Convalescent plasma for treatment of COVID-19: study protocol for an open randomised controlled trial in SwedenCovid-19의 치료를위한 회복기 혈장 : 스웨덴의 공개 무작위 대조 시험을위한 연구 프로토콜Infectious Diseases Published on 2021-12-072022-09-10 Journal: BMJ Open [Category] Fulltext, SARS, 임상, [키워드] airway Analysis antibody antibody levels article authority benefit block Block randomisation Blood blood bank & transfusion medicine blood sample Blood samples clinical study control arm convalescent plasma COVID-19 dissemination dose doses Endpoint enrolled Ethical approval Ethics group hospital include infection control intensive & critical care literature review Mortality neutralising antibody titre open participant Patient patients with COVID-19 plasma positive primary endpoint public health randomisation randomised controlled trial reduced registration number Result review SARS-CoV-2 secondary Secondary endpoints standard care study inclusion Study protocol Swedish Swedish Ethical Review Authority the patient therapy titre Treatment treatment of COVID-19 Trial Trial Registration Number Viraemia Virology virus [DOI] 10.1136/bmjopen-2020-048337 PMC 바로가기 [Article Type] Infectious Diseases
Previous COVID-19 Infection and Antibody Levels After Vaccination이전 백신 접종 후 COVID-19 감염 및 항체 수준Public Health Published on 2021-12-012022-09-11 Journal: Frontiers in Public Health [Category] MERS, SARS, 변종, [키워드] adjusted Analysis antibodies antibody antibody levels association average BNT162b2 ChAdOx1 ChAdOx1 vaccine ChAdOx1 vaccines Characteristics circumvent Comorbidities Comorbidity country COVID-19 COVID-19 infection COVID-19 infections COVID-19 vaccination COVID-19 vaccine COVID-19 vaccines distribution dose effort elicit followed by generalized linear regression greater health authorities high risk Humoral immunity Humoral response IgA IgG Immunoglobulin individual Infection Kuwait Level Neutralizing antibodies neutralizing antibody protocol public health authority recruited Regression regression analysis robust SARS-CoV-2 SARS-CoV-2 antibodies SARS-CoV-2 antibody serological analysis student subject sustained t -test the vaccine vaccinate vaccinated individual vaccinated individuals vaccination Vaccine variants of concern was performed [DOI] 10.3389/fpubh.2021.778243 PMC 바로가기 [Article Type] Public Health
Age-Dependent Reduction in Neutralization against Alpha and Beta Variants of BNT162b2 SARS-CoV-2 Vaccine-Induced ImmunityBNT162b2 SARS-CoV-2 백신 유도 면역의 알파 및 베타 변이체에 대한 중화의 연령 의존적 감소Research Article Published on 2021-12-012022-09-10 Journal: Microbiology Spectrum [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus-2 age All participants anti-RBD antibody antibody level antibody levels Antibody test Antigen basic Beta binding domain BNT162b2 BNT162b2 vaccine Clinical characteristics collected Coronavirus-2 correlated Cutoff decrease female groups Health care Health care worker health care workers heterogeneity high risk higher risk Humoral immunity Immunity include individual Infection interquartile range introduced IQR median mRNA vaccine mRNA vaccines neutralization Neutralizing Neutralizing activity Neutralizing antibodies of BNT162b2 Older age participant Patient patient age positive Pseudotyped virus questionnaire Questionnaires Randomly Receptor-binding domain reduction respiratory SARS-CoV-2 SARS-COV-2 infection second dose selected sera serum dilution Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus Spike protein Toyama U/mL university vaccination variant variants Viral viral variant Viral variants virus viruses was obtained were measured wild type wild-type wild-type SARS-CoV-2 wild-type virus [DOI] 10.1128/Spectrum.00561-21 PMC 바로가기 [Article Type] Research Article
Modelling the concentration of anti-SARS-CoV-2 immunoglobulin G in intravenous immunoglobulin product batches정맥주사용 면역글로불린 제품 배치에서 항-SARS-CoV-2 면역글로불린 G의 농도 모델링Research Article Published on 2021-11-292022-09-12 Journal: PLoS ONE [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus anti-SARS-CoV-2 anti-SARS-CoV-2 antibody anti-SARS-CoV-2 IgG antibody antibody half-life antibody levels Antibody titre anticipated binding Concentration convalescent convalescent plasma coronavirus coronavirus disease Coronavirus disease 2019 Diseases Donor early phase elevated expected group half-life IgG Immunoglobulin implication incidence indicated Intravenous immunoglobulin IVIG mathematical mathematical model measurement parameter Patient Phadia physician plasma plasma concentration predict produced reactivity Result retained SARS-CoV-2 SARS-CoV-2 vaccination status Study design the mean Vaccination Status were used [DOI] 10.1371/journal.pone.0259731 PMC 바로가기 [Article Type] Research Article
Profiling the Quality and Quantity of Naturally Induced Antibody Responses Against Pfs230 and Pfs48/45 Among Non-Febrile Children Living in Southern Ghana: A Longitudinal Study남부 가나에 거주하는 비열성 아동을 대상으로 한 Pfs230 및 Pfs48/45에 대한 자연 유도 항체 반응의 질과 양 프로파일링: 종단적 연구Original Research Published on 2021-11-252024-08-08 Journal: Frontiers in Cellular and Infection Microbiology [Category] 말라리아, [키워드] antibody levels gametocyte P. falciparum Polymerase chain reaction (PCR) relative avidity [DOI] 10.3389/fcimb.2021.770821 PMC 바로가기 [Article Type] Original Research
Analysis of Serological Biomarkers of SARS-CoV-2 Infection in Convalescent Samples From Severe, Moderate and Mild COVID-19 Cases중증, 중등도 및 경증 COVID-19 사례의 회복기 샘플에서 SARS-CoV-2 감염의 혈청학적 바이오마커 분석Comparative Study Published on 2021-11-192022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 바이오마커, 변종, 진단, 치료기술, 치료법, [키워드] acute respiratory syndrome addition antibodies antibody Antibody binding antibody levels Antibody Response Antibody responses Antibody Units Antigen Asymptomatic asymptomatic infection average BAU binding antibodies binding antibody binding antibody units Biomarker Biomarkers candidate Clinical severity convalescent sera correlated correlates of protection COVID-19 COVID-19 disease COVID-19 immune response COVID-19 pandemic COVID-19 patients Electroporation ELISA epidemiological studies Epidemiological study flow cytometry HCW healthcare worker Humoral immunity identify IgA IgM increasingly International international standard international units Lateral flow test microneutralisation test Mild mild or asymptomatic infections multiplex neutralisation neutralisation assay Neutralising Antibodies neutralising antibody neutralising antibody response Neutralising antibody responses nucleocapsid positive correlation Prevalence protection pseudotyped RBD Re-infection respiratory Sample SARS-CoV-2 SARS-CoV-2 antigen SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 spike SARS-CoV-2-specific IgG Serological biomarkers SEROLOGICAL STUDY seronegative seropositive Severe acute respiratory syndrome Severe acute respiratory syndrome-related coronavirus Severe acute respiratory syndrome-related coronavirus-2 severe COVID-19 patient severe COVID-19 patients severity significantly higher spike statistically to define unit vaccination Vaccine vaccine trial variants of concern Virus neutralisation virus neutralisation assay virus neutralising antibody VoC were expressed WHO WHO guideline WHO International Standard World Health Organisation [DOI] 10.3389/fimmu.2021.748291 PMC 바로가기 [Article Type] Comparative Study
Infection, recovery and re-infection of farmed mink with SARS-CoV-2SARS-CoV-2로 사육된 밍크의 감염, 회복 및 재감염Research Article Published on 2021-11-152022-09-10 Journal: PLoS Pathogens [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] absence animal animals anti-SARS-CoV-2 antibodies anti-SARS-CoV-2 antibody antibody antibody levels change circulating Course dead Deletion demonstrated Denmark disease farm First wave Follow-up follow-up studies immune response in some infected with SARS-CoV-2 Infection initial less maintenance mink Mortality much higher Mutation nucleotide nucleotides occurred outbreak over positive Prevalence proportion Protein re-infected Re-infection remained residue responsible resulting SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 infections SARS-CoV-2 RNA scored second wave sequence seropositive serum sample serum samples shown Spike protein supported tested the SARS-CoV-2 the spike protein throat swab throat swabs virus virus detection viruses Whole genome sequencing Y453F [DOI] 10.1371/journal.ppat.1010068 PMC 바로가기 [Article Type] Research Article
Humoral response to SARS‐CoV‐2 and seasonal coronaviruses in COVID‐19 patientsCOVID-19 환자의 SARS-CoV-2 및 계절성 코로나바이러스에 대한 체액 반응Research Article Published on 2021-11-082022-09-10 Journal: Journal of medical virology [Category] MERS, SARS, 치료법, [키워드] 229E acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 antibody antibody levels Antibody Response Antibody responses association both groups Cohort control group convalescent plasma coronavirus Coronaviruses correlated correlation COVID COVID‐19 patient Definition disease severity Donor elevated Evidence evidence of HCoV HCoV 229E high responder human coronavirus human coronaviruses humoral humoral immune response Humoral response immunoassay in both group individual Infection lead levels of antibodies levels of antibody no evidence of nucleocapsid Postinfection predisposition Prevalence Protein respiratory SARS‐CoV‐2 SARS‐CoV‐2 antibodies SARS‐CoV‐2 antibody SARS‐CoV‐2 seasonal coronavirus seasonal coronaviruses severe acute respiratory syndrome Coronavirus significantly symptom onset tested while [DOI] 10.1002/jmv.27427 PMC 바로가기 [Article Type] Research Article
Cross-reactivity of antibodies from non-hospitalized COVID-19 positive individuals against the native, B.1.351, B.1.617.2, and P.1 SARS-CoV-2 spike proteins근원이없는 COVID-19 긍정적 인 개체로부터의 항체의 교차 반응성, B.1.351, B.1.617.2 및 p.1 SARS-COV-2 스파이크 단백질Article Published on 2021-11-082022-09-01 Journal: Scientific Reports [Category] MERS, SARS, 변종, 진단, 치료기술, [키워드] ACE-2 ACE-2 receptor Adults affinity analyzed antibodies antibody antibody level antibody levels B.1.351 B.1.617.1 B.1.617.2 Beta BNT162b2 ChAdOx1 ChAdOx1 nCoV-19 collected COVID-19 cross-reactivity Delta ectodomain Effectiveness elicited enrolled Evidence evidence of except for Gamma humoral Humoral response implication individual individuals infected with SARS-CoV-2 inhibited Interaction interactions nCoV neutralization Optical sensors P.1 P.1 variant pandemic PCR-confirmed positive individual Proteins relative SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2 variant SARS-CoV-2 variants sera Spike protein Spike proteins SPR Spread sustained the spike protein vaccinated individual vaccinated individuals vaccination variant spike VoC VOCs [DOI] 10.1038/s41598-021-00844-z PMC 바로가기 [Article Type] Article
Comparison of immunogenicity and reactogenicity of inactivated SARS-CoV-2 vaccine (CoronaVac) in previously SARS-CoV-2 infected and uninfected health care workers이전에 SARS-CoV-2 감염 및 감염되지 않은 의료 종사자의 비활성화된 SARS-CoV-2 백신(CoronaVac)의 면역원성 및 반응성 비교Comparative Study Published on 2021-11-022022-09-11 Journal: Human vaccines & immunotherapeutics [Category] MERS, SARS, 진단, 치료기술, [키워드] administration Adverse reaction Adverse reactions antibody antibody levels Antibody Response Antibody titer Antibody titers Asymptomatic Care CoronaVac detection dose Effect elicit enrolled first dose HCW HCWs Health Health care Health care worker health care workers health-care Hospitalized immunized immunogenicity inactivated infected individual infected individuals infections intramuscularly median Mild nasopharyngeal natural infection not differ Pneumonia questionnaire RBD reactogenicity Receptor-binding domain reported respiratory Respiratory tract infections Safe SARS-CoV-2 SARS-coV-2 inactivated virus vaccine SARS-CoV-2 positivity SARS-CoV-2 spike protein SARS-CoV-2 vaccine second dose Seven significantly higher Spike protein the receptor-binding domain the vaccine Turkey uninfected upper respiratory tract upper respiratory tract infections vaccination Vaccine vaccine administration vaccine adverse effects vaccine antibody response. vaccine dose virus was done [DOI] 10.1080/21645515.2021.1953344 PMC 바로가기 [Article Type] Comparative Study