Phylogenetic and Ancestral Sequence Reconstruction of SARS-CoV-2 Reveals Latent Capacity to Bind Human ACE2 ReceptorSARS-CoV-2의 계통 발생 및 조상 서열 재구성으로 인간 ACE2 수용체 결합에 대한 잠재 능력 밝혀Article Published on 2021-12-012022-09-11 Journal: Journal of molecular evolution [Category] MERS, SARS, 진단, 치료기술, 치료제, [키워드] ACE2 Ancestral sequence reconstruction assumption bat bats bind binding affinity binding domain Capacity cellular circulating domain effort Evolution functional genetic change Human human ACE2 receptor human populations humans infect Infection Latent molecular dynamics Molecular dynamics simulation MONITOR Phylogenetic analysis phylogenetics populations Protein RaTG13 RBD reconstruction SARS-CoV-2 sequence Spike protein target the Spike unique Viral viral evolution viral pathogen virus viruses zoonotic [DOI] 10.1007/s00239-021-10034-0 PMC 바로가기 [Article Type] Article
Correlation of dried blood spots and plasma for quantification of Immunoglobulin (IgG) against Receptor binding domain and full length spike protein of SARS-CoV-2Comparative Study Published on 2021-11-302022-10-04 Journal: Journal of virological methods [Category] COVID19(2023년), MERS, SARS, 진단, 치료기술, [키워드] binding domain Blood correlation dried blood spot Dried blood spots full length Full length spike protein full-length spike protein IgG Immunoglobulin (IgG) plasma Pragmatic quantification Receptor binding domain SARS-CoV-2 SARS-CoV-2 IgG antibodies SARS-COV-2 infection Spike protein [DOI] 10.1016/j.jviromet.2021.114394 PMC 바로가기 [Article Type] Comparative Study
Measurement of SARS-CoV-2-Specific Humoral and Cellular Immunity in Coronavirus Disease 2019 Convalescent Health Care Workers in Iraq코로나바이러스 질병 2019 이라크의 회복기 의료 종사자의 SARS-CoV-2 특정 체액 및 세포 면역 측정Article Published on 2021-11-302022-09-12 Journal: Archives of Razi Institute [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome adaptive addition Anti-RBD IgG antibody level binding domain Cell-mediated immunity conducted convalescent convalescent individual coronavirus coronavirus disease Coronavirus disease 2019 (COVID-19) COVID-19 disease severity eight enrolled enzyme-linked immunosorbent evaluated global pandemic HCW Health care worker humoral immune response Humoral immunity IgG antibody Immunity increase in Iraq knowledge lymphocyte measurement Mild moderate MTT proliferation quartile RBD Reinfection respiratory reveal robust S1 protein SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) severe COVID-19 Symptom symptomatic the Coronaviridae the median time interval virus worker [DOI] 10.22092/ari.2021.356135.1785 PMC 바로가기 [Article Type] Article
SARS-CoV-2 receptor binding domain radio-probe: a non-invasive approach for angiotensin-converting enzyme 2 mapping in mice Research Published on 2021-11-232022-10-05 Journal: Acta pharmacologica Sinica [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] ACE2 ACE2 expression angiotensin-converting enzyme 2 approach BALB/c mice bind binding binding domain biodistribution blocked C-terminus Cell COVID-19 distribution expression profile hACE2 high uptake in vivo Infection Inflammation inhibiting injection interact intrapulmonary Intravenous injection low-dose lung mammals metabolism mice moderate molecular Non-invasive organ pathway probe purification Radiation Radiotherapy RBD Receptor binding domain Recombinant spike protein reduce respiratory epithelial cells SARS-CoV-2 SARS-CoV-2 receptor Spike protein was obtained [DOI] 10.1038/s41401-021-00809-y [Article Type] Research
Efficient Maternofetal Transplacental Transfer of Anti- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike Antibodies After Antenatal SARS-CoV-2 BNT162b2 Messenger RNA Vaccination산전 SARS-CoV-2 BNT162b2 메신저 RNA 예방접종 후 항중증급성호흡기증후군 코로나바이러스 2(SARS-CoV-2) 스파이크 항체의 효율적인 모태반 전이Article Published on 2021-11-162022-09-12 Journal: Clinical Infectious Diseases: An Official Publicat [Category] MERS, SARS, 진단, [키워드] acute respiratory syndrome antibody concentration binding domain Blood BNT162b2 vaccine collected Cord blood coronavirus coronavirus 2 correlated efficient Immunoglobulin Infant Maternal messenger Neonatal parturient positive Pregnancy respiratory RNA SARS-CoV-2 SARS-CoV-2 BNT162b2 sera serology spike Transplacental vaccination women [DOI] 10.1093/cid/ciab266 PMC 바로가기 [Article Type] Article
Persistence of Neutralizing Antibodies to SARS-CoV-2 in First Wave Infected Individuals at Ten Months Post-Infection: The UnIRSA Cohort Study감염 후 10 개월에 첫 파동 감염된 개체에서 SARS-COV-2에 대한 항체 중화 항체의 지속성 : UNIRSA 코호트 연구Brief Report Published on 2021-11-122022-09-01 Journal: Viruses [Category] MERS, SARS, 진단, [키워드] Anti-spike antibody binding domain Bio-Techne Cohort collected COVID-19 Critical elicited first positive First wave fraction geometric geometric mean humoral IgG antibody IgG titers immune response individual Infection Italy longitudinal longitudinal analysis Mild Mild disease Month natural infection neutralization titer Neutralizing activity neutralizing antibody neutralizing humoral response pandemic PCR test performed pseudotype public health R&D Systems RBD Re-infection SARS-CoV-2 SARS-CoV-2 IgG SARS-CoV-2 immunity seroconverted seronegative Seropositivity serum sample subject subjects USA Vaccine development was tested Wave were infected [DOI] 10.3390/v13112270 PMC 바로가기 [Article Type] Brief Report
A rapid simple point-of-care assay for the detection of SARS-CoV-2 neutralizing antibodies Research Published on 2021-11-112022-10-05 Journal: Communications Medicine [Category] 바이오마커, [키워드] Accuracy ACE2 antibody approach binding domain can be used cause Cellulose comparable complex convalescent plasma COVID-19 Critical detect detection develop disrupt Efficacy evaluate host cells Human plasma Immunity infecting Interaction MONITOR NAb NAbs pathogen Pathogens point-of-care Prevent pull-down RBD variant Result SARS-CoV-2 SARS-CoV-2 NAb SARS-CoV-2 neutralizing antibody Sensitivity and specificity Vaccine virus [DOI] 10.1038/s43856-021-00045-9 [Article Type] Research
Differences in IgG Antibody Responses following BNT162b2 and mRNA-1273 SARS-CoV-2 VaccinesResearch Article Published on 2021-11-102022-10-30 Journal: Microbiology Spectrum [Category] COVID-19, [키워드] age and gender antibodies antibody antibody kinetics Antibody Response average binding domain BNT162b2 BNT162b2 vaccine changes in clinically clinician Cohort COVID-19 COVID-19 pandemic defined difference dosage dose regimen elicited first dose Follow-up human cell IgG IgG antibody IgG response immune system immunization immunosuppressive drugs linear Moderna mRNA mRNA platform mRNA vaccine mRNA-1273 mRNA-1273 vaccine overcome participant peaked Pfizer/BioNTech powerful tool Prospective regimens regression modeling remained response S-protein SARS-CoV-2 SARS-CoV-2 vaccine second dose seroconverted serological Serologically seronegative participants significantly higher Spike protein the SARS-CoV-2 the vaccine titer translated vaccination Vaccine Vaccines virus spike protein was used were measured [DOI] 10.1128/Spectrum.01162-21 PMC 바로가기 [Article Type] Research Article
Distinct SARS-CoV-2 antibody reactivity patterns elicited by natural infection and mRNA vaccinationArticle Published on 2021-11-042022-10-30 Journal: NPJ Vaccines [Category] COVID-19, [키워드] analyzed antibodies antibody Antibody Response Antibody titer Antigen binding domain Blood can be used Care center collected common CoV COVID-19 cross-reactive cross-reactivity domain elicited full length healthcare worker IgG level individuals induce infected individual intensive care MERS Microarray mild cases mRNA vaccination multiplex natural infection nucleocapsid orange Patient pre-vaccination Protein RBD reactivity reactivity pattern RNA vaccines S2 domain SARS S1 SARS-CoV-2 SARS-CoV-2 antibody SARS-COV-2 infection serological survey seropositive individual Seroprevalence severe disease significantly higher specimen stick Symptom the RBD the vaccine University of California vaccination vaccinee [DOI] 10.1038/s41541-021-00396-3 PMC 바로가기 [Article Type] Article
Humoral immune response following SARS-CoV-2 mRNA vaccination concomitant to anti-CD20 therapy in multiple sclerosis다발성 경화증에서 항 CD20 요법과 함께 SARS-CoV-2 mRNA 백신 접종 후 체액 면역 반응Article Published on 2021-11-012022-09-11 Journal: Multiple sclerosis and related disorders [Category] MERS, SARS, 진단, 치료기술, [키워드] Abbott Abbott Laboratories anti-CD20 anti-CD20 therapy B-cell binding domain BNT162b2 BNT162b2 mRNA Booster vaccine CD20 clinical clinical trials COVID-19 COVID-19 vaccine depleting determine domain Efficacy exposure to FIVE Future humoral IgG immune protection immune response immunogenicity Immunoglobulin Immunoglobulin G implication investigated monoclonal antibody mounted mRNA vaccination multiple sclerosis Ocrelizumab Patient patients patients treated positive Predictive Predictive value receiving SARS-CoV-2 SARS-CoV-2 IgG II Quant assay SARS-CoV-2 spike SARS-CoV-2 spike receptor-binding domain SARS-CoV-2 vaccine second dose second dose of vaccine seronegative seropositive the SARS-CoV-2 therapy treated patient Treatment vaccination Vaccine vaccine efficacy were measured [DOI] 10.1016/j.msard.2021.103251 PMC 바로가기 [Article Type] Article