TLR4 – Page 8 – Communicable Diseases Research

A Multifunctional Peptide From Bacillus Fermented Soybean for Effective Inhibition of SARS-CoV-2 S1 Receptor Binding Domain and Modulation of Toll Like Receptor 4: A Molecular Docking Study

Molecular Biosciences

Published on 2021-03-312022-10-31
Journal: Frontiers in Molecular Biosciences [Category] COVID-19,

Effects of Different Dialysis Strategies on Inflammatory Cytokine Profile in Maintenance Hemodialysis Patients with COVID-19: A Randomized Trial

Article

Published on 2021-03-302022-10-30
Journal: Journal of Clinical Medicine [Category] COVID-19,

[키워드] affected approaches both groups circulating clinical outcomes collected Coronavirus disease-19 correlation COVID-19 COVID-19 patient cut-off cytokine level Cytokines Diagnosis dialysis Effect expanded hemodialysis ferritin Hemodialysis IFN-γ IL-10 IL-6 IL-8 inflammaging Inflammation Inflammatory marker Inflammatory response interleukin-6 lactate dehydrogenase lymphopenia maintenance medium membrane Modification modulation non-infected Pathogenesis Patient patients patients with COVID-19 performed profile Prospective Study protein-leaking dialyzer Randomized reduction in standard treatment Strategy sustained therapeutic target TLR4 Treatment two groups uncontrolled
[DOI] 10.3390/jcm10071383 PMC 바로가기 [Article Type] Article

MicroLet-7b Regulates Neutrophil Function and Dampens Neutrophilic Inflammation by Suppressing the Canonical TLR4/NF-κB Pathway

Immunology

Published on 2021-03-292022-11-01
Journal: Frontiers in Immunology [Category] Coronavirus, SARS,

[키워드] Anti-inflammatory C57BL/6 caused changes in circulating COVID-19 cytokine Defense described down-regulate downstream dysregulated expression Factor function heterogeneous Histopathology Host host response IL-10 IL-6 IL-8 in vitro in vivo Infection Inflammation inhibited Injury interleukin-6 investigated involved less liver lung male mice MicroLet-7b Necrosis neutrophil neutrophil count neutrophil recruitment neutrophilic Neutrophils NF-κB nuclear overexpression post-transcriptional level Previous studies proinflammatory regulatory pathway released Sepsis significantly suggested Suppressing survival syndrome therapeutic effect TLR4 TLR4/NF-κB TNF-α toll-like receptor 4 Treatment upregulation was reduced weight loss were recorded
[DOI] 10.3389/fimmu.2021.653344 PMC 바로가기 [Article Type] Immunology

Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Research Article

Published on 2021-03-252022-10-27
Journal: BMC Immunology [Category] COVID-19,

[키워드] acute respiratory syndrome Amino acid antigenic approach assist average B-lymphocytes binding energy Cell China cloned Combination composed conserved Coronavirus-2 country demonstrated Disulfide DNA sequence effective ENhance epitope expression greater hydrophilic immunogenic immunoglobulins immunoinformatics INF-γ Infection linkers microbial multi Multiepitopes vaccine Novel coronavirus ORF1ab polyprotein pandemic physiochemical property polyprotein predicted ProSA-web Protein protocol provided Ramachandran plot reduce Region Result reverse transcribed S protein SARS CoV-2 SARS-CoV-2 SARSCoV-2 shown significantly Spike S protein Spread stability T lymphocyte T-helper cells T-lymphocytes the vaccine TLR4 translational unique Vaccine vaccine construct was performed
[DOI] 10.1186/s12865-021-00412-0 PMC 바로가기 [Article Type] Research Article

Vaccinomic approach for novel multi epitopes vaccine against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)

Research Article

Published on 2021-03-252022-10-27
Journal: BMC Immunology [Category] Coronavirus, COVID-19, Fulltext, SARS,

[키워드] acute respiratory syndrome Amino acid antigenic approach assist average B-lymphocytes binding energy Cell China cloned Combination composed conserved Coronavirus-2 country demonstrated Disulfide DNA sequence effective ENhance epitope expression greater hydrophilic immunogenic immunoglobulins immunoinformatics INF-γ Infection linkers microbial multi Multiepitopes vaccine Novel coronavirus ORF1ab polyprotein pandemic physiochemical property polyprotein predicted ProSA-web Protein protocol provided Ramachandran plot reduce Region Result reverse transcribed S protein SARS CoV-2 SARS-CoV-2 SARSCoV-2 shown significantly Spike S protein Spread stability T lymphocyte T-helper cells T-lymphocytes the vaccine TLR4 translational unique Vaccine vaccine construct was performed
[DOI] 10.1186/s12865-021-00412-0 PMC 바로가기 [Article Type] Research Article

Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions

Review

Published on 2021-02-202022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,

[키워드] “cytokine storm” activate Activation acute lung injury acute lung injury (ALI) acute respiratory distress acute respiratory distress syndrome (ARDS) Bacterial Bacterial coinfection characteristic characterized Combination coronavirus COVID-19 Cytokine release syndrome Cytokine storm effective eight Evidence exhibiting fungal fungal coinfection Fungal infection fungal infections healthy control hyperinflammation implication Infection Innate Innate immunity Interaction Involving Making mechanism melatonin microbes Mild mild cases mild COVID-19 patient Model NLR NLRP3 novel nucleotide-oligomer-recognition-domain-like receptors (NLR) oligomerization outlined pattern prediction receptor respiratory resulting review SARS-CoV-2 Sepsis severe COVID-19 severe COVID-19 patients suggestion Symptoms syndrome synergistic synergy therapeutic TLR TLR antagonists TLR2 TLR3 TLR4 TLR7 TLR9 Toll-like receptor toll-like receptors (TLR) treating COVID-19
[DOI] 10.3390/ijms22042108 PMC 바로가기 [Article Type] Review

Dual targeting of toll-like receptor 4 and angiotensin-converting enzyme 2: a proposed approach to SARS-CoV-2 treatment

톨 유사 수용체 4 및 안지오텐신 전환 효소 2의 이중 표적화: SARS-CoV-2 치료에 대한 제안된 접근법

Editorial

Published on 2021-02-112022-09-10
Journal: Future Microbiology [Category] MERS, SARS, 치료제,

[키워드] ACE2 Angiotensin-converting enzyme angiotensin-converting enzyme 2 approach coronavirus Coronavirus disease 2019 COVID-19 SARS-CoV-2 SARS-CoV-2 treatment TLR4 Toll-like receptor toll-like receptor 4
[DOI] 10.2217/fmb-2021-0018 PMC 바로가기 [Article Type] Editorial

SARS-CoV-2 spike protein S1 subunit induces pro-inflammatory responses via toll-like receptor 4 signaling in murine and human macrophages

Research Article

Published on 2021-02-022022-10-31
Journal: Heliyon [Category] COVID-19,

[키워드] abrogate activate activated Activation acute respiratory syndrome caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients cytokine develop Effect examined excessive inflammation experiment exposure to human macrophage human macrophages induce Infectious disease Inflammation Inflammatory inhibitor intracellular signaling involved JNK Macrophage macrophages mechanism Mortality multiple organ failure murine N-terminal neutralizing antibody NF-κB nuclear Pathways Patient pro-inflammatory cytokine pro-inflammatory mediator pro-inflammatory response produced Protein receptor S1 subunit SARS-CoV-2 SARS-CoV-2 spike protein selective severe complication severity Signaling signaling pathways spike Spike protein Spread suggested suppressed the disease THP-1 TLR2 TLR4 toll-like receptor 4
[DOI] 10.1016/j.heliyon.2021.e06187 PMC 바로가기 [Article Type] Research Article

COVID-19 and Toll-Like Receptor 4 (TLR4): SARS-CoV-2 May Bind and Activate TLR4 to Increase ACE2 Expression, Facilitating Entry and Causing Hyperinflammation

COVID-19 및 Toll-Like Receptor 4(TLR4): SARS-CoV-2는 TLR4에 결합하고 활성화하여 ACE2 발현을 증가시켜 진입을 촉진하고 과염증을 유발할 수 있습니다

Review

Published on 2021-01-142022-09-10
Journal: Mediators of Inflammation [Category] 치료제,

[키워드] ACE2 activate Activation alveolar cell antagonist Antiviral appear ARDS bind binding cause causes causing Cell cell surface cells clinical trial contribute COVID-19 COVID-19 patients Cytokines decrease entry receptor Evidence expressed expression Facilitating heart failure hyperinflammation Immune cell immune cells include increase Infection Inflammation Injury innate immune innate immune response interferons lung Lungs Mortality multiorgan failure multiple-organ myocarditis PAMPs pathogen pathogen-associated molecular pattern pathogen-associated molecular patterns Pathogenesis pathogenesis of SARS-CoV-2 pathophysiological Proinflammatory cytokine proinflammatory cytokines promise protein-protein interaction Pulmonary surfactants receptor recognize reported Respiratory failure SARS-CoV-1 SARS-CoV-2 SARS-CoV-2 spike glycoprotein secrete Sepsis severe COVID-19 significantly spike glycoprotein Spike protein surface tension tension the cell the SARS-CoV-2 the spike protein the strongest therapeutic target TLR4 Treatment Trigger triggers type I interferon type I interferons Viral Viral protein Viral proteins
[DOI] 10.1155/2021/8874339 PMC 바로가기 [Article Type] Review

C-reactive protein as a possible marker for severity and mortality of COVID-19 infection

Original Article

Published on 2021-01-012022-10-31
Journal: Gastroenterology and Hepatology From Bed to Bench [Category] COVID-19,