Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations인간에서 Plasmodium Knowlesi의 핵 및 소기관 게놈 분석은 고대 개체군 구조와 숙주 특이적 하위 개체군 간의 최근 재조합을 보여줍니다Research Article Published on 2017-09-182022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 말라리아, [키워드] Analysis Appropriate Asia assist chromosome complex comprehensive analysis Contact contact with deforestation described Disruption ecological Evidence evidence of Evolution expected expressed genes encoding Genetic genetics Genome genome sequence genomic genotypes growth Host hosts Human human infection human population humans infecting Infection infections Interaction isolate Isolation likelihood Lineage lineages macaque macaques malaria malaria control Malaysia molecular nuclear organelle parasite parasites Plasmodium Population population growth Prevalence Protein Rapid Recombination reference genome Region resulting reveal sampling selected stages subpopulation subpopulations Surveillance switching traits Transmission [DOI] 10.1371/journal.pgen.1007008 PMC 바로가기 [Article Type] Research Article
The nucleoid occlusion factor Noc controls DNA replication initiation in Staphylococcus aureusnucleoid occlusion factor Noc는 황색 포도구균에서 DNA 복제 개시를 조절합니다Research Article Published on 2017-07-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] assembly Author Bacillus subtilis Bacteria binding site biological processe block Cell cell division chromosome chromosome segregation chromosomes connection Control cytokinetic ring division DNA replication DNA sequence DNA sequences dnaA Economy ENhance event Factors help inactivation inhibit initiated mechanism mutant mutants Mutation organism over-expression pathogen phenotype problem Protein reduced Replication S . aureus screened segregation shown Staphylococcus aureus suppress the cell thought underlie unique Volume [DOI] 10.1371/journal.pgen.1006908 PMC 바로가기 [Article Type] Research Article
A chromosome 5q31.1 locus associates with tuberculin skin test reactivity in HIV-positive individuals from tuberculosis hyper-endemic regions in east Africa염색체 5q31.1 유전자좌는 동부 아프리카의 결핵 고 풍토병 지역에서 온 HIV 양성인 개인의 투베르쿨린 피부 검사 반응성과 연관됩니다.Research Article Published on 2017-06-192022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] Active disease Airway inflammation Analysis approach association Author bacterium causal variant cause Cell chromosome chromosomes Cohort combined cohort complex cytokine detect determine develop dominant downstream Enrollment Evidence evidence of Genes Genetic genetic loci Genome-wide association study genome-wide significant Haplotype HIV-infection HIV-positive individual HIV-positive individuals identify IL9 Immunological response increase individual individuals infected individuals Infection Infectious disease Inflammation Inflammatory responses loci locus mast cell Mast cells Missense mutation missense variant Mycobacterium Mycobacterium tuberculosis Odds ratio participant Patient performed positive positive individuals power produced Prospective Study reactivity Region replicated risk significantly Skin test skin tests SLC25A48 subpopulation tested TST tuberculin skin test Tuberculosis Uganda uninfected unique variant variants [DOI] 10.1371/journal.pgen.1006710 PMC 바로가기 [Article Type] Research Article
Allelic Variation in the Toll-Like Receptor Adaptor Protein Ticam2 Contributes to SARS-Coronavirus Pathogenesis in MiceMultiparental Populations Published on 2017-06-052022-10-31 Journal: G3 (Bethesda, Md.) [Category] Coronavirus, [키워드] adaptor affected chromosome collaborative cross contribute coronavirus correlated Critical disease driving early stage exhibiting F2 Factor Genetic Genetic variation hemorrhage highlight Host host susceptibility genes Infection loci locus mice mouse model MPP Multi-parent Advanced Generation Inter-Cross (MAGIC) multiparental populations Pathogenesis phenotype Phenotypes Protein pulmonary hemorrhage Quantitative respiratory responses responsible SARS-CoV SARS-CoV infection Strains susceptibility susceptible Ticam2 TLR signaling pathways Viral load viral titer virus titer weight weight loss [DOI] 10.1534/g3.117.041434 PMC 바로가기 [Article Type] Multiparental Populations
Evidence for the evolutionary steps leading to mecA -mediated β-lactam resistance in staphylococci포도상구균에서 mecA 매개 β-락탐 내성으로 이어지는 진화 단계에 대한 증거Research Article Published on 2017-04-102022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] accumulation acquisition adaptation Amino acid Analysis antibiotic Antibiotic resistance Antibiotics Author Bacteria Bacterial Bayesian analysis binding binding domain cell wall cell wall synthesis changes in chromosome Community core genome development domain driving epidemiologically Evolution exposure to food additives gene encoding Genetic genetic background genomes highlight homologue identify involved isolates livestock mechanism mechanisms methicillin methicillin-resistant Staphylococcus aureus Mortality MRSA mutation rate Mutation rates non-binding nucleotide occur occurred oxacillin Pandemics PBP penicillin phenotype Phylogenetic analysis precursor predicted profiles promoter promoters Protein representing resistance gene resource responsible S . aureus SCC selective sequence sequence alignments sequenced genome single-nucleotide polymorphism SNP species Spread Staphylococcus Staphylococcus aureus strain Substitution substitutions susceptibility variety was performed [DOI] 10.1371/journal.pgen.1006674 PMC 바로가기 [Article Type] Research Article
Development of the full-length cDNA clones of two porcine epidemic diarrhea disease virus isolates with different virulenceResearch Article Published on 2017-03-162022-10-28 Journal: PLoS ONE [Category] Coronavirus, [키워드] 48 hours BAC Bacterial caused Cell culture Chinese chromosome clone Cluster CMV promoter development diarrhea disease Epidemic epidemic diarrhea fatality full-length cDNA genetics Genome intestinal epithelium isolate isolates pandemic parental PEDV platform replicate rescued virus Strains survived tested the vaccine tissue damage variant virulence virulent virus virus isolate [DOI] 10.1371/journal.pone.0173998 PMC 바로가기 [Article Type] Research Article
A genome wide association study identifies a lncRna as risk factor for pathological inflammatory responses in leprosy게놈 전체 관련 연구에서 lncRna가 나병의 병리학적 염증 반응에 대한 위험 인자로 확인됨Research Article Published on 2017-02-212022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 한센병, [키워드] 95% CI Affect Analysis association Brazil chromosome clinically Combined dataset disease eQTL etiologies evaluated Evidence evidence of example excessive inflammatory response experimental evidence Factor Genetic genetic control genetic factors Genetic variant Genome Genome-wide association study genomic GWAS GWAS meta-analysis Host IBD identify independent Inflammatory bowel disease inflammatory disorders Inflammatory response initial leprosy lncRNA loci locus mechanism nerve nerve damage occur offspring overlap Patient peripheral nerve reaction Reactions replicated Replication responses risk risk factor Risk factors separated SNP SNPs Support susceptibility undergo [DOI] 10.1371/journal.pgen.1006637 PMC 바로가기 [Article Type] Research Article
Interacting networks of resistance, virulence and core machinery genes identified by genome-wide epistasis analysis게놈 전반에 걸친 상위성 분석으로 식별된 저항성, 독성 및 핵심 기계 유전자의 상호 작용 네트워크Research Article Published on 2017-02-162022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, 폐렴구균 감염증, [키워드] activity Algorithm Analysis Antibiotic resistance applied approach arising Bacteria Bacterial bases Beta-lactam beta-lactam antibiotics candidate cellular change chromosome coding sequence complement contribute Critical data set data sets dataset dihydrofolate Diversity DNA driver ENhance epistasis epistatic interaction epistatic interactions Evolution experimental work functions Genes Genetic variation Genome Genome-wide association studies Genome-wide association study genomic Genomic analysis genomic data highlight human pathogen hypothese hypotheses identify Interaction interactions lack Linkage disequilibrium loci locus non-susceptibility Organisms over parameter Pathogens pbp1a phenotype pneumococcus polymorphism Polymorphisms Protein pseudouridine recent representing reveal RNA sequence sequences significantly statistical statistical model statistically Streptococcus Streptococcus pneumoniae Streptococcus pyogene Streptococcus pyogenes structural biology synthases Systems biology target targets the strongest trimethoprim underlie virulence [DOI] 10.1371/journal.pgen.1006508 PMC 바로가기 [Article Type] Research Article
Beyond the MHC: A canine model of dermatomyositis shows a complex pattern of genetic risk involving novel lociMHC 너머: 피부근염의 송곳니 모델은 새로운 유전자좌와 관련된 유전적 위험의 복잡한 패턴을 보여줍니다Research Article Published on 2017-02-032022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] affected age of onset alleles allelic combination animal model artificial selection association Autoimmune disease biological samples canine chromosome chromosomes Combination complex complex disease complex diseases components conducted conserved conserved regions contribute correlated dermatomyositis disease disease pathogenesis Disease progression disease risk driven by dysfunction encoding Evidence explain exploration Frequency gene-gene interaction Genetic genetic interactions genetic risk genetic risk factor genetic study Genome Genome-wide association studies Genome-wide association study Genotype genotype-phenotype correlation genotypic genotyping Haplotype haplotypes healthy heterogeneity high risk highlight homozygosity human populations identify immunological impacted incidence independent independent of indicated Inflammatory inflammatory disease influences Interaction inverse correlation investigated involved Isolation juvenile dermatomyositis loci major histocompatibility complex MAP3K7CL mapping MHC moderate muscle Myopathy nine PAN2 pattern Phenotypes polymorphism Probability provided Region risk risk allele skin subjects susceptibility susceptibility loci target targets the major histocompatibility thought unique utility Vasculopathy whole genome [DOI] 10.1371/journal.pgen.1006604 PMC 바로가기 [Article Type] Research Article
Ku Binding on Telomeres Occurs at Sites Distal from the Physical Chromosome Ends텔로미어의 Ku 결합은 물리적 염색체 말단에서 먼 부위에서 발생Research Article Published on 2016-12-082022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] association bind binding Cancer caused cells chromatin chromosome chromosomes complex difficulty DNA DNA binding DNA break DNA breaks DNA replication double-stranded elements elongation End facilitate finding followed by function generate Genome hallmark independent induce interstitial lead mechanism NHEJ non-homologous occur physical predict Previous studies protein-protein interaction proximal reduce Region repair Replication replication fork reported Site solution telomerase telomere telomeres transition turn yeast [DOI] 10.1371/journal.pgen.1006479 PMC 바로가기 [Article Type] Research Article