A population-based cohort study of obesity, ethnicity and COVID-19 mortality in 12.6 million adults in EnglandArticle Published on 2022-02-022022-10-04 Journal: Nature Communications [Category] MERS, 치료법, [키워드] association black BMI body mass index census Combination COVID-19 COVID-19 mortality death Electronic health record Electronic health records England Epidemiology ethnic group examined groups Mortality mortality data National obesity outcomes pandemic population-based cohort resulting risk risk factor Risk factors risk of COVID-19 SARS-CoV-2 severe COVID-19 disease South Asian with COVID-19 [DOI] 10.1038/s41467-022-28248-1 PMC 바로가기 [Article Type] Article
Fire association with respiratory disease and COVID-19 complications in the State of Pará, BrazilResearch article Published on 2022-02-012022-10-05 Journal: The Lancet Regional Health - Americas [Category] 유전자 메커니즘, [키워드] accompanied affected Algorithm Analysis ARIMAX association average Brazil caused Cluster Clustering confidence level contribute COVID COVID-19 COVID-19 complication COVID-19 mortality COVID-19 pandemic Critical death deaths development environmental factor evaluate Exogenous finding fire funding funding source GDP Gross group Health high mortality rate highest highlight Hospitalization hospitalizations Human identify incidence rate Incidence rate ratio index K-Means knowledge lowest measure Mortality mortality rate mortality risk Occurrence Pandemics problem product public health Region required Respiratory disease respiratory diseases risk SARS-CoV-2 selected serial correlation state Support Time series analysis [DOI] 10.1016/j.lana.2021.100102 [Article Type] Research article
Calming the cytokine storm of COVID-19 through inhibition of JAK2/STAT3 signalingJAK2/STAT3 신호 전달 억제를 통한 코로나19 사이토카인 폭풍 진정Review Published on 2022-02-012022-09-11 Journal: Drug discovery today [Category] 변종, 신약개발, 치료제, [키워드] acute respiratory distress acute respiratory distress syndrome acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Antiviral treatment caused clinically evaluated coronavirus COVID-19 COVID-19 mortality COVID-19 pandemic cytokine release Cytokine storm drug Drug discovery effective antiviral treatment herd immunity hyper-inflammation Immunity JAK inhibitor jak inhibitors JAK/STAT signaling JAK2/STAT3 life-threatening lung Lungs New outbreak Pathways Patient reached reported respiratory distress Respiratory failure SARS-CoV-2 SARS-COV-2 infection severe acute respiratory syndrome Coronavirus severe COVID-19 Signaling STAT syndrome the cytokine storm tissue damage Treatment Vaccines viral variant Viral variants [DOI] 10.1016/j.drudis.2021.10.016 PMC 바로가기 [Article Type] Review
The link between Toxoplasma gondii infections and higher mortality in COVID-19 patients having schizophrenia톡소플라스마 곤디(Toxoplasma gondii) 감염과 정신분열증이 있는 COVID-19 환자의 사망률 증가 사이의 연관성Meta-Analysis Published on 2022-02-012022-09-12 Journal: European archives of psychiatry and clinical neuro [Category] MERS, 진단, [키워드] addition age antibody Brain infections COVID-19 COVID-19 infection COVID-19 mortality COVID-19 patient General population indicate indicated Infection infections Latent Latent infections likelihood Meta-analysis Mortality mortality rate Odds ratio Patient patients Protozoa protozoan infections reported resulting Risk factors SARS-COV-2 infection Schizophrenia Sex Toxoplasma gondii [DOI] 10.1007/s00406-021-01341-0 PMC 바로가기 [Article Type] Meta-Analysis
Spatio-temporal modeling of COVID-19 prevalence and mortality using artificial neural network algorithmsResearch article Published on 2022-02-012022-10-05 Journal: Spatial and spatio-temporal epidemiology [Category] COVID19(2023년), SARS, 변종, [키워드] Algorithm Analysis Artificial neural network concerning coronavirus disease COVID-19 COVID-19 mortality diabete disease GIS highest hospital identify indicated MONITOR Mortality outbreak Prevalence public health Research significant variables Spatio-temporal analysis Spread Support Topology variable Variable importance analysis variables while [DOI] 10.1016/j.sste.2021.100471 [Article Type] Research article
An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection실리코 분석은 SARS-CoV-2 감염에 의해 유발된 사이토카인 폭풍을 잠재적으로 조절하는 약물을 식별합니다Article Published on 2022-01-312022-09-10 Journal: Scientific Reports [Category] 신약개발, 유전자 메커니즘, 치료제, [키워드] “cytokine storm” addition Analysis anti-inflammatory properties anti-inflammatory property approach BALF Bronchoalveolar lavage fluid cause causes Computational biology and bioinformatics connectivity COVID-19 COVID-19 mortality COVID-19 pandemic COVID-19 patient Cytokines Data mining dataset drug Effect expected female hormone glucocorticoid Glucocorticoids Health help human cell lines identify immune response immune responses in silico analysis in vitro data Inflammatory Map MEK inhibitor modulating molecules Mortality negative regulation pathology pathway Pathways PKC predicted reveal SARS-CoV-2 SARS-COV-2 infection small molecule Small molecules supported the cytokine storm these compounds Transcription Transcriptome transcriptomic data Treatment triggered [DOI] 10.1038/s41598-022-05597-x PMC 바로가기 [Article Type] Article
Influence of state reopening policies in COVID-19 mortalityArticle Published on 2022-01-312022-10-04 Journal: Scientific Reports [Category] 치료기술, [키워드] adopted approach Computational models correlation COVID-19 mitigation measures COVID-19 mortality death Effectiveness Epidemiology Face mask Government hypothetical influence measure Pearson correlation coefficient Population dynamics provide question shown significant difference [DOI] 10.1038/s41598-022-05286-9 PMC 바로가기 [Article Type] Article
Efficacy of antiviral therapies for COVID-19: a systematic review of randomized controlled trialsCOVID-19에 대한 항 바이러스 요법의 효능 : 무작위 대조 시험의 체계적인 검토Research Published on 2022-01-312022-09-10 Journal: BMC Infectious Diseases [Category] SARS, 임상, 치료제, [키워드] Administered Antiviral antiviral therapy Antiviral treatment approved article Clinical improvement clinical outcomes controlled trials coronavirus disease Coronavirus disease 2019 Course COVID-19 COVID-19 mortality COVID-19 patients COVID-19 treatment daclatasvir demonstrated Descriptive statistics disease course effective Efficacy Evidence examined exhibited guideline heterogeneity identify improve clinical outcome include inferential statistics network not performed patients performed public health randomized clinical trial randomized clinical trials Randomized controlled trial Randomized controlled trials RCT reducing reducing mortality Remdesivir Result retrieved SARS-CoV-2 Scottish sofosbuvir sofosbuvir/daclatasvir Statistical power study heterogeneity suggested supplementary material systematic literature search systematic review the disease therapeutic Time to recovery Treatment trials was performed were excluded were expressed [DOI] 10.1186/s12879-022-07068-0 PMC 바로가기 [Article Type] Research
Serum Vitamin D Levels Are Associated With Increased COVID-19 Severity and Mortality Independent of Whole-Body and Visceral AdiposityNutrition Published on 2022-01-262022-10-31 Journal: Frontiers in Nutrition [Category] COVID-19, [키워드] 95%CI Adipose tissue adjusted age association BMI body-mass clinical evaluation Computerized tomography contribute COVID-19 COVID-19 mortality Critical D-dimer Deficient defined disease evaluated examined fat Follow-up global pandemic Increased increased risk independent independent of Infectious disease laboratory measurement Level Mediation analysis Mexico City Mortality outcome outcomes Patient pro-inflammatory pro-thrombotic Result risk SARS-CoV-2 severe COVID-19 Sex susceptibility Thoracic visceral Vitamin D vitamin D deficiency vitamin D level with COVID-19 [DOI] 10.3389/fnut.2022.813485 PMC 바로가기 [Article Type] Nutrition
A Tale of Two Surges: Differences in Outcomes in the COVID-19 Pandemic in a Community Teaching Hospital in MassachusettsInternal Medicine Published on 2022-01-242022-10-31 Journal: Cureus [Category] COVID-19, [키워드] acute respiratory syndrome Admission antiviral therapy both group Care CCI center Characteristics Charlson Comorbidity Index Clinical data clinical outcomes Community Comorbidity conducted coronavirus coronavirus disease Corticosteroid COVID-19 COVID-19 cases COVID-19 mortality death Dementia diabetes difference DNR English examined hospital ICU implementation independent Infection infectious disease medicine information Inpatient intensive care Lung disease Massachusett Mechanical mechanical ventilation median median age Mortality obesity outcome overall mortality pandemic Patient patients patients with COVID-19 PCR polymerase chain predicted primary endpoint Remdesivir reported required Result retrospective research SARS-CoV-2 Scientific community survival Teaching the patient Therapies Treatment Ventilation [DOI] 10.7759/cureus.21547 PMC 바로가기 [Article Type] Internal Medicine