immune responses – Page 87 – Communicable Diseases Research

Mucosal immune responses in COVID19 – a living review

Short Communication

Published on 2021-01-252022-10-29
Journal: Oxford Open Immunology [Category] COVID-19,

A Missing Link: Engagements of Dendritic Cells in the Pathogenesis of SARS-CoV-2 Infections

Review

Published on 2021-01-232022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19, MERS,

IgA dominates the early neutralizing antibody response to SARS-CoV-2

IgA는 SARS-CoV-2에 대한 초기 중화 항체 반응을 지배합니다

Comparative Study

Published on 2021-01-202022-09-10
Journal: Science Translational Medicine [Category] MERS, SARS, 바이오마커, 진단, 치료기술, 치료제,

[키워드] antibody Antibody Response antibody-secreting cell antibody-secreting cells bronchoalveolar Bronchoalveolar lavage fluid Characteristics characterized composed Concentration contributed COVID-19 disease COVID-19 disease severity Critical detectable expansion followed by Frequency greater highlight homing humoral immune response humoral immune responses Humoral response IgA IgA antibodies IgA antibody IgA response IgE IgG IgG and IgM IgM IgM antibody immune memory immune response immune responses include individual Infection information mucosal neutralize Neutralizing Neutralizing antibodies neutralizing antibody Neutralizing antibody response observation onset of symptom onset of symptoms patients with COVID-19 peaked peripheral plasmablast regimen Reinfection remained response Saliva SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2–infected patient SARS-CoV-2–infected patients SARS-CoV-2–specific antibody secondary antibody serum short-lived Specific symptom onset the disease Vaccine virus Virus neutralization
[DOI] 10.1126/scitranslmed.abd2223 PMC 바로가기 [Article Type] Comparative Study

Immunological perspectives on the pathogenesis, diagnosis, prevention and treatment of COVID-19

Review

Published on 2021-01-202022-10-30
Journal: Molecular Biomedicine [Category] COVID-19,

[키워드] acute respiratory disease acute respiratory syndrome anti-viral agent Antibody Response approach caused coronavirus Coronavirus disease 2019 COVID-19 COVID-19 patients CRS Cytokine release syndrome develop Diagnosis dysregulated effective exacerbated help identify immune response immune responses Immunity immunological characteristics Immunotherapy IMPROVE lymphocyte lymphopenia management modulating multiple organ failure Pathogenesis Perspective Prognosis SARS-COV-2 infection severe COVID-19 patient spread to Treatment treatment strategy triggered understanding Vaccine viral infection virus worldwide pandemic
[DOI] 10.1186/s43556-020-00015-y PMC 바로가기 [Article Type] Review

The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery

GRL0617과 SARS-CoV-2 PLpro의 복잡한 구조는 항바이러스 약물 발견을 위한 핫스팟을 보여줍니다

Article

Published on 2021-01-202022-09-10
Journal: Nature Communications [Category] 변종, 신약개발, 진단, 치료제,

[키워드] Analysis Antiviral antiviral drug antiviral immune responses approved drug approved drugs assays binding binding energy binding pocket block C-terminus complex Compound contribute COVID-19 pandemic crystal structure cysteine cysteine protease domain dominant Drug discovery drug target dysregulation effective examined function Host hot spot identify immune responses implicated in vitro indicate Inflammation inhibit inhibitor inhibitors ISG15 library maturation mechanism mechanism of action mutants Nanocrystallography NMR Papain-like protease pathogen PLPro PPI Protein–protein interaction responsible reveal SARS-CoV-2 screened Structural analysis structural biology viral infection virus
[DOI] 10.1038/s41467-020-20718-8 PMC 바로가기 [Article Type] Article

In silico dynamics of COVID-19 phenotypes for optimizing clinical management

임상 관리 최적화를 위한 COVID-19 표현형의 인 실리코 역학

Biological Sciences

Published on 2021-01-192022-09-10
Journal: Proceedings of the National Academy of Sciences of [Category] 유전자 메커니즘,

[키워드] ACE2 activated acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Adaptive immune response adaptive immune responses age Antiviral baseline best CD8 cellular entry Clinical data clinical heterogeneity Clinical management Clinical outcome clinical outcomes Coagulation coagulation cascade Combination Comorbidities Comorbidity coronavirus COVID-19 COVID-19 patients COVID-19 phenotype COVID-19 progression Cytokines diabetes Disease progression distinctive feature dysregulated immune response element elements Evolution extreme Factors framework Health status healthy heterogeneity hypertension identify immune immune cells immune responses Infection Inflammatory cytokines innate immune response life life threatening management mathematical mathematical model mechanism Model modulating obesity Older Older age outcome oxygen oxygen saturation Patient pharmaceutical intervention predict presence of comorbidities protocols provide Renin response rate reveal risk factor SARS-CoV-2 SARS-CoV-2 pathogenesis severe acute respiratory syndrome Coronavirus Significance Simulation sustained symptomatic T cell T cells the disease the patient therapeutic Therapies thrombosis Thrombus thrombus formation Trajectories Treatment Treatment response understanding Viral viral dynamics Viral load viral replication virus were used
[DOI] 10.1073/pnas.2021642118 PMC 바로가기 [Article Type] Biological Sciences

Sex bias of females in survival from cancer and infections. Is X the answer?

Comment

Published on 2021-01-192022-10-28
Journal: British Journal of Cancer [Category] Coronavirus, MERS, SARS,

Structure, Activation and Regulation of NLRP3 and AIM2 Inflammasomes

Review

Published on 2021-01-162022-10-29
Journal: International Journal of Molecular Sciences [Category] COVID-19,

Tissue-Specific Immunopathology in Fatal COVID-19

치명적인 COVID-19의 조직 특이적 면역병리학

Original Articles

Published on 2021-01-152022-09-10
Journal: American Journal of Respiratory and Critical Care [Category] 치료기술, 치료제,

[키워드] aberrant immune response aberrant macrophage and plasma-cell responses acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 addition anatomic sites arteritis Autopsy cellular distribution cellular resolution characterized coronavirus coronavirus disease Corticosteroid Corticosteroids COVID-19 death deleterious inflammation determine direct reaction effort evidence of excessive reactive plasmacytosis fatal COVID-19 highlight Histologic evidence immune response immune responses Immune-mediated independent immunopathologic process Inflammation influx iron iron-laden macrophages life-threatening coronavirus disease lung lymphoid tissues Macrophage macrophage/monocyte-lineage cell macrophage/monocyte-lineage cells macrophages mapped measurement monocyte/myeloid-rich vasculitis Multiple Multiple aberrant immune responses multiplex immunofluorescence Multiplex PCR novel immunopathologic mechanism novel immunopathologic mechanisms occur occurred organ dysfunction organ injury organ-specific inflammatory response organ-specific inflammatory responses organotropism pathogen tolerance postmortem examinations primary mechanism promote Protein pulmonary immune response pulmonary parenchyma quantified rationale reduce mortality respiratory response responses reticuloendothelial reticuloendothelial system SARS-CoV-2 SARS-CoV-2 RNA Sequencing severe acute respiratory syndrome Coronavirus severe disease significant component stereotyped abnormal reticuloendothelial responses therapeutically target tissue Tissue-specific immunopathology tissues Vasculitis Viral viral presence viral S virus virus-independent immunopathologic process
[DOI] 10.1164/rccm.202008-3265OC PMC 바로가기 [Article Type] Original Articles

Dynamics of Neutralizing Antibody Titers in the Months After Severe Acute Respiratory Syndrome Coronavirus 2 Infection

중증 급성 호흡기 증후군 코로나 바이러스 2 감염 후 몇 개월 동안 항체 역가 중화의 역학

Major Articles and Brief Reports

Published on 2021-01-152022-09-12
Journal: The Journal of Infectious Diseases [Category] MERS, 진단,

[키워드] accompanied acute respiratory syndrome acute respiratory syndrome coronavirus antibody Antibody dynamics antibody levels Antibody titer Antibody titers Asymptomatic average B cell B cells binding collected coronavirus coronavirus 2 COVID-19 declined determine develop disease domain Dynamics expected fold followed by Frame immune response immune responses Immunity individual Infection initial longitudinal samples Mild moderate-severe Month MOST Neutralizing antibodies neutralizing antibody Neutralizing antibody titer neutralizing antibody titers Other respiratory viruses prospective cohort quantified RBD Receptor-binding domain respiratory respiratory viruses SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 spike Spike protein symptom onset time frames titer total antibodies total antibody Viral viral infection viral spike protein
[DOI] 10.1093/infdis/jiaa618 PMC 바로가기 [Article Type] Major Articles and Brief Reports