Metformin Use Is Associated with Decreased Mortality in COVID-19 Patients with Diabetes: Evidence from Retrospective Studies and Biological MechanismArticle Published on 2021-08-092022-10-30 Journal: Journal of Clinical Medicine [Category] COVID-19, [키워드] 95% confidence interval acute lung damage Anti-inflammatory article articles Asia association Biological carried collected coronavirus disease COVID-19 COVID-19 patients database Decreased diabete diabetes Effectiveness endothelial damage Europe Evidence heterogeneity hyperglycemia hyperinflammatory state immunosuppressive effects inclusion criteria Inconclusive increase independent information insulin investigated Meta-analysis metformin Mortality mortality rate North America participant Patient patients with COVID-19 previous study random-effects model reduced risk reducing risk risk ratio RRs selected severity shown significantly subgroup analysis Support the patient Treatment Trial type 2 diabete Vascular was used Web of Science [DOI] 10.3390/jcm10163507 PMC 바로가기 [Article Type] Article
Forecasting of phenotypic and genetic outcomes of experimental evolution in Pseudomonas protegens슈도모나스 단백질 겐에서 표현형 및 유전 적 결과의 예측Research Article Published on 2021-08-052022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation adaptive addition Air-liquid interface Amino acid Bacterial Biological Biology can not Cancer Cellulose changed Climate change colonize condition conditions conserved core dependent on develop Diseases disrupt Evolution expected experiments Factor fitness followed by Forecasting Genetic Genotype growth hot spot identity Infectious diseases lack majority mathematical mathematical model microbe microbes model system model systems MOST motility mutant mutants Mutation mutation rate Mutation rates mutations negative regulation nucleotide outcome outcomes pathway phenotype Phenotypes phenotypic polysaccharide Population predict predictability predicted predicted gene predicted genes Predictive model prevented problems promoter regions Protein provide Pseudomona Pseudomonas Pseudomonas species Pseudomonas specy real time reduced Region resulting sequence tested Variation [DOI] 10.1371/journal.pgen.1009722 PMC 바로가기 [Article Type] Research Article
Shorter leukocyte telomere length is associated with adverse COVID-19 outcomes: A cohort study in UK Biobank더 짧은 백혈구 텔로미어 길이는 부정적인 COVID-19 결과와 관련이 있습니다: UK Biobank의 코호트 연구Research Paper Published on 2021-07-232022-09-11 Journal: EBioMedicine [Category] MERS, SARS, 변종, 유전자 메커니즘, [키워드] 95% CI adjusted age Analysis association Biological Biotechnology Causality cohort study collider bias Community Composite conducted coronavirus coronavirus disease Coronavirus disease-19 Council COVID-19 Critical care defined determine Ethnicity evaluate exploratory finding foundation funding genetic variants heart higher risk Hospital admission independent independent of infection with SARS-CoV-2 information leucocyte leukocyte marker Medical Research Council Mortality MR analyses Odds ratio outcome outcomes participant positive randomisation recorded recruited reduced reflect respiratory Respiratory Support risk risk factor Science Sex tested UK biobank UKB with COVID-19 [DOI] 10.1016/j.ebiom.2021.103485 PMC 바로가기 [Article Type] Research Paper
Relationship Between the COVID-19 Pandemic and Ecological, Economic, and Social ConditionsPublic Health Published on 2021-07-232022-10-31 Journal: Frontiers in Public Health [Category] Coronavirus, MERS, SARS, [키워드] analyzed Biological Biological Capacity Capacity Coexistence collected condition conditions correlated country COVID-19 COVID-19 pandemic creating ecological Ecological Footprint ecosystem Footprint four group GDP GDP per Capita group Health Human Impact infection rate infection rates median age medium microbial Microbiome pandemic positive regression models relationship representing Resilience These data urban population [DOI] 10.3389/fpubh.2021.694191 PMC 바로가기 [Article Type] Public Health
Molecular Mechanisms of Palmitic Acid Augmentation in COVID-19 PathologiesCOVID-19 병리학에서 팔미트산 증대의 분자 메커니즘Article Published on 2021-07-012022-09-12 Journal: International Journal of Molecular Sciences [Category] SARS, 진단, [키워드] ACE2 Activation Affect affected apoptotic attenuate augmentation base Biological biological molecules canonical CCL2 CCL5 Cell cell surface receptor chemokines claimed coronavirus disease Coronavirus disease 2019 coronavirus pathogenesis COVID-19 COVID-19 pathology Cytokines dataset EEF1A1 elevated exacerbate expression Fatty acid fatty acids FFA FFAs free fatty acid free fatty acids IL1β Inflammatory mediators Ingenuity Pathway Analysis inhibiting knowledge base modulate molecular mechanism molecular mechanisms Mortality n-3 fatty acid NFκB obese obesity palmitic acid pandemic Pathologies pathway progression PTGS2 retrieved SARS-CoV-2 spike protein severity Spike protein subjects surface receptor the SARS-CoV-2 transcription factors translation were used [DOI] 10.3390/ijms22137127 PMC 바로가기 [Article Type] Article
[Low dose radiotherapy for COVID-19 pneumopathy: Biological rationale and literature review][COVID-19 폐렴에 대한 저선량 방사선 치료: 생물학적 근거 및 문헌 고찰]Review Published on 2021-07-012022-09-11 Journal: Cancer radiothérapie : journal de la Société franç [Category] 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 anti-inflammatory activity anti-inflammatory properties anti-inflammatory property Antibiotics Bacterial Biological clinical presentation Clinical presentations clinical trial Controlled trial coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 demonstrated dose English Entire lung explain Faible dose feasibility forme French greater in vitro in vitro data in vivo less low dose low-dose lung Lung disease Mortality over pandemic Pathologies Patient pneumopathy Radiobiologie radiobiology Radiothérapie Radiotherapy Randomized Randomized controlled trial report risk SARS-CoV-2 SARS-CoV-2 pneumonia severe acute respiratory syndrome Coronavirus therapy Treatment Trial [DOI] 10.1016/j.canrad.2021.03.005 PMC 바로가기 [Article Type] Review
Impact of gender on patients hospitalized for SARS-COV-2 infection: A prospective observational studyObservational Study Published on 2021-07-012022-10-05 Journal: Journal of medical virology [Category] SARS, 임상, [키워드] acute respiratory syndrome adjusted odds ratio Affect age Anemia AOR Biological clinically confidence interval coronavirus COVID-19 COVID-19 patient Critical disease Critically ill D-dimer death disease disease severity enrolled female Gender glomerular filtration rate higher odd hospital Hospital admission Hospitalized hospitalized COVID-19 patients Impact Infection interquartile lactate dehydrogenase male median age Mortality multivariable multivariable analysis obesity occurred outcomes Patient patients hospitalized predicted Primary outcome proportion prospective observational study regression models secondary outcome Sex study period variables [DOI] 10.1002/jmv.26933 PMC 바로가기 [Article Type] Observational Study
Archiving time series sewage samples as biological records of built environmentsReview Published on 2021-06-242022-10-28 Journal: BMC Infectious Diseases [Category] COVID-19, MERS, SARS, [키워드] Anthropocene Biological Biological diaries biological fluids Community correlation COVID-19 current facilitate Historical epidemiology identity living cell nucleic acid Prevalence public health Repository resource retrospective Sample archiving SARS-CoV-2 sewage tissue virus wastewater [DOI] 10.1186/s12879-021-06268-4 PMC 바로가기 [Article Type] Review
Long COVID or Post-acute Sequelae of COVID-19 (PASC): An Overview of Biological Factors That May Contribute to Persistent SymptomsMicrobiology Published on 2021-06-232022-10-31 Journal: Frontiers in Microbiology [Category] COVID-19, [키워드] acute COVID-19 acute respiratory syndrome acute SARS-CoV-2 infection Autoimmunity Biological Brainstem Care caused condition consequence Consequences coronavirus coronavirus disease Course COVID COVID-19 Diagnosis driving Factor fatigue globe Health herpesvirus Host host proteins immune cells immune dysregulation include Infection Injury Interaction Long Long COVID mechanism Microbiome molecular multiple organs pandemic PASC pathogen Patient persistent Potential required reservoir RNA virus SARS-CoV-2 Signaling subset Symptom Symptoms syndrome Therapeutic approach tissues Vagus virus [DOI] 10.3389/fmicb.2021.698169 PMC 바로가기 [Article Type] Microbiology
The first Chinese national standards for SARS-CoV-2 neutralizing antibodySARS-CoV-2 중화항체 중국 최초 국가표준Article Published on 2021-06-232022-09-12 Journal: Vaccine [Category] MERS, SARS, 진단, [키워드] accelerated antibody approved assigned Biological Biological product China Chinese Committee comparability contribute coronavirus disease Coronavirus disease 2019 COVID-19 Degradation determined by drug Efficacy immunogenicity IMPROVE lab milliliter National national standards Neutralization assay neutralization titer neutralization titers neutralizing antibody potency product reduce reference standard Reference standards respiratory Sample SARS-CoV-2 SARS-CoV-2 neutralizing antibody Severe acute respiratory syndrome severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus-2 stability Standard therapeutic Therapeutics U/mL Vaccine Variation variations [DOI] 10.1016/j.vaccine.2021.05.047 PMC 바로가기 [Article Type] Article