A Comparative Analysis of Factors Influencing Two Outbreaks of Middle Eastern Respiratory Syndrome (MERS) in Saudi Arabia and South KoreaReview Published on 2019-12-032022-10-28 Journal: Viruses [Category] Coronavirus, Fulltext, MERS, 조류인플루엔자, [키워드] addition Analysis Comparative coronavirus country death Endemic epidemiological Factor Fatality rate healthcare healthcare worker hospital IMPROVE information knowledge laboratory-confirmed MERS MERS-CoV middle Middle East Middle East Respiratory Syndrome (MERS), zoonosis occurred outbreak Outbreaks outcome Patient Perspective progression PROTECT reservoirs respiratory responses Saudi Arabia South Korea spread to synchronization Transmission viral infection virus World Health Organization [DOI] 10.3390/v11121119 PMC 바로가기 [Article Type] Review
Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trialDNA 또는 NYVAC 벡터(HVTN 096)가 있는 외피 단백질을 포함하는 다가 HIV 백신의 안전성 및 면역원성: 1b상, 이중 맹검, 위약 대조 시험Article Published on 2019-10-072022-09-06 Journal: The Lancet. HIV [Category] Communicable Disease, [키워드] active treatment Administered administration adverse event allergy antibodies antibody Antibody Response Antibody responses antibody-dependent cell-mediated cytotoxicity approach assigned binding binding antibody boost Cell-mediated cytotoxicity Combination component computer-generated Coverage cranial cytotoxicity died DNA dose doses double-blind early administration effective Efficacy enrolled envelope protein epitope finding followed by foundation funding glycoprotein gp120 healthy healthy volunteer healthy volunteers HIV infection HIV vaccine IgG IgG response IgG responses immunogenicity individual Infection Infectious diseases injection Lymphadenopathy marker measure Melinda Gate Melinda Gates motor vehicle Neutralising Antibodies outcome participant Participants Placebo placebo group placebo-controlled placebo-controlled trial Primary outcomes priming product Protein purified random Randomly reactogenicity regimen Registered responses risk Safety screened Serious Adverse Event Serious Adverse Events Switzerland the placebo group the vaccine trauma Treatment treatment group treatment groups Trial trials vaccination vaccination schedule Vaccinations Vaccine vector Volunteer [DOI] 10.1016/S2352-3018(19)30262-0 PMC 바로가기 [Article Type] Article
Mucosal immune responses induced by oral administration recombinant Bacillus subtilis expressing the COE antigen of PEDV in newborn pigletsResearch Articles Published on 2019-02-262022-10-28 Journal: Bioscience Reports [Category] Coronavirus, MERS, [키워드] administration antibody Antigen B. subtilis Bacillus subtilis candidate vaccine cause CD3 CD4 cells COE Contact contagious demonstrated develop disease effective epidemic diarrhea evaluated expressing IgA IgG immune immune response immunization Immunoglobulin immunoglobulin A Infection Local lymphocyte mucosal mucosal immune mucosal immunity Newborn oral administration Oral vaccine PEDV Peyer’s patche Piglets Porcine epidemic diarrhea virus prevented recombinant Bacillus subtilis responses secreting serum SIgA significantly significantly increased Spread systemic immune response T cells up-regulated Vaccine Vaccines virus [DOI] 10.1042/BSR20182028 PMC 바로가기 [Article Type] Research Articles
Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria복잡하지 않은 말라리아와 중증 말라리아 아동의 지연된 치료 요청과 관련된 간병인 반응Research Published on 2018-12-182024-08-11 Journal: Malaria Journal [Category] 말라리아, [키워드] Caregiver Delayed care-seeking malaria responses [DOI] 10.1186/s12936-018-2630-9 PMC 바로가기 [Article Type] Research
Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine스트레스 반응 및 대사 유전자 조절은 낮은 S-아데노실메티오닌에서 변경됩니다.Research Article Published on 2018-11-282022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated activating Acute stress affected alcohol analyzed animal animals assays Bacterial Caenorhabditis elegan Caenorhabditis elegans choline chromatin cystic fibrosis deficiencies deficiency disease Disease progression DNA Donor elegan elegans enzyme Enzymes exacerbate expression fibrosis Gene Expression Gene regulation Genes Genetic group Heat shock heat stress histone Histones in some influence less metabolism metabolite methionine methyl groups Methylation Modification modify nucleic acid organism Organisms pathogen Phosphatidylcholine Phospholipids produced Protective provide Reactions reduced Regulation required respond response responses RNA S-adenosylmethionine SAM Stress stress conditions survival tissue injury Transcription transcriptional response transcriptional responses variety [DOI] 10.1371/journal.pgen.1007812 PMC 바로가기 [Article Type] Research Article
Chimeric camel/human heavy-chain antibodies protect against MERS-CoV infection키메라 낙타/인간 중쇄 항체는 MERS-CoV 감염으로부터 보호합니다Research Article Published on 2018-08-082022-09-14 Journal: Science Advances [Category] 비임상, 진단, [키워드] Affinity maturation antibodies antibody Antibody Response binding blocked Bone marrow caused chimeric complementarity-determining region concentrations develop domain Dromedary epitope event expression heavy chain high affinity Human humans Intervention MERS coronavirus MERS-CoV MERS-CoV infection mice Middle East mild infection nanobodies outbreak Pathogens PROTECT Receptor binding domain recognize repeated respiratory syndrome coronavirus responses selected serum unique viral spike protein virus virus entry virus-neutralizing antibody [DOI] 10.1126/sciadv.aas9667 PMC 바로가기 [Article Type] Research Article
Alpha/Beta Interferon (IFN-α/β) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-γ-Dependent ResponsesCellular Response to Infection Published on 2018-02-282022-10-30 Journal: Journal of Virology [Category] Coronavirus, MERS, [키워드] Ablation adaptive affected Antiviral Astrocyte astrocytes Cell Central nervous system CNS components contribute coronavirus Critical dissemination effective elevated elicit Encephalomyelitis evaluated expression function Gene Expression Glia histocompatibility complex IFN-α IFN-β IFN-α/β IFN-γ IFNAR immune Immunity inducer Infection infiltration initial Innate immunity Interaction interferon interferon-stimulated gene ISG ISGs lack lethal MHC MHV mice microglia Mortality mouse hepatitis virus mRNA mRNA level Neuron neurons pathway pattern recognition receptor promote PROTECT protection Protective PRRs receptor reduced Regulatory response responses robust Signaling Single Cell subsequent Support supported sustained T cell upregulated viral infection viral spread virus virus replication virus spread while [DOI] 10.1128/JVI.01901-17 PMC 바로가기 [Article Type] Cellular Response to Infection
Quaternized chitosan nanoparticles loaded with the combined attenuated live vaccine against Newcastle disease and infectious bronchitis elicit immune response in chicken after intranasal administrationResearch Article Published on 2017-10-132022-10-31 Journal: Drug Delivery [Category] Coronavirus, MERS, [키워드] 1:1 administration Ammonium Antigen antigens Bioactivity bronchitis cellular chloride CMC cytotoxicity disease Diseases drug elicit exhibited humoral IBV IFN-γ IgA antibodies IL-2 IL-4 immune response immunization in vitro indicated induce Infection Infectious bronchitis initial interferon-γ intranasal intranasal delivery intranasally lymphocyte mucosal mucosal immune N-2-hydroxypropyl trimethyl ammonium chloride chitosan nanoparticles Newcastle disease proliferation promoted Release released Respiratory disease responses resulting significantly SOTA stability titers of IgG Vaccine vaccine adjuvant virulent [DOI] 10.1080/10717544.2017.1388450 PMC 바로가기 [Article Type] Research Article
Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in MiceMultiparental Populations Published on 2017-06-052022-10-31 Journal: G3 (Bethesda, Md.) [Category] Coronavirus, [키워드] adaptor affected chromosome collaborative cross contribute coronavirus correlated Critical disease driving early stage exhibiting F2 Factor Genetic Genetic variation hemorrhage highlight Host host susceptibility genes Infection loci locus mice mouse model MPP Multi-parent Advanced Generation Inter-Cross (MAGIC) multiparental populations Pathogenesis phenotype Phenotypes Protein pulmonary hemorrhage Quantitative respiratory responses responsible SARS-CoV SARS-CoV infection Strains susceptibility susceptible Ticam2 TLR signaling pathways Viral load viral titer virus titer weight weight loss [DOI] 10.1534/g3.117.041434 PMC 바로가기 [Article Type] Multiparental Populations
Elucidation of the calcineurin-Crz1 stress response transcriptional network in the human fungal pathogen Cryptococcus neoformans인간 진균 병원체 크립토코커스 네오포르만스에서 칼시뉴린-Crz1 스트레스 반응 전사 네트워크의 해명Research Article Published on 2017-04-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] activated appear ascomycete ascomycetes Aspergillus fumigatus binding calcineurin calcium calmodulin Candida albican Candida albicans cascade Cell cell wall cellular cna1 conserved contribute Control Cryptococcus neoforman Cryptococcus neoformans docking domain down-regulated downstream Evidence expression of gene Factor function functions fungal fungal pathogen fungal pathogens fungi high temperature involved majority motif mRNA mRNA expression mutant mutants nuclear translocation nucleus P-bodies P-body pathogen pathogenic Pathogens pathway phenotype Phenotypes pheromone phosphatase post-transcriptional levels predicted promote promoter promoter region promoter regions Protein regulate regulated regulatory network responses RNA-sequencing Saccharomyces cerevisiae Serine Signal transduction Signaling small molecule Stress stress granule stress granules stress response survival target target gene Target genes targets threonine Transcription transcription factor transcriptional Transport virulence wild-type [DOI] 10.1371/journal.pgen.1006667 PMC 바로가기 [Article Type] Research Article