High-Resolution Genetics Identifies the Lipid Transfer Protein Sec14p as Target for Antifungal Ergolines고해상도 유전학, 지질 전달 단백질 Sec14p를 항진균성 에르골린의 표적으로 식별Research Article Published on 2016-11-172022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] analogue analogues Antibiotics Antifungal binding pocket clinic Compound Cryptococcus neoforman Cryptococcus neoformans death determinant develop disease Diseases dual Efficacy and safety ergoline ergolines Evidence fluconazole fungal fungal pathogen fungal pathogens fungi fungicidal activity Genetic genetic evidence growth homolog implicated Infection Infectious diseases inhibit inhibiting initial Interaction involved isolate knowledge Lipid malaria mammalian cells Medicines Mutation pathogenic pathogenicity Pathogens Protein resistance to antibiotics secretion selectivity significantly starting point target therapy transfer variety viability virulence was used [DOI] 10.1371/journal.pgen.1006374 PMC 바로가기 [Article Type] Research Article