 임상, 진단, [키워드] animals Antibody Response assessment background level Beta binding antibody boost booster comparable delta variant elicit generate globe Heterologous homologous immune evasion in vivo increase injection LNP mice mRNA vaccination mRNA vaccine neutralization potency Neutralizing titer neutralizing titers omicron Omicron variant reduce reduction in responses against SARS-CoV SARS-CoV-2 These data titers vaccination Vaccine variant variant of SARS-CoV-2 [DOI] 10.1038/s41467-022-30878-4 PMC 바로가기 [Article Type] Article
Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics치료제로서의 최적 기능을 위한 Anti-SARS-CoV-2 단일클론항체 변형 전략 평가Article Published on 2022-06-032022-09-11 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition alleviate antibody Antibody-dependent enhancement caused Cell circulating closure Combination coronavirus country COVID-19 infection COVID-19 infections COVID-19 pandemic death disease Economy Effect epitope Epitopes Health crisis Human human population humoral immune response in vitro infecting investigated LALA lockdown mAb mAbs modify monoclonal antibodies monoclonal antibody Mutation neutralize produced public health crisis public health measure public health measures reduce reported respiratory resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 SARS-CoV2 spike protein serum severe acute respiratory syndrome Coronavirus Spike protein Spread the antibody the disease the spike protein therapeutic option therapy These data Viral viral variant virus writing [DOI] 10.1371/journal.pone.0267796 PMC 바로가기 [Article Type] Article
Association between dexamethasone treatment and the host response in COVID-19 patients admitted to the general ward일반병동에 입원한 코로나19 환자의 덱사메타손 치료와 숙주반응의 연관성Article Published on 2022-06-032022-09-11 Journal: Respiratory Research [Category] 바이오마커, [키워드] Activation Admission Biomarker Cell Clinical outcome clinical outcomes Coagulation comparable COVID-19 COVID-19 patient Dexamethasone Endothelial cell host response IL-1 IL-1 receptor antagonist implementation IMPROVE Inflammation investigated mechanism mechanism of action Modification not affected oxygen parameter Patient plasma receptor antagonist response Standard of care supplementary oxygen These data Treatment [DOI] 10.1186/s12931-022-02060-3 PMC 바로가기 [Article Type] Article
Increased Seroprevalence and Improved Antibody Responses Following Third Primary SARS-CoV-2 Immunisation: An Update From the COV-AD Study3차 1차 SARS-CoV-2 예방접종 후 혈청유병률 증가 및 항체 반응 개선: COV-AD 연구의 업데이트Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] Anti-spike antibody Antibody Response AstraZeneca B.1.1.529 cellular immunity cellular response ChAdOx1 ChAdOx1 nCoV-19 cohort of patient COVID-19 cross-reactive CVID deficiency detectable determine dose ELISA ELISpot assays ENhance enrolled glycoprotein healthy control healthy controls heterogeneous heterologous vaccine humoral Humoral immunity immunodeficiency immunogenicity Improved Inborn errors inborn errors of immunity Increased individual initial magnitude mounted neutralisation neutralising no differences participant Pfizer Primary Immunodeficiency remained response SARS-CoV-2 SARS-CoV-2 vaccination SARS-CoV-2 vaccine secondary antibody secondary immunodeficiency Seroconversion serological response seronegative Seroprevalence significantly increased significantly lower significantly more Support T cell T cell response the antibody response the SARS-CoV-2 These data vaccination Vaccine vaccine dose vaccine doses variant widespread [DOI] 10.3389/fimmu.2022.912571 PMC 바로가기 [Article Type] Article
mRNA or ChAd0x1 COVID-19 Vaccination of Adolescents Induces Robust Antibody and Cellular Responses With Continued Recognition of Omicron Following mRNA-1273청소년의 mRNA 또는 ChAd0x1 COVID-19 예방 접종은 mRNA-1273에 이어 오미크론을 계속 인식하여 강력한 항체 및 세포 반응을 유도합니다Article Published on 2022-06-022022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), MERS, SARS, 변종, 진단, [키워드] Adolescent antibody antibody level antibody levels Antibody Response BNT162b2 CD4+ T-cell Cell cellular response Cellular responses ChAdOx1 comprehensive analysis COVID-19 COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines cytokine develop dominant Donor doses dual elicit Evidence generate health condition High-risk patients IL-10 immune response immune responses immunogenic Infection measure memory Mild mRNA mRNA vaccination mRNA vaccine mRNA-1273 natural infection neuro-disabilities neutralisation titre Neutralisation titres omicron Omicron variant paediatric physical populations reactivity Recognition remained response risk robust severe disease significantly increased single vaccination Strong T-cell T-cell Response T-cell responses T-cells These data vaccination Vaccine vaccine dose variant [DOI] 10.3389/fimmu.2022.882515 PMC 바로가기 [Article Type] Article
COVID-19 vaccine booster dose needed to achieve Omicron-specific neutralisation in nursing home residents요양원 거주자에서 Omicron-specific 중화를 달성하는 데 필요한 COVID-19 백신 부스터 용량Article Published on 2022-06-012022-09-11 Journal: EBioMedicine [Category] COVID19(2023년), MERS, SARS, 변종, 진단, 치료기술, [키워드] anti-RBD Anti-spike binding domain BNT162b2 BNT162b2 mRNA BNT162b2 mRNA vaccine booster booster dose booster vaccination CDC COVID-19 COVID-19 vaccine death detectable dose enrolled Evidence examined Geriatrics HCW HCWs healthcare worker Healthcare workers high-risk population Hope hospitalisation Humoral immunity initial lifted limit of detection Long-term care majority median age morbidity and mortality mRNA vaccine neutralisation neutralisation activity neutralisation titre Neutralisation titres Neutralising activity NIH nursing home omicron Omicron variant PROTECT RBD SARS-CoV-2 SARS-COV-2 infection significantly increased Support These data titre vaccination variant variants vulnerable population waning immunity Wuhan strain [DOI] 10.1016/j.ebiom.2022.104066 PMC 바로가기 [Article Type] Article
Remdesivir in Coronavirus Disease 2019 patients treated with anti-CD20 monoclonal antibodies: a case series코로나바이러스 질병 2019 환자의 렘데시비르 항-CD20 단일클론항체 치료: 사례 시리즈Randomized Controlled Trial Published on 2022-06-012022-09-11 Journal: Infection [Category] COVID19(2023년), MERS, SARS, 임상, 진단, 치료제, [키워드] administration anti-CD20 Anti-CD20 antibodies anti-CD20 treatment antiviral therapy approved baseline baseline data benefit Case series case sery Clinical improvement Clinical outcome consecutive patient control group convalescent plasma COVID-19 COVID-19 patient COVID-19 symptoms Diagnosis died disease course Follow-up healthcare Infection lack majority malignancy management median monoclonal not performed one patient outcomes pandemic Patient patient population patients patients died patients treated PCR performed Randomized controlled trial Randomized controlled trials reductions reductions in relapsing Remdesivir reported rituximab SARS-CoV-2 Study design symptom onset Symptoms These data Treatment two patients Viral viral clearance viral loads [DOI] 10.1007/s15010-022-01821-y PMC 바로가기 [Article Type] Randomized Controlled Trial