Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 PatientsPerspective Published on 2020-06-072022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] acute respiratory distress caused clinical clinical setting clinical testing clinical trial coronavirus COVID-19 Cytokine storm drug candidate effective evaluate expected function global pandemic global public health Host IL-6 immune Infection Inflammatory cytokine inhibitor interferon Jak limit lymphopenia mechanism monoclonal antibody novel coronavirus SARS-CoV-2 Open-label Patient predicted provide Randomized reduce Remdesivir replication/transcription machinery responses RNA-dependent RNA polymerase senescence severe COVID-19 Signaling silibinin Spain STAT3 storm syndrome T-cell targeting the cytokine storm therapeutic efficacy Viral load virus replication [DOI] 10.3390/jcm9061770 PMC 바로가기 [Article Type] Perspective
Considerations for an Individual-Level Population Notification System for Pandemic Response: A Review and PrototypeViewpoint Published on 2020-06-052022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, [키워드] acute respiratory syndrome added advance benefit caused cellular China Community complementary Consequences coronavirus coronavirus disease country COVID-19 COVID-19 pandemic effective Epidemic Epidemics Extensive Government Health hygiene implementation Implementing include intensity Local lockdown measure media Mobile technology moderate New notification Notification system organized outbreak pandemic penetration physical distancing Population prototype public health authority real time required responses review severity Spread Surveillance System this system threat transmitted United Kingdom [DOI] 10.2196/19930 PMC 바로가기 [Article Type] Viewpoint
The Prediction of miRNAs in SARS-CoV-2 Genomes: hsa-miR Databases Identify 7 Key miRs Linked to Host Responses and Virus Pathogenicity-Related KEGG Pathways Significant for ComorbiditiesArticle Published on 2020-06-042022-10-28 Journal: Viruses [Category] COVID-19, SARS, [키워드] “cytokine storm” 229E acute respiratory syndrome alteration Betacoronavirus cause cell signalling pathways Comorbidities Consequences coronavirus Coronavirus-2 COVID-19 COVID-19 disease Critical database decrease effective exacerbated FIVE geographical region greater highest highlight host responses Human identify increased mortality Inflammatory response KEGG KEGG pathway KEGG pathway analysis Lung pathology mechanism MERS microRNAs (miRs 8066, 5197, 3611, 3934-3p, 1307-3p, 3691-3p, 1468-5p) miRNA Mutation number of comorbidities OC43 Pandemics pathogenicity pathway Phylogenetic relationship physiological effect prediction reduced reported response responses resulting SARS-CoV-2 SARS-CoV-2 sequence SARS–CoV-2 selected sequence sequence motif Seven Significant significant pathways similarity Symptom the SARS-CoV-2 Therapeutic approach transcriptional transcriptomic alteration viral pathogenesis viral pathogenicity virus viruses whole-genome [DOI] 10.3390/v12060614 PMC 바로가기 [Article Type] Article
Using Reports of Symptoms and Diagnoses on Social Media to Predict COVID-19 Case Counts in Mainland China: Observational Infoveillance StudyOriginal Paper Published on 2020-05-282022-10-30 Journal: Journal of Medical Internet Research [Category] COVID-19, MERS, SARS, [키워드] activities addition affected agency analyzed approach Care China Classifier count country COVID-19 COVID-19 case diagnose diagnosis of COVID-19 disease Disease surveillance distribution Effectiveness Health identify IMPROVE infect Infection Infectious disease infodemiology information infoveillance initial knowledge machine learning approach mainland media Novel coronavirus objective outbreak outcome Patient predict predicted Predictive Predictive model predictive power Public public health system report reported resource responses Result retrieved SARS-CoV-2 sick significantly social media subset Surveillance Symptom Weibo [DOI] 10.2196/19421 PMC 바로가기 [Article Type] Original Paper
Humoral Immune Responses in COVID-19 Patients: A Window on the State of the ArtImmunology Published on 2020-05-152022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, [키워드] antibodies antibody-based therapy antiviral therapy asymptomatic subject contributing to COVID-19 COVID-19 patients Cytokine storm death develop diagnostic disease Government humoral immune response Infection management mechanism Mild pandemic Patient Prevent response responses SARS-CoV-2 SARS-CoV-2 RT-PCR Serological tests severe symptoms Specific Spread state subject subset Symptom symptomatic the antibody response the cytokine storm the disease therapeutic Treatment triggered undetectable Vaccine Vaccine design variety Viral load viral spread Viral transmission virus window with COVID-19 [DOI] 10.3389/fimmu.2020.01049 PMC 바로가기 [Article Type] Immunology
Epidemiological Aspects and Psychological Reactions to COVID-19 of Dental Practitioners in the Northern Italy Districts of Modena and Reggio EmiliaArticle Published on 2020-05-152022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, MERS, SARS, [키워드] accompanied affected Anxiety anxiety symptoms aspect association caused clinical activity Clinical practice composed consequence COVID-19 COVID-19 case COVID-19 emergency COVID-19 pandemic dental dental practice dental practitioner dentist diffusion District emotional Epidemiology equipment Europe GAD-7 Generalized health system help highest highlighting Infection introduced Italian Italy likelihood Local majority measure Modena National outbreak pandemic Patient patients PPE Practitioner practitioners Protective psychological Impact question reaction reduced reduction Registered reported respiratory responses SARS-CoV-2 severity survey [DOI] 10.3390/ijerph17103459 PMC 바로가기 [Article Type] Article
Prioritizing vulnerable populations and women on the frontlines: COVID-19 in humanitarian contextsCommentary Published on 2020-05-132022-10-29 Journal: International journal for equity in health [Category] Coronavirus, MERS, SARS, [키워드] Community COVID-19 COVID-19 outbreak death dependent on Displaced populations Effect elevated Ensuring Essential workers Gender Gender bias global pandemic greater Health Humanitarian contexts Humanitarian organizations imperative Infection information measure Personal protective equipment Population populations reducing reported responses risk women [DOI] 10.1186/s12939-020-01186-4 PMC 바로가기 [Article Type] Commentary
Highlight of Immune Pathogenic Response and Hematopathologic Effect in SARS-CoV, MERS-CoV, and SARS-Cov-2 InfectionImmunology Published on 2020-05-122022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, MERS, SARS, [키워드] acute respiratory distress addition ARDS Care caused clinical trial combined treatment Complication complications coronavirus Coronavirus infection COVID-19 Cytokine storm direct infection Effect global healthcare global pandemic Guidance hematopathologic effect Host immune response immune Immune cell immune response immune responses immune therapy infection mechanism infection-induced lymphopenia Invasion killing mechanism medication MERS-CoV molecular mechanism Novel coronavirus outbreak Patient Potential treatment Prevent Prophylactic pulmonary fibrosis reduce Replication required response responses resulting risk SARS-CoV SARS-CoV-2 SARS-CoV-2 infected patient Severe case severe respiratory syndrome Spread syndrome the disease Therapeutic approach therapeutic approaches therapy Vaccine Vaccine development Wuhan, China [DOI] 10.3389/fimmu.2020.01022 PMC 바로가기 [Article Type] Immunology
Different longitudinal patterns of nucleic acid and serology testing results based on disease severity of COVID-19 patientsLetter Published on 2020-05-022022-10-31 Journal: Emerging Microbes & Infections [Category] COVID-19, MERS, SARS, [키워드] 2019 novel coronavirus acute respiratory syndrome antibody Antibody Response Antibody responses assist Asymptomatic carrier Asymptomatic carriers Clinical diagnosis Clinical symptoms collected complementary conducted Consensus coronavirus COVID-19 COVID-19 patient COVID-19 patients disease severity follow-up period groups Hospitalization Humoral response individual infected with SARS-CoV-2 information Jiangsu longitudinal pattern mitigate non-severe cases nucleic acid nucleic acid test observation period pandemic Prognosis reported responses SARS-CoV-2 sera Seroconversion seroconverted Serological testing serology testing severe cases severe COVID-19 patient swab sample symptomatic Vaccine design Viral antigen viral nucleic acid viral replication Viral RNA virus [DOI] 10.1080/22221751.2020.1756699 PMC 바로가기 [Article Type] Letter
Psychological and Behavioral Responses in South Korea During the Early Stages of Coronavirus Disease 2019 (COVID-19)Article Published on 2020-04-252022-10-29 Journal: International Journal of Environmental Research an [Category] COVID-19, SARS, [키워드] Analysis average center collected consequence Control coronavirus Coronavirus disease 2019 COVID-19 COVID-19 pandemic Diseases early stage Efficacy efficacy belief events facial hygiene Infection investigated majority pandemic Pandemics participant Perceived risk Precautionary behaviors precautions prevention Psychological public health public health emergency public health emergency preparedness reducing reported Resilience response responses severity significantly South South Korea Stage subject [DOI] 10.3390/ijerph17092977 PMC 바로가기 [Article Type] Article