A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy게놈 전체 관련 연구에서 lncRna가 나병의 병리학적 염증 반응에 대한 위험 인자로 확인됨Research Article Published on 2017-02-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 한센병, [키워드] 95% CI Affect Analysis association Brazil chromosome clinically Combined dataset disease eQTL etiologies evaluated Evidence evidence of example excessive inflammatory response experimental evidence Factor Genetic genetic control genetic factors Genetic variant Genome Genome-wide association study genomic GWAS GWAS meta-analysis Host IBD identify independent Inflammatory bowel disease inflammatory disorders Inflammatory response initial leprosy lncRNA loci locus mechanism nerve nerve damage occur offspring overlap Patient peripheral nerve reaction Reactions replicated Replication responses risk risk factor Risk factors separated SNP SNPs Support susceptibility undergo [DOI] 10.1371/journal.pgen.1006637 PMC 바로가기 [Article Type] Research Article
Early immune responses and development of pathogenesis of avian infectious bronchitis viruses with different virulence profilesResearch Article Published on 2017-02-152022-10-28 Journal: PLoS ONE [Category] Coronavirus, MERS, [키워드] Activation association bronchitis changes CMI downregulation early immune response epithelial cell expression expression profile Genotype IBV immune immune modulatory immune response Increased Infectious Bronchitis Virus Inflammatory isolate kidney lesion local immune response lower expression mechanism Morphological Pathogenesis pathological change pathway pro-inflammatory response profile renal replicate Replication response responses TLR7 tracheal upper respiratory tract Viral load viral replication virulence virus [DOI] 10.1371/journal.pone.0172275 PMC 바로가기 [Article Type] Research Article
Knowledge, Attitudes and Behaviours of Healthcare Workers in the Kingdom of Saudi Arabia to MERS Coronavirus and Other Emerging Infectious DiseasesArticle Published on 2016-12-062022-10-29 Journal: International Journal of Environmental Research an [Category] Coronavirus, MERS, [키워드] Anxiety Asymptomatic Attitude Attitudes Behaviours coronavirus described Descriptive statistics Diseases Emerging infectious diseases HCW HCWs health care workers healthcare worker Infection infection control Infectious disease information investigated Isolation Kingdom knowledge Measures MERS MERS coronavirus MERS-CoV Middle East Ministry of Health Nurse objective Other outbreak patients Personal protective equipment Physicians Practice psychological problem questionnaire reported respiratory responses Result risk Saudi Arabia was used worker [DOI] 10.3390/ijerph13121214 PMC 바로가기 [Article Type] Article
Comparative Proteome Analysis of Porcine Jejunum Tissues in Response to a Virulent Strain of Porcine Epidemic Diarrhea Virus and Its Attenuated StrainArticle Published on 2016-11-292022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Analysis Attenuated carried change Comparative diarrhea epidemic diarrhea eukaryotic expressed groups Heat shock heterogeneous immune system Infection inoculated Interaction interferon-stimulated gene involved ISGs iTRAQ Jejunum labeling Laboratory mechanism Mortality nuclear organ Pathogenesis pathogenicity PEDV Porcine epidemic diarrhea virus predominant produced Protein proteomic quantitation quantitative proteome analysis response responses responsible ribonucleoprotein Signal transduction strain Strains Stress tissue up-regulated virulent virus [DOI] 10.3390/v8120323 PMC 바로가기 [Article Type] Article
Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity비복제 Toxoplasma gondii Uracil Auxotrophs에 의한 Rhoptry 및 Dense Granule Effector 단백질의 분비는 항종양 면역의 발달을 제어합니다Research Article Published on 2016-07-222022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] abrogated activate activated acute infection Auxotroph auxotrophic mutants axis CD4 CD8 Cell Nucleus Cell signaling cellular signaling pathway cellular signaling pathways conjunction Control deleted Deletion dendritic cells Dense development effective effective therapy effector effector molecule effector molecules effector protein effector proteins function Granule GTPase GTPases Host host cell host cell nucleus host cell response Host immune response host immune responses host innate immunity host response host responses identify IFN-γ immune responses Immune suppression Immunity independent Infection interferon Invasion latent infection mammalian cell mechanism membrane mice mutant not affect nucleus ovarian cancer parasite pathway Pathways Protein required responses rhoptry Safe secreted secretion shown Signaling solid tumor solid tumors survival T cell T cells target therapeutic These data Toxoplasma gondii transcriptional Trigger Tumor tumor microenvironment tumors type I uracil vaccination vaccine strain virulence [DOI] 10.1371/journal.pgen.1006189 PMC 바로가기 [Article Type] Research Article
Regulation of Stress Responses and Translational Control by CoronavirusReview Published on 2016-07-042022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] association cellular stress response Control coronavirus Coronavirus infection Coronavirus replication eIF2α Endoplasmic reticulum ER stress GADD34/PP1 host cells in viral JNK mechanism modulate nsp1 overcome p38 Pathogenesis Pathways PERK PKR Protein protein synthesis protein translation reduce response responses Stress translational translational control Trigger turn unfolded protein response Viral protein viruses [DOI] 10.3390/v8070184 PMC 바로가기 [Article Type] Review
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure심부전의 사망률과 관련된 염색체 5q22의 유전적 변이 발견Research Article Published on 2016-05-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acting activate addition African allergic allergy applied approach assays association Asthma Blood Cell chemokine chemokines chromosome clinical trial clinical trials cytokine death dendritic cell dendritic cells determinant development DNA methylation ENhance enhancer region epigenomic Evidence evidence of expressing expression Factor failure Follow-up gene encode Genetic Genetic variant Genome-wide association studies Genome-wide association study genotyping heart heart failure HEK293 high mortality human cell human tissues identify increase increased risk independent induce inhibiting knockdown leads maintain Mast cells maturation Meta-analysis molecular Monocytes Mortality multiple tissues NHLH1 Patient performed polymorphism Population populations Positive selection predicted promote replicated reporter reporter gene responses risk allele subject T helper T-cell therapeutic Therapeutics Therapies transcription factor TSLP turn variant Whole blood [DOI] 10.1371/journal.pgen.1006034 PMC 바로가기 [Article Type] Research Article
Comparative and kinetic analysis of viral shedding and immunological responses in MERS patients representing a broad spectrum of disease severityArticle Published on 2016-05-052022-10-29 Journal: Scientific Reports [Category] Coronavirus, MERS, [키워드] affecting Analysis analyzed antibody antiviral therapy Blood level chemokine Clinical data Comparative correlated correlation cytokine Deceased disease disease severity early phase effective EGF Factor febrile illness four group hospital IL-10 IL-15 Immunity Immunological response increases in kinetic kinetic analysis knowledge lymphocyte response lymphopenia MERS MERS patient MERS-CoV infection Mild Monocytes Mortality neutrophil outcomes Patient patients Pneumonia prognostic representing required response responses severity specimen Spread TGF-β the patient treated viral loads viral shedding Virological [DOI] 10.1038/srep25359 PMC 바로가기 [Article Type] Article
Systems Level Analyses Reveal Multiple Regulatory Activities of CodY Controlling Metabolism, Motility and Virulence in Listeria monocytogenes시스템 수준 분석을 통해 Listeria monocytogenes에서 대사, 운동성 및 독성을 제어하는 CodY의 여러 조절 활동이 밝혀졌습니다.Research Article Published on 2016-02-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] actA activate activator activity adaptation Affect Amino acid amino acids Analysis Bacteria bacterial pathogen Bacterial pathogens BCAA bind binding branch CodY condition conditions controlling dependent on DNA DNA binding environmental cues expression facilitate function functions Gene Expression Genes Genome gram Gram-positive bacteria growth Host identify identifying L . monocytogene Level Ligand ligands Listeria Listeria monocytogene Listeria monocytogenes mammalian metabolic genes metabolism modulate motility Multiple multiple pathway multiple pathways observation pathogen Pathogens pathway Pathways performed previous study prfA raised regulated regulator gene Regulatory regulatory network reported repress repressor respond response responses Sequencing Stress stress responses System Target genes thought traits Transcription transcription factor transcription factors virulence virulence gene virulence genes [DOI] 10.1371/journal.pgen.1005870 PMC 바로가기 [Article Type] Research Article
Abacavir, zidovudine, or stavudine as paediatric tablets for African HIV-infected children (CHAPAS-3): an open-label, parallel-group, randomised controlled trial아바카비르, 지도부딘 또는 스타부딘을 아프리카 HIV 감염 소아용 정제로 사용(CHAPAS-3): 공개 라벨, 병렬 그룹, 무작위 대조 시험Articles Published on 2016-02-012022-09-06 Journal: The Lancet. Infectious Diseases [Category] Communicable Disease, [키워드] abacavir adverse event adverse events African analysed Antiretroviral therapy ART children clinical database Developing drugs dual efavirenz enrolled European finding Follow-up funding groups hazard ratio hypersensitivity hypersensitivity reactions immunological inhibitor Intention intention to treat ISRCTN registry Laboratory lamivudine less Lipodystrophy median median age nevirapine nucleoside occurred Open-label parallel-group partnership primary endpoint randomisation randomised controlled trial Randomised trial Registered responses stavudine suppression Tablet Toxicity Treatment Trial Uganda Viral Viral load Virological were excluded WHO zidovudine [DOI] 10.1016/S1473-3099(15)00319-9 PMC 바로가기 [Article Type] Articles