Distribution of antiretroviral therapy through private pharmacies and postal courier services during COVID‐19 in Botswana: acceptability and reach of two out‐of‐facility individual differentiated service delivery modelsSupplement: Research Article Published on 2021-10-282022-10-31 Journal: Journal of the International AIDS Society [Category] Coronavirus, MERS, SARS, [키워드] Analysis Antiretroviral therapy ART ARV Botswana cascade conducted country courier services COVID‐19 COVID‐19 Differentiated care distribution East eligible enrolled enrolment health system healthcare home delivery indicated mapped measure National offered pandemic participated Pharmacy PLHIV Providing reached receiving reduce Result risk of transmission scaled up with HIV [DOI] 10.1002/jia2.25814 PMC 바로가기 [Article Type] Supplement: Research Article
Genome-Wide Profiling Reveals Alternative Polyadenylation of Innate Immune-Related mRNA in Patients With COVID-19게놈 전체 프로파일링, COVID-19 환자에서 선천적 면역 관련 mRNA의 대체 폴리아데닐화 밝혀냄Immunology Published on 2021-10-272022-09-11 Journal: Frontiers in Immunology [Category] MERS, SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 alternative polyadenylation alternative splicing APA APA regulator Biomarker cascade category caused Clinical treatment coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine production dataset de novo death Diseases effective event highlight human gene human genes human peripheral blood mononuclear cell Immune escape Immunity Infection Infectious diseases Innate innate immune response Innate immunity Interferon-gamma MAPK mechanism mechanisms mononuclear cell mRNA neutrophil neutrophil activation Ontology pandemic patients PBMC performed Peripheral blood Polyadenylation potential therapeutic target Profiling Regulation reported respiratory RNA RNA-seq data SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus Variation Viral [DOI] 10.3389/fimmu.2021.756288 PMC 바로가기 [Article Type] Immunology
Quantification of pulmonary involvement in COVID-19 pneumonia by means of a cascade of two U-nets: training and assessment on multiple datasets using different annotation criteriaOriginal Article Published on 2021-10-262022-10-29 Journal: International Journal of Computer Assisted Radiolo [Category] COVID-19, COVID19(2023년), MERS, SARS, [키워드] Accuracy affected analysed Analysis annotations automated bounding box cascade Chest computed tomography COVID-19 criteria dataset datasets Dice Effect evaluate evaluated Factor Ground-glass opacities identify independent investigated lesions lung machine learning Mask Measures Pneumonia predicted pulmonary involvement pulmonary lesions quantification quantified released Result score Segmentation supplementary material Tolerance U-NET volumetric were measured were used [DOI] 10.1007/s11548-021-02501-2 PMC 바로가기 [Article Type] Original Article
Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19 Reviews Published on 2021-10-182022-10-05 Journal: Cell Death and Differentiation [Category] 바이오마커, 신약개발, 임상, 치료제, [키워드] Activation age Cancer cardiovascular diseases cascade cells characteristic complications COVID-19 COVID-19 cases deficiency described develop diabetes drug dysregulated Effect exacerbate Glutamine group groups High-risk patients human immunity hyperinflammation hypertension immune response include Infection lung metabolism metabolomics NAD+ NET Neutrophil extracellular traps obesity overproduced Pathologies pathophysiology pathway Patient predisposition Prevent profile Proinflammatory cytokine promote reduced regulatory T cells risk SARS-COV-2 infection SARS-CoV-2 vaccination severe COVID-19 severe COVID-19 patient Severe COVID-19 pneumonia STAT3 suggested suppressed the disease Treg while [DOI] 10.1038/s41418-021-00892-y [Article Type] Reviews
Sphingolipids in Lung Pathology in the Coronavirus Disease Era: A Review of Sphingolipid Involvement in the Pathogenesis of Lung DamagePhysiology Published on 2021-10-082022-10-31 Journal: Frontiers in Physiology [Category] COVID-19, [키워드] “cytokine storm” antagonistic anti-apoptotic cascade cause Cell ceramide ceramide synthase change chronic lung disease contribute COVID COVID-19 Cytokine storm damage de novo Diseases Efficacy effort endothelial epithelial Evidence fibrosis Hyperinflammatory implicated indicate Inflammation inflammatory effects inflammatory process Inflammatory response initiate investigated involved Involvement Lipid lung lung cancer lung damage Lung disease Lung injury novel coronavirus disease PAH Pathogenesis Pathologies pathway pro-apoptotic produced proliferation proliferative pulmonary arterial hypertension pulmonary fibrosis recent receptor Regulation review S1P pathway SARS-CoV-2 shown Signaling sphingolipid sphingolipids sphingosine survival therapeutic option Treatment [DOI] 10.3389/fphys.2021.760638 PMC 바로가기 [Article Type] Physiology
Anti-SARS-CoV-2 and anti-cytokine storm neutralizing antibody therapies against COVID-19: Update, challenges, and perspectivesCOVID-19에 대한 Anti-SARS-CoV-2 및 항사이토카인 폭풍 중화 항체 요법: 업데이트, 도전 및 전망Review Published on 2021-10-012022-09-12 Journal: International immunopharmacology [Category] SARS, 변종, 유전자 메커니즘, 진단, [키워드] ACE2 acute respiratory syndrome angiotensin-converting enzyme 2 anti-cytokine storm antibody Antibody-based treatments Asymptomatic cascade caused characterized clinical trials Contamination coronavirus Coronavirus disease 2019 COVID-19 Critical Cytokine storm death Developing disease hygiene immunological Infection Interaction Lung injury Masks mild symptoms moderate Neutralizing neutralizing antibody pandemic Passive Passive immunotherapy Patient Perspective physical distancing Proinflammatory cytokine Protein receptor reduce Research research finding SARS-CoV-2 severe disease spike surgical Therapeutic approach therapy Transmission treat Treatment treatment strategy virus WHO World Health Organization [DOI] 10.1016/j.intimp.2021.108036 PMC 바로가기 [Article Type] Review
Targeting SARS-CoV-2 spike protein of COVID-19 with naturally occurring phytochemicals: an in silico study for drug development자연 발생 파이토케미칼로 코로나19의 SARS-CoV-2 스파이크 단백질 표적화: 약물 개발을 위한 in silico 연구Article Published on 2021-10-012022-09-11 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 신약개발, [키워드] ACE2 ACE2 receptor ACE2 receptors addition ADME Analysis angiotensin Angiotensin-converting enzyme anti-SARS-CoV-2 approved attachment binding binding free energy cascade cell surface receptor class class I fusion protein complex Compound COVID-19 disease drug-likeness engage enzyme FDA Fisetin flavonoids flavonoids and non-flavonoids free energy fusion fusion protein glycoprotein hACE2 HCQ Host host cell host cell surface host cells Hydroxychloroquine in silico indication Infection internalization membrane fusion molecular molecular docking molecular docking studies Molecular docking study molecular dynamics performed phytochemicals pre-fusion provided quercetin receptor Recognition SARS-CoV-2 SARS-CoV-2 spike protein spike spike glycoprotein Spike protein suggested targeting the SARS-CoV-2 tissue tropism transition Trigger viral envelope viral infection virus [DOI] 10.1080/07391102.2020.1796811 PMC 바로가기 [Article Type] Article
Systematic investigation of cytokine signaling activity at the tissue and single-cell levels Research Published on 2021-09-302022-10-05 Journal: Nature methods [Category] SARS, 유전자 메커니즘, 임상, [키워드] activity Analyzer Anti-inflammatory BMP6 Cancer cascade cell population chemokine chronic inflammation collected Critical CXCL8 cytokine cytokine signaling Cytokines database disease Diseases functions growth factor half-live Health human inflammatory diseases Intercellular communication modulated Predictive remained responses severe coronavirus disease Signaling single-cell single-cell level target gene therapeutic target tissue transcriptional transcriptome profile transcriptomic data transcriptomic profiles [DOI] 10.1038/s41592-021-01274-5 [Article Type] Research
Patient Nutrition and Probiotic Therapy in COVID-19: What Do We Know in 2021?Review Published on 2021-09-262022-10-30 Journal: Nutrients [Category] COVID-19, SARS, [키워드] ACE2 receptor B12 cascade caused Cell consequence COVID-19 COVID-19 infection COVID-19 patient effective element Fatty acid fiber Gut immune response include individual Infection information inhibiting Malnutrition microbiota micronutrients nutrition nutritional status omega-3 outcome Patient patients hospitalized patients with SARS-CoV-2 Probiotic Probiotics Proinflammatory cytokine prophylactically Protein rapid muscle reduced SARS-CoV-2 Support the SARS-CoV-2 virus therapy Treatment turn virus Vitamin [DOI] 10.3390/nu13103385 PMC 바로가기 [Article Type] Review
Self-sustaining IL-8 loops drive a prothrombotic neutrophil phenotype in severe COVID-19자체 유지 IL-8 루프는 심각한 COVID-19에서 전혈전성 호중구 표현형을 유도합니다Research Article Published on 2021-09-222022-09-12 Journal: JCI Insight [Category] SARS, 진단, [키워드] activated Activation acute respiratory distress acute respiratory distress syndrome Analysis ARDS attenuate autocrine cascade characterized Coagulation complement Complement cascade contribute contributing to coronavirus coronavirus 2 coronavirus disease Coronavirus disease 2019 COVID-19 Critical CXCL8 Cytokines Defense degranulation dissect dysregulation functional highlighting identify IL-8 immune response immune responses immunopathology in vitro in vivo Infection initiate interfere intrinsic Lung injury mechanism mice NET NETosis neutrophil neutrophil activation Neutrophil extracellular trap Neutrophils Pathogens Patient patients phenotype positive feedback positive feedback loop procoagulant progression proinflammatory proteomics prothrombotic pulmonary microthrombosis recent reduce respiratory distress Respiratory distress syndrome SARS-CoV-2 SARS-COV-2 infection self-damage severe acute respiratory distress syndrome severe COVID-19 severe SARS severe SARS-CoV-2 Signaling syndrome systemic targeting therapeutic target transcriptomic transition TRAP Vascular Biology vicious cycle [DOI] 10.1172/jci.insight.150862 PMC 바로가기 [Article Type] Research Article