T cells – Page 84 – Communicable Diseases Research

High levels of SARS-CoV-2–specific T cells with restricted functionality in severe courses of COVID-19

Clinical Medicine

Published on 2020-10-152022-10-30
Journal: JCI Insight [Category] COVID-19, MERS, SARS,

Elevated Exhaustion Levels of NK and CD8 + T Cells as Indicators for Progression and Prognosis of COVID-19 Disease

COVID-19 질병의 진행 및 예후 지표로서의 NK 및 CD8 + T 세포의 고갈 수준 증가

Immunology

Published on 2020-10-142022-09-11
Journal: Frontiers in Immunology [Category] MERS, SARS, 치료기술,

[키워드] (PD-1) acute respiratory syndrome coronavirus analyzed association Blood CD16 CD244 CD3 CD4 CD56 CD8 Cell cell population Characteristics circulating Clinical data collected contribute coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 Coronavirus disease 2019 (COVID-19) COVID-19 COVID-19 patient Critical Critical illness cytokine Cytokines demographic disease disease severity dysregulation effector molecule elevated eliminating enrolled evaluated Exhaustion expression flow cytometry functional IL-10 IL-6 immune dysregulation immune system IMPROVE Indicator infected cells Level Logistic regression logistic regression model lymphocyte Lymphocyte subset Lymphocyte subsets natural killer natural killer (NK) cells NK cell NK cells NKT cell NKT cells Pathogenesis Patient patients with COVID-19 PD-1 percentage percentages perforin phenotypic predict Prognosis progression public health reduced Regulatory respiratory Result risk factor Risk factors SARS-CoV-2 screened serum Serum IL-6 Serum level serum levels severe acute respiratory syndrome coronavirus 2 Severe case severe cases severe COVID-19 patients severe patients severe symptoms severity of COVID-19 significantly significantly increased subset T cell T cells TNF-α Union Hospital virus Wuhan
[DOI] 10.3389/fimmu.2020.580237 PMC 바로가기 [Article Type] Immunology

Immunopathogenesis of SARS-CoV-2-induced pneumonia: lessons from influenza virus infection

Review

Published on 2020-10-122022-10-30
Journal: Inflammation and Regeneration [Category] COVID-19,

[키워드] Activation acute respiratory syndrome alveolar alveolar epithelial cell Asymptomatic Asymptomatic individuals cause CCL2 CD4 CD8 characteristic chemokines Coronavirus-2 Critical Cytokines Diffuse alveolar damage disease severity effector molecule Endothelial cell Factor foci Host IL-1β induce infect Infection inflammatory monocyte Influenza virus Injury interstitial inflammation involved life-threatening Ligand lung Macrophage memory Mild Necrosis neutrophil infiltration nitric oxide Pathogenesis pathology Pneumonia Prevent progression pulmonary lesion SARS-CoV-2 Signaling spread to systemic symptom T cell T cells T-cell Response T-cell responses tissue injury type I interferon upper respiratory tract vicious cycle viral spread virus clearance
[DOI] 10.1186/s41232-020-00148-1 PMC 바로가기 [Article Type] Review

Descriptive, Retrospective Study of the Clinical Characteristics of Asymptomatic COVID-19 Patients

Research Article

Published on 2020-10-072022-10-30
Journal: mSphere [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome Alpha antibody Asymptomatic Asymptomatic COVID-19 Asymptomatic disease asymptomatic individual asymptomatic patient asymptomatic patients B cell B cells Biochemistry Blood Cellular immune response clinical Clinical characteristics clinical symptom collected complete blood count coronavirus coronavirus disease COVID-19 COVID-19 patients Diagnosis disease elevated epidemicity evaluated examined Face mask faster flow cytometry greater IFN-γ IgG and IgM IL-10 IL-2 IL-4 IL-6 immune response indicated infection control interferon interleukin 2 liver Liver damage liver enzyme Liver function Lymphocytes Necrosis NK cell NK cells outbreak outcome pandemic Patient performed Person phenotype Prevent proceed Protein public health Public health intervention Public health interventions qRT-PCR Quantitative resulting reverse transcription-PCR risk risk factor SARS-CoV-2 serum significantly significantly lower social distancing Spread symptomatic Symptomatic patients T cell T cells throat swab TNF-α Transmission Treatment viral clearance Viral load viral shedding viral titer virus virus transmission were measured while Wuhan, China
[DOI] 10.1128/mSphere.00922-20 PMC 바로가기 [Article Type] Research Article

Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

Research Article

Published on 2020-10-072022-10-29
Journal: Science Translational Medicine [Category] COVID-19, MERS, SARS,

[키워드] acute respiratory syndrome adaptive immune responses Adults age Anti-spike Antibody titer Antibody-dependent cellular phagocytosis antiviral immune response caused CD25 CD4 Cellular immune response children circulating clinical manifestation clinical outcomes Concentration concentrations coronavirus coronavirus disease correlated COVID-19 cytokine described difference disease evidenced Factor Frequency generate hospital Hospitalization Hospitalized human coronaviruses humoral identify IFN-γ IL-17A IL-6 immune response increased expression Inflammatory interferon-γ interleukin-17A lower mortality mechanical ventilation mechanisms modulate Mortality mounted Necrosis Neutralizing antibody titer New York City no difference outcome Patient patients with COVID-19 pediatric Pediatric patient people with COVID-19 Pierce Protein response robust SARS-CoV-2 SARS-COV-2 infection serum Serum neutralizing antibody syndrome T cell T cell response T cells TNF-α viral spike protein with COVID-19 younger patients
[DOI] 10.1126/scitranslmed.abd5487 PMC 바로가기 [Article Type] Research Article

Immunesenescence: A Predisposing Risk Factor for the Development of COVID-19?

Immunology

Published on 2020-10-062022-11-01
Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS,

[키워드] accelerated activated acute respiratory syndrome advanced age aging Bearing characterized co-morbidity coronavirus Coronavirus disease 2019 COVID-19 COVID-19 treatment demographic group described development dysregulated effective exacerbate Factor feature females functional Gender group high risk highlight immune dysfunction Immune profile immune response immune system Immunesenescence inflammaging Inflammatory less Lymphocytes male Monocytes obese obesity occur Older pathogen patients phenotypic Premature question response risk factor SARS-Cov_2 SARS-CoV-2 senescent severe COVID-19 subject susceptibility T cells T2D therapeutic options Treatment type 2 diabete
[DOI] 10.3389/fimmu.2020.573662 PMC 바로가기 [Article Type] Immunology

Increased CD95 (Fas) and PD-1 expression in peripheral blood T lymphocytes in COVID-19 patients

COVID-19 환자의 말초혈액 T 림프구에서 CD95(Fas) 및 PD-1 발현 증가

Article

Published on 2020-10-012022-08-31
Journal: British Journal of Haematology [Category] MERS, SARS, 바이오마커,

Peripheral lymphocyte subset alterations in COVID-19 patients

COVID-19 환자의 말초 림프구 하위 집합 변경

Article

Published on 2020-10-012022-09-11
Journal: International journal of laboratory hematology [Category] 바이오마커,

[키워드] Abstract alteration COVID-19 COVID-19 patient Flow flow cytometry lymphocyte peripheral subset T cells Virology
[DOI] 10.1111/ijlh.13276 PMC 바로가기 [Article Type] Article

Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study

심각한 치명적인 COVID-19를 가진 영국 환자의 조직병리학적 발견 및 바이러스 친화성: 사후 연구

Article

Published on 2020-10-012022-09-11
Journal: The Lancet. Microbe [Category] SARS, 치료기술,

[키워드] Activation active viral replication acute pancreatitis acute respiratory syndrome alveolar damage aortic dissection Autopsies Autopsy Biological Biotechnology Brain Case series cause of death Clinical course Clinical data clinically Cohort Comprehensive coronavirus Council COVID-19 death description Diagnosis died diffuse Diffuse alveolar damage disseminated mucormycosis dominant eight eligible Endocarditis Evidence evidence of examined feature FIVE Genome heart high mortality rate histopathological finding histopathological findings Immune cell Immunohistochemical analysis Infarction Infection Injury IQR kidney lung lymphocyte Major major organs marantic endocarditis median age microglial Mucormycosis nine Older organ Pancreatitis Pathologists Patient patients Pericarditis Post-mortem provided Quantitative reported respiratory respiratory tract RT-PCR analysis sampling Science severe acute respiratory syndrome Coronavirus severe COVID-19 subset Support T cells thrombosis thrombotic tissue sample tissue samples transcript Viral viral genomes Viral RNA viral tropism was done Wellcome Trust
[DOI] 10.1016/S2666-5247(20)30115-4 PMC 바로가기 [Article Type] Article

Suboptimal SARS-CoV-2−specific CD8 + T cell response associated with the prominent HLA-A*02:01 phenotype

530

Published on 2020-09-292022-10-29
Journal: Proceedings of the National Academy of Sciences of [Category] COVID-19, SARS,

[키워드] Activation acute respiratory syndrome CD38 CD4 CD8 CD8+ T cells Cell Cell-mediated immunity central memory circulating classical Clinical severity comparable convalescent convalescent COVID-19 patient coronavirus COVID-19 COVID-19 convalescent patient COVID-19 patients diminishe Donor effector memory ENhance Epstein–Barr virus Ex vivo example experience expressed Frequency HLA type HLA-A*02:01 HLA-DR Immunity in vitro indicated Infection Influenza investigated majority memory mononuclear cell naïve overlapping patients peptide Peripheral blood phenotype Phenotypes Phenotyping Population populations Prevalence priming promote recall Reinfection robust SARS-CoV-2 SARS-CoV-2 epitopes SARS-COV-2 infection Significance Stimulating T cell T cell activation T cell epitopes T cell memory T cells therapeutic uninfected Vaccine
[DOI] 10.1073/pnas.2015486117 PMC 바로가기 [Article Type] 530