Experimental Evidence of Intrinsic Disorder and Amyloid Formation by the Henipavirus W ProteinsArticle Published on 2022-01-152023-08-30 Journal: International Journal of Molecular Sciences [Category] E형 간염, [키워드] amyloid-like fibrils biocondensates Congo red and Thioflavin T binding assays fibrillation innate immune response evasion intrinsically disordered proteins/regions negative-staining electron microscopy phase separation small-angle X-ray scattering Viral proteins [DOI] 10.3390/ijms23020923 PMC 바로가기 [Article Type] Article
Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2Article Published on 2022-01-112022-10-04 Journal: Nature Communications [Category] SARS, 변종, 유전자 메커니즘, [키워드] ACE2 receptor binding addition amino-acid cell type cell types cleavage site Cryoelectron microscopy deletion variant domain eight Evolution functional furin recognition motif genetic diversity Host Intra-host diversity modulate molecular Molecular modelling pathology provide RNA virus S1/S2 cleavage site SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant subpopulation Support trajectory Transmissibility variant viral cell Viral proteins viral variant virus infectivity wild-type [DOI] 10.1038/s41467-021-27881-6 PMC 바로가기 [Article Type] Article
SCoV2-MD: a database for the dynamics of the SARS-CoV-2 proteome and variant impact predictionsSCoV2-MD: SARS-CoV-2 단백질체의 역학 및 변이체 영향 예측을 위한 데이터베이스Article Published on 2022-01-072022-09-11 Journal: Nucleic Acids Research [Category] SARS, 변종, [키워드] Amino acid amino acid substitution Analysis analyzed antibody attributes binding affinities binding affinity build database dynamic Evolution experiment GISAID group hydrogen hydrogen bonding include Interaction interactions Local Metrics molecular molecular data molecular dynamics Mutation nine pandemic Phylogenetic Point mutation produced Protein protein structure proteome resource SARS-CoV-2 proteome sequenced solvent steric the SARS-CoV-2 trajectory variant variety Viral protein Viral proteins [DOI] 10.1093/nar/gkab977 PMC 바로가기 [Article Type] Article
RNA structure-altering mutations underlying positive selection on Spike protein reveal novel putative signatures to trace crossing host-species barriers in BetacoronavirusArticle Published on 2022-01-012022-11-16 Journal: RNA Biology [Category] 변종, [키워드] analysed Analysis Antiviral bat bat virus bats Betacoronavirus build changes in coding complement conserved cross-species horizontal transmission D614G develop disrupt events Factor function Genome genome-wide analysis Health hosts hotspot Human Impact in viral information investigated jumping the species barrier MERS-CoV Missense mutation molecular molecular evolution Mutation natural selection overlap Positive selection Protein Proteins Research reservoir RNA RNA genome RNA structure RNA structures RNA viruses S protein SARS-CoV SARS-CoV-2 secondary RNA structures selected small RNA spike Surveillance the Betacoronavirus the S protein Therapeutic strategies Transmission viral genome Viral proteins viral RNA genome viral RNA genome. Viral transmission [DOI] 10.1080/15476286.2022.2115750 PMC 바로가기
An entropy-based study on mutational trajectory of SARS-CoV-2 in India인도 SARS-CoV-2 돌연변이 궤적에 대한 엔트로피 기반 연구Article Published on 2022-01-012022-09-11 Journal: Infection, genetics and evolution : journal of mol [Category] SARS, 변종, 유전자 메커니즘, [키워드] analysed approach B.1.617.2 COVID-19 delta variant Entropy event Evolution Hellinger distance India initial Mutation mutation rate Mutation rates non-structural protein non-structural proteins pandemic pandemic of COVID-19 protein sequence protein sequences Proteins reduce SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 protein SARS-CoV-2 virus second wave structural protein structural proteins the SARS-CoV-2 virus trajectory vaccination Viral protein Viral proteins virus [DOI] 10.1016/j.meegid.2021.105154 PMC 바로가기 [Article Type] Article
Interpretable network propagation with application to expanding the repertoire of human proteins that interact with SARS-CoV-2Research Published on 2021-12-292022-10-31 Journal: GigaScience [Category] COVID-19, SARS, [키워드] Algorithms approach arise Community component connection contribute COVID-19 develop drug Endoplasmic reticulum expand functional gene function help highest HSPA5 human protein include Interpretable Machine Learning network network propagation observation parameter Phenotypes predict Protein protein-protein interaction Proteins provenance tracing question reduce resource Result SARS-CoV-2 SARS-CoV-2 proteins second Stress the SARS-CoV-2 viral infection Viral proteins virus-host protein interaction networks viruses [DOI] 10.1093/gigascience/giab082 PMC 바로가기 [Article Type] Research
Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ DamageCOVID-19 환자의 단일 세포 및 벌크 RNaseQ 프로파일 링은 감염에 의한 장기 손상의 면역 및 염증 메커니즘을 나타냅니다.Article Published on 2021-12-022022-09-10 Journal: Viruses [Category] SARS, 유전자 메커니즘, [키워드] accounted Analysis analyzed cardiac hypertrophy correlated COVID-19 COVID-19 infection COVID-19 organ damage COVID-19 patients gene expression Critical Cytokines damage deleterious effect determine downregulated downstream Effect effective Effectiveness eIF2 eukaryotic eukaryotic initiation factor 2 fibrosis Host host protein host proteins hypercytokinemia hypertrophy IL-17A IL-2 IL-6 IL-8 immune and inflammatory mechanisms of COVID-19 imperative induce Inflammation Inflammatory inflammatory genes inhibitors inhibitory initiation factor innate immune response Interaction interleukin investigation lead lung Lungs mechanism Mild moderate multiple organ failure NF-κB organ Organ failure organ injury organs overactive pathway Pathways patients peptide peptides potential therapeutic target potential therapeutic targets pro-inflammatory cytokine pro-inflammatory cytokines Profiling reduced RNAseq SARS-CoV-2 SARS-CoV-2 virus severe and critical patients severely infected patients Severity of infection single and bulk RNASeq cell profiling and analysis single-cell Stimulation suppress suppression therapeutic targets tissues translation Treatment upregulation Viral viral infection Viral protein Viral proteins viral-host protein was increased [DOI] 10.3390/v13122418 PMC 바로가기 [Article Type] Article
Advances in the computational landscape for repurposed drugs against COVID-19COVID-19에 대한 용도가있는 약물에 대한 계산 환경의 발전Review Published on 2021-12-012022-08-31 Journal: Drug discovery today [Category] 신약개발, 치료제, [키워드] accelerate advance analyses caused clinical trials Compound Computational drug Computational drug repurposing COVID-19 COVID-19 pandemic de novo death distress docking Docking and molecular dynamics drug drugs Efficacy effort highlight Host in silico Interaction limitation list machine learning mechanism methodology molecular molecular docking molecular dynamics network analysis pathway predicted produced recent Repository Repurposed drug Research SARS-CoV-2 Structure-guided machine learning Viral protein Viral proteins Virus–host interaction network analysis. [DOI] 10.1016/j.drudis.2021.07.026 PMC 바로가기 [Article Type] Review
IFN-γ + cell response and IFN-γ release concordance after in vitro SARS-CoV-2 stimulation시험관 내 SARS-CoV-2 자극 후 IFN-γ + 세포 반응 및 IFN-γ 방출 일치Article Published on 2021-12-012022-09-11 Journal: European Journal of Clinical Investigation [Category] SARS, 치료법, [키워드] Analysis anti-SARS-CoV-2 anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody case-control study CD4 T-cell CD8 CD8 T-cell Cell cellular Cellular immune response cellular response Concordance convalescent COVID-19 cross-sectional determine ELISA exposed healthcare workers. flow cytometry greater HCW HCWs healthcare healthcare worker Healthcare workers IFN-γ immune in vitro increased risk individual Infection less magnitude proportion protective immunity quantification SARS-CoV-2 SARS-CoV-2-infected patients Stimulation susceptibility Symptoms T cell T cells T-cell Response uninfected Viral protein Viral proteins [DOI] 10.1111/eci.13636 PMC 바로가기 [Article Type] Article
Perspectives on electrochemical biosensing of COVID-19Review article Published on 2021-12-012022-10-05 Journal: Current Opinion in Electrochemistry [Category] 바이오마커, [키워드] acute respiratory syndrome antibodies biosensor clinical setting coronavirus coronavirus disease COVID-19 COVID-19 infection Diagnosis Electrochemistry immune responses Infection novel nucleocapsid point of care point-of-care polymerase chain potential biomarkers Proteins Rapid reactive oxygen species SARS-CoV-2 time-consuming viral infections Viral proteins viral ribonucleic acid [DOI] 10.1016/j.coelec.2021.100794 [Article Type] Review article