Clinical Improvement, Outcomes, Antiviral Activity, and Costs Associated With Early Treatment With Remdesivir for Patients With Coronavirus Disease 2019 (COVID-19)코로나바이러스 감염증 2019(COVID-19) 환자를 위한 렘데시비르의 조기 치료와 관련된 임상 개선, 결과, 항바이러스 활성 및 비용Article Published on 2022-04-282022-09-11 Journal: Clinical Infectious Diseases: An Official Publicat [Category] COVID19(2023년), SARS, 진단, 치료제, [키워드] activity addition Admission Antiviral antiviral activity benefit changes in changes in viral load clinical Clinical deterioration Clinical improvement clinical outcomes Control cost COVID-19 COVID-19 patients Disease progression Follow-up groups Hong Kong hospital discharge Hospital stay Hospitalized hospitalized patient hospitalized patients IgG antibody improvement In-hospital death Inconclusive intensive care invasive ventilation lower risk median Mild-to-moderate Moderate COVID-19 multiple imputation on admission outcome oxygen Oxygen therapy Patient patients with COVID-19 positive progression Remdesivir retrospective cohort risk significantly shorter study outcomes the disease time Treatment Viral viral clearance Viral load WHO [DOI] 10.1093/cid/ciab631 PMC 바로가기 [Article Type] Article
SARS-CoV-2 Testing in the Community: Testing Positive Samples with the TaqMan SARS-CoV-2 Mutation Panel To Find Variants in Real Time커뮤니티에서 SARS-CoV-2 테스트: 실시간으로 변이를 찾기 위해 TaqMan SARS-CoV-2 돌연변이 패널로 양성 샘플 테스트Article Published on 2022-04-202022-09-11 Journal: Journal of Clinical Microbiology [Category] COVID19(2023년), SARS, 변종, [키워드] clinical sample COG-UK complement COVID-19 generate Genome Genome sequencing Genomics genotyping Health help identify Laboratory limitation Mutation mutations over Panel PCR powerful tool real time Sample SARS-CoV-2 SARS-CoV-2 variant sequence Sequencing sequencing data SNPs specific mutations TaqMan Testing Thermofisher ThermoFisher Scientific time variants variants of concern [DOI] 10.1128/jcm.02408-21 PMC 바로가기 [Article Type] Article
Auxora vs. placebo for the treatment of patients with severe COVID-19 pneumonia: a randomized-controlled clinical trialClinical Trial Published on 2022-04-082022-10-05 Journal: Critical Care [Category] COVID19(2023년), SARS, 임상, [키워드] acute respiratory distress addition adverse event all-cause mortality all-cause mortality rate Auxora baseline calcium channel inhibitor chest imaging clinical trial Corticosteroid COVID-19 hospitalization CRAC CRAC channel inhibitor Day declining determine diagnosis of COVID-19 double-blind Efficacy endothelial integrity Enrollment enrolment groups Guidance Infection Invasive mechanical ventilation Laboratory testing less medication nasal Non-invasive occurred Oxygen therapy PaO Patient patients treated Placebo placebo-controlled trial Pneumonia polymerase chain primary endpoint Proinflammatory cytokine pulse oximetry Randomized randomized patients randomized-controlled receiving Regulatory required Respiratory failure SAE SAEs Safe secondary endpoint severe COVID-19 Severe COVID-19 pneumonia Standard of care Symptom syndrome time Time to recovery treat Treatment Trial with COVID-19 [DOI] 10.1186/s13054-022-03964-8 PMC 바로가기 [Article Type] Clinical Trial
A phase II, double blind, placebo-controlled, randomized evaluation of the safety and efficacy of tafenoquine in patients with mild-moderate COVID-19 diseaseResearch article Published on 2022-04-012022-10-05 Journal: New Microbes and New Infections [Category] 임상, 치료제, [키워드] accelerated Administered administration adverse event Analysis ARMS bpm clinical recovery clinical trial cough COVID-19 COVID-19 disease COVID-19 patients COVID-19 symptom COVID-19 symptoms Day defined disease dose double blind Dyspnea Efficacy evaluated exhibited facilitate FDA-Approved Regimen for Malaria Pophylaxis Fever Hospitalization individual ITT population Mild Moderate COVID-19 occurred Outpatient outpatients Patient per day Placebo placebo-controlled PP population primary endpoint proportion Randomized recorded respiratory rate response Shortness of breath tafenoquine the primary endpoint Therapeutic benefit time Trial [DOI] 10.1016/j.nmni.2022.100986 [Article Type] Research article
Metrics to relate COVID-19 wastewater data to clinical testing dynamicsCOVID-19 폐수 데이터를 임상 테스트 역학과 연관시키는 메트릭Article Published on 2022-04-012022-09-11 Journal: Water research [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis applied changes in clinical testing clinically collected Concentration COVID-19 COVID-19 pandemic death disease spread Epidemiology events First wave help increase Massachusett Metrics MONITOR pandemic Pandemics public health Quantitative reported Reporting RNA concentrations RT-qPCR SARS-CoV-2 SARS-CoV-2 RNA second wave Surveillance Temporal temporal dynamics time time lag transfer Treatment utility wastewater wastewater surveillance Wastewater-based epidemiology were measured while [DOI] 10.1016/j.watres.2022.118070 PMC 바로가기 [Article Type] Article
Resuscitation with blood products in patients with trauma-related haemorrhagic shock receiving prehospital care (RePHILL): a multicentre, open-label, randomised, controlled, phase 3 trialClinical Trial Published on 2022-04-012022-10-05 Journal: The Lancet. Haematology [Category] Fulltext, MERS, 임상, [키워드] 1:1 absence acute respiratory distress adjusted adjusted relative risk Administered adverse event age assigned average benefit Blood blood product Care caused characteristics of patient clearance Complication concealed COVID-19 pandemic Critical care deaths defined eligibility Follow-up identify Injury intention-to-treat population intravenous investigated involved IQR Lactate Liver function male median median age Mortality multicentre nine occurred Open-label outcome parallel group participant participants randomly assigned Patient phase 3 trial plasma Primary outcome pulse randomisation randomised Randomly receive receiving recruitment red blood cell reducing mortality Registered remains uncertain required Research Resuscitation risk Sample size Serious Adverse Events severity Shock Sodium chloride stratified syndrome Systolic blood pressure time tissue trauma Treatment treatment group Trial were assessed [DOI] 10.1016/S2352-3026(22)00040-0 PMC 바로가기 [Article Type] Clinical Trial
Time from Exposure to Diagnosis among Quarantined Close Contacts of SARS-CoV-2 Omicron Variant Index Case-Patients, South KoreaSARS-CoV-2 오미크론 변이 지수 사례 환자의 격리 된 밀접 접촉자 중 노출부터 진단까지의 시간, 한국Article Published on 2022-04-012022-09-11 Journal: Emerging Infectious Diseases [Category] COVID19(2023년), SARS, 변종, [키워드] 2019 novel coronavirus disease acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 close contact coronavirus coronavirus disease COVID-19 determine diagnose diagnoses Diagnosis evaluated exposure to index Novel coronavirus novel coronavirus disease omicron quarantine respiratory infections SARS-CoV-2 severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 South Korea time variant viruses VoC zoonoses [DOI] 10.3201/eid2804.220153 PMC 바로가기 [Article Type] Article
Effect of Short Time of SARS-CoV-2 Infection in Caco-2 CellsCaco-2 세포에서 SARS-CoV-2 감염의 짧은 시간 효과Article Published on 2022-03-292022-09-11 Journal: Viruses [Category] SARS, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 affecting Caco-2 Caco-2 cell Caco-2 cell line Caco-2 cells Cell cell line children clinical manifestation clinical manifestations coronavirus coronavirus disease coronavirus disease 19 COVID-19 Cytopathic effect Effect epithelial cell epithelial cell line gastrointestinal tract highlight immunofluorescence immunofluorescence staining in vitro include infect intestinal multiplicity multiplicity of infection SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus short time of infection staining subsequent the viral nucleocapsid these cell These cells time viral absorption. was tested [DOI] 10.3390/v14040704 PMC 바로가기 [Article Type] Article
Sedentary Time and Fast-Food Consumption Associated With Weight Gain During COVID-19 Lockdown in Children and Adolescents With Overweight or ObesityObservational Study Published on 2022-03-282022-10-04 Journal: Journal of Korean medical science [Category] 임상, [키워드] 95% CI 95% confidence interval Adolescent association baseline BMI BMI Z-Score body mass index cardiometabolic change changes in children conducted Consumption coronavirus disease correlated COVID-19 COVID-19 pandemic determine Effect Factor Fast-Food Intake Gain Health healthy increase in liver enzymes lockdown maintain marker muscular obese obesity overweight pandemic participant Pediatric Obesity physical activity Physical inactivity predicted Prevent regression analysis risk sedentary time Sex time Triglyceride variable was performed weight weight gain [DOI] 10.3346/jkms.2022.37.e103 PMC 바로가기 [Article Type] Observational Study
Rapid Antigen Test LumiraDx TM vs. Real Time Polymerase Chain Reaction for the Diagnosis of SARS-CoV-2 Infection: A Retrospective Cohort StudySARS-CoV-2 감염 진단을 위한 신속한 항원 테스트 LumiraDx TM 대 실시간 중합효소 연쇄 반응: 후향적 코호트 연구Article Published on 2022-03-232022-09-11 Journal: International Journal of Environmental Research an [Category] SARS, 치료기술, [키워드] Accuracy Ag-RDT Ag-RDTs agreement Antigen antigenic chain Chain Reaction Control COVID-19 Diagnosis diagnosis of SARS-CoV-2 diagnostic early phase ECDC European expand False negative gold gold standard infections Infectious disease less Logistic regression meet Negative predictive value new SARS-CoV-2 Patient polymerase chain polymerase chain reaction positive Positive predictive value Predictive Predictive value prevention Prevention and control Rapid rapid antigen test rapid antigen testing Rapid antigen tests RDTs reaction real time Real time reverse transcription polymerase chain reaction retrospective cohort study reverse transcription reverse transcription polymerase chain reaction RT-PCR RT-PCR test SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 infections sensitivity significantly specificity suggested Swab Symptom Test tested the patient time unit was performed were recorded [DOI] 10.3390/ijerph19073826 PMC 바로가기 [Article Type] Article