A comprehensive analysis of COVID-19 transmission and mortality rates at the county level in the United States considering socio-demographics, health indicators, mobility trends and health care infrastructure attributesResearch Article Published on 2021-04-012022-10-28 Journal: PLoS ONE [Category] COVID-19, MERS, [키워드] agency Analysis analyzed approach attribute Care comprehensive analysis contribute COVID-19 COVID-19 mortality COVID-19 transmission disease effort evaluate evaluated Factor Factors Government group Health HIV identify individuals intensive care unit linear mixed model Linear regression mortality rate mortality rates predict proportion reduced reduction Region Research sensitivity analysis subset Support the United State Transmission transmission rate vaccination [DOI] 10.1371/journal.pone.0249133 PMC 바로가기 [Article Type] Research Article
Impact of COVID-19 on the social, economic, environmental and energy domains: Lessons learnt from a global pandemicReview article Published on 2021-04-012022-10-05 Journal: Sustainable Production and Consumption [Category] 신약개발, [키워드] affected Analysis benefit comprehensive analysis coronavirus vaccine COVID-19 COVID-19 outbreak Delay domain domains ecological Efficacy Environmental pollution expected global pandemic globe growth Health Impact information lesson NO2 emission pandemic PM emission preventive measure quarantine reduce response robust SARS-CoV-2 significantly Spread Transmission virus Waste generation [DOI] 10.1016/j.spc.2020.10.016 [Article Type] Review article
Integrated characterization of SARS-CoV-2 genome, microbiome, antibiotic resistance and host response from single throat swabsArticle Published on 2021-03-302022-10-04 Journal: Cell Discovery [Category] 진단, [키워드] Accuracy acute respiratory syndrome Antibiotic resistance approach caused clinical sample comprehensive analysis coronavirus coronavirus disease COVID-19 COVID-19 patient Critical demonstrated diagnostic Diseases Genome Host host response IMPROVE Infection information Metatranscriptomic analysis Microbiome pandemic pathogen Pathogenesis performed Rapid RNA-Seq SARS-CoV-2 SARS-CoV-2 genome sequencing data Therapies throat swab throat swabs time-consuming transcriptomics Transposition [DOI] 10.1038/s41421-021-00248-3 PMC 바로가기 [Article Type] Article
Comprehensive transcriptomic analysis of COVID-19 blood, lung, and airwayArticle Published on 2021-03-292022-10-04 Journal: Scientific Reports [Category] SARS, 신약개발, 임상, 치료제, [키워드] absence Activation airway approach Blood carried Cell clearance Comprehensive comprehensive analysis Computational biology and bioinformatics contribute coronavirus COVID-19 COVID-19 pandemic COVID-19 pathogenesis COVID-19 patients disease pathogenesis driven by drugs Gene Expression gene expression profile host response identify Infection Inflammation Inflammatory Inflammatory mediators Innate immune cells lung myeloid cell pathogenesis of COVID-19 patients Population potential therapeutic target SARS-CoV2 therapy transcriptional transcriptomic transcriptomic analysis viral infection virus [DOI] 10.1038/s41598-021-86002-x PMC 바로가기 [Article Type] Article
Myoglobin and C-reactive protein are efficient and reliable early predictors of COVID-19 associated mortality미오글로빈 및 C 반응성 단백질은 COVID-19 관련 사망률의 효율적이고 신뢰할 수 있는 조기 예측 인자입니다Article Published on 2021-03-162022-09-01 Journal: Scientific Reports [Category] SARS, 바이오마커, 임상, 진단, [키워드] age average Biomarkers Blood BNP C-reactive protein cardiac injury collected Comorbidities Comorbidity comprehensive analysis Consensus correlated COVID-19 COVID-19 disease COVID-19 severity CRE CRP D-dimer Deceased demise determine diagnosed with COVID-19 dysfunction elevated full recovery Health care hepatic impairment Huoshenshan Hospital indicated initial symptoms Laboratory lack LDH Medical research Mortality multiple organ failure Myoglobin onset of symptom Organ failure Patient patients predict predictor renal renal damage retrospective cohort study risk factor Risk factors SARS-CoV-2 severely ill patient significantly Signs and symptoms troponin Troponin-I Wuhan [DOI] 10.1038/s41598-021-85426-9 PMC 바로가기 [Article Type] Article
Elucidating the Antiviral Mechanism of Different MARCH FactorsResearch Article Published on 2021-03-022022-10-29 Journal: mBio [Category] COVID-19, [키워드] antiretroviral Antiviral Cell comprehensive analysis E3 ubiquitin ligases envelope glycoproteins Factor glycoprotein HIV-1 homologues host restriction factors Human immunodeficiency virus Immunity Infection information intrinsic mechanism Murine leukemia virus plasma membrane Protein Proteins recent reducing restrict retrovirus retroviruses shown transmembrane protein virions viruses [DOI] 10.1128/mBio.03264-20 PMC 바로가기 [Article Type] Research Article
Inhibitory efficiency of potential drugs against SARS-CoV-2 by blocking human angiotensin converting enzyme-2: Virtual screening and molecular dynamics study인간 안지오텐신 전환 효소-2를 차단하여 SARS-CoV-2에 대한 잠재적 약물의 억제 효율: 가상 스크리닝 및 분자 역학 연구Article Published on 2021-03-012022-08-31 Journal: Microbial pathogenesis [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 ACE-2 receptor Analysis angiotensin anti-bacterial anti-viral drug Anti-viral drugs best bind binding affinity binding site block blocking Cefpiramide comprehensive analysis COVID-19 CPM drug effective Efficiency enzyme gyration highest binding affinity human Angiotensin-converting enzyme molecular molecular docking molecular dynamics Molecular dynamics simulation parameter radius of gyration receptor RMSD RMSF SARS-CoV-2 SARS-CoV-2 spike protein screened selected solvent Spike protein surface area Till Vaccine virus [DOI] 10.1016/j.micpath.2021.104762 PMC 바로가기 [Article Type] Article
DisCoVering potential candidates of RNAi-based therapy for COVID-19 using computational methodsBioinformatics Published on 2021-02-262022-10-28 Journal: PeerJ [Category] COVID-19, [키워드] Analysis bat candidate comprehensive analysis computational approach computational method conducted conserved COVID-19 down-regulate experimental validation facilitate FIVE high affinity humans implementation independent International Intervention material miRNA miRNA-mRNA interaction Novel coronavirus pandemic Region RNA RNA interference RNA intervention-based therapy SARS-CoV-2 Side effect Side effects siRNA siRNA design suggested the SARS-CoV-2 genome therapy therapy for COVID-19 time-consuming Treatment viral infections Virology [DOI] 10.7717/peerj.10505 PMC 바로가기 [Article Type] Bioinformatics
A Negative Feedback Model to Explain Regulation of SARS-CoV-2 Replication and TranscriptionGenetics Published on 2021-02-262022-10-31 Journal: Frontiers in Genetics [Category] COVID-19, [키워드] acute respiratory syndrome caused cleavage site cleaving comprehensive analysis Control coronavirus Coronavirus disease 2019 CoV CoV replication COVID-19 CoVs derivatives drug explain expression level feedback Gene Expression genome sequence genomic RNA hosts influence knowledge mechanism Model molecular basis motif negative Nsp15 persistence proportion Protein regulate regulated Regulation regulation model Replication Result RNA SARS-CoV-2 sgRNA sgRNAs subgenomic RNA Transcription transcription regulatory sequence TRS TRSs turn uridine [DOI] 10.3389/fgene.2021.641445 PMC 바로가기 [Article Type] Genetics
Distinct antibody repertoires against endemic human coronaviruses in children and adultsResearch Article Published on 2021-02-222022-10-30 Journal: JCI Insight [Category] COVID-19, MERS, [키워드] Acidic Acute respiratory infection antibody antibody repertoire Antibody Response B cell epitopes B cell response children Cohort comprehensive analysis conserved Coronavirus infection Coronaviruses cross-reactive dominant donors endemic HCoV endemic human coronavirus Epidemic fusion peptide HCoV-HKU1 human antibody response humans IgG immunoglobulins immunology immunoprecipitation Infectious disease linear monoclonal antibody N-terminal nucleocapsid peptide polyprotein predominant Prophylactic Proteins ranged Region S2′ cleavage Sequencing Seroprevalence specificity the spike protein therapeutic Vaccine design virus [DOI] 10.1172/jci.insight.144499 PMC 바로가기 [Article Type] Research Article