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[키워드] 95% CI 95% confidence interval acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody treatment association average bottleneck bottlenecks carried characterized clinical sample clinical samples Coinfection concerning Consensus consensus sequence Contact Contamination coronavirus cycle threshold dataset de novo mutation de novo mutations described detectable determinant Diagram dissemination Diversity dN/dS early infection Effect eight escape mutation events Evidence explained Extensive First wave fixation fixed functional genetic diversity Genetic variation Genome sequencing genomic help helping high viral load hospital Host Households identify Implications indicate individual individuals Infection initiated interquartile iSNV iSNVs isolate Limited genetic diversity MAF MAFs mapped minor allele frequency mixed infection MONITOR MOST Mutation Narrow nonsynonymous nucleotide observation OC43 offer pandemic pandemic virus Patient pattern persistence Phylogenetic tree phylogenetically Phylogeny Population reached replicate researcher respiratory responsible resulting RNA sample RNA samples robust SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 variant SARS-CoV-2 variants Science sequenced Sequencing severe acute respiratory syndrome Coronavirus shown Single nucleotide variant spike spike gene Spike protein spike variants Spread subset synonymous the mean the Spike the spike protein therapeutic threshold Transmissibility Transmission transmission cluster transmission clusters transmitted United Kingdom unlikely Vaccine variant variant frequencies variant frequency variants variants of concern veSEQ Viral viral entry viral evolution viral infectivity Viral load viral loads virus viruses Waves were excluded whole genome
[DOI] 10.1126/science.abg0821 PMC 바로가기 [Article Type] Research Article