The safety and feasibility of the screening for retinopathy of prematurity assisted by telemedicine network during COVID-19 pandemic in Wuhan, ChinaResearch Published on 2021-06-112022-10-28 Journal: BMC ophthalmology [Category] COVID-19, MERS, SARS, [키워드] age analyzed blindness blockade caused children conducted coronavirus disease COVID-19 COVID-19 outbreak COVID-19 pandemic cross effective Epidemic evaluate feasibility feasible Follow-up hospital Infant Infection males measure median Medical resources performed platform Premature preventive measure receive reported Result retinopathy of prematurity Retrospective study Safe screened Screening Telemedicine the epidemic the median Treatment Wuhan Wuhan, China [DOI] 10.1186/s12886-021-02018-x PMC 바로가기 [Article Type] Research
C-type lectins and extracellular vesicles in virus-induced NETosisReview Published on 2021-06-112022-10-29 Journal: Journal of Biomedical Science [Category] COVID-19, MERS, SARS, [키워드] activate acute respiratory syndrome acute viral infections attenuate blockade C-type lectin C-type lectin receptor (CLR) caused CLEC10A CLEC2 CLEC5A Coagulopathy contribute Coronavirus-2 COVID-19 Cytokine storm danger signals DC-SIGN dengue virus Dengue virus (DV) disease severity ENhance EVs exacerbate Exosome Exosome (EXO) extracellular vesicle Extracellular vesicle (EV) facilitate glycan Inflammation inflammatory reactions intercellular Japanese L-SIGN microvesicle Microvesicle (MV) NET NETosis NETs neuronal Neutrophil extracellular trap organ Pathogenesis Patient pattern recognition receptor Platelet receptor reported responsible SARS-CoV-2 shown spleen stimulate TLR TLR2 tyrosine virus [DOI] 10.1186/s12929-021-00741-7 PMC 바로가기 [Article Type] Review
Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike ProteinArticle Published on 2021-06-032022-10-28 Journal: Biomedicines [Category] COVID-19, [키워드] abnormal coagulation Activation antagonist blockade complications COVID-19 patients downstream dysfunction Effect ELISA endothelial Endothelial cell endothelial cells galectin-3 induced Inflammation Inflammatory Inflammatory response inhibitor interferon-γ interleukin-6 involved marker Mineralocorticoid mineralocorticoid receptor monocyte chemoattractant protein-1 pathogenesis of COVID-19 pathway prevented Protein receptor recombinant S protein reduce reversed S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV2 secretion Signaling spike supernatant thrombosis treated were assessed western blotting [DOI] 10.3390/biomedicines9060639 PMC 바로가기 [Article Type] Article
Effect of ramipril on kidney, lung and heart ACE2 in a diabetic mice model당뇨병 마우스 모델에서 신장, 폐 및 심장 ACE2에 대한 라미프릴의 효과Article Published on 2021-06-012022-09-11 Journal: Molecular and cellular endocrinology [Category] SARS, 변종, [키워드] ACE2 ACE2 expression acute respiratory syndrome acute respiratory syndrome coronavirus affected angiotensin Angiotensin-converting enzyme angiotensin-converting enzyme 2 angiotensin-converting enzyme inhibitor angiotensin-converting enzyme inhibitors blockade blocker blockers concerning controls coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 diabete diabetes Diabetic diabetic patient diabetic patients drug Effect had no heart in some Infection kidney lung Lungs mice mouse model no difference no differences no significant effect organ RAAS RAAS blockade. raised ramipril receptor Renin renin-angiotensin system responsible risk risk factor SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe acute respiratory syndrome coronavirus 2 significant effect significantly target cells tissue treated type 2 diabetes unlikely virus was increased [DOI] 10.1016/j.mce.2021.111263 PMC 바로가기 [Article Type] Article
Interleukin-6 receptor blockade in patients with COVID-19: placing clinical trials into contextCOVID-19 환자의 인터루킨-6 수용체 차단: 상황에 따른 임상 시험 적용Review Published on 2021-06-012022-09-11 Journal: The Lancet. Respiratory Medicine [Category] MERS, SARS, 임상, 진단, [키워드] acute respiratory illness binding blockade Characteristics clinical and methodological heterogeneity clinical decision clinical trial concomitant use contributed Corticosteroid Corticosteroids cytokine Decision making Efficacy and safety enrichment Evidence Factor heterogeneity IL-6 IL-6 receptor antagonists implicated interleukin-6 measurement scales methodological outcome Pathogenesis pathogenesis of COVID-19 Patient patients pleiotropic potential benefit potential benefits randomised randomised trials receptor receptor antagonists reported respiratory sarilumab Sery severity severity of illness tested the disease Tocilizumab Treatment treatment effects Trial trials Variability [DOI] 10.1016/S2213-2600(21)00139-9 PMC 바로가기 [Article Type] Review
Cytokine release syndrome in a patient with colorectal cancer after vaccination with BNT162b2Brief Communication Published on 2021-05-262022-10-04 Journal: Nature Medicine [Category] MERS, SARS, 변종, [키워드] administration adverse event anti-PD1 association blockade BNT162b2 Cancer Cancer immunotherapy Colon cancer Colorectal cancer coronavirus disease COVID-19 COVID-19 vaccination COVID-19 vaccine CRS cytokine level Cytokine release syndrome Diagnosis elevated evidenced favor Immune checkpoint inhibitors include inflammatory markers monotherapy mRNA mRNA vaccine mRNA vaccines occurred Patient Patients with cancer Pfizer-BioNTech raised reported RNA vaccines Support syndrome vaccination [DOI] 10.1038/s41591-021-01387-6 PMC 바로가기 [Article Type] Brief Communication
Soluble interleukin-6 receptor in the COVID-19 cytokine storm syndromeCOVID-19 사이토카인 폭풍 증후군의 가용성 인터루킨-6 수용체Article Published on 2021-05-182022-09-12 Journal: Cell Reports Medicine [Category] MERS, SARS, 진단, [키워드] blockade COVID-19 COVID-19 cytokine storm cytokine Cytokine storm elevated help IL-6 interleukin-6 interleukin-6 receptor patients reduce mortality severe COVID-19 sIL-6R syndrome threshold threshold concept Tocilizumab treat [DOI] 10.1016/j.xcrm.2021.100269 PMC 바로가기 [Article Type] Article
SARS-CoV-2 variants B.1.351 and P.1 escape from neutralizing antibodiesArticle Published on 2021-04-292022-10-06 Journal: Cell [Category] SARS, 진단, [키워드] Alter antibodies antibody B.1.1.7 B.1.351 bamlanivimab blockade Brazil camostat Casirivimab cell interaction convalescent COVID-19 patient COVID-19 COVID-19 pandemic effort Entry inhibitor escape health system host cell Host cell entry human cell implication individuals inhibited inhibitor less Mutation neutralization neutralizing antibody neutralizing antibody responses P.1 P.1 variant pandemic plasma Protein pseudoparticles recombinant SARS-CoV-2 SARS-CoV-2 variant sera soluble ACE2 South Africa Spike protein Spread susceptible Treatment variant variants variants of concern viral spike VoC [DOI] 10.1016/j.cell.2021.03.036 PMC 바로가기 [Article Type] Article
Attenuation of COVID-19-induced cytokine storm in a young male patient with severe respiratory and neurological symptomsShort Report Published on 2021-04-272022-10-29 Journal: Wiener Klinische Wochenschrift [Category] COVID-19, MERS, SARS, [키워드] acute respiratory syndrome attenuation Baricitinib blockade blocked cause Central nervous system condition contribute coronavirus coronavirus disease COVID-19 Cytokine storm delirium disease effective etiological agent healthy hospital Inflammation initiated male manifestation Neurological symptom organ systems Patient positive Proinflammatory cytokine reaction Remdesivir SARS-CoV-2 Standard of care Treatment Ventilation verbal was tested [DOI] 10.1007/s00508-021-01867-2 PMC 바로가기 [Article Type] Short Report
Interferon lambda in inflammation and autoimmune rheumatic diseases Reviews Published on 2021-04-272022-10-05 Journal: Nature reviews. Rheumatology [Category] 치료제, [키워드] Adaptive immune response addition Antiviral antiviral cytokine Autoimmune Autoimmune diseases Autoimmunity blockade Blood complex contribute Critical danger signals described Effect epithelial Evidence functions IFNα and IFNβ IFNλ immune dysregulation Immunity Infection Inflammation Inflammatory inhibit interferon Laboratory parameters modulate Pathogenesis pathogenic review rheumatic disease Rheumatic diseases Systemic autoimmune diseases systemic lupus erythematosus tissue tissue damage treatment strategy type I interferon type III interferon viral replication [DOI] 10.1038/s41584-021-00606-1 [Article Type] Reviews