Activation of TLR7 and Innate Immunity as an Efficient Method Against COVID-19 Pandemic: Imiquimod as a Potential TherapyImmunology Published on 2020-06-112022-10-31 Journal: Frontiers in Immunology [Category] Coronavirus, MERS, SARS, [키워드] Against COVID-19 efficient imiquimod Imiquimod (IMQ) immune activation Innate Innate immunity Potential SARS - CoV-2 TLR7 [DOI] 10.3389/fimmu.2020.01373 PMC 바로가기 [Article Type] Immunology
Bioinformatic analysis and identification of single-stranded RNA sequences recognized by TLR7/8 in the SARS-CoV-2, SARS-CoV, and MERS-CoV genomesArticle Published on 2020-05-012023-07-13 Journal: Microbes and infection [Category] SARS, [키워드] MERS SARS SARS-CoV-2 TLR7 TLR8. [DOI] 10.1016/j.micinf.2020.04.009 PMC 바로가기
Sodium ferulate protects against influenza virus infection by activation of the TLR7/9-MyD88-IRF7 signaling pathway and inhibition of the NF-κB signaling pathwayArticle Published on 2019-05-142023-06-23 Journal: Biochemical and Biophysical Research Communication [Category] 신종인플루엔자, [키워드] Influenza NF-κB Sodium ferulate TLR7 TLR9 [DOI] 10.1016/j.bbrc.2019.03.113
Safety and efficacy of vesatolimod (GS-9620) in patients with chronic hepatitis B who are not currently on antiviral treatmentClinical Trial Published on 2018-11-012023-06-19 Journal: Journal of viral hepatitis [Category] B형 간염, [키워드] HBeAg HBsAg Hepatitis B virus immune response TLR7 vesatolimod. [DOI] 10.1111/jvh.12942 [Article Type] Clinical Trial
Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody ProductionOriginal Research Published on 2018-10-122023-06-08 Journal: Frontiers in Immunology [Category] Fulltext, 신종인플루엔자, [키워드] A(H1N1)pdm09 B cell imiquimod inactivated influenza mouse peritoneal TLR7 [DOI] 10.3389/fimmu.2018.02370 PMC 바로가기 [Article Type] Original Research
TLR7 polymorphism, sex and chronic HBV infection influence plasmacytoid DC maturation by TLR7 ligandsArticle Published on 2018-09-012023-06-18 Journal: Antiviral Research [Category] B형 간염, [키워드] Hepatitis B virus Immunotherapy plasmacytoid dendritic cell rs179008. Sex TLR7 [DOI] 10.1016/j.antiviral.2018.06.015
Selective Packaging in Murine Coronavirus Promotes Virulence by Limiting Type I Interferon ResponsesResearch Article Published on 2018-05-012022-10-29 Journal: mBio [Category] Coronavirus, MERS, [키워드] absence antibodies Betacoronavirus caused cellular coronavirus CoV CoVs cultured cells Effect genomic genomic RNA gRNA IFN IFNAR in viral in vitro in vivo increases in Infection innate immune innate immune response innate immune system interferon interferon response interferon signaling locus marrow-derived macrophage MAVS mechanism MHV mice murine hepatitis virus mutant mutant virus Mutation not affect Nsp15 ORF1b packaged packaging signal Pathogenesis pathogenicity positive positive-sense promote receptor reduced remained replicated Replication required response restored RNA RNA molecule RNA packaging RNAs selective selective packaging significantly strain subgenomic RNAs These data TLR7 treated Type virion virions virulence virus virus replication viruses weight loss [DOI] 10.1128/mBio.00272-18 PMC 바로가기 [Article Type] Research Article
Anti-HBV response to toll-like receptor 7 agonist GS-9620 is associated with intrahepatic aggregates of T cells and B cellsArticle Published on 2018-05-012023-06-18 Journal: Journal of hepatology [Category] B형 간염, Fulltext, [키워드] B cell CD8 T cell Chimpanzee animal model Hepatitis B virus immunomodulation interferon-alpha interferon-stimulated gene Lymphocyte aggregate NK cell Tertiary lymphoid structure. TLR7 [DOI] 10.1016/j.jhep.2017.12.008 PMC 바로가기
Toll-like receptor 7 agonist GS-9620 induces prolonged inhibition of HBV via a type I interferon-dependent mechanismArticle Published on 2018-05-012023-06-19 Journal: Journal of hepatology [Category] B형 간염, [키워드] APOBEC cccDNA GS-9620 Hepatitis B virus Immunoproteasome interferon-alpha interferon-stimulated gene MHC SMC5/6 TLR7 [DOI] 10.1016/j.jhep.2017.12.007
Safety, efficacy and pharmacodynamics of vesatolimod (GS-9620) in virally suppressed patients with chronic hepatitis BClinical Trial Published on 2018-03-012023-06-19 Journal: Journal of hepatology [Category] B형 간염, [키워드] HBsAg Hepatitis B virus immune response TLR7 [DOI] 10.1016/j.jhep.2017.10.027 [Article Type] Clinical Trial