Network controllability solutions for computational drug repurposing using genetic algorithmsArticle Published on 2022-01-262022-10-04 Journal: Scientific Reports [Category] 신약개발, [키워드] Algorithm Algorithms approaches Cancer Combination drug therapy Computational drug connection Control theory disease drug target FDA-approved drug Genetic Intervention network Network topology offer oncology protein-protein interaction random Research seeking target therapeutic Topic [DOI] 10.1038/s41598-022-05335-3 PMC 바로가기 [Article Type] Article
Innate Immune Responses of Vaccinees Determine Early Neutralizing Antibody Production After ChAdOx1nCoV-19 VaccinationImmunology Published on 2022-01-252022-11-01 Journal: Frontiers in Immunology [Category] COVID-19, [키워드] Activation adaptive adenoviral vector vaccine adenovirus vector vaccine age antibody Antibody titer association AZD1222 B cell CD14 CD27 CD3 CD56 CD86 Cell ChAdOx1 nCoV-19 collected connection correlated CpG Critical cytokine production double-negative B cell enrolled Ex vivo expression first vaccination FIVE flow cytometry granzyme B IFN-γ IGD imiquimod Immune cell immune response Immunity immunosenescence information Innate innate immune innate immune activation innate immune response Innate immunity LPS marker memory B cell monocyte naïve naïve B cell natural killer neutralization Neutralizing antibodies neutralizing antibody NK cell Older pattern recognition receptor Production response responses Result SARS-CoV-2 vaccines SARS-CoV2 serum significantly higher stimulated subject sVNT TLR TLR agonist TLR stimulation TLR9 Toll-like receptor vaccination vaccinee Virus neutralization were measured [DOI] 10.3389/fimmu.2022.807454 PMC 바로가기 [Article Type] Immunology
Parkinson’s Disease in Light of the COVID-19 PandemicReview Published on 2022-01-212022-10-28 Journal: Brain Sciences [Category] COVID-19, [키워드] acute respiratory syndrome assumption Clinical course connection coronavirus coronavirus disease cough Course COVID-19 Dyspnea etiology Evidence Gut impairment include initial LIGHT Meta-analysis Microbiome muscles Parkinson’s disease Parkinson’s disease Parkinsonism pathophysiology Patient rigidity SARS-CoV-2 susceptible Symptoms viral infection [DOI] 10.3390/brainsci12020143 PMC 바로가기 [Article Type] Review
Nosocomial transmission clusters and lineage diversity characterized by SARS-CoV-2 genomes from two large hospitals in Paris, France, in 20202020 년 프랑스 파리의 두 대형 병원의 SARS-COV-2 게놈을 특징으로하는 병원 전달 클러스터 및 계통 다양성Clinical Trial Published on 2022-01-202022-09-10 Journal: Scientific Reports [Category] 변종, 임상, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 change characterized clade clades Cluster Clustering Clusters connection Contamination coronavirus Course COVID-19 epidemic wave epidemic waves epidemiological data Epidemiology France genetic diversity Genome sequencing HCW HCWs Health care Health care worker health care workers healthcare help highest hospital hospitals identify incidence involved joint Lineage Next-generation sequencing nosocomial Nosocomial transmission pandemic Paris participant Patient performed Phylogenetic Phylogenetic analysis Phylogeny potential transmission prevalent proportion public health Region respiratory SARS-CoV-2 SARS-CoV-2 genome Sequencing severe acute respiratory syndrome Coronavirus summer the SARS-CoV-2 transmission clusters two groups Viral viral epidemiology viral evolution viral infection were used [DOI] 10.1038/s41598-022-05085-2 PMC 바로가기 [Article Type] Clinical Trial
Experiences of Black and Latinx health care workers in support roles during the COVID-19 pandemic: A qualitative studyResearch Article Published on 2022-01-182022-10-28 Journal: PLoS ONE [Category] COVID-19, SARS, [키워드] assistant black Care changed changes in Community condition conducted connection coronavirus disease COVID-19 Critical described English examined experience HCW HCWs Health Health care worker health systems healthcare Healthcare system IMPROVE individuals infecting information Latinx Nurses pandemic participant Patient care patients Perspective physician public health emergency reduced reported Resilience resource Spanish Spanish language Stress suffered Support their family members vaccination Vaccine women [DOI] 10.1371/journal.pone.0262606 PMC 바로가기 [Article Type] Research Article
A Comparative and Comprehensive Review of Antibody Applications in the Treatment of Lung DiseaseReview Published on 2022-01-172022-10-29 Journal: International Review of Cell and Molecular Biology [Category] COVID-19, [키워드] ACE2 protein addition antibodies antibody Antigen application Autoimmune disease B cell benefit bioinformatics Cancer cancer patient Cancer patients Clinical use Comparative Comprehensive connection COVID-19 CTLA-4 cytokine debatable disease Diseases explain IL-1β IL-6 immune Immunotherapy Infectious disease mechanism monoclonal antibody neutralizing antibody Patient PD-L1 potential mechanism produced Protein provided review signaling pathway somatic cells subsequent therapeutic effect therapy Treatment tyrosine Vaccine VEGF virus entry [DOI] 10.3390/life12010130 PMC 바로가기 [Article Type] Review
Increase in Depression and Anxiety Among Australian Gay and Bisexual Men During COVID-19 Restrictions: Findings from a Prospective Online Cohort StudySpecial Section: Impact of Covid-19 on Sexual Health and Behavior Published on 2022-01-172022-10-28 Journal: Archives of Sexual Behavior [Category] COVID-19, SARS, [키워드] Anxiety assessment Cohort conducted connection COVID-19 COVID-19 pandemic defined Depression determine examined finding GAD-7 gay Gay and bisexual men Generalized Impact increase Increased Increases men mental health moderate-severe participant PHQ-9 proportion Prospective reduction in required sexual orientation supplementary material Support [DOI] 10.1007/s10508-021-02276-2 PMC 바로가기 [Article Type] Special Section: Impact of Covid-19 on Sexual Health and Behavior
Integrative COVID-19 biological network inference with probabilistic core decompositionArticle Published on 2022-01-172022-10-04 Journal: Briefings in Bioinformatics [Category] SARS, 신약개발, [키워드] acute respiratory syndrome addition Comorbidities connection contribute core Core Decomposition coronavirus COVID-19 Data analysis Data mining database death disease enrichment analysis evaluate gene function generate Genes graph Graph theory help hypothese hypotheses identify in silico Inference information knowledge network Network Inference. overlap PPI PPI network Protein protein interactions protein-protein interaction Proteins responsible SARS-CoV-2 Support targeting gene tissue virus [DOI] 10.1093/bib/bbab455 PMC 바로가기 [Article Type] Article
Infant Pneumococcal Carriage in Belgium Not Affected by COVID-19 Containment Measures벨기에의 유아 폐렴구균 보유는 COVID-19 방역 조치의 영향을 받지 않음Cellular and Infection Microbiology Published on 2022-01-172022-10-31 Journal: Frontiers in Cellular and Infection Microbiology [Category] COVID-19, SARS, 폐렴구균 감염증, [키워드] bacterial species Belgium carriage carried caused children connection Containment Containment measure containment measures COVID-19 COVID-19 pandemic disease Diseases healthy Infant Invasion invasive invasive disease invasive pneumococcal disease Mask measure Measures Meningitis Microbiome nasopharyngeal nasopharyngeal carriage Older performed pneumococcal pneumococci Pneumonia Protective reduction in respiratory pathogen Sepsis social distancing Spread Streptococcus pneumoniae sustained the SARS-CoV-2 virus Transmission [DOI] 10.3389/fcimb.2021.825427 PMC 바로가기 [Article Type] Cellular and Infection Microbiology
The COVID-19 Infection Diffusion in the US and Japan: A Graph-Theoretical ApproachArticle Published on 2022-01-132022-10-28 Journal: Biology [Category] COVID-19, [키워드] analyzed application applied approach Clustering complex conducted confirmed case connection Coronavirus disease 2019 country COVID-19 COVID-19 pandemic COVID-19 virus diffusion domain Effect Efficiency explained globe Graph theory hypothese Infection Japan linear Local methodology Metrics network density pandemic pandemic diffusion quantitative assessment Region regions Research Scientific community selected simple Spread virus [DOI] 10.3390/biology11010125 PMC 바로가기 [Article Type] Article