Characteristics of the emerging chicken-origin highly pathogenic H7N9 viruses: A new threat to public health and poultry industryComment Published on 2018-02-012023-06-21 Journal: The Journal of Infection [Category] 조류인플루엔자, [키워드] cleavage site H7N9 poultry [DOI] 10.1016/j.jinf.2017.09.005 [Article Type] Comment
Pathogenicity of the Egyptian A/H5N1 avian influenza viruses in chickensArticle Published on 2017-09-012023-06-02 Journal: Microbial pathogenesis [Category] 조류인플루엔자, [키워드] Clade 2.2.1.2 cleavage site Egypt H5N1 highly pathogenic avian influenza IVPI Mean death time pathogenicity [DOI] 10.1016/j.micpath.2017.07.026
Identification and characterization of a Golgi retention signal in feline coronavirus accessory protein 7bResearch Article Published on 2017-08-312022-10-30 Journal: The Journal of General Virology [Category] Coronavirus, MERS, [키워드] accessory protein addition approach C-terminal C-terminus cause cells cellular cellular trafficking changes in cleavage site Control coronavirus coronavirus accessory proteins Effect Endoplasmic reticulum expressing expression Feline coronavirus Feline infectious peritonitis FIVE FLAG-tagged form functions Genetic glycosylation Golgi Golgi retention identification information investigated motif mutant N-terminal predicted processed Protein Proteins provide purified recombinant residues resulting retained retention signal reverse genetics secretion sequence Sequence analysis Substitution virus [DOI] 10.1099/jgv.0.000879 PMC 바로가기 [Article Type] Research Article
Co-circulation of paramyxo- and influenza viruses in pigeons in EgyptArticle Published on 2017-08-012023-06-02 Journal: Avian Pathology [Category] 조류인플루엔자, [키워드] cleavage site genotypes HPAIV NDV PPMV-1 [DOI] 10.1080/03079457.2017.1285391
Real-time reverse transcription PCR-based sequencing-independent pathotyping of Eurasian avian influenza A viruses of subtype H7Short Report Published on 2017-07-242023-05-31 Journal: Virology Journal [Category] Fulltext, [키워드] Avian Influenza cleavage site Diagnosis Hemagglutinin subtype H7 Pathotyping real-time RT-PCR [DOI] 10.1186/s12985-017-0808-3 PMC 바로가기 [Article Type] Short Report
Characterization of clade 2.3.4.4 H5N8 highly pathogenic avian influenza viruses from wild birds possessing atypical hemagglutinin polybasic cleavage sitesArticle Published on 2017-02-012023-06-21 Journal: Virus Genes [Category] 조류인플루엔자, [키워드] Clade 2.3.4.4 cleavage site H5N8 subtype highly pathogenic avian influenza virulence wild bird [DOI] 10.1007/s11262-016-1399-6
A camel-derived MERS-CoV with a variant spike protein cleavage site and distinct fusion activation propertiesOriginal Article Published on 2016-12-212022-10-31 Journal: Emerging Microbes & Infections [Category] Coronavirus, [키워드] Activation assays Camel cleavage cleavage site complex coronavirus Critical demonstrated Efficiency Evolution furin fusion activation Human infectivity assay MERS MERS-CoV Middle East motif outbreak peptide protease protein cleavage Pseudotyped virus reduced respiratory syndrome coronavirus resulting retained Serine shown spike Spike protein Substitution the spike protein variant variant spike viral entry viral tropism virus western blot [DOI] 10.1038/emi.2016.125 PMC 바로가기 [Article Type] Original Article
The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase VariationPilin N-말단 도메인은 Pilus 단계 변이 동안 Neisseria gonorrhoeae 변환 능력을 유지합니다Research Article Published on 2016-05-232022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] adaptation Amino acid amino acids Antibiotic resistance antigenic variant antigenic variation Bacteria bacterium can not Cell cleavage cleavage site competence Critical Defense demonstrated DNA domain ELISA ELISAs exhibited fiber foreign DNA form function gene transfer genetic determinant genetic determinants gonococcal gonococcal infection gonorrhea horizontal gene Horizontal gene transfer human pathogen Immune escape Infection isolates killing lead locus maintain mechanism Microscopy morphology Mutagenesis Mutation N-terminal N-terminal domain N-terminus natural transformation Neisseria gonorrhoeae neutrophil nonsense mutation Nonsense mutations nucleotide occur pathogenic phase PilE pili pilin pilus producing Protein purification Recombination recombination event Release released required residue residues responsible retained sexually transmitted infection single nucleotide Spread strain Strains subunit the disease these cell These cells thought transfer transformation transmitted twitching Type Type IV pilus undetectable unique uptake variant while wild-type [DOI] 10.1371/journal.pgen.1006069 PMC 바로가기 [Article Type] Research Article
Cleavage of a Neuroinvasive Human Respiratory Virus Spike Glycoprotein by Proprotein Convertases Modulates Neurovirulence and Virus Spread within the Central Nervous SystemResearch Article Published on 2015-11-062022-10-29 Journal: PLoS Pathogens [Category] Coronavirus, MERS, [키워드] affecting Amino acid amino acid change amino acid residue appear ATCC cDNA Central nervous system characterized cleavage cleavage site clone CNS colds contribute convertase coronavirus degenerative demonstrated dissemination Encephalitis etiologies feature functional functions furin-like cleavage site generate Genes glycoprotein HCoV-OC43 Human human respiratory tract identify Impact in viral Infection involved isolate isolates Laboratory less mechanism molecular Mutation nervous neurodegenerative Neuroinvasive neurologic neurological Neurological diseases neurotropic OC43 pathogenic Pathologies pathology Point mutation predominant proportion Proprotein Protein respiratory respiratory pathogen resulting retained S gene S glycoprotein S protein S1 and S2 sequence significantly spike System the S protein variant viral spike virulence virus virus spread while [DOI] 10.1371/journal.ppat.1005261 PMC 바로가기 [Article Type] Research Article
Novel Betacoronavirus in Dromedaries of the Middle East, 2013Research Published on 2014-04-012022-10-31 Journal: Emerging Infectious Diseases [Category] Coronavirus, [키워드] Analysis association Betacoronavirus Camel camel coronavirus cleavage site Complete conducted coronavirus DcCoV DcCoVUAE-HKU23 dromedaries Dromedary dromedary camel coronavirus UAE-HKU23 dromedary coronavirus Dubai Fecal sample G+C Genome genomes humans infect Lineage membrane protein MERS-CoV Middle East Middle East respiratory syndrome Coronavirus novel novel Betacoronavirus nucleocapsid protein phylogenetically serum sample Surveillance tested United Arab Emirates virus virus transmission viruses zoonoses [DOI] 10.3201/eid2004.131769 PMC 바로가기 [Article Type] Research