SARS-CoV-2 Vaccines: Inactivation by Gamma Irradiation for T and B Cell ImmunityOpinion Published on 2020-11-102022-10-28 Journal: Pathogens [Category] COVID-19, [키워드] accumulating antibodies COVID-19 COVID-19 vaccine Cytotoxic T cell effort Gamma Gamma-ray irradiated vaccine Immunity inactivation irradiation potential benefit preclinical data SARS-CoV-2 T cell T cells tested viral infections [DOI] 10.3390/pathogens9110928 PMC 바로가기 [Article Type] Opinion
The role of senescent T cells in immunopathologyReview Published on 2020-11-092022-10-28 Journal: Aging Cell [Category] Coronavirus, MERS, SARS, [키워드] aging Antigen attribute Autoimmune disease Cell cell type cells cellular cellular senescence contribute COVID‐19 develop Evidence exacerbated example Express expressed functional healthy highlight immune system immunopathology independent Infection infections Inflammation Inflammatory Interaction investigated Ligand natural killer cell NK receptor occur organ organ damage receptor recognize regulated rheumatoid arthritis secrete senescence senescent senescent cell specificity Stress T cell T cells TCR tissue tissue damage tissues while [DOI] 10.1111/acel.13272 PMC 바로가기 [Article Type] Review
CD4 and CD8 Lymphocyte Counts as Surrogate Early Markers for Progression in SARS-CoV-2 Pneumonia: A Prospective StudyCD4 및 CD8 림프구는 SARS-CoV-2 폐렴의 진행을 위한 대리 조기 마커로 계산: 전향적 연구Article Published on 2020-11-092022-09-10 Journal: Viruses [Category] SARS, 바이오마커, [키워드] Admission appear Area association AUC best bilateral pneumonia CD3+CD4+ CD3+CD8+ CD4 CD4+ CD4+ T cells CD8 Complete count COVID-19 criteria Critical Curve decrease demographics disease dysregulation evaluate Evolution Factor Follow-up high correlation Hospital admission hospital discharge involved IQR Laboratory tests Linear regression model linear regression models lymphocyte Lymphocyte subset Lymphocyte subsets Lymphocytes median medical history parameter pathophysiology Patient patients with SARS-CoV-2 Pneumonia Predictive Predictive value predictive values Prospective prospective cohort study receiver receiver operating characteristic recruited ROC ROC Curve ROC curves SARS-CoV-2 SARS-COV-2 infection severe disease severity subset suggested surrogate T cell T cells Treatment were recorded were used [DOI] 10.3390/v12111277 PMC 바로가기 [Article Type] Article
Expanded circulating follicular dendritic cells facilitate immune responses in chronic HBV infectionResearch Published on 2020-11-072023-06-03 Journal: Journal of Translational Medicine [Category] B형 간염, Fulltext, [키워드] B cells follicular dendritic cells Hepatitis B virus T cells [DOI] 10.1186/s12967-020-02584-6 PMC 바로가기 [Article Type] Research
Peripheral CD4 + T cell subsets and antibody response in COVID-19 convalescent individualsClinical Trial Published on 2020-11-032023-06-14 Journal: The Journal of Clinical Investigation [Category] MERS, SARS, [키워드] Adaptive immunity COVID-19 immunoglobulins immunology T cells [DOI] 10.1172/JCI141054 PMC 바로가기 [Article Type] Clinical Trial
Dynamics of NK, CD8 and Tfh cell mediated the production of cytokines and antiviral antibodies in Chinese patients with moderate COVID‐19NK, CD8 및 Tfh 세포의 역학은 중등도 COVID-19 환자에서 사이토카인 및 항바이러스 항체 생성을 매개합니다Original Article Published on 2020-11-032022-09-12 Journal: Journal of Cellular and Molecular Medicine [Category] MERS, SARS, 진단, [키워드] abnormal increase acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 analysed antibody antiviral antibody B‐cell benefit caused CD226 CD4 CD8 Cell cell count cellular change Chinese patient contribute control patient control patients convalescent convalescent patient coronavirus coronavirus disease Coronavirus disease 2019 COVID‐19 COVID‐19 cytokine cytokine level cytokine levels Cytokines decrease demonstrated Dynamics effector effector memory electrochemiluminescence immunoassay enrolled expression flow cytometry iCoS immune responses increase in Inflammatory cytokine Inflammatory cytokines inhibitory innate immune response lymphocyte maintenance memory moderate NK NK cell NK cells Patient patients with moderate peripheral lymphocyte Pneumonia Prevent recent respiratory RT‐PCR SARS‐CoV‐2 SARS‐CoV‐2‐specific antibodies SARS‐CoV‐2‐specific antibody severe acute respiratory syndrome Coronavirus Severe case severe cases significantly higher significantly increased subset T cell T cells T‐cell Tfh TIM‐3 [DOI] 10.1111/jcmm.16044 PMC 바로가기 [Article Type] Original Article
The effects of allium sativum on immunity within the scope of COVID-19 infection코로나19 감염 범위 내에서 부추속이 면역력에 미치는 영향Article Published on 2020-11-012022-09-11 Journal: Medical Hypotheses [Category] SARS, 치료기술, [키워드] abnormality activated active against Acute respiratory infection adipose Adipose tissue Allium allium sativum antiinflammatory antimicrobial antiviral efficiency appear Appetite Asymptomatic disease boost characteristic Compound Concentration coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 infection Cytokines decrease Decreased demonstrated dry cough dysfunction Dyspnea Effect expression fatigue Features functional functional food Garlic Gustatory helper helper T cells immune system immune system cell immune system cells Immune system dysfunction Immunity immunological immunomodulatory infected with SARS-CoV-2 Infection Leptin loss of appetite macrophages manifestation Manifestations Monocytes monocytes/macrophage monocytes/macrophages myalgia natural Natural killer cells olfactory parameters patients with COVID-19 prevalent preventive measure proinflammatory Proinflammatory cytokine proinflammatory cytokines Protein protein kinase protozoan parasites receptor regulatory T cells repress SARS-CoV-2 virus secretion severity suggested suppressed Symptom Symptoms T cells T lymphocytes tissue virus [DOI] 10.1016/j.mehy.2020.109934 PMC 바로가기 [Article Type] Article
Distribution of ACE2, CD147, CD26, and other SARS-CoV-2 associated molecules in tissues and immune cells in health and in asthma, COPD, obesity, hypertension, and COVID-19 risk factors건강 및 천식, COPD, 비만, 고혈압 및 COVID-19 위험 요소의 조직 및 면역 세포에서 ACE2, CD147, CD26 및 기타 SARS-CoV-2 관련 분자의 분포Article Published on 2020-11-012022-08-31 Journal: Allergy [Category] SARS, 바이오마커, 유전자 메커니즘, 치료제, [키워드] ACE2 Adults age Altered analyzed Asthma atopic dermatitis B cells BAL Blood BMI bronchial epithelial cells Bronchoalveolar lavage fluid BSG caused CD147 CD26 CD4 CD8 clinical presentation co-expression coexpressed Comorbidity contribute COPD correlated COVID-19 COVID-19 children database DCs disease disease status DPP4 epithelial epithelial cells expression expression profile Factor Gender Gene Expression Health healthy children healthy subject healthy subjects human cell human cells hypertension Immune cell immune cells Infection involved lung male material molecular Monocytes mononuclear cell mononuclear cells morbidity Mortality Neutrophils NK cells Novel coronavirus novel coronavirus SARS-CoV-2 obesity Patient PBMC PBMCs performed Peripheral blood Peripheral blood mononuclear cells plasmablasts PPIA PPIB primary human bronchial epithelial cells primary human cell primary human cells receptor reported risk factor Risk factors RNA sequencing SARS receptor SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 receptor SARS-CoV-2 receptors severity skin skin biopsies smoking T cell T cells the disease the SARS-CoV-2 tissue tissues TMPRSS2 were expressed Whole blood [DOI] 10.1111/all.14429 PMC 바로가기 [Article Type] Article
Inflammasome activation and pyroptosis in lymphopenic liver patients with COVID-19Comment Published on 2020-11-012023-06-19 Journal: Journal of hepatology [Category] Fulltext, SARS, [키워드] caspase-1 chronic liver disease Comorbidities COVID-19 Inflammasome Liver cirrhosis Liver transplantation lymphopenia pyroptosis T cells [DOI] 10.1016/j.jhep.2020.06.034 PMC 바로가기 [Article Type] Comment
COVID-19 in a multiple sclerosis (MS) patient treated with alemtuzumab: Insight to the immune response after COVID알렘투주맙으로 치료받은 다발성 경화증(MS) 환자의 COVID-19: COVID 이후의 면역 반응에 대한 통찰력Case Reports Published on 2020-11-012022-09-12 Journal: Multiple sclerosis and related disorders [Category] MERS, SARS, 진단, [키워드] Activation acute respiratory syndrome Alemtuzumab Antigen antiviral response CD52 clinical evidence Comorbidity Complete coronavirus Coronavirus 2019 COVID COVID-19 deplete develop disease Hospitalization Hypothesis IgG immune response Immunity immunosuppressant agent immunosuppressed patient insight lymphocyte Mild monoclonal antibody monocyte Multiple multiple sclerosis Patient patient symptom Potential treatment Reinfection remittent risk SARS-CoV-2 Spread T cell T cell depletion T cells tested the disease Thompson treated [DOI] 10.1016/j.msard.2020.102447 PMC 바로가기 [Article Type] Case Reports