transcriptomic – Page 8 – Communicable Diseases Research

COVID-19 Transcriptomic Atlas: A Comprehensive Analysis of COVID-19 Related Transcriptomics Datasets

Genetics

Published on 2021-12-222022-10-31
Journal: Frontiers in Genetics [Category] COVID-19,

SARS-CoV-2 Exacerbates Beta-Amyloid Neurotoxicity, Inflammation and Oxidative Stress in Alzheimer’s Disease Patients

SARS-CoV-2는 알츠하이머병 환자의 베타-아밀로이드 신경 독성, 염증 및 산화 스트레스를 악화시킵니다

Article

Published on 2021-12-192022-09-10
Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘,

[키워드] activated acute respiratory syndrome acute respiratory syndrome coronavirus Alzheimer’s disease Alzheimer’s disease beta-amyloid biological process Brain can not Cell cell cycle clearance Cohort collected Comorbidity coronavirus coronavirus disease COVID-19 COVID-19 cohort deaths Dementia deregulated died Gene Expression Omnibus Health higher risk immune response individuals Inflammation interactome neurotoxicity Next-generation sequencing Ontology oxidative stress pandemic Patient profile Repository respiratory reveal SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 Transcriptome transcriptomic triggered Viral viral replication
[DOI] 10.3390/ijms222413603 PMC 바로가기 [Article Type] Article

Association of Complement and MAPK Activation With SARS-CoV-2–Associated Myocardial Inflammation

SARS-CoV-2–관련 심근 염증과 보체 및 MAPK 활성화의 연관성

Research

Published on 2021-12-152022-09-10
Journal: JAMA Cardiology [Category] MERS, SARS, 유전자 메커니즘,

[키워드] abundance age Analysis assessment biopsies C1q capture capture sequencing cardiac Cardiomyopathy cascade case sery CD163 center Characteristics characterized clade Cohort cohort of patients collected complement Complement cascade component confirmation cysteine Endomyocardial biopsy Ethnicity Exome exploratory exposure Factor finding Future Germany highest histologic Hospitalized immune pathway immune signature Immune-mediated implication Importance individual Infection Inflammatory inflammatory condition inflammatory conditions inhibitor Injury kinases lymphocyte Lymphocyte count lymphocyte counts Macrophage macrophages male MAPK mass mass spectrometry Maximilian measure median age mitogen mitogen-activated protein kinase Munich Myocardial inflammation myocardial injury myocarditis objective participant Participants pathway Pathways Patient patients with SARS-CoV-2 phenotype Point Protein protein kinase protein kinases proteinase Proteins proteomic Proteomic analysis reduce Referral Relevance Result RNA SARS-COV-2 infection Sequencing Serine setting signaling cascade similarities specimen specimens subunit the median threonine tissue transcript transcriptomic transcriptomic analysis Treatment strategies treatment strategy Tübingen university upregulated upregulation Viral viral myocarditis were measured
[DOI] 10.1001/jamacardio.2021.5133 PMC 바로가기 [Article Type] Research

Randomized trial drug controlled compendious transcriptome analysis supporting broad and phase specific therapeutic potential of multiple candidates in COVID-19

Randomized Controlled Trial

Published on 2021-12-012022-10-04
Journal: Cytokine [Category] 바이오마커, 신약개발, 임상, 치료제,

[키워드] Admissions Affect Analysis Anticytokines antiinflammatory assumption benefit Biomarker candidate cellular clinical study coronavirus disease COVID-19 cytokine cytokine release Deceased Dexamethasone discharged disease Drug discovery drugs Effect effective Effectiveness examined expected hydroxychloroquine/chloroquine hyperinflammation ICU implicated inhibiting intensive care Intervention non-ICU opposite outcomes oxygen supplementation patients Predictive Proinflammatory cytokine proinflammatory cytokines randomized clinical trial RCT Regulation severity Stage supported the disease therapeutic effects therapeutic potential Therapeutics therapy Tofacitinib Transcriptome transcriptomic transcriptomic data Treatment Trial underlie Ventilation
[DOI] 10.1016/j.cyto.2021.155719 PMC 바로가기 [Article Type] Randomized Controlled Trial

Type I interferon response and vascular alteration in chilblain-like lesions during the COVID-19 outbreak

Observational Study

Published on 2021-12-012022-10-05
Journal: The British journal of dermatology [Category] 임상,

Integrated multi-omics approach identified molecular mechanism and pathogenetic processes of COVID-19 that affect patient with Parkinson’s disorder

Research article

Published on 2021-12-012022-10-05
Journal: Saudi Journal of Biological Sciences [Category] 유전자 메커니즘,

Developmental Aspects of SARS-CoV-2, Potential Role of Exosomes and Their Impact on the Human Transcriptome

Review

Published on 2021-11-292022-10-29
Journal: Journal of Developmental Biology [Category] COVID-19,

[키워드] aspect Cell cellular children combating component connection COVID-19 COVID-19-related complication death develop development developmental diagnostic elevated Exosome Exosomes Future host tissue Human immune response immune-related genes Impact impacts Infection mother mRNA vaccine Neonate older population Outbreaks outcome pathophysiology placental placental transmission Potential predicted Pregnancy pregnant reported Research RNA-sequencing role SARS-CoV-2 spreads Stage Sub-genomic RNA therapeutic transcript Transcriptome transcriptomic Transmission upregulation Viral RNA were infected
[DOI] 10.3390/jdb9040054 PMC 바로가기 [Article Type] Review

Heterogeneity of Early Host Response to Infection with Four Low-Pathogenic H7 Viruses with a Different Evolutionary History in the Field

Article

Published on 2021-11-212023-05-31
Journal: Viruses [Category] Fulltext,

[키워드] Influenza LPAI-HPAI evolution RNA-Seq transcriptomic
[DOI] 10.3390/v13112323 PMC 바로가기 [Article Type] Article

Discovering common pathogenetic processes between COVID-19 and diabetes mellitus by differential gene expression pattern analysis

차등 유전자 발현 패턴 분석에 의한 COVID-19와 당뇨병 사이의 일반적인 병원성 과정 발견

Case Study

Published on 2021-11-172022-09-01
Journal: Briefings in Bioinformatics [Category] MERS, SARS, 유전자 메커니즘, 진단,

[키워드] analyses Analysis biological processe biological processes blood gene expression caused characterized Comorbidity coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient dataset DEGs diabete diabetes Diabetes Mellitus Differential gene expression differentially expressed gene downregulated dysregulated followed by functional Functional assessment Gene ontology GO term identify implicated Increased Infectious disease involved islets modulated molecular pathways mononuclear cell mononuclear cells Ontology Organoid pancrea pancreas pathway Pathways patients with diabete PBMC PBMCs Peripheral blood Peripheral blood mononuclear cells prediction RELA SARS-CoV-2 severity of COVID-19 T1D T2D transcription factor transcription factors transcriptional transcriptional signatures transcriptomic Treatment Type 1 diabetes type 2 diabete type 2 diabetes upregulated upregulation whole-genome
[DOI] 10.1093/bib/bbab262 PMC 바로가기 [Article Type] Case Study

The NF-κB Transcriptional Footprint Is Essential for SARS-CoV-2 Replication

NF-κB 전사 발자국은 SARS-CoV-2 복제에 필수적입니다

Article

Published on 2021-11-092022-09-11
Journal: Journal of Virology [Category] SARS, 변종, 유전자 메커니즘,

[키워드] absence Activation Analysis Antiviral approach canonical caused characterized COVID-19 COVID-19 pandemic cytokine production Defense dependency develop Disruption driving effective antiviral treatment effective vaccine Effective vaccines effort Essential etiological agent Factor Footprint IFN-I IFN-I response in vitro infected cells inhibitors molecular basis morbidity Mortality new SARS-CoV-2 NF-κB NF-κB signaling P50 p65 product reduced rescued robust SARS-CoV-2 SARS-CoV-2 biology SARS-CoV-2 replication screenings selective single-cell These data transcription factor transcription factors transcriptomic type I interferon variant viral replication virus replication
[DOI] 10.1128/JVI.01257-21 PMC 바로가기 [Article Type] Article